Genomic profiling of malignant melanoma using tiling-resolution arrayCGH View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2007-07

AUTHORS

G Jönsson, C Dahl, J Staaf, T Sandberg, P-O Bendahl, M Ringnér, P Guldberg, Å Borg

ABSTRACT

Malignant melanoma is an aggressive, heterogeneous disease where new biomarkers for diagnosis and clinical outcome are needed. We searched for chromosomal aberrations that characterize its pathogenesis using 47 different melanoma cell lines and tiling-resolution bacterial artificial chromosome-arrays for comparative genomic hybridization. Major melanoma genes, including BRAF, NRAS, CDKN2A, TP53, CTNNB1, CDK4 and PTEN, were examined for mutations. Distinct copy number alterations were detected, including loss or gain of whole chromosomes but also minute amplifications and homozygous deletions. Most common overlapping regions with losses were mapped to 9p24.3-q13, 10 and 11q14.1-qter, whereas copy number gains were most frequent on chromosomes 1q, 7, 17q and 20q. Amplifications were delineated to oncogenes such as MITF (3p14), CCND1 (11q13), MDM2 (12q15), CCNE1 (19q12) and NOTCH2 (1p12). Frequent findings of homozygous deletions on 9p21 and 10q23 confirmed the importance of CDKN2A and PTEN. Pair-wise comparisons revealed distinct sets of alterations, for example, mutually exclusive mutations in BRAF and NRAS, mutual mutations in BRAF and PTEN, concomitant chromosome 7 gain and 10 loss and concomitant chromosome 15q22.2-q26.3 gain and 20 gain. Moreover, alterations of the various melanoma genes were associated with distinct chromosomal imbalances suggestive of specific genomic programs in melanoma development. More... »

PAGES

4738

References to SciGraph publications

  • 2000-11. Senescence bypass screen identifies TBX2, which represses Cdkn2a (p19ARF) and is amplified in a subset of human breast cancers in NATURE GENETICS
  • 2005-09. Growth factors rescue cutaneous melanoma cells from apoptosis induced by knockdown of mutated (V600E) B-RAF in ONCOGENE
  • 2007-02. Melanocyte differentiation antigen RAB38/NY-MEL-1 induces frequent antibody responses exclusively in melanoma patients in CANCER IMMUNOLOGY, IMMUNOTHERAPY
  • 2004-03. Parsing the Polarity Code in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 2002-07. BioArray Software Environment (BASE): a platform for comprehensive management and analysis of microarray data in GENOME BIOLOGY
  • 2004-08. BRAF alterations are associated with complex mutational profiles in malignant melanoma in ONCOGENE
  • 2003-05. Melanoma etiology: where are we? in ONCOGENE
  • 2004-05. Microarray expression profiling in melanoma reveals a BRAF mutation signature in ONCOGENE
  • 2000-10. Concurrent disruption of p16INK4a and the ARF-p53 pathway predicts poor prognosis in aggressive non-Hodgkin's lymphoma in LEUKEMIA
  • 2001-11. Assembly of microarrays for genome-wide measurement of DNA copy number in NATURE GENETICS
  • 2004-11. Involvement of overexpressed wild-type BRAF in the growth of malignant melanoma cell lines in ONCOGENE
  • 2005-08. Constitutive Activation of the Mitogen-Activated Protein Kinase Signaling Pathway in Acral Melanomas in JOURNAL OF INVESTIGATIVE DERMATOLOGY
  • 2003-05. Genetics of melanoma predisposition in ONCOGENE
  • 2006-04. Evidence for differential expression of Notch receptors and their ligands in melanocytic nevi and cutaneous malignant melanoma in MODERN PATHOLOGY
  • 2003-01. High frequency of BRAF mutations in nevi in NATURE GENETICS
  • 2004-02. Genetic Interaction Between NRAS and BRAF Mutations and PTEN/MMAC1 Inactivation in Melanoma in JOURNAL OF INVESTIGATIVE DERMATOLOGY
  • 2000-08. Molecular classification of cutaneous malignant melanoma by gene expression profiling in NATURE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/sj.onc.1210252

    DOI

    http://dx.doi.org/10.1038/sj.onc.1210252

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1013514250

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/17260012


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