Preclinical and clinical evaluation of epratuzumab (anti-CD22 IgG) in B-cell malignancies View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2007-05

AUTHORS

J P Leonard, D M Goldenberg

ABSTRACT

The vast majority of non-Hodgkin's lymphomas are of B-cell phenotype. Development of unlabeled or radiolabeled therapeutic monoclonal antibodies against the cell surface antigen, CD20, has revolutionized the treatment of these malignancies. It is clear that antibodies targeting other B-cell-specific molecules, such as CD22, also offer potential therapeutic benefit. Epratuzumab is a humanized anti-CD22 monoclonal, which has undergone preclinical and phase I/II clinical evaluation in patients with indolent or aggressive lymphoma. Data suggest that this agent is well tolerated, and can induce tumor regressions. Trials are currently evaluating its safety and activity in combination with rituximab (chimeric anti-CD20) and standard chemotherapy are ongoing. Initial results suggest that these regimens have acceptable toxicity, and that epratuzumab warrants further evaluation as an adjunct to standard lymphoma treatment regimens. More... »

PAGES

1210370

Journal

TITLE

Oncogene

ISSUE

25

VOLUME

26

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/sj.onc.1210370

    DOI

    http://dx.doi.org/10.1038/sj.onc.1210370

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1046267859

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/17530024


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    416 https://www.grid.ac/institutes/grid.57764.37 schema:alternateName Immunomedics (United States)
    417 schema:name Garden State Cancer Center, Center for Molecular Medicine and Immunology, Belleville, NJ, USA
    418 Immunomedics, Inc., Morris Plains, NJ, USA
    419 rdf:type schema:Organization
     




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