Inhibition of IL-6-dependent growth of myeloma cells by an acidic peptide repressing the gp130-mediated activation of Src family kinases View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2007-07

AUTHORS

A Hausherr, R Tavares, M Schäffer, A Obermeier, C Miksch, O Mitina, J Ellwart, M Hallek, G Krause

ABSTRACT

An acidic domain (AD) of gp130 was previously found to interact with the Src family kinase (SFK) Hck. Here, the influence of myristoylated peptides derived from this AD was assessed in the mouse myeloma cell line, 7TD1. The IL-6-dependent growth of 7TD1 cells was reduced by approximately 75%, if 100 microM of myristoylated 18mer peptide (18AD) was included in the growth medium, but was unaffected by a control peptide with scrambled sequence (18sc). A similar differential inhibition by peptides 18AD and 18sc was observed for the erythropoietin-dependent growth of BaF-EH cells expressing chimeric erythropoietin receptor-gp130 and human Hck and for the human myeloma cell line INA-6. While the peptide 18AD concentration inhibiting 50% was approximately 30 microM in 7TD1 and BaF-EH cells, peptide 18AD did not significantly inhibit growth of IL-6-independent MM1.S myeloma and OKT1 hybridoma cells or of BaF-EH cells supplied with IL-3. Treatment with 100 microM peptide 18AD caused the same degree or 60% of apoptosis induction as IL-6 deprivation in 7TD1 or INA-6 cells, respectively. Co-immunoprecipitation experiments revealed that peptide 18AD interfered with the association of Hck and gp130 in 7TD1 lysates in a concentration-dependent manner. IL-6-treatment of INA-6 cells induced the kinase activities of Fyn, Lyn and Hck, but not Src, and the IL-6-induced SFK activities were inhibited by peptide 18AD. Expression in 7TD1 cells of a kinase-inactive Hck mutant (K269R) elicited a dominant-negative effect on cell number increases providing further evidence that SFKs are required for gp130 signalling in myeloma cells. More... »

PAGES

1210306

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/sj.onc.1210306

DOI

http://dx.doi.org/10.1038/sj.onc.1210306

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1012417866

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/17310994


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Amino Acid Sequence", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Apoptosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Biological Transport", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Cycle", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Line", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Line, Tumor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Proliferation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cytokine Receptor gp130", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Interleukin-6", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Molecular Sequence Data", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Multiple Myeloma", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Peptide Fragments", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Proto-Oncogene Proteins c-hck", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "STAT3 Transcription Factor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "src-Family Kinases", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Helmholtz Zentrum M\u00fcnchen", 
          "id": "https://www.grid.ac/institutes/grid.4567.0", 
          "name": [
            "Clinical Cooperation Group Gene Therapy, GSF \u2013 National Research Center for Environment and Health, Munich, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hausherr", 
        "givenName": "A", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Helmholtz Zentrum M\u00fcnchen", 
          "id": "https://www.grid.ac/institutes/grid.4567.0", 
          "name": [
            "Clinical Cooperation Group Gene Therapy, GSF \u2013 National Research Center for Environment and Health, Munich, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tavares", 
        "givenName": "R", 
        "id": "sg:person.0703231435.71", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0703231435.71"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "SIREEN AG, Am Klopferspitz, Martinsried, Germany", 
            "CRELUX GmbH, Am Klopferspitz, Martinsried, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sch\u00e4ffer", 
        "givenName": "M", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "SIREEN AG, Am Klopferspitz, Martinsried, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Obermeier", 
        "givenName": "A", 
        "id": "sg:person.01371115434.66", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01371115434.66"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "SIREEN AG, Am Klopferspitz, Martinsried, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Miksch", 
        "givenName": "C", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Helmholtz Zentrum M\u00fcnchen", 
          "id": "https://www.grid.ac/institutes/grid.4567.0", 
          "name": [
            "Clinical Cooperation Group Gene Therapy, GSF \u2013 National Research Center for Environment and Health, Munich, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mitina", 
        "givenName": "O", 
        "id": "sg:person.0577701374.74", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0577701374.74"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Helmholtz Zentrum M\u00fcnchen", 
          "id": "https://www.grid.ac/institutes/grid.4567.0", 
          "name": [
            "Institute of Molecular Immunology, GSF \u2013 National Research Center for Environment and Health, Munich, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ellwart", 
        "givenName": "J", 
        "id": "sg:person.01323720602.02", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01323720602.02"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University Hospital Cologne", 
          "id": "https://www.grid.ac/institutes/grid.411097.a", 
          "name": [
            "Clinical Cooperation Group Gene Therapy, GSF \u2013 National Research Center for Environment and Health, Munich, Germany", 
            "Clinic I for Internal Medicine, University Hospital Cologne, Cologne, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hallek", 
        "givenName": "M", 
        "id": "sg:person.01025161256.58", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01025161256.58"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University Hospital Cologne", 
          "id": "https://www.grid.ac/institutes/grid.411097.a", 
          "name": [
            "Clinical Cooperation Group Gene Therapy, GSF \u2013 National Research Center for Environment and Health, Munich, Germany", 
            "Clinic I for Internal Medicine, University Hospital Cologne, Cologne, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Krause", 
        "givenName": "G", 
        "id": "sg:person.0663146776.37", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0663146776.37"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/s0301-472x(03)00023-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001460289"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0301-472x(03)00023-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001460289"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2002-01-0288", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002862073"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(00)81277-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005105876"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m309909200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005634809"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.272.52.33260", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007582615"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/cyto.2002.1988", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010091353"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/cyto.2002.1988", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010091353"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2003-04-1048", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012899443"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m306723200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016904469"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1099480", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017542958"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/028418600750063497", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017650523"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m208636200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018073671"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.21.23.8068-8081.2001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024384828"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2002-01-0102", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028543131"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.c300081200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028898832"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.273.48.32129", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029906401"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.peptides.2003.06.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030212327"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.peptides.2003.06.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030212327"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc952", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030651335", 
          "https://doi.org/10.1038/nrc952"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc952", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030651335", 
          "https://doi.org/10.1038/nrc952"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m303670200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035240741"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1201714", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035771507", 
          "https://doi.org/10.1038/sj.onc.1201714"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1201714", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035771507", 
          "https://doi.org/10.1038/sj.onc.1201714"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/eji.1830260217", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036739384"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.022460899", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037163704"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1074-7613(00)80162-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037439534"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m305783200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038753632"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0024-3205(00)00476-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038851102"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.tig.2003.11.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040621767"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m108459200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042193091"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1359-6101(02)00027-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048125241"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0409650102", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050300912"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng1343", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050682184", 
          "https://doi.org/10.1038/ng1343"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng1343", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050682184", 
          "https://doi.org/10.1038/ng1343"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bj20030407", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052909234"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bj20030407", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052909234"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.thj.6200075", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056649344", 
          "https://doi.org/10.1038/sj.thj.6200075"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1096/fj.14.11.1529", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060111307"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.2047859", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062519680"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.8272873", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062653932"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci22094", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063416740"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074254091", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074487433", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1076587282", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/j.1460-2075.1994.tb06420.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1082677762"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082799935", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083138890", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083187036", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083191030", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083390129", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2007-07", 
    "datePublishedReg": "2007-07-01", 
    "description": "An acidic domain (AD) of gp130 was previously found to interact with the Src family kinase (SFK) Hck. Here, the influence of myristoylated peptides derived from this AD was assessed in the mouse myeloma cell line, 7TD1. The IL-6-dependent growth of 7TD1 cells was reduced by approximately 75%, if 100 microM of myristoylated 18mer peptide (18AD) was included in the growth medium, but was unaffected by a control peptide with scrambled sequence (18sc). A similar differential inhibition by peptides 18AD and 18sc was observed for the erythropoietin-dependent growth of BaF-EH cells expressing chimeric erythropoietin receptor-gp130 and human Hck and for the human myeloma cell line INA-6. While the peptide 18AD concentration inhibiting 50% was approximately 30 microM in 7TD1 and BaF-EH cells, peptide 18AD did not significantly inhibit growth of IL-6-independent MM1.S myeloma and OKT1 hybridoma cells or of BaF-EH cells supplied with IL-3. Treatment with 100 microM peptide 18AD caused the same degree or 60% of apoptosis induction as IL-6 deprivation in 7TD1 or INA-6 cells, respectively. Co-immunoprecipitation experiments revealed that peptide 18AD interfered with the association of Hck and gp130 in 7TD1 lysates in a concentration-dependent manner. IL-6-treatment of INA-6 cells induced the kinase activities of Fyn, Lyn and Hck, but not Src, and the IL-6-induced SFK activities were inhibited by peptide 18AD. Expression in 7TD1 cells of a kinase-inactive Hck mutant (K269R) elicited a dominant-negative effect on cell number increases providing further evidence that SFKs are required for gp130 signalling in myeloma cells.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/sj.onc.1210306", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1097543", 
        "issn": [
          "0950-9232", 
          "1476-5594"
        ], 
        "name": "Oncogene", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "34", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "26"
      }
    ], 
    "name": "Inhibition of IL-6-dependent growth of myeloma cells by an acidic peptide repressing the gp130-mediated activation of Src family kinases", 
    "pagination": "1210306", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "3b2953e25e1b04c747ec9829a9410a8a6c877f5f1be034cb20d5b6cc26de6df7"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "17310994"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "8711562"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/sj.onc.1210306"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1012417866"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/sj.onc.1210306", 
      "https://app.dimensions.ai/details/publication/pub.1012417866"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T12:57", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8659_00000422.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://www.nature.com/articles/1210306"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/sj.onc.1210306'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/sj.onc.1210306'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/sj.onc.1210306'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/sj.onc.1210306'


 

This table displays all metadata directly associated to this object as RDF triples.

334 TRIPLES      21 PREDICATES      91 URIs      39 LITERALS      27 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/sj.onc.1210306 schema:about N01af3cf966e54834abf9ed4eae5ef0d7
2 N02fa5ee56be643d7980159b060bbf7b3
3 N0d1f555d5fc14965b9e1f1ad33495a4a
4 N1d696c33c4d44d8eb2be15a1a62ef39f
5 N22e113b216b347bd8e30857dd31f6326
6 N307c1f221835493dadc59d9315179a34
7 N45110acb45ad4a5cb3f5829370a3a84d
8 N539f80008ea4467c98503836a52b567d
9 N8a6a5c51bc41424ba8825e8aec6c6c47
10 N9c6e89cdf7ab482e9eaf8a7cfba3935b
11 Na09ecb77fafb4d589cb1a0f545bdc7d3
12 Na0a534d153834a9490f43c85261c35f8
13 Nbbd6cbe04336449b9319f927cee4267b
14 Nbcfa178f940a4248a4d2fcc7ee94bd1c
15 Nc38cf89b6f8444c99b65bd81ea2e9445
16 Nde4419d0a9154972bd40ae4969a9c1cc
17 Ne091a20ad56744e799f5a24f9681e074
18 Nfe3d5febd3f94bcf80753ea03ea4aefb
19 anzsrc-for:06
20 anzsrc-for:0601
21 schema:author N5959c7031b3f4ecfb0396eb55394c22f
22 schema:citation sg:pub.10.1038/ng1343
23 sg:pub.10.1038/nrc952
24 sg:pub.10.1038/sj.onc.1201714
25 sg:pub.10.1038/sj.thj.6200075
26 https://app.dimensions.ai/details/publication/pub.1074254091
27 https://app.dimensions.ai/details/publication/pub.1074487433
28 https://app.dimensions.ai/details/publication/pub.1076587282
29 https://app.dimensions.ai/details/publication/pub.1082799935
30 https://app.dimensions.ai/details/publication/pub.1083138890
31 https://app.dimensions.ai/details/publication/pub.1083187036
32 https://app.dimensions.ai/details/publication/pub.1083191030
33 https://app.dimensions.ai/details/publication/pub.1083390129
34 https://doi.org/10.1002/eji.1830260217
35 https://doi.org/10.1002/j.1460-2075.1994.tb06420.x
36 https://doi.org/10.1006/cyto.2002.1988
37 https://doi.org/10.1016/j.peptides.2003.06.005
38 https://doi.org/10.1016/j.tig.2003.11.003
39 https://doi.org/10.1016/s0024-3205(00)00476-8
40 https://doi.org/10.1016/s0092-8674(00)81277-5
41 https://doi.org/10.1016/s0301-472x(03)00023-7
42 https://doi.org/10.1016/s1074-7613(00)80162-4
43 https://doi.org/10.1016/s1359-6101(02)00027-8
44 https://doi.org/10.1042/bj20030407
45 https://doi.org/10.1073/pnas.022460899
46 https://doi.org/10.1073/pnas.0409650102
47 https://doi.org/10.1074/jbc.272.52.33260
48 https://doi.org/10.1074/jbc.273.48.32129
49 https://doi.org/10.1074/jbc.c300081200
50 https://doi.org/10.1074/jbc.m108459200
51 https://doi.org/10.1074/jbc.m208636200
52 https://doi.org/10.1074/jbc.m303670200
53 https://doi.org/10.1074/jbc.m305783200
54 https://doi.org/10.1074/jbc.m306723200
55 https://doi.org/10.1074/jbc.m309909200
56 https://doi.org/10.1080/028418600750063497
57 https://doi.org/10.1096/fj.14.11.1529
58 https://doi.org/10.1126/science.1099480
59 https://doi.org/10.1126/science.2047859
60 https://doi.org/10.1126/science.8272873
61 https://doi.org/10.1128/mcb.21.23.8068-8081.2001
62 https://doi.org/10.1172/jci22094
63 https://doi.org/10.1182/blood-2002-01-0102
64 https://doi.org/10.1182/blood-2002-01-0288
65 https://doi.org/10.1182/blood-2003-04-1048
66 schema:datePublished 2007-07
67 schema:datePublishedReg 2007-07-01
68 schema:description An acidic domain (AD) of gp130 was previously found to interact with the Src family kinase (SFK) Hck. Here, the influence of myristoylated peptides derived from this AD was assessed in the mouse myeloma cell line, 7TD1. The IL-6-dependent growth of 7TD1 cells was reduced by approximately 75%, if 100 microM of myristoylated 18mer peptide (18AD) was included in the growth medium, but was unaffected by a control peptide with scrambled sequence (18sc). A similar differential inhibition by peptides 18AD and 18sc was observed for the erythropoietin-dependent growth of BaF-EH cells expressing chimeric erythropoietin receptor-gp130 and human Hck and for the human myeloma cell line INA-6. While the peptide 18AD concentration inhibiting 50% was approximately 30 microM in 7TD1 and BaF-EH cells, peptide 18AD did not significantly inhibit growth of IL-6-independent MM1.S myeloma and OKT1 hybridoma cells or of BaF-EH cells supplied with IL-3. Treatment with 100 microM peptide 18AD caused the same degree or 60% of apoptosis induction as IL-6 deprivation in 7TD1 or INA-6 cells, respectively. Co-immunoprecipitation experiments revealed that peptide 18AD interfered with the association of Hck and gp130 in 7TD1 lysates in a concentration-dependent manner. IL-6-treatment of INA-6 cells induced the kinase activities of Fyn, Lyn and Hck, but not Src, and the IL-6-induced SFK activities were inhibited by peptide 18AD. Expression in 7TD1 cells of a kinase-inactive Hck mutant (K269R) elicited a dominant-negative effect on cell number increases providing further evidence that SFKs are required for gp130 signalling in myeloma cells.
69 schema:genre research_article
70 schema:inLanguage en
71 schema:isAccessibleForFree true
72 schema:isPartOf N08ffef2c3e9e40a985c2a3060627f64d
73 N4ed16700f0c14d6a86516cff379601c9
74 sg:journal.1097543
75 schema:name Inhibition of IL-6-dependent growth of myeloma cells by an acidic peptide repressing the gp130-mediated activation of Src family kinases
76 schema:pagination 1210306
77 schema:productId N348a119207804e31bb293d0768852f48
78 N4c539efbb40946e6a2ed17f263520da7
79 N785d54a0d89648298c78e95a9c808a66
80 N92171102c8834a17adc5833555402453
81 Nd0eb7ceca14f4fd989cb64be13895e87
82 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012417866
83 https://doi.org/10.1038/sj.onc.1210306
84 schema:sdDatePublished 2019-04-10T12:57
85 schema:sdLicense https://scigraph.springernature.com/explorer/license/
86 schema:sdPublisher Nf9c541c8ad484cf3b520985d1fda01cc
87 schema:url http://www.nature.com/articles/1210306
88 sgo:license sg:explorer/license/
89 sgo:sdDataset articles
90 rdf:type schema:ScholarlyArticle
91 N01af3cf966e54834abf9ed4eae5ef0d7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
92 schema:name Multiple Myeloma
93 rdf:type schema:DefinedTerm
94 N0205ea8404a7473a86f632d5e2dc541a rdf:first sg:person.01371115434.66
95 rdf:rest Ncbc2b453c27b4689952965e9710b300c
96 N02fa5ee56be643d7980159b060bbf7b3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
97 schema:name Biological Transport
98 rdf:type schema:DefinedTerm
99 N08ffef2c3e9e40a985c2a3060627f64d schema:volumeNumber 26
100 rdf:type schema:PublicationVolume
101 N0d1f555d5fc14965b9e1f1ad33495a4a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
102 schema:name Molecular Sequence Data
103 rdf:type schema:DefinedTerm
104 N1d696c33c4d44d8eb2be15a1a62ef39f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
105 schema:name Interleukin-6
106 rdf:type schema:DefinedTerm
107 N22e113b216b347bd8e30857dd31f6326 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
108 schema:name STAT3 Transcription Factor
109 rdf:type schema:DefinedTerm
110 N2c7508f32f41422193df53baa77e86d0 schema:affiliation https://www.grid.ac/institutes/grid.4567.0
111 schema:familyName Hausherr
112 schema:givenName A
113 rdf:type schema:Person
114 N2cdc7c6aff724f75a3923b6742a82fef rdf:first sg:person.01025161256.58
115 rdf:rest N73c755c22cd245c486100bb4f6cc5816
116 N307c1f221835493dadc59d9315179a34 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
117 schema:name Mice
118 rdf:type schema:DefinedTerm
119 N348a119207804e31bb293d0768852f48 schema:name readcube_id
120 schema:value 3b2953e25e1b04c747ec9829a9410a8a6c877f5f1be034cb20d5b6cc26de6df7
121 rdf:type schema:PropertyValue
122 N45110acb45ad4a5cb3f5829370a3a84d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
123 schema:name Animals
124 rdf:type schema:DefinedTerm
125 N4c539efbb40946e6a2ed17f263520da7 schema:name pubmed_id
126 schema:value 17310994
127 rdf:type schema:PropertyValue
128 N4ed16700f0c14d6a86516cff379601c9 schema:issueNumber 34
129 rdf:type schema:PublicationIssue
130 N539f80008ea4467c98503836a52b567d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
131 schema:name Apoptosis
132 rdf:type schema:DefinedTerm
133 N5959c7031b3f4ecfb0396eb55394c22f rdf:first N2c7508f32f41422193df53baa77e86d0
134 rdf:rest N7c74beb2e8e7448db84f7fcae0724af3
135 N5feda2244daf4808852064cf890d823b schema:name CRELUX GmbH, Am Klopferspitz, Martinsried, Germany
136 SIREEN AG, Am Klopferspitz, Martinsried, Germany
137 rdf:type schema:Organization
138 N6fedfcf1baae4094af7c545e970bd0e9 schema:name SIREEN AG, Am Klopferspitz, Martinsried, Germany
139 rdf:type schema:Organization
140 N73c755c22cd245c486100bb4f6cc5816 rdf:first sg:person.0663146776.37
141 rdf:rest rdf:nil
142 N785d54a0d89648298c78e95a9c808a66 schema:name doi
143 schema:value 10.1038/sj.onc.1210306
144 rdf:type schema:PropertyValue
145 N7c74beb2e8e7448db84f7fcae0724af3 rdf:first sg:person.0703231435.71
146 rdf:rest Nbb8e2ea957404bd7bf7d2611bfe90c1d
147 N8a6a5c51bc41424ba8825e8aec6c6c47 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
148 schema:name Cell Line
149 rdf:type schema:DefinedTerm
150 N92171102c8834a17adc5833555402453 schema:name dimensions_id
151 schema:value pub.1012417866
152 rdf:type schema:PropertyValue
153 N9c6e89cdf7ab482e9eaf8a7cfba3935b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
154 schema:name Amino Acid Sequence
155 rdf:type schema:DefinedTerm
156 Na0512868645e4cb399302d1fbae24b75 schema:affiliation N5feda2244daf4808852064cf890d823b
157 schema:familyName Schäffer
158 schema:givenName M
159 rdf:type schema:Person
160 Na09ecb77fafb4d589cb1a0f545bdc7d3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
161 schema:name Cell Cycle
162 rdf:type schema:DefinedTerm
163 Na0a534d153834a9490f43c85261c35f8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
164 schema:name Proto-Oncogene Proteins c-hck
165 rdf:type schema:DefinedTerm
166 Nbb8e2ea957404bd7bf7d2611bfe90c1d rdf:first Na0512868645e4cb399302d1fbae24b75
167 rdf:rest N0205ea8404a7473a86f632d5e2dc541a
168 Nbbd6cbe04336449b9319f927cee4267b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
169 schema:name src-Family Kinases
170 rdf:type schema:DefinedTerm
171 Nbc04a9bb014b4015b166c4b4d9a98cf9 rdf:first sg:person.0577701374.74
172 rdf:rest Nd2f26b2fa3154cb8ac6c7550fa0e8833
173 Nbcfa178f940a4248a4d2fcc7ee94bd1c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
174 schema:name Cell Line, Tumor
175 rdf:type schema:DefinedTerm
176 Nc38cf89b6f8444c99b65bd81ea2e9445 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
177 schema:name Peptide Fragments
178 rdf:type schema:DefinedTerm
179 Ncbc2b453c27b4689952965e9710b300c rdf:first Nf8f2329eab764641950d316c42642c04
180 rdf:rest Nbc04a9bb014b4015b166c4b4d9a98cf9
181 Nd0eb7ceca14f4fd989cb64be13895e87 schema:name nlm_unique_id
182 schema:value 8711562
183 rdf:type schema:PropertyValue
184 Nd2f26b2fa3154cb8ac6c7550fa0e8833 rdf:first sg:person.01323720602.02
185 rdf:rest N2cdc7c6aff724f75a3923b6742a82fef
186 Nddb16c743e644bf7ae82a6e9463e79dc schema:name SIREEN AG, Am Klopferspitz, Martinsried, Germany
187 rdf:type schema:Organization
188 Nde4419d0a9154972bd40ae4969a9c1cc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
189 schema:name Cell Proliferation
190 rdf:type schema:DefinedTerm
191 Ne091a20ad56744e799f5a24f9681e074 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
192 schema:name Humans
193 rdf:type schema:DefinedTerm
194 Nf8f2329eab764641950d316c42642c04 schema:affiliation Nddb16c743e644bf7ae82a6e9463e79dc
195 schema:familyName Miksch
196 schema:givenName C
197 rdf:type schema:Person
198 Nf9c541c8ad484cf3b520985d1fda01cc schema:name Springer Nature - SN SciGraph project
199 rdf:type schema:Organization
200 Nfe3d5febd3f94bcf80753ea03ea4aefb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
201 schema:name Cytokine Receptor gp130
202 rdf:type schema:DefinedTerm
203 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
204 schema:name Biological Sciences
205 rdf:type schema:DefinedTerm
206 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
207 schema:name Biochemistry and Cell Biology
208 rdf:type schema:DefinedTerm
209 sg:journal.1097543 schema:issn 0950-9232
210 1476-5594
211 schema:name Oncogene
212 rdf:type schema:Periodical
213 sg:person.01025161256.58 schema:affiliation https://www.grid.ac/institutes/grid.411097.a
214 schema:familyName Hallek
215 schema:givenName M
216 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01025161256.58
217 rdf:type schema:Person
218 sg:person.01323720602.02 schema:affiliation https://www.grid.ac/institutes/grid.4567.0
219 schema:familyName Ellwart
220 schema:givenName J
221 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01323720602.02
222 rdf:type schema:Person
223 sg:person.01371115434.66 schema:affiliation N6fedfcf1baae4094af7c545e970bd0e9
224 schema:familyName Obermeier
225 schema:givenName A
226 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01371115434.66
227 rdf:type schema:Person
228 sg:person.0577701374.74 schema:affiliation https://www.grid.ac/institutes/grid.4567.0
229 schema:familyName Mitina
230 schema:givenName O
231 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0577701374.74
232 rdf:type schema:Person
233 sg:person.0663146776.37 schema:affiliation https://www.grid.ac/institutes/grid.411097.a
234 schema:familyName Krause
235 schema:givenName G
236 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0663146776.37
237 rdf:type schema:Person
238 sg:person.0703231435.71 schema:affiliation https://www.grid.ac/institutes/grid.4567.0
239 schema:familyName Tavares
240 schema:givenName R
241 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0703231435.71
242 rdf:type schema:Person
243 sg:pub.10.1038/ng1343 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050682184
244 https://doi.org/10.1038/ng1343
245 rdf:type schema:CreativeWork
246 sg:pub.10.1038/nrc952 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030651335
247 https://doi.org/10.1038/nrc952
248 rdf:type schema:CreativeWork
249 sg:pub.10.1038/sj.onc.1201714 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035771507
250 https://doi.org/10.1038/sj.onc.1201714
251 rdf:type schema:CreativeWork
252 sg:pub.10.1038/sj.thj.6200075 schema:sameAs https://app.dimensions.ai/details/publication/pub.1056649344
253 https://doi.org/10.1038/sj.thj.6200075
254 rdf:type schema:CreativeWork
255 https://app.dimensions.ai/details/publication/pub.1074254091 schema:CreativeWork
256 https://app.dimensions.ai/details/publication/pub.1074487433 schema:CreativeWork
257 https://app.dimensions.ai/details/publication/pub.1076587282 schema:CreativeWork
258 https://app.dimensions.ai/details/publication/pub.1082799935 schema:CreativeWork
259 https://app.dimensions.ai/details/publication/pub.1083138890 schema:CreativeWork
260 https://app.dimensions.ai/details/publication/pub.1083187036 schema:CreativeWork
261 https://app.dimensions.ai/details/publication/pub.1083191030 schema:CreativeWork
262 https://app.dimensions.ai/details/publication/pub.1083390129 schema:CreativeWork
263 https://doi.org/10.1002/eji.1830260217 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036739384
264 rdf:type schema:CreativeWork
265 https://doi.org/10.1002/j.1460-2075.1994.tb06420.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1082677762
266 rdf:type schema:CreativeWork
267 https://doi.org/10.1006/cyto.2002.1988 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010091353
268 rdf:type schema:CreativeWork
269 https://doi.org/10.1016/j.peptides.2003.06.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030212327
270 rdf:type schema:CreativeWork
271 https://doi.org/10.1016/j.tig.2003.11.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040621767
272 rdf:type schema:CreativeWork
273 https://doi.org/10.1016/s0024-3205(00)00476-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038851102
274 rdf:type schema:CreativeWork
275 https://doi.org/10.1016/s0092-8674(00)81277-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005105876
276 rdf:type schema:CreativeWork
277 https://doi.org/10.1016/s0301-472x(03)00023-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001460289
278 rdf:type schema:CreativeWork
279 https://doi.org/10.1016/s1074-7613(00)80162-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037439534
280 rdf:type schema:CreativeWork
281 https://doi.org/10.1016/s1359-6101(02)00027-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048125241
282 rdf:type schema:CreativeWork
283 https://doi.org/10.1042/bj20030407 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052909234
284 rdf:type schema:CreativeWork
285 https://doi.org/10.1073/pnas.022460899 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037163704
286 rdf:type schema:CreativeWork
287 https://doi.org/10.1073/pnas.0409650102 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050300912
288 rdf:type schema:CreativeWork
289 https://doi.org/10.1074/jbc.272.52.33260 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007582615
290 rdf:type schema:CreativeWork
291 https://doi.org/10.1074/jbc.273.48.32129 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029906401
292 rdf:type schema:CreativeWork
293 https://doi.org/10.1074/jbc.c300081200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028898832
294 rdf:type schema:CreativeWork
295 https://doi.org/10.1074/jbc.m108459200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042193091
296 rdf:type schema:CreativeWork
297 https://doi.org/10.1074/jbc.m208636200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018073671
298 rdf:type schema:CreativeWork
299 https://doi.org/10.1074/jbc.m303670200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035240741
300 rdf:type schema:CreativeWork
301 https://doi.org/10.1074/jbc.m305783200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038753632
302 rdf:type schema:CreativeWork
303 https://doi.org/10.1074/jbc.m306723200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016904469
304 rdf:type schema:CreativeWork
305 https://doi.org/10.1074/jbc.m309909200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005634809
306 rdf:type schema:CreativeWork
307 https://doi.org/10.1080/028418600750063497 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017650523
308 rdf:type schema:CreativeWork
309 https://doi.org/10.1096/fj.14.11.1529 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060111307
310 rdf:type schema:CreativeWork
311 https://doi.org/10.1126/science.1099480 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017542958
312 rdf:type schema:CreativeWork
313 https://doi.org/10.1126/science.2047859 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062519680
314 rdf:type schema:CreativeWork
315 https://doi.org/10.1126/science.8272873 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062653932
316 rdf:type schema:CreativeWork
317 https://doi.org/10.1128/mcb.21.23.8068-8081.2001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024384828
318 rdf:type schema:CreativeWork
319 https://doi.org/10.1172/jci22094 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063416740
320 rdf:type schema:CreativeWork
321 https://doi.org/10.1182/blood-2002-01-0102 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028543131
322 rdf:type schema:CreativeWork
323 https://doi.org/10.1182/blood-2002-01-0288 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002862073
324 rdf:type schema:CreativeWork
325 https://doi.org/10.1182/blood-2003-04-1048 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012899443
326 rdf:type schema:CreativeWork
327 https://www.grid.ac/institutes/grid.411097.a schema:alternateName University Hospital Cologne
328 schema:name Clinic I for Internal Medicine, University Hospital Cologne, Cologne, Germany
329 Clinical Cooperation Group Gene Therapy, GSF – National Research Center for Environment and Health, Munich, Germany
330 rdf:type schema:Organization
331 https://www.grid.ac/institutes/grid.4567.0 schema:alternateName Helmholtz Zentrum München
332 schema:name Clinical Cooperation Group Gene Therapy, GSF – National Research Center for Environment and Health, Munich, Germany
333 Institute of Molecular Immunology, GSF – National Research Center for Environment and Health, Munich, Germany
334 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...