Hypermethylation and transcriptional downregulation of the CITED4 gene at 1p34.2 in oligodendroglial tumours with allelic losses on 1p and 19q View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2007-07

AUTHORS

B Tews, P Roerig, C Hartmann, M Hahn, J Felsberg, B Blaschke, M Sabel, A Kunitz, G Toedt, K Neben, A Benner, A von Deimling, G Reifenberger, P Lichter

ABSTRACT

Deletions of chromosomal arms 1p and 19q are frequent in oligodendroglial tumours and have been associated with sensitivity to radio- and chemotherapy as well as favourable prognosis. By using microarray-based expression profiling, we found that oligodendroglial tumours with 1p and 19q losses showed significantly lower expression of the CBP/p300-interacting transactivator with glutamic acid/aspartic acid-rich carboxyl-terminal domain 4 gene (CITED4) at 1p34.2 as compared to tumours without 1p and 19q losses. Mutational analysis showed no CITED4 mutations in gliomas. However, 1p and 19q losses as well as low expression of CITED4 transcripts were significantly associated with hypermethylation of the CITED4-associated CpG island. In line with the latter finding, treatment of CITED4 hypermethylated glioma cell lines with 5-aza-2'-deoxycytidine and trichostatine A resulted in a marked increase of the CITED4 transcript levels. Furthermore, CITED4 hypermethylation was significantly associated with longer recurrence-free and overall survival of patients with oligodendroglial tumours. Taken together, our results indicate that CITED4 is epigenetically silenced in the vast majority of oligodendroglial tumours with 1p and 19q deletions and suggest CITED4 hypermethylation as a novel prognostic marker in oligodendroglioma patients. More... »

PAGES

1210297

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/sj.onc.1210297

DOI

http://dx.doi.org/10.1038/sj.onc.1210297

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1053061176

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/17311001


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Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/sj.onc.1210297'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/sj.onc.1210297'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/sj.onc.1210297'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/sj.onc.1210297'


 

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318 Department of Neurosurgery, Heinrich-Heine-University, Düsseldorf, Germany
319 rdf:type schema:Organization
320 https://www.grid.ac/institutes/grid.6363.0 schema:alternateName Charité
321 schema:name Department of Neuropathology, Charité University Medicine, Berlin, Germany
322 rdf:type schema:Organization
323 https://www.grid.ac/institutes/grid.7497.d schema:alternateName German Cancer Research Center
324 schema:name Central Unit Biostatistics (C060), Deutsches Krebsforschungszentrum, Heidelberg, Germany
325 Division of Molecular Genetics (B060), Deutsches Krebsforschungszentrum, Heidelberg, Germany
326 rdf:type schema:Organization
 




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