Histone deacetylases and cancer View Full Text


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Article Info

DATE

2007-08-13

AUTHORS

M A Glozak, E Seto

ABSTRACT

Histone deacetylases (HDACs) regulate the expression and activity of numerous proteins involved in both cancer initiation and cancer progression. By removal of acetyl groups from histones, HDACs create a non-permissive chromatin conformation that prevents the transcription of genes that encode proteins involved in tumorigenesis. In addition to histones, HDACs bind to and deacetylate a variety of other protein targets including transcription factors and other abundant cellular proteins implicated in control of cell growth, differentiation and apoptosis. This review provides a comprehensive examination of the transcriptional and post-translational mechanisms by which HDACs alter the expression and function of cancer-associated proteins and examines the general impact of HDAC activity in cancer. More... »

PAGES

5420-5432

References to SciGraph publications

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  • 1998-02. Retinoblastoma protein recruits histone deacetylase to repress transcription in NATURE
  • 2002-02-19. Higher-order structure in pericentric heterochromatin involves a distinct pattern of histone modification and an RNA component in NATURE GENETICS
  • 2002-01-17. Histone deacetylases inhibitors as anti-angiogenic agents altering vascular endothelial growth factor signaling in ONCOGENE
  • 2003-08-06. Repression of MUC2 gene expression by butyrate, a physiological regulator of intestinal cell maturation in ONCOGENE
  • 2006-06-12. RUNX3 protein is overexpressed in human basal cell carcinomas in ONCOGENE
  • 2005-03-13. Loss of acetylation at Lys16 and trimethylation at Lys20 of histone H4 is a common hallmark of human cancer in NATURE GENETICS
  • 2003-12-11. Altered interaction of HDAC5 with GATA-1 during MEL cell differentiation in ONCOGENE
  • 2005-01-21. Inhibition of histone deacetylase 2 increases apoptosis and p21Cip1/WAF1 expression, independent of histone deacetylase 1 in CELL DEATH & DIFFERENTIATION
  • 2006-04-16. A truncating mutation of HDAC2 in human cancers confers resistance to histone deacetylase inhibition in NATURE GENETICS
  • 1998-02. Retinoblastoma protein represses transcription by recruiting a histone deacetylase in NATURE
  • 2002-06-24. The t(8;21) fusion protein, AML1–ETO, specifically represses the transcription of the p14ARF tumor suppressor in acute myeloid leukemia in NATURE MEDICINE
  • 2001-04-01. Histone deacetylases induce angiogenesis by negative regulation of tumor suppressor genes in NATURE MEDICINE
  • 2004-04-26. Invasion of v-FosFBR-transformed cells is dependent upon histone deacetylase activity and suppression of histone deacetylase regulated genes in ONCOGENE
  • 2006-07-24. Smad3 is acetylated by p300/CBP to regulate its transactivation activity in ONCOGENE
  • 2006-10-30. Nuclear factor-κB and inhibitor of κB kinase pathways in oncogenic initiation and progression in ONCOGENE
  • 2002-10-28. Acetylation inactivates the transcriptional repressor BCL6 in NATURE GENETICS
  • 2005-06. Global histone modification patterns predict risk of prostate cancer recurrence in NATURE
  • 2006-04-10. Histone modifications silence the GATA transcription factor genes in ovarian cancer in ONCOGENE
  • 2005-04-04. Significance of HDAC6 regulation via estrogen signaling for cell motility and prognosis in estrogen receptor-positive breast cancer in ONCOGENE
  • 2006-05-01. RUNX1 associates with histone deacetylases and SUV39H1 to repress transcription in ONCOGENE
  • 2006-06-26. Histone deacetylase inhibitors induce the degradation of the t(8;21) fusion oncoprotein in ONCOGENE
  • 1998-12. Regulation of activity of the transcription factor GATA-1 by acetylation in NATURE
  • Journal

    TITLE

    Oncogene

    ISSUE

    37

    VOLUME

    26

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/sj.onc.1210610

    DOI

    http://dx.doi.org/10.1038/sj.onc.1210610

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1023418889

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/17694083


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