Increase in PGE2 biosynthesis induces a Bax dependent apoptosis correlated to patients’ survival in glioblastoma multiforme View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2007-07

AUTHORS

L Lalier, P-F Cartron, F Pedelaborde, C Olivier, D Loussouarn, S A Martin, K Meflah, J Menanteau, F M Vallette

ABSTRACT

Prostaglandin E(2) plays multiple roles both in the physiology and the physiopathology of human brain, which are not completely understood. We have identified in a subset of human glioblastoma multiforme (GBM) tumors, the most common form of adult brain cancer, an increased expression of mPGES-1, the enzyme which catalyses the isomerization of PGH(2) into PGE(2) downstream of cyclooxygenase 2 (COX-2). The sensitivity of primary cultures of GBM to apoptosis was augmented by the overexpression of mPGES-1, whereas the knockdown of its expression by shRNA decreased the apoptotic threshold in vitro and stimulated tumor growth in vivo. Adding extracellular PGE(2) in the culture medium failed to reproduce mPGES-1 effect on the cell viability in vitro. However, the intracellular injection of PGE(2) induced a dose-dependent apoptosis in GBM cultures, which was dependent on the presence of Bax, a pro-apoptotic protein. We show that PGE(2) physically associates with Bax, triggering its apoptotic-like change in conformation and its subsequent association with mitochondria. Our results raise questions about the role of PGE(2) in the control of apoptosis and in its potential impact in central nervous system pathologies. More... »

PAGES

4999

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/sj.onc.1210303

DOI

http://dx.doi.org/10.1038/sj.onc.1210303

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1024237307

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/17369862


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Apoptosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Brain Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Line, Tumor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Dinoprostone", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Glioblastoma", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Intramolecular Oxidoreductases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Nude", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prostaglandin-E Synthases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Survival Rate", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "bcl-2-Associated X Protein", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University of Nantes", 
          "id": "https://www.grid.ac/institutes/grid.4817.a", 
          "name": [
            "INSERM U 601-Equipe 4, 9 Quai MONCOUSU, Cedex 01, Nantes, France", 
            "Faculty of Medicine, University of Nantes, 9 quai MONCOUSU, Cedex 01, Nantes, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lalier", 
        "givenName": "L", 
        "id": "sg:person.0647100325.23", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0647100325.23"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Nantes", 
          "id": "https://www.grid.ac/institutes/grid.4817.a", 
          "name": [
            "INSERM U 601-Equipe 4, 9 Quai MONCOUSU, Cedex 01, Nantes, France", 
            "Faculty of Medicine, University of Nantes, 9 quai MONCOUSU, Cedex 01, Nantes, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cartron", 
        "givenName": "P-F", 
        "id": "sg:person.01123160502.00", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01123160502.00"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Nantes", 
          "id": "https://www.grid.ac/institutes/grid.4817.a", 
          "name": [
            "INSERM U 601-Equipe 4, 9 Quai MONCOUSU, Cedex 01, Nantes, France", 
            "Faculty of Medicine, University of Nantes, 9 quai MONCOUSU, Cedex 01, Nantes, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pedelaborde", 
        "givenName": "F", 
        "id": "sg:person.01116773263.54", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01116773263.54"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Nantes", 
          "id": "https://www.grid.ac/institutes/grid.4817.a", 
          "name": [
            "INSERM U 601-Equipe 4, 9 Quai MONCOUSU, Cedex 01, Nantes, France", 
            "Faculty of Medicine, University of Nantes, 9 quai MONCOUSU, Cedex 01, Nantes, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Olivier", 
        "givenName": "C", 
        "id": "sg:person.01306422555.43", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01306422555.43"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "H\u00f4pital Laennec", 
          "id": "https://www.grid.ac/institutes/grid.414200.3", 
          "name": [
            "Department of Anatomo-Pathology, G&R Laennec Hospital, CHU, Nantes, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Loussouarn", 
        "givenName": "D", 
        "id": "sg:person.0761754075.66", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0761754075.66"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "H\u00f4pital Laennec", 
          "id": "https://www.grid.ac/institutes/grid.414200.3", 
          "name": [
            "Department of Neurosurgery, G&R Laennec Hospital, CHU, Nantes, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Martin", 
        "givenName": "S A", 
        "id": "sg:person.01161077345.65", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01161077345.65"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Nantes", 
          "id": "https://www.grid.ac/institutes/grid.4817.a", 
          "name": [
            "INSERM U 601-Equipe 4, 9 Quai MONCOUSU, Cedex 01, Nantes, France", 
            "Faculty of Medicine, University of Nantes, 9 quai MONCOUSU, Cedex 01, Nantes, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Meflah", 
        "givenName": "K", 
        "id": "sg:person.0630355017.80", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0630355017.80"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Nantes", 
          "id": "https://www.grid.ac/institutes/grid.4817.a", 
          "name": [
            "INSERM U 601-Equipe 4, 9 Quai MONCOUSU, Cedex 01, Nantes, France", 
            "Faculty of Medicine, University of Nantes, 9 quai MONCOUSU, Cedex 01, Nantes, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Menanteau", 
        "givenName": "J", 
        "id": "sg:person.0755334326.88", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0755334326.88"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Nantes", 
          "id": "https://www.grid.ac/institutes/grid.4817.a", 
          "name": [
            "INSERM U 601-Equipe 4, 9 Quai MONCOUSU, Cedex 01, Nantes, France", 
            "Faculty of Medicine, University of Nantes, 9 quai MONCOUSU, Cedex 01, Nantes, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Vallette", 
        "givenName": "F M", 
        "id": "sg:person.01227517014.09", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01227517014.09"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1152/jn.00696.2004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002128259"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35094017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002632915", 
          "https://doi.org/10.1038/35094017"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35094017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002632915", 
          "https://doi.org/10.1038/35094017"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1470-2045(03)01220-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004241190"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1470-2045(03)01220-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004241190"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm1362", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004626805", 
          "https://doi.org/10.1038/nm1362"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm1362", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004626805", 
          "https://doi.org/10.1038/nm1362"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ana.20078", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004732075"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci22218", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004762480"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1124/mol.104.002618", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004952187"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.94.8.3668", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005318975"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1110/ps.8.3.689", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007631870"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1110/ps.8.3.689", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007631870"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/gut.2005.073403", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008208215"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc883", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008451806", 
          "https://doi.org/10.1038/nrc883"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc883", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008451806", 
          "https://doi.org/10.1038/nrc883"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cellsig.2006.04.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011588759"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.23.13.4701-4712.2003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013448453"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0307453101", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013631316"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00401-004-0860-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014696350", 
          "https://doi.org/10.1007/s00401-004-0860-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.273.28.17559", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017183810"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ydbio.2005.10.013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017321957"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm1323", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018164278", 
          "https://doi.org/10.1038/nm1323"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm1323", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018164278", 
          "https://doi.org/10.1038/nm1323"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m208955200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020179553"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m309409200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020182481"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.96.13.7220", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020390495"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/38525", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023661637", 
          "https://doi.org/10.1038/38525"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/38525", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023661637", 
          "https://doi.org/10.1038/38525"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/gut.2004.047100", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024718061"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.272.21.13829", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027253862"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.clim.2006.01.016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028219853"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.1033060100", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030010366"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1750-3639.2005.tb00512.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030191099"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev.pharmtox.41.1.661", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030715235"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1523/jneurosci.4485-03.2004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031942258"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0165-3806(00)00033-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032345312"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.molcel.2004.10.028", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033776786"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncb950", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036115088", 
          "https://doi.org/10.1038/ncb950"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncb950", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036115088", 
          "https://doi.org/10.1038/ncb950"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci9621", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036717477"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.5483/bmbrep.2005.38.6.633", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040593114"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0304-3940(01)02449-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043128846"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0006-2952(83)90390-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044713388"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0006-2952(83)90390-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044713388"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.febslet.2004.10.080", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048278044"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0090-6980(02)00030-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048488434"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0837397100", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049930155"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1116221", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062452503"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074829581", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077206171", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082941719", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2007-07", 
    "datePublishedReg": "2007-07-01", 
    "description": "Prostaglandin E(2) plays multiple roles both in the physiology and the physiopathology of human brain, which are not completely understood. We have identified in a subset of human glioblastoma multiforme (GBM) tumors, the most common form of adult brain cancer, an increased expression of mPGES-1, the enzyme which catalyses the isomerization of PGH(2) into PGE(2) downstream of cyclooxygenase 2 (COX-2). The sensitivity of primary cultures of GBM to apoptosis was augmented by the overexpression of mPGES-1, whereas the knockdown of its expression by shRNA decreased the apoptotic threshold in vitro and stimulated tumor growth in vivo. Adding extracellular PGE(2) in the culture medium failed to reproduce mPGES-1 effect on the cell viability in vitro. However, the intracellular injection of PGE(2) induced a dose-dependent apoptosis in GBM cultures, which was dependent on the presence of Bax, a pro-apoptotic protein. We show that PGE(2) physically associates with Bax, triggering its apoptotic-like change in conformation and its subsequent association with mitochondria. Our results raise questions about the role of PGE(2) in the control of apoptosis and in its potential impact in central nervous system pathologies.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/sj.onc.1210303", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1097543", 
        "issn": [
          "0950-9232", 
          "1476-5594"
        ], 
        "name": "Oncogene", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "34", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "26"
      }
    ], 
    "name": "Increase in PGE2 biosynthesis induces a Bax dependent apoptosis correlated to patients\u2019 survival in glioblastoma multiforme", 
    "pagination": "4999", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "73783e4acb37a0c78eced989e9aa6369d210f6aa663ff57b96f7d0fcbe84b278"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "17369862"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "8711562"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/sj.onc.1210303"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1024237307"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/sj.onc.1210303", 
      "https://app.dimensions.ai/details/publication/pub.1024237307"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T20:34", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8684_00000424.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/1210303"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/sj.onc.1210303'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/sj.onc.1210303'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/sj.onc.1210303'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/sj.onc.1210303'


 

This table displays all metadata directly associated to this object as RDF triples.

319 TRIPLES      21 PREDICATES      86 URIs      35 LITERALS      23 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/sj.onc.1210303 schema:about N250b6820dff14a42b44d3232e3d006e1
2 N2cfb7bbf2f994389860b1b9a2d3cd6bc
3 N38fed7cee3e848988f17becd05ed3a41
4 N463fe352baab45149bb948f952a37fd9
5 N52b0704ebf2444ffb70291af4023da89
6 Na0952cd3a1e444baa0a68a6db12e5bc9
7 Na9cfd8f20d834a4199e434152311f511
8 Nb6ee782166494c308b53bb95ff849520
9 Nbdf04f1bbfee4cdc88f9ee617c5e3939
10 Nc2fee5ec86fa4416a0df2e91e4ec30dc
11 Nd26dd599b7394efda49c3794fc69f4ef
12 Ndb8620cb4efa48c29b941781c966ad7f
13 Nf22f561969cd432bb18d491df38d35c7
14 Nf60bd4093e254cbe8212dca4196406f4
15 anzsrc-for:06
16 anzsrc-for:0601
17 schema:author N6230df3e73bf46e097204eba5aa8fa69
18 schema:citation sg:pub.10.1007/s00401-004-0860-0
19 sg:pub.10.1038/35094017
20 sg:pub.10.1038/38525
21 sg:pub.10.1038/ncb950
22 sg:pub.10.1038/nm1323
23 sg:pub.10.1038/nm1362
24 sg:pub.10.1038/nrc883
25 https://app.dimensions.ai/details/publication/pub.1074829581
26 https://app.dimensions.ai/details/publication/pub.1077206171
27 https://app.dimensions.ai/details/publication/pub.1082941719
28 https://doi.org/10.1002/ana.20078
29 https://doi.org/10.1016/0006-2952(83)90390-8
30 https://doi.org/10.1016/j.cellsig.2006.04.003
31 https://doi.org/10.1016/j.clim.2006.01.016
32 https://doi.org/10.1016/j.febslet.2004.10.080
33 https://doi.org/10.1016/j.molcel.2004.10.028
34 https://doi.org/10.1016/j.ydbio.2005.10.013
35 https://doi.org/10.1016/s0090-6980(02)00030-8
36 https://doi.org/10.1016/s0165-3806(00)00033-x
37 https://doi.org/10.1016/s0304-3940(01)02449-1
38 https://doi.org/10.1016/s1470-2045(03)01220-8
39 https://doi.org/10.1073/pnas.0307453101
40 https://doi.org/10.1073/pnas.0837397100
41 https://doi.org/10.1073/pnas.1033060100
42 https://doi.org/10.1073/pnas.94.8.3668
43 https://doi.org/10.1073/pnas.96.13.7220
44 https://doi.org/10.1074/jbc.272.21.13829
45 https://doi.org/10.1074/jbc.273.28.17559
46 https://doi.org/10.1074/jbc.m208955200
47 https://doi.org/10.1074/jbc.m309409200
48 https://doi.org/10.1110/ps.8.3.689
49 https://doi.org/10.1111/j.1750-3639.2005.tb00512.x
50 https://doi.org/10.1124/mol.104.002618
51 https://doi.org/10.1126/science.1116221
52 https://doi.org/10.1128/mcb.23.13.4701-4712.2003
53 https://doi.org/10.1136/gut.2004.047100
54 https://doi.org/10.1136/gut.2005.073403
55 https://doi.org/10.1146/annurev.pharmtox.41.1.661
56 https://doi.org/10.1152/jn.00696.2004
57 https://doi.org/10.1172/jci22218
58 https://doi.org/10.1172/jci9621
59 https://doi.org/10.1523/jneurosci.4485-03.2004
60 https://doi.org/10.5483/bmbrep.2005.38.6.633
61 schema:datePublished 2007-07
62 schema:datePublishedReg 2007-07-01
63 schema:description Prostaglandin E(2) plays multiple roles both in the physiology and the physiopathology of human brain, which are not completely understood. We have identified in a subset of human glioblastoma multiforme (GBM) tumors, the most common form of adult brain cancer, an increased expression of mPGES-1, the enzyme which catalyses the isomerization of PGH(2) into PGE(2) downstream of cyclooxygenase 2 (COX-2). The sensitivity of primary cultures of GBM to apoptosis was augmented by the overexpression of mPGES-1, whereas the knockdown of its expression by shRNA decreased the apoptotic threshold in vitro and stimulated tumor growth in vivo. Adding extracellular PGE(2) in the culture medium failed to reproduce mPGES-1 effect on the cell viability in vitro. However, the intracellular injection of PGE(2) induced a dose-dependent apoptosis in GBM cultures, which was dependent on the presence of Bax, a pro-apoptotic protein. We show that PGE(2) physically associates with Bax, triggering its apoptotic-like change in conformation and its subsequent association with mitochondria. Our results raise questions about the role of PGE(2) in the control of apoptosis and in its potential impact in central nervous system pathologies.
64 schema:genre research_article
65 schema:inLanguage en
66 schema:isAccessibleForFree true
67 schema:isPartOf N38dc6e59e8ee46afb00a05a759e6ad4d
68 Na9e724fa07a34d50ab7ee030fae4a755
69 sg:journal.1097543
70 schema:name Increase in PGE2 biosynthesis induces a Bax dependent apoptosis correlated to patients’ survival in glioblastoma multiforme
71 schema:pagination 4999
72 schema:productId N4ae9fa36297441f3b194400625888e10
73 N50118fe83b9445629caf7ed8b11c7d9c
74 N69977bf9d6e9431f9b83fcadad577acc
75 Nb8a69eb0dc634dacb4afad86d674a753
76 Ne2fe5dba854b4df08f56efd8acf0d914
77 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024237307
78 https://doi.org/10.1038/sj.onc.1210303
79 schema:sdDatePublished 2019-04-10T20:34
80 schema:sdLicense https://scigraph.springernature.com/explorer/license/
81 schema:sdPublisher N98403f4e896e4ba4b8525b0de062d34a
82 schema:url https://www.nature.com/articles/1210303
83 sgo:license sg:explorer/license/
84 sgo:sdDataset articles
85 rdf:type schema:ScholarlyArticle
86 N182b740f91854defb30891de3e5a1073 rdf:first sg:person.0761754075.66
87 rdf:rest N627f86216fab41909284439927602072
88 N1a337934c139444dbe73a5d1590f72f4 rdf:first sg:person.0630355017.80
89 rdf:rest N7bae9b83931c4d42948631800323ab21
90 N250b6820dff14a42b44d3232e3d006e1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
91 schema:name Glioblastoma
92 rdf:type schema:DefinedTerm
93 N2cfb7bbf2f994389860b1b9a2d3cd6bc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
94 schema:name bcl-2-Associated X Protein
95 rdf:type schema:DefinedTerm
96 N38dc6e59e8ee46afb00a05a759e6ad4d schema:issueNumber 34
97 rdf:type schema:PublicationIssue
98 N38fed7cee3e848988f17becd05ed3a41 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
99 schema:name Brain Neoplasms
100 rdf:type schema:DefinedTerm
101 N3a29e943fffa4630998ba9fd14327a0b rdf:first sg:person.01123160502.00
102 rdf:rest N3b1328a695884c0aa279425f980cd9d8
103 N3b1328a695884c0aa279425f980cd9d8 rdf:first sg:person.01116773263.54
104 rdf:rest Ne917f13a1ad74909ac16a4dee45f3853
105 N3dceb0989df0420fb0779192e638c2f5 rdf:first sg:person.01227517014.09
106 rdf:rest rdf:nil
107 N463fe352baab45149bb948f952a37fd9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
108 schema:name Humans
109 rdf:type schema:DefinedTerm
110 N4ae9fa36297441f3b194400625888e10 schema:name nlm_unique_id
111 schema:value 8711562
112 rdf:type schema:PropertyValue
113 N50118fe83b9445629caf7ed8b11c7d9c schema:name pubmed_id
114 schema:value 17369862
115 rdf:type schema:PropertyValue
116 N52b0704ebf2444ffb70291af4023da89 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
117 schema:name Cell Line, Tumor
118 rdf:type schema:DefinedTerm
119 N6230df3e73bf46e097204eba5aa8fa69 rdf:first sg:person.0647100325.23
120 rdf:rest N3a29e943fffa4630998ba9fd14327a0b
121 N627f86216fab41909284439927602072 rdf:first sg:person.01161077345.65
122 rdf:rest N1a337934c139444dbe73a5d1590f72f4
123 N69977bf9d6e9431f9b83fcadad577acc schema:name readcube_id
124 schema:value 73783e4acb37a0c78eced989e9aa6369d210f6aa663ff57b96f7d0fcbe84b278
125 rdf:type schema:PropertyValue
126 N7bae9b83931c4d42948631800323ab21 rdf:first sg:person.0755334326.88
127 rdf:rest N3dceb0989df0420fb0779192e638c2f5
128 N98403f4e896e4ba4b8525b0de062d34a schema:name Springer Nature - SN SciGraph project
129 rdf:type schema:Organization
130 Na0952cd3a1e444baa0a68a6db12e5bc9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
131 schema:name Intramolecular Oxidoreductases
132 rdf:type schema:DefinedTerm
133 Na9cfd8f20d834a4199e434152311f511 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
134 schema:name Mice, Nude
135 rdf:type schema:DefinedTerm
136 Na9e724fa07a34d50ab7ee030fae4a755 schema:volumeNumber 26
137 rdf:type schema:PublicationVolume
138 Nb6ee782166494c308b53bb95ff849520 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
139 schema:name Dinoprostone
140 rdf:type schema:DefinedTerm
141 Nb8a69eb0dc634dacb4afad86d674a753 schema:name dimensions_id
142 schema:value pub.1024237307
143 rdf:type schema:PropertyValue
144 Nbdf04f1bbfee4cdc88f9ee617c5e3939 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name Apoptosis
146 rdf:type schema:DefinedTerm
147 Nc2fee5ec86fa4416a0df2e91e4ec30dc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
148 schema:name Mice
149 rdf:type schema:DefinedTerm
150 Nd26dd599b7394efda49c3794fc69f4ef schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
151 schema:name Male
152 rdf:type schema:DefinedTerm
153 Ndb8620cb4efa48c29b941781c966ad7f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
154 schema:name Prostaglandin-E Synthases
155 rdf:type schema:DefinedTerm
156 Ne2fe5dba854b4df08f56efd8acf0d914 schema:name doi
157 schema:value 10.1038/sj.onc.1210303
158 rdf:type schema:PropertyValue
159 Ne917f13a1ad74909ac16a4dee45f3853 rdf:first sg:person.01306422555.43
160 rdf:rest N182b740f91854defb30891de3e5a1073
161 Nf22f561969cd432bb18d491df38d35c7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
162 schema:name Animals
163 rdf:type schema:DefinedTerm
164 Nf60bd4093e254cbe8212dca4196406f4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
165 schema:name Survival Rate
166 rdf:type schema:DefinedTerm
167 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
168 schema:name Biological Sciences
169 rdf:type schema:DefinedTerm
170 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
171 schema:name Biochemistry and Cell Biology
172 rdf:type schema:DefinedTerm
173 sg:journal.1097543 schema:issn 0950-9232
174 1476-5594
175 schema:name Oncogene
176 rdf:type schema:Periodical
177 sg:person.01116773263.54 schema:affiliation https://www.grid.ac/institutes/grid.4817.a
178 schema:familyName Pedelaborde
179 schema:givenName F
180 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01116773263.54
181 rdf:type schema:Person
182 sg:person.01123160502.00 schema:affiliation https://www.grid.ac/institutes/grid.4817.a
183 schema:familyName Cartron
184 schema:givenName P-F
185 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01123160502.00
186 rdf:type schema:Person
187 sg:person.01161077345.65 schema:affiliation https://www.grid.ac/institutes/grid.414200.3
188 schema:familyName Martin
189 schema:givenName S A
190 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01161077345.65
191 rdf:type schema:Person
192 sg:person.01227517014.09 schema:affiliation https://www.grid.ac/institutes/grid.4817.a
193 schema:familyName Vallette
194 schema:givenName F M
195 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01227517014.09
196 rdf:type schema:Person
197 sg:person.01306422555.43 schema:affiliation https://www.grid.ac/institutes/grid.4817.a
198 schema:familyName Olivier
199 schema:givenName C
200 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01306422555.43
201 rdf:type schema:Person
202 sg:person.0630355017.80 schema:affiliation https://www.grid.ac/institutes/grid.4817.a
203 schema:familyName Meflah
204 schema:givenName K
205 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0630355017.80
206 rdf:type schema:Person
207 sg:person.0647100325.23 schema:affiliation https://www.grid.ac/institutes/grid.4817.a
208 schema:familyName Lalier
209 schema:givenName L
210 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0647100325.23
211 rdf:type schema:Person
212 sg:person.0755334326.88 schema:affiliation https://www.grid.ac/institutes/grid.4817.a
213 schema:familyName Menanteau
214 schema:givenName J
215 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0755334326.88
216 rdf:type schema:Person
217 sg:person.0761754075.66 schema:affiliation https://www.grid.ac/institutes/grid.414200.3
218 schema:familyName Loussouarn
219 schema:givenName D
220 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0761754075.66
221 rdf:type schema:Person
222 sg:pub.10.1007/s00401-004-0860-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014696350
223 https://doi.org/10.1007/s00401-004-0860-0
224 rdf:type schema:CreativeWork
225 sg:pub.10.1038/35094017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002632915
226 https://doi.org/10.1038/35094017
227 rdf:type schema:CreativeWork
228 sg:pub.10.1038/38525 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023661637
229 https://doi.org/10.1038/38525
230 rdf:type schema:CreativeWork
231 sg:pub.10.1038/ncb950 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036115088
232 https://doi.org/10.1038/ncb950
233 rdf:type schema:CreativeWork
234 sg:pub.10.1038/nm1323 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018164278
235 https://doi.org/10.1038/nm1323
236 rdf:type schema:CreativeWork
237 sg:pub.10.1038/nm1362 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004626805
238 https://doi.org/10.1038/nm1362
239 rdf:type schema:CreativeWork
240 sg:pub.10.1038/nrc883 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008451806
241 https://doi.org/10.1038/nrc883
242 rdf:type schema:CreativeWork
243 https://app.dimensions.ai/details/publication/pub.1074829581 schema:CreativeWork
244 https://app.dimensions.ai/details/publication/pub.1077206171 schema:CreativeWork
245 https://app.dimensions.ai/details/publication/pub.1082941719 schema:CreativeWork
246 https://doi.org/10.1002/ana.20078 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004732075
247 rdf:type schema:CreativeWork
248 https://doi.org/10.1016/0006-2952(83)90390-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044713388
249 rdf:type schema:CreativeWork
250 https://doi.org/10.1016/j.cellsig.2006.04.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011588759
251 rdf:type schema:CreativeWork
252 https://doi.org/10.1016/j.clim.2006.01.016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028219853
253 rdf:type schema:CreativeWork
254 https://doi.org/10.1016/j.febslet.2004.10.080 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048278044
255 rdf:type schema:CreativeWork
256 https://doi.org/10.1016/j.molcel.2004.10.028 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033776786
257 rdf:type schema:CreativeWork
258 https://doi.org/10.1016/j.ydbio.2005.10.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017321957
259 rdf:type schema:CreativeWork
260 https://doi.org/10.1016/s0090-6980(02)00030-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048488434
261 rdf:type schema:CreativeWork
262 https://doi.org/10.1016/s0165-3806(00)00033-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1032345312
263 rdf:type schema:CreativeWork
264 https://doi.org/10.1016/s0304-3940(01)02449-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043128846
265 rdf:type schema:CreativeWork
266 https://doi.org/10.1016/s1470-2045(03)01220-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004241190
267 rdf:type schema:CreativeWork
268 https://doi.org/10.1073/pnas.0307453101 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013631316
269 rdf:type schema:CreativeWork
270 https://doi.org/10.1073/pnas.0837397100 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049930155
271 rdf:type schema:CreativeWork
272 https://doi.org/10.1073/pnas.1033060100 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030010366
273 rdf:type schema:CreativeWork
274 https://doi.org/10.1073/pnas.94.8.3668 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005318975
275 rdf:type schema:CreativeWork
276 https://doi.org/10.1073/pnas.96.13.7220 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020390495
277 rdf:type schema:CreativeWork
278 https://doi.org/10.1074/jbc.272.21.13829 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027253862
279 rdf:type schema:CreativeWork
280 https://doi.org/10.1074/jbc.273.28.17559 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017183810
281 rdf:type schema:CreativeWork
282 https://doi.org/10.1074/jbc.m208955200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020179553
283 rdf:type schema:CreativeWork
284 https://doi.org/10.1074/jbc.m309409200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020182481
285 rdf:type schema:CreativeWork
286 https://doi.org/10.1110/ps.8.3.689 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007631870
287 rdf:type schema:CreativeWork
288 https://doi.org/10.1111/j.1750-3639.2005.tb00512.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1030191099
289 rdf:type schema:CreativeWork
290 https://doi.org/10.1124/mol.104.002618 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004952187
291 rdf:type schema:CreativeWork
292 https://doi.org/10.1126/science.1116221 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062452503
293 rdf:type schema:CreativeWork
294 https://doi.org/10.1128/mcb.23.13.4701-4712.2003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013448453
295 rdf:type schema:CreativeWork
296 https://doi.org/10.1136/gut.2004.047100 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024718061
297 rdf:type schema:CreativeWork
298 https://doi.org/10.1136/gut.2005.073403 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008208215
299 rdf:type schema:CreativeWork
300 https://doi.org/10.1146/annurev.pharmtox.41.1.661 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030715235
301 rdf:type schema:CreativeWork
302 https://doi.org/10.1152/jn.00696.2004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002128259
303 rdf:type schema:CreativeWork
304 https://doi.org/10.1172/jci22218 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004762480
305 rdf:type schema:CreativeWork
306 https://doi.org/10.1172/jci9621 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036717477
307 rdf:type schema:CreativeWork
308 https://doi.org/10.1523/jneurosci.4485-03.2004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031942258
309 rdf:type schema:CreativeWork
310 https://doi.org/10.5483/bmbrep.2005.38.6.633 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040593114
311 rdf:type schema:CreativeWork
312 https://www.grid.ac/institutes/grid.414200.3 schema:alternateName Hôpital Laennec
313 schema:name Department of Anatomo-Pathology, G&R Laennec Hospital, CHU, Nantes, France
314 Department of Neurosurgery, G&R Laennec Hospital, CHU, Nantes, France
315 rdf:type schema:Organization
316 https://www.grid.ac/institutes/grid.4817.a schema:alternateName University of Nantes
317 schema:name Faculty of Medicine, University of Nantes, 9 quai MONCOUSU, Cedex 01, Nantes, France
318 INSERM U 601-Equipe 4, 9 Quai MONCOUSU, Cedex 01, Nantes, France
319 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...