The cytoplasmic part of L1-CAM controls growth and gene expression in human tumors that is reversed by therapeutic antibodies View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2008-02

AUTHORS

D Gast, S Riedle, Y Issa, M Pfeifer, P Beckhove, M P Sanderson, M Arlt, G Moldenhauer, M Fogel, A Krüger, P Altevogt

ABSTRACT

L1 cell adhesion molecule (L1-CAM) is a transmembrane cell adhesion molecule involved in cell migration and axon guidance in the developing nervous system. L1 is also overexpressed in ovarian and endometrial carcinomas and is associated with a bad prognosis. In carcinoma cell lines, L1 overexpression augments cell motility, tumor growth in mice and induces expression of Erk-dependent genes. Here, we show that a mutation in the cytoplasmic portion of L1 (T1247A, S1248A) abrogates Erk activation, blocks cell migration on extracellular matrix proteins and did not augment tumor growth in non-obese diabetic/severe combined immuno-deficient mice. In cells expressing mutant L1, the induction of Erk-dependent genes such as beta3-integrin, cathepsin-B and several transcription factors is eliminated and the invasive phenotype is abrogated. L1 antibodies showed similar effects. They prevented Erk activation and interfered with the Erk-dependent gene expression pattern. These findings provide a rationale for the mode of action of L1 antibodies and suggest that interference with L1 function could become a valuable target for therapy. More... »

PAGES

1210747

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/sj.onc.1210747

DOI

http://dx.doi.org/10.1038/sj.onc.1210747

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1007818304

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/17952127


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antibodies, Monoclonal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Line", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Line, Tumor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Proliferation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cytoplasm", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Expression Regulation, Neoplastic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Inbred NOD", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, SCID", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasm Invasiveness", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasms, Experimental", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neural Cell Adhesion Molecule L1", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein Structure, Tertiary", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "German Cancer Research Center", 
          "id": "https://www.grid.ac/institutes/grid.7497.d", 
          "name": [
            "Tumor Immunology Programme, German Cancer Research Center, Heidelberg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gast", 
        "givenName": "D", 
        "id": "sg:person.01270134306.10", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01270134306.10"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "German Cancer Research Center", 
          "id": "https://www.grid.ac/institutes/grid.7497.d", 
          "name": [
            "Tumor Immunology Programme, German Cancer Research Center, Heidelberg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Riedle", 
        "givenName": "S", 
        "id": "sg:person.0732007421.57", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0732007421.57"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "German Cancer Research Center", 
          "id": "https://www.grid.ac/institutes/grid.7497.d", 
          "name": [
            "Tumor Immunology Programme, German Cancer Research Center, Heidelberg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Issa", 
        "givenName": "Y", 
        "id": "sg:person.01156570474.48", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01156570474.48"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "German Cancer Research Center", 
          "id": "https://www.grid.ac/institutes/grid.7497.d", 
          "name": [
            "Tumor Immunology Programme, German Cancer Research Center, Heidelberg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pfeifer", 
        "givenName": "M", 
        "id": "sg:person.01272014534.73", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01272014534.73"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "German Cancer Research Center", 
          "id": "https://www.grid.ac/institutes/grid.7497.d", 
          "name": [
            "Tumor Immunology Programme, German Cancer Research Center, Heidelberg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Beckhove", 
        "givenName": "P", 
        "id": "sg:person.0706377750.28", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0706377750.28"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "German Cancer Research Center", 
          "id": "https://www.grid.ac/institutes/grid.7497.d", 
          "name": [
            "Tumor Immunology Programme, German Cancer Research Center, Heidelberg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sanderson", 
        "givenName": "M P", 
        "id": "sg:person.0767456534.07", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0767456534.07"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Technical University Munich", 
          "id": "https://www.grid.ac/institutes/grid.6936.a", 
          "name": [
            "Institute for Experimental Oncology and Therapy, Technical University of Munich, Munich, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Arlt", 
        "givenName": "M", 
        "id": "sg:person.0774725375.71", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0774725375.71"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "German Cancer Research Center", 
          "id": "https://www.grid.ac/institutes/grid.7497.d", 
          "name": [
            "German Cancer Research Center, Heidelberg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Moldenhauer", 
        "givenName": "G", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Kaplan Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.415014.5", 
          "name": [
            "Department of Pathology, Kaplan Medical Center, Rehovot, Israel"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fogel", 
        "givenName": "M", 
        "id": "sg:person.0660756606.71", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0660756606.71"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Technical University Munich", 
          "id": "https://www.grid.ac/institutes/grid.6936.a", 
          "name": [
            "Institute for Experimental Oncology and Therapy, Technical University of Munich, Munich, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kr\u00fcger", 
        "givenName": "A", 
        "id": "sg:person.01334512522.20", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01334512522.20"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "German Cancer Research Center", 
          "id": "https://www.grid.ac/institutes/grid.7497.d", 
          "name": [
            "Tumor Immunology Programme, German Cancer Research Center, Heidelberg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Altevogt", 
        "givenName": "P", 
        "id": "sg:person.01000067774.85", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01000067774.85"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1074/jbc.274.53.37965", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000611879"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-06-2106", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000936104"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ijc.21880", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001898993"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ijc.21880", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001898993"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-06-1486", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004568481"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1096/fj.02-0430fje", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004971226"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1471-4159.2005.03254.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005275712"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1523/jneurosci.4097-04.2005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007271821"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ijc.20869", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008274489"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ijc.20869", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008274489"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ijc.20869", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008274489"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ijc.20869", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008274489"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/334701a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010624456", 
          "https://doi.org/10.1038/334701a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1034/j.1600-0749.2001.140202.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011447627"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m404075200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022832939"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-05-1818", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027935486"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/bies.10355", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028273713"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/glia.10058", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028730305"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0896-6273(94)90339-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030996224"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0959-8049(02)00105-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033051259"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(03)14342-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034562480"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0304-3835(02)00513-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035454268"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0304-3835(02)00513-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035454268"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.275.20.15490", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036513192"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/excr.1997.3877", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036577492"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.humpath.2006.03.014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037524996"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bjc.1987.276", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041443389", 
          "https://doi.org/10.1038/bjc.1987.276"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1471-4159.2006.03649.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047670933"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.200101099", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048110820"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.19.4.2435", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048446985"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1535-6108(03)00169-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050785006"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.200408051", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052438328"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1523/jneurosci.20-11-04177.2000", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074642347"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1523/jneurosci.22-12-04918.2002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1075073769"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1523/jneurosci.22-12-04918.2002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1075073769"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077007510", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1096/fasebj.10.9.8801164", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1082959737"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2008-02", 
    "datePublishedReg": "2008-02-01", 
    "description": "L1 cell adhesion molecule (L1-CAM) is a transmembrane cell adhesion molecule involved in cell migration and axon guidance in the developing nervous system. L1 is also overexpressed in ovarian and endometrial carcinomas and is associated with a bad prognosis. In carcinoma cell lines, L1 overexpression augments cell motility, tumor growth in mice and induces expression of Erk-dependent genes. Here, we show that a mutation in the cytoplasmic portion of L1 (T1247A, S1248A) abrogates Erk activation, blocks cell migration on extracellular matrix proteins and did not augment tumor growth in non-obese diabetic/severe combined immuno-deficient mice. In cells expressing mutant L1, the induction of Erk-dependent genes such as beta3-integrin, cathepsin-B and several transcription factors is eliminated and the invasive phenotype is abrogated. L1 antibodies showed similar effects. They prevented Erk activation and interfered with the Erk-dependent gene expression pattern. These findings provide a rationale for the mode of action of L1 antibodies and suggest that interference with L1 function could become a valuable target for therapy.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/sj.onc.1210747", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1097543", 
        "issn": [
          "0950-9232", 
          "1476-5594"
        ], 
        "name": "Oncogene", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "9", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "27"
      }
    ], 
    "name": "The cytoplasmic part of L1-CAM controls growth and gene expression in human tumors that is reversed by therapeutic antibodies", 
    "pagination": "1210747", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "253e01ac92936b8e92e591a6d3d4c1181cb723031dab027086146ebc7f9640d6"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "17952127"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "8711562"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/sj.onc.1210747"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1007818304"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/sj.onc.1210747", 
      "https://app.dimensions.ai/details/publication/pub.1007818304"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T21:24", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8687_00000422.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://www.nature.com/articles/1210747"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/sj.onc.1210747'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/sj.onc.1210747'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/sj.onc.1210747'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/sj.onc.1210747'


 

This table displays all metadata directly associated to this object as RDF triples.

307 TRIPLES      21 PREDICATES      77 URIs      38 LITERALS      26 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/sj.onc.1210747 schema:about N018caf38647747288df255ad5541df61
2 N0d9ad0e93b4947718097002999100a8f
3 N18cde5ca8a3e4401835f4c0df85a26c3
4 N36e4d8e41b1741dd815b012486dee387
5 N590659602275491c9794daee447c05eb
6 N72999b77cbde413cb461af5d1de43769
7 N7b343d8960964221846adcab9c14983b
8 N7e3fd4964ec84108bdf399ef6be5b403
9 N8fc5e7fd09a04ba1ad6ef8640a2f6b33
10 Na45d0ef71e154b558feede2586df4759
11 Na991cfa2e5694336b474964b364c9f9c
12 Na993c5e5ea6a4806a93c53ff38bcf9f0
13 Nb06409dd8c20414dac07e08e25200801
14 Nb753fb35ae2f4761b955749b2427bd57
15 Nc590ad67b8b5407e96f50a34d6842bdd
16 Nd0aac9184ece4b03a5b8b2045d1c7d92
17 Nfd5e956b4304440d8bfd6c708add0440
18 anzsrc-for:06
19 anzsrc-for:0601
20 schema:author N430cad6abd4143dab8070a7e837066ea
21 schema:citation sg:pub.10.1038/334701a0
22 sg:pub.10.1038/bjc.1987.276
23 https://app.dimensions.ai/details/publication/pub.1077007510
24 https://doi.org/10.1002/bies.10355
25 https://doi.org/10.1002/glia.10058
26 https://doi.org/10.1002/ijc.20869
27 https://doi.org/10.1002/ijc.21880
28 https://doi.org/10.1006/excr.1997.3877
29 https://doi.org/10.1016/0896-6273(94)90339-5
30 https://doi.org/10.1016/j.humpath.2006.03.014
31 https://doi.org/10.1016/s0140-6736(03)14342-5
32 https://doi.org/10.1016/s0304-3835(02)00513-x
33 https://doi.org/10.1016/s0959-8049(02)00105-3
34 https://doi.org/10.1016/s1535-6108(03)00169-7
35 https://doi.org/10.1034/j.1600-0749.2001.140202.x
36 https://doi.org/10.1074/jbc.274.53.37965
37 https://doi.org/10.1074/jbc.275.20.15490
38 https://doi.org/10.1074/jbc.m404075200
39 https://doi.org/10.1083/jcb.200101099
40 https://doi.org/10.1083/jcb.200408051
41 https://doi.org/10.1096/fasebj.10.9.8801164
42 https://doi.org/10.1096/fj.02-0430fje
43 https://doi.org/10.1111/j.1471-4159.2005.03254.x
44 https://doi.org/10.1111/j.1471-4159.2006.03649.x
45 https://doi.org/10.1128/mcb.19.4.2435
46 https://doi.org/10.1158/0008-5472.can-05-1818
47 https://doi.org/10.1158/0008-5472.can-06-2106
48 https://doi.org/10.1158/1078-0432.ccr-06-1486
49 https://doi.org/10.1523/jneurosci.20-11-04177.2000
50 https://doi.org/10.1523/jneurosci.22-12-04918.2002
51 https://doi.org/10.1523/jneurosci.4097-04.2005
52 schema:datePublished 2008-02
53 schema:datePublishedReg 2008-02-01
54 schema:description L1 cell adhesion molecule (L1-CAM) is a transmembrane cell adhesion molecule involved in cell migration and axon guidance in the developing nervous system. L1 is also overexpressed in ovarian and endometrial carcinomas and is associated with a bad prognosis. In carcinoma cell lines, L1 overexpression augments cell motility, tumor growth in mice and induces expression of Erk-dependent genes. Here, we show that a mutation in the cytoplasmic portion of L1 (T1247A, S1248A) abrogates Erk activation, blocks cell migration on extracellular matrix proteins and did not augment tumor growth in non-obese diabetic/severe combined immuno-deficient mice. In cells expressing mutant L1, the induction of Erk-dependent genes such as beta3-integrin, cathepsin-B and several transcription factors is eliminated and the invasive phenotype is abrogated. L1 antibodies showed similar effects. They prevented Erk activation and interfered with the Erk-dependent gene expression pattern. These findings provide a rationale for the mode of action of L1 antibodies and suggest that interference with L1 function could become a valuable target for therapy.
55 schema:genre research_article
56 schema:inLanguage en
57 schema:isAccessibleForFree true
58 schema:isPartOf N7cb6bd59aa4e467285038c1483f3d7c6
59 Nfdca04b907eb4084ba36965b3144dbc7
60 sg:journal.1097543
61 schema:name The cytoplasmic part of L1-CAM controls growth and gene expression in human tumors that is reversed by therapeutic antibodies
62 schema:pagination 1210747
63 schema:productId N13bdc9d7c40f40a5813d57fcee985cdd
64 N76c1dfcf95f643aca234d0349a8c4a09
65 N7d027af97ab749b3af057b0386db5f1f
66 Nacbd86360dfd4bac9524a3b1d3579a3d
67 Nd1fe5da68d794976854f5861cd9fe9e2
68 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007818304
69 https://doi.org/10.1038/sj.onc.1210747
70 schema:sdDatePublished 2019-04-10T21:24
71 schema:sdLicense https://scigraph.springernature.com/explorer/license/
72 schema:sdPublisher N463233e72d5346d8b7a4b124b69c7ecd
73 schema:url http://www.nature.com/articles/1210747
74 sgo:license sg:explorer/license/
75 sgo:sdDataset articles
76 rdf:type schema:ScholarlyArticle
77 N018caf38647747288df255ad5541df61 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
78 schema:name Female
79 rdf:type schema:DefinedTerm
80 N0d9ad0e93b4947718097002999100a8f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
81 schema:name Cytoplasm
82 rdf:type schema:DefinedTerm
83 N13bdc9d7c40f40a5813d57fcee985cdd schema:name readcube_id
84 schema:value 253e01ac92936b8e92e591a6d3d4c1181cb723031dab027086146ebc7f9640d6
85 rdf:type schema:PropertyValue
86 N18cde5ca8a3e4401835f4c0df85a26c3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
87 schema:name Cell Proliferation
88 rdf:type schema:DefinedTerm
89 N36e4d8e41b1741dd815b012486dee387 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
90 schema:name Gene Expression Regulation, Neoplastic
91 rdf:type schema:DefinedTerm
92 N430cad6abd4143dab8070a7e837066ea rdf:first sg:person.01270134306.10
93 rdf:rest N8f58db4993464a02892d2c48ec7840b0
94 N463233e72d5346d8b7a4b124b69c7ecd schema:name Springer Nature - SN SciGraph project
95 rdf:type schema:Organization
96 N590659602275491c9794daee447c05eb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
97 schema:name Neural Cell Adhesion Molecule L1
98 rdf:type schema:DefinedTerm
99 N72999b77cbde413cb461af5d1de43769 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
100 schema:name Antibodies, Monoclonal
101 rdf:type schema:DefinedTerm
102 N76c1dfcf95f643aca234d0349a8c4a09 schema:name dimensions_id
103 schema:value pub.1007818304
104 rdf:type schema:PropertyValue
105 N7761dd08a2b341b1b57f343eb54ee6df rdf:first sg:person.01272014534.73
106 rdf:rest Nf7a67a928ca948158faf0a7b31d3d597
107 N7b343d8960964221846adcab9c14983b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
108 schema:name Mice, Inbred NOD
109 rdf:type schema:DefinedTerm
110 N7cb6bd59aa4e467285038c1483f3d7c6 schema:volumeNumber 27
111 rdf:type schema:PublicationVolume
112 N7d027af97ab749b3af057b0386db5f1f schema:name doi
113 schema:value 10.1038/sj.onc.1210747
114 rdf:type schema:PropertyValue
115 N7e1a78090715420a9c354827e95866bc rdf:first sg:person.0767456534.07
116 rdf:rest Nc18e53d844bc4d5db74a2fa0a7f8134e
117 N7e3fd4964ec84108bdf399ef6be5b403 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
118 schema:name Neoplasms, Experimental
119 rdf:type schema:DefinedTerm
120 N8f58db4993464a02892d2c48ec7840b0 rdf:first sg:person.0732007421.57
121 rdf:rest Naae881b19b4348048a56eb18b13986b6
122 N8f609730b2b34d77a77335d766df9677 schema:affiliation https://www.grid.ac/institutes/grid.7497.d
123 schema:familyName Moldenhauer
124 schema:givenName G
125 rdf:type schema:Person
126 N8fc5e7fd09a04ba1ad6ef8640a2f6b33 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
127 schema:name Animals
128 rdf:type schema:DefinedTerm
129 Na45d0ef71e154b558feede2586df4759 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name Neoplasm Invasiveness
131 rdf:type schema:DefinedTerm
132 Na7295b487d9a443598e1809710d92e89 rdf:first sg:person.01000067774.85
133 rdf:rest rdf:nil
134 Na991cfa2e5694336b474964b364c9f9c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name Cell Line, Tumor
136 rdf:type schema:DefinedTerm
137 Na993c5e5ea6a4806a93c53ff38bcf9f0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name Neoplasms
139 rdf:type schema:DefinedTerm
140 Naae881b19b4348048a56eb18b13986b6 rdf:first sg:person.01156570474.48
141 rdf:rest N7761dd08a2b341b1b57f343eb54ee6df
142 Nacbd86360dfd4bac9524a3b1d3579a3d schema:name pubmed_id
143 schema:value 17952127
144 rdf:type schema:PropertyValue
145 Nb06409dd8c20414dac07e08e25200801 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
146 schema:name Cell Line
147 rdf:type schema:DefinedTerm
148 Nb753fb35ae2f4761b955749b2427bd57 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
149 schema:name Mice
150 rdf:type schema:DefinedTerm
151 Nc18e53d844bc4d5db74a2fa0a7f8134e rdf:first sg:person.0774725375.71
152 rdf:rest Nd6da2f88cbff4843a6388cf54fe1dc7b
153 Nc590ad67b8b5407e96f50a34d6842bdd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
154 schema:name Humans
155 rdf:type schema:DefinedTerm
156 Nc7781ad801964e199ddf721deb9bbbe2 rdf:first sg:person.01334512522.20
157 rdf:rest Na7295b487d9a443598e1809710d92e89
158 Nd0aac9184ece4b03a5b8b2045d1c7d92 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
159 schema:name Mice, SCID
160 rdf:type schema:DefinedTerm
161 Nd1fe5da68d794976854f5861cd9fe9e2 schema:name nlm_unique_id
162 schema:value 8711562
163 rdf:type schema:PropertyValue
164 Nd3082d87265846aa8127b4cdc3e4c18c rdf:first sg:person.0660756606.71
165 rdf:rest Nc7781ad801964e199ddf721deb9bbbe2
166 Nd6da2f88cbff4843a6388cf54fe1dc7b rdf:first N8f609730b2b34d77a77335d766df9677
167 rdf:rest Nd3082d87265846aa8127b4cdc3e4c18c
168 Nf7a67a928ca948158faf0a7b31d3d597 rdf:first sg:person.0706377750.28
169 rdf:rest N7e1a78090715420a9c354827e95866bc
170 Nfd5e956b4304440d8bfd6c708add0440 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
171 schema:name Protein Structure, Tertiary
172 rdf:type schema:DefinedTerm
173 Nfdca04b907eb4084ba36965b3144dbc7 schema:issueNumber 9
174 rdf:type schema:PublicationIssue
175 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
176 schema:name Biological Sciences
177 rdf:type schema:DefinedTerm
178 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
179 schema:name Biochemistry and Cell Biology
180 rdf:type schema:DefinedTerm
181 sg:journal.1097543 schema:issn 0950-9232
182 1476-5594
183 schema:name Oncogene
184 rdf:type schema:Periodical
185 sg:person.01000067774.85 schema:affiliation https://www.grid.ac/institutes/grid.7497.d
186 schema:familyName Altevogt
187 schema:givenName P
188 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01000067774.85
189 rdf:type schema:Person
190 sg:person.01156570474.48 schema:affiliation https://www.grid.ac/institutes/grid.7497.d
191 schema:familyName Issa
192 schema:givenName Y
193 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01156570474.48
194 rdf:type schema:Person
195 sg:person.01270134306.10 schema:affiliation https://www.grid.ac/institutes/grid.7497.d
196 schema:familyName Gast
197 schema:givenName D
198 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01270134306.10
199 rdf:type schema:Person
200 sg:person.01272014534.73 schema:affiliation https://www.grid.ac/institutes/grid.7497.d
201 schema:familyName Pfeifer
202 schema:givenName M
203 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01272014534.73
204 rdf:type schema:Person
205 sg:person.01334512522.20 schema:affiliation https://www.grid.ac/institutes/grid.6936.a
206 schema:familyName Krüger
207 schema:givenName A
208 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01334512522.20
209 rdf:type schema:Person
210 sg:person.0660756606.71 schema:affiliation https://www.grid.ac/institutes/grid.415014.5
211 schema:familyName Fogel
212 schema:givenName M
213 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0660756606.71
214 rdf:type schema:Person
215 sg:person.0706377750.28 schema:affiliation https://www.grid.ac/institutes/grid.7497.d
216 schema:familyName Beckhove
217 schema:givenName P
218 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0706377750.28
219 rdf:type schema:Person
220 sg:person.0732007421.57 schema:affiliation https://www.grid.ac/institutes/grid.7497.d
221 schema:familyName Riedle
222 schema:givenName S
223 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0732007421.57
224 rdf:type schema:Person
225 sg:person.0767456534.07 schema:affiliation https://www.grid.ac/institutes/grid.7497.d
226 schema:familyName Sanderson
227 schema:givenName M P
228 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0767456534.07
229 rdf:type schema:Person
230 sg:person.0774725375.71 schema:affiliation https://www.grid.ac/institutes/grid.6936.a
231 schema:familyName Arlt
232 schema:givenName M
233 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0774725375.71
234 rdf:type schema:Person
235 sg:pub.10.1038/334701a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010624456
236 https://doi.org/10.1038/334701a0
237 rdf:type schema:CreativeWork
238 sg:pub.10.1038/bjc.1987.276 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041443389
239 https://doi.org/10.1038/bjc.1987.276
240 rdf:type schema:CreativeWork
241 https://app.dimensions.ai/details/publication/pub.1077007510 schema:CreativeWork
242 https://doi.org/10.1002/bies.10355 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028273713
243 rdf:type schema:CreativeWork
244 https://doi.org/10.1002/glia.10058 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028730305
245 rdf:type schema:CreativeWork
246 https://doi.org/10.1002/ijc.20869 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008274489
247 rdf:type schema:CreativeWork
248 https://doi.org/10.1002/ijc.21880 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001898993
249 rdf:type schema:CreativeWork
250 https://doi.org/10.1006/excr.1997.3877 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036577492
251 rdf:type schema:CreativeWork
252 https://doi.org/10.1016/0896-6273(94)90339-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030996224
253 rdf:type schema:CreativeWork
254 https://doi.org/10.1016/j.humpath.2006.03.014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037524996
255 rdf:type schema:CreativeWork
256 https://doi.org/10.1016/s0140-6736(03)14342-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034562480
257 rdf:type schema:CreativeWork
258 https://doi.org/10.1016/s0304-3835(02)00513-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1035454268
259 rdf:type schema:CreativeWork
260 https://doi.org/10.1016/s0959-8049(02)00105-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033051259
261 rdf:type schema:CreativeWork
262 https://doi.org/10.1016/s1535-6108(03)00169-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050785006
263 rdf:type schema:CreativeWork
264 https://doi.org/10.1034/j.1600-0749.2001.140202.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1011447627
265 rdf:type schema:CreativeWork
266 https://doi.org/10.1074/jbc.274.53.37965 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000611879
267 rdf:type schema:CreativeWork
268 https://doi.org/10.1074/jbc.275.20.15490 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036513192
269 rdf:type schema:CreativeWork
270 https://doi.org/10.1074/jbc.m404075200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022832939
271 rdf:type schema:CreativeWork
272 https://doi.org/10.1083/jcb.200101099 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048110820
273 rdf:type schema:CreativeWork
274 https://doi.org/10.1083/jcb.200408051 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052438328
275 rdf:type schema:CreativeWork
276 https://doi.org/10.1096/fasebj.10.9.8801164 schema:sameAs https://app.dimensions.ai/details/publication/pub.1082959737
277 rdf:type schema:CreativeWork
278 https://doi.org/10.1096/fj.02-0430fje schema:sameAs https://app.dimensions.ai/details/publication/pub.1004971226
279 rdf:type schema:CreativeWork
280 https://doi.org/10.1111/j.1471-4159.2005.03254.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1005275712
281 rdf:type schema:CreativeWork
282 https://doi.org/10.1111/j.1471-4159.2006.03649.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1047670933
283 rdf:type schema:CreativeWork
284 https://doi.org/10.1128/mcb.19.4.2435 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048446985
285 rdf:type schema:CreativeWork
286 https://doi.org/10.1158/0008-5472.can-05-1818 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027935486
287 rdf:type schema:CreativeWork
288 https://doi.org/10.1158/0008-5472.can-06-2106 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000936104
289 rdf:type schema:CreativeWork
290 https://doi.org/10.1158/1078-0432.ccr-06-1486 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004568481
291 rdf:type schema:CreativeWork
292 https://doi.org/10.1523/jneurosci.20-11-04177.2000 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074642347
293 rdf:type schema:CreativeWork
294 https://doi.org/10.1523/jneurosci.22-12-04918.2002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1075073769
295 rdf:type schema:CreativeWork
296 https://doi.org/10.1523/jneurosci.4097-04.2005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007271821
297 rdf:type schema:CreativeWork
298 https://www.grid.ac/institutes/grid.415014.5 schema:alternateName Kaplan Medical Center
299 schema:name Department of Pathology, Kaplan Medical Center, Rehovot, Israel
300 rdf:type schema:Organization
301 https://www.grid.ac/institutes/grid.6936.a schema:alternateName Technical University Munich
302 schema:name Institute for Experimental Oncology and Therapy, Technical University of Munich, Munich, Germany
303 rdf:type schema:Organization
304 https://www.grid.ac/institutes/grid.7497.d schema:alternateName German Cancer Research Center
305 schema:name German Cancer Research Center, Heidelberg, Germany
306 Tumor Immunology Programme, German Cancer Research Center, Heidelberg, Germany
307 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...