Chromosomal instability by β-catenin/TCF transcription in APC or β-catenin mutant cells View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2007-05

AUTHORS

K Aoki, M Aoki, M Sugai, N Harada, H Miyoshi, T Tsukamoto, T Mizoshita, M Tatematsu, H Seno, T Chiba, M Oshima, C-L Hsieh, M M Taketo

ABSTRACT

Adenomatous polyposis coli (APC/Apc) gene encodes a key tumor suppressor whose mutations activate beta-catenin/T-cell factor (TCF)-mediated transcription (canonical Wnt signaling). Here, we show that Wnt signaling can cause chromosomal instability (CIN). As an indicator of CIN, we scored anaphase bridge index (ABI) in mouse polyps and ES cells where Wnt signaling was activated by Apc or beta-catenin mutations. We found three to nine times higher ABI than in wild-type controls. Furthermore, karyotype analysis confirmed that the Wnt signal-activated ES cells produced new chromosomal aberrations at higher rates; hence CIN. Consistently, expression of dominant-negative TCFs in these cells reduced their ABI. We also found that Wnt signal activation increased phosphorylation of Cdc2 (Cdk1) that inhibited its activity, and suppressed apoptosis upon exposure of the cells to nocodazole or colcemid. The data suggest that Wnt signaling stimulates the cells to escape from mitotic arrest and apoptosis, resulting in CIN. In human gastric cancer tissues with nuclear beta-catenin, ABI was significantly higher than in those without. These results collectively indicate that beta-catenin/TCF-mediated transcription itself increases CIN through dysregulation of G2/M progression. More... »

PAGES

1210141

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/sj.onc.1210141

DOI

http://dx.doi.org/10.1038/sj.onc.1210141

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1034793137

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/17160019


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adenoma", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adenomatous Polyposis Coli Protein", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Division", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Survival", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cells, Cultured", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chromosomal Instability", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chromosome Aberrations", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Colonic Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Embryonic Stem Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "G2 Phase", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Intestinal Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Intestinal Polyps", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Microtubules", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mutation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Signal Transduction", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "TCF Transcription Factors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Transcription, Genetic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Wnt Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "beta Catenin", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Kyoto University", 
          "id": "https://www.grid.ac/institutes/grid.258799.8", 
          "name": [
            "Department of Pharmacology, Graduate School of Medicine, Kyoto University, Kyoto, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Aoki", 
        "givenName": "K", 
        "id": "sg:person.010144232201.38", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010144232201.38"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Kyoto University", 
          "id": "https://www.grid.ac/institutes/grid.258799.8", 
          "name": [
            "Department of Pharmacology, Graduate School of Medicine, Kyoto University, Kyoto, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Aoki", 
        "givenName": "M", 
        "id": "sg:person.0671034461.30", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0671034461.30"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Kyoto University", 
          "id": "https://www.grid.ac/institutes/grid.258799.8", 
          "name": [
            "Center for Molecular Biology and Genetics, Kyoto University, Kyoto, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sugai", 
        "givenName": "M", 
        "id": "sg:person.010162413401.73", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010162413401.73"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "MSD (Japan)", 
          "id": "https://www.grid.ac/institutes/grid.473495.8", 
          "name": [
            "Banyu Tsukuba Research Institute (Merck), Ibaraki, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Harada", 
        "givenName": "N", 
        "id": "sg:person.01004540071.38", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01004540071.38"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Kyoto University", 
          "id": "https://www.grid.ac/institutes/grid.258799.8", 
          "name": [
            "Department of Pharmacology, Graduate School of Medicine, Kyoto University, Kyoto, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Miyoshi", 
        "givenName": "H", 
        "id": "sg:person.01372474503.30", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01372474503.30"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Aichi Cancer Center", 
          "id": "https://www.grid.ac/institutes/grid.410800.d", 
          "name": [
            "Division of Oncological Pathology, Aichi Cancer Center Research Institute, Aichi, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tsukamoto", 
        "givenName": "T", 
        "id": "sg:person.01252761467.85", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01252761467.85"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Aichi Cancer Center", 
          "id": "https://www.grid.ac/institutes/grid.410800.d", 
          "name": [
            "Division of Oncological Pathology, Aichi Cancer Center Research Institute, Aichi, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mizoshita", 
        "givenName": "T", 
        "id": "sg:person.01111330405.64", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01111330405.64"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Aichi Cancer Center", 
          "id": "https://www.grid.ac/institutes/grid.410800.d", 
          "name": [
            "Division of Oncological Pathology, Aichi Cancer Center Research Institute, Aichi, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tatematsu", 
        "givenName": "M", 
        "id": "sg:person.01015162364.98", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01015162364.98"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Kyoto University", 
          "id": "https://www.grid.ac/institutes/grid.258799.8", 
          "name": [
            "Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, Kyoto, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Seno", 
        "givenName": "H", 
        "id": "sg:person.01077750644.53", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01077750644.53"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Kyoto University", 
          "id": "https://www.grid.ac/institutes/grid.258799.8", 
          "name": [
            "Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, Kyoto, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chiba", 
        "givenName": "T", 
        "id": "sg:person.015663113665.59", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015663113665.59"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Kyoto University", 
          "id": "https://www.grid.ac/institutes/grid.258799.8", 
          "name": [
            "Department of Pharmacology, Graduate School of Medicine, Kyoto University, Kyoto, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Oshima", 
        "givenName": "M", 
        "id": "sg:person.01320307366.35", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01320307366.35"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Southern California", 
          "id": "https://www.grid.ac/institutes/grid.42505.36", 
          "name": [
            "Department of Urology, University of Southern California, Los Angeles, CA, USA", 
            "Department of Biochemistry and Molecular Biology, University of Southern California, Los Angeles, CA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hsieh", 
        "givenName": "C-L", 
        "id": "sg:person.016327170752.58", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016327170752.58"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Kyoto University", 
          "id": "https://www.grid.ac/institutes/grid.258799.8", 
          "name": [
            "Department of Pharmacology, Graduate School of Medicine, Kyoto University, Kyoto, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Taketo", 
        "givenName": "M M", 
        "id": "sg:person.011640603564.72", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011640603564.72"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1101/gad.2.6.718", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005694212"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0065-230x(03)87293-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006057816"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1097-2765(02)00524-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009224712"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1535-6108(04)00033-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009712886"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0408454102", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009836788"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1097-0320(20000215)42:1<27::aid-cyto5>3.0.co;2-n", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010809430"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1242/dev.02398", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011760806"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/32688", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011887818", 
          "https://doi.org/10.1038/32688"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/32688", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011887818", 
          "https://doi.org/10.1038/32688"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature03099", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012218108", 
          "https://doi.org/10.1038/nature03099"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature03099", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012218108", 
          "https://doi.org/10.1038/nature03099"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1098-1004(1998)11:2<114::aid-humu3>3.0.co;2-j", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015242411"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.92.10.4482", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015460383"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature02313", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016242812", 
          "https://doi.org/10.1038/nature02313"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature02313", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016242812", 
          "https://doi.org/10.1038/nature02313"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/88871", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019751960", 
          "https://doi.org/10.1038/88871"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/88871", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019751960", 
          "https://doi.org/10.1038/88871"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.200307070", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019902363"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng1265", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023759725", 
          "https://doi.org/10.1038/ng1265"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng1265", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023759725", 
          "https://doi.org/10.1038/ng1265"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1097-2765(02)00510-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024283825"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-05-2145", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026567961"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.090013497", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026747570"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35070123", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027104291", 
          "https://doi.org/10.1038/35070123"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35070123", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027104291", 
          "https://doi.org/10.1038/35070123"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(02)01014-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029474411"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0012-1606(02)00020-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029639694"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0012-1606(02)00020-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029639694"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1535-6108(03)00302-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031673155"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35053094", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035074433", 
          "https://doi.org/10.1038/35053094"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35053094", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035074433", 
          "https://doi.org/10.1038/35053094"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1091/mbc.e03-08-0613", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036399145"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00432-003-0499-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036429089", 
          "https://doi.org/10.1007/s00432-003-0499-6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35070129", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036988128", 
          "https://doi.org/10.1038/35070129"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35070129", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036988128", 
          "https://doi.org/10.1038/35070129"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/18884", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037595361", 
          "https://doi.org/10.1038/18884"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/18884", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037595361", 
          "https://doi.org/10.1038/18884"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng1045", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038615904", 
          "https://doi.org/10.1038/ng1045"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng1045", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038615904", 
          "https://doi.org/10.1038/ng1045"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1242/jcs.01556", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040731411"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m310876200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041897132"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1349-7006.2006.00190.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042514978"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1349-7006.2006.00190.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042514978"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.281.5382.1509", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042662127"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.molcel.2004.07.009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043205288"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.molcel.2004.07.009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043205288"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc1170", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044830086", 
          "https://doi.org/10.1038/nrc1170"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc1170", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044830086", 
          "https://doi.org/10.1038/nrc1170"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/emboj/18.21.5931", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049664537"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1075277", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062446854"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.275.5307.1784", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062556119"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3892/ijo.21.4.769", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071514779"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074775077", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1075060952", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2007-05", 
    "datePublishedReg": "2007-05-01", 
    "description": "Adenomatous polyposis coli (APC/Apc) gene encodes a key tumor suppressor whose mutations activate beta-catenin/T-cell factor (TCF)-mediated transcription (canonical Wnt signaling). Here, we show that Wnt signaling can cause chromosomal instability (CIN). As an indicator of CIN, we scored anaphase bridge index (ABI) in mouse polyps and ES cells where Wnt signaling was activated by Apc or beta-catenin mutations. We found three to nine times higher ABI than in wild-type controls. Furthermore, karyotype analysis confirmed that the Wnt signal-activated ES cells produced new chromosomal aberrations at higher rates; hence CIN. Consistently, expression of dominant-negative TCFs in these cells reduced their ABI. We also found that Wnt signal activation increased phosphorylation of Cdc2 (Cdk1) that inhibited its activity, and suppressed apoptosis upon exposure of the cells to nocodazole or colcemid. The data suggest that Wnt signaling stimulates the cells to escape from mitotic arrest and apoptosis, resulting in CIN. In human gastric cancer tissues with nuclear beta-catenin, ABI was significantly higher than in those without. These results collectively indicate that beta-catenin/TCF-mediated transcription itself increases CIN through dysregulation of G2/M progression.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/sj.onc.1210141", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1097543", 
        "issn": [
          "0950-9232", 
          "1476-5594"
        ], 
        "name": "Oncogene", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "24", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "26"
      }
    ], 
    "name": "Chromosomal instability by \u03b2-catenin/TCF transcription in APC or \u03b2-catenin mutant cells", 
    "pagination": "1210141", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "a5bde5788fb83f1c5763c0e36965ba610a15626081fa99fc9108b17ed4f56f62"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "17160019"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "8711562"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/sj.onc.1210141"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1034793137"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/sj.onc.1210141", 
      "https://app.dimensions.ai/details/publication/pub.1034793137"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T12:15", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000361_0000000361/records_54014_00000000.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://www.nature.com/articles/1210141"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/sj.onc.1210141'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/sj.onc.1210141'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/sj.onc.1210141'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/sj.onc.1210141'


 

This table displays all metadata directly associated to this object as RDF triples.

383 TRIPLES      21 PREDICATES      91 URIs      43 LITERALS      31 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/sj.onc.1210141 schema:about N09868253ebd744d3bc4bb167724347c8
2 N1b833f632e5248e69a162c0867cb9029
3 N1debc73d6f3f42f98d6ca23877255cd6
4 N30fb502600094ce285f978c52bf49f3d
5 N32626371e050473f899d7f414eb7301e
6 N415205763f8644a695c7c4abcee0120c
7 N5aaa52e2fb4c44c881ab44405b1434a7
8 N5bd061ee04364955abef06889fbdf356
9 N64b9d59eea8544eaaa5d92cb36bf93a3
10 N77a05287ad17401a9b5774389c9a4a9e
11 N78b8706adeb947fe816ffdf8f77e553d
12 N7c3e76076dca4b269e79d27d4d54ac29
13 N85c2be4280ef4bc2a9f0862b8bf50af3
14 N9d663fe1b7b84707af36863ae5e40d26
15 N9ddbd616457442f2942e5a50e58c99cd
16 N9de1965e234744ea90dedc69584f3e20
17 Nc54b942e7b6a45de9f15cbb892911dec
18 Nd06c9edd955c48f0aaffed423fe3fda1
19 Ne1ba647d7f6f43dfbe425ec1c4a0aa08
20 Ne5982ab042e74c4fac3d4c6c4591b2da
21 Nfa6a2cd753c0459ba56c9595eb324d01
22 Nfda78ea0a6484f709282e81f9622a7b9
23 anzsrc-for:06
24 anzsrc-for:0601
25 schema:author Nbb288b17d5ee43e49f40e3714851e41e
26 schema:citation sg:pub.10.1007/s00432-003-0499-6
27 sg:pub.10.1038/18884
28 sg:pub.10.1038/32688
29 sg:pub.10.1038/35053094
30 sg:pub.10.1038/35070123
31 sg:pub.10.1038/35070129
32 sg:pub.10.1038/88871
33 sg:pub.10.1038/nature02313
34 sg:pub.10.1038/nature03099
35 sg:pub.10.1038/ng1045
36 sg:pub.10.1038/ng1265
37 sg:pub.10.1038/nrc1170
38 https://app.dimensions.ai/details/publication/pub.1074775077
39 https://app.dimensions.ai/details/publication/pub.1075060952
40 https://doi.org/10.1002/(sici)1097-0320(20000215)42:1<27::aid-cyto5>3.0.co;2-n
41 https://doi.org/10.1002/(sici)1098-1004(1998)11:2<114::aid-humu3>3.0.co;2-j
42 https://doi.org/10.1016/j.molcel.2004.07.009
43 https://doi.org/10.1016/s0012-1606(02)00020-9
44 https://doi.org/10.1016/s0065-230x(03)87293-7
45 https://doi.org/10.1016/s0092-8674(02)01014-0
46 https://doi.org/10.1016/s1097-2765(02)00510-5
47 https://doi.org/10.1016/s1097-2765(02)00524-5
48 https://doi.org/10.1016/s1535-6108(03)00302-7
49 https://doi.org/10.1016/s1535-6108(04)00033-9
50 https://doi.org/10.1073/pnas.0408454102
51 https://doi.org/10.1073/pnas.090013497
52 https://doi.org/10.1073/pnas.92.10.4482
53 https://doi.org/10.1074/jbc.m310876200
54 https://doi.org/10.1083/jcb.200307070
55 https://doi.org/10.1091/mbc.e03-08-0613
56 https://doi.org/10.1093/emboj/18.21.5931
57 https://doi.org/10.1101/gad.2.6.718
58 https://doi.org/10.1111/j.1349-7006.2006.00190.x
59 https://doi.org/10.1126/science.1075277
60 https://doi.org/10.1126/science.275.5307.1784
61 https://doi.org/10.1126/science.281.5382.1509
62 https://doi.org/10.1158/0008-5472.can-05-2145
63 https://doi.org/10.1242/dev.02398
64 https://doi.org/10.1242/jcs.01556
65 https://doi.org/10.3892/ijo.21.4.769
66 schema:datePublished 2007-05
67 schema:datePublishedReg 2007-05-01
68 schema:description Adenomatous polyposis coli (APC/Apc) gene encodes a key tumor suppressor whose mutations activate beta-catenin/T-cell factor (TCF)-mediated transcription (canonical Wnt signaling). Here, we show that Wnt signaling can cause chromosomal instability (CIN). As an indicator of CIN, we scored anaphase bridge index (ABI) in mouse polyps and ES cells where Wnt signaling was activated by Apc or beta-catenin mutations. We found three to nine times higher ABI than in wild-type controls. Furthermore, karyotype analysis confirmed that the Wnt signal-activated ES cells produced new chromosomal aberrations at higher rates; hence CIN. Consistently, expression of dominant-negative TCFs in these cells reduced their ABI. We also found that Wnt signal activation increased phosphorylation of Cdc2 (Cdk1) that inhibited its activity, and suppressed apoptosis upon exposure of the cells to nocodazole or colcemid. The data suggest that Wnt signaling stimulates the cells to escape from mitotic arrest and apoptosis, resulting in CIN. In human gastric cancer tissues with nuclear beta-catenin, ABI was significantly higher than in those without. These results collectively indicate that beta-catenin/TCF-mediated transcription itself increases CIN through dysregulation of G2/M progression.
69 schema:genre research_article
70 schema:inLanguage en
71 schema:isAccessibleForFree true
72 schema:isPartOf N9bdeed4231bc49c790ace38033d33db9
73 Na23803b795c144b599bc0e0499fe210b
74 sg:journal.1097543
75 schema:name Chromosomal instability by β-catenin/TCF transcription in APC or β-catenin mutant cells
76 schema:pagination 1210141
77 schema:productId N74cc491604ed4fbf9b1b0ab665b03b67
78 N8b78529527cd4541934726685d8d35c5
79 Ndcdbbbdd34364300b8801cdff641f91b
80 Ne1df439e963f434bb51a3a06f7118800
81 Ne2c425f832c0446f9069d52123b180ee
82 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034793137
83 https://doi.org/10.1038/sj.onc.1210141
84 schema:sdDatePublished 2019-04-11T12:15
85 schema:sdLicense https://scigraph.springernature.com/explorer/license/
86 schema:sdPublisher Na730317b01e5479a97595e38b8d550da
87 schema:url http://www.nature.com/articles/1210141
88 sgo:license sg:explorer/license/
89 sgo:sdDataset articles
90 rdf:type schema:ScholarlyArticle
91 N09868253ebd744d3bc4bb167724347c8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
92 schema:name Wnt Proteins
93 rdf:type schema:DefinedTerm
94 N1b833f632e5248e69a162c0867cb9029 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
95 schema:name Cell Survival
96 rdf:type schema:DefinedTerm
97 N1debc73d6f3f42f98d6ca23877255cd6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
98 schema:name G2 Phase
99 rdf:type schema:DefinedTerm
100 N2bca1cde563e440a812450959e14a925 rdf:first sg:person.01015162364.98
101 rdf:rest N9d621bb484894a9788ef3d31cf4a4aa4
102 N30fb502600094ce285f978c52bf49f3d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
103 schema:name Mutation
104 rdf:type schema:DefinedTerm
105 N32626371e050473f899d7f414eb7301e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
106 schema:name Chromosome Aberrations
107 rdf:type schema:DefinedTerm
108 N3397616d463e4fa78b2878b601db7c2f rdf:first sg:person.0671034461.30
109 rdf:rest N4410138341f64ddcaabcf29e9e7f1bf5
110 N415205763f8644a695c7c4abcee0120c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
111 schema:name Embryonic Stem Cells
112 rdf:type schema:DefinedTerm
113 N4410138341f64ddcaabcf29e9e7f1bf5 rdf:first sg:person.010162413401.73
114 rdf:rest Na779443838b74c898bb17cbcb555cfde
115 N5aaa52e2fb4c44c881ab44405b1434a7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
116 schema:name Mice
117 rdf:type schema:DefinedTerm
118 N5bd061ee04364955abef06889fbdf356 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
119 schema:name Intestinal Neoplasms
120 rdf:type schema:DefinedTerm
121 N64b9d59eea8544eaaa5d92cb36bf93a3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
122 schema:name Humans
123 rdf:type schema:DefinedTerm
124 N74cc491604ed4fbf9b1b0ab665b03b67 schema:name dimensions_id
125 schema:value pub.1034793137
126 rdf:type schema:PropertyValue
127 N77a05287ad17401a9b5774389c9a4a9e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
128 schema:name Cells, Cultured
129 rdf:type schema:DefinedTerm
130 N78b8706adeb947fe816ffdf8f77e553d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
131 schema:name Colonic Neoplasms
132 rdf:type schema:DefinedTerm
133 N7c3e76076dca4b269e79d27d4d54ac29 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
134 schema:name Intestinal Polyps
135 rdf:type schema:DefinedTerm
136 N7dc5c593961b45258e3a41f911f04e8d rdf:first sg:person.015663113665.59
137 rdf:rest Nabb3cfdc07924ccab631004e23cb6902
138 N8535b62384954a258a008a9d46c2fc92 rdf:first sg:person.01111330405.64
139 rdf:rest N2bca1cde563e440a812450959e14a925
140 N85c2be4280ef4bc2a9f0862b8bf50af3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
141 schema:name TCF Transcription Factors
142 rdf:type schema:DefinedTerm
143 N8b78529527cd4541934726685d8d35c5 schema:name readcube_id
144 schema:value a5bde5788fb83f1c5763c0e36965ba610a15626081fa99fc9108b17ed4f56f62
145 rdf:type schema:PropertyValue
146 N9bdeed4231bc49c790ace38033d33db9 schema:issueNumber 24
147 rdf:type schema:PublicationIssue
148 N9d621bb484894a9788ef3d31cf4a4aa4 rdf:first sg:person.01077750644.53
149 rdf:rest N7dc5c593961b45258e3a41f911f04e8d
150 N9d663fe1b7b84707af36863ae5e40d26 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
151 schema:name Chromosomal Instability
152 rdf:type schema:DefinedTerm
153 N9ddbd616457442f2942e5a50e58c99cd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
154 schema:name Signal Transduction
155 rdf:type schema:DefinedTerm
156 N9de1965e234744ea90dedc69584f3e20 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
157 schema:name Transcription, Genetic
158 rdf:type schema:DefinedTerm
159 Na23803b795c144b599bc0e0499fe210b schema:volumeNumber 26
160 rdf:type schema:PublicationVolume
161 Na730317b01e5479a97595e38b8d550da schema:name Springer Nature - SN SciGraph project
162 rdf:type schema:Organization
163 Na779443838b74c898bb17cbcb555cfde rdf:first sg:person.01004540071.38
164 rdf:rest Nf5a6a8fbd41548b484bb7618890cf03d
165 Nabb3cfdc07924ccab631004e23cb6902 rdf:first sg:person.01320307366.35
166 rdf:rest Ncab20f2ffc8f4e0c9961bb66a5d291c9
167 Nbb288b17d5ee43e49f40e3714851e41e rdf:first sg:person.010144232201.38
168 rdf:rest N3397616d463e4fa78b2878b601db7c2f
169 Nc54b942e7b6a45de9f15cbb892911dec schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
170 schema:name Adenomatous Polyposis Coli Protein
171 rdf:type schema:DefinedTerm
172 Ncab20f2ffc8f4e0c9961bb66a5d291c9 rdf:first sg:person.016327170752.58
173 rdf:rest Nfd21bc18df63446c88fd6b3bf8ed53f5
174 Nd06c9edd955c48f0aaffed423fe3fda1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
175 schema:name Adenoma
176 rdf:type schema:DefinedTerm
177 Ndcdbbbdd34364300b8801cdff641f91b schema:name nlm_unique_id
178 schema:value 8711562
179 rdf:type schema:PropertyValue
180 Ne1ba647d7f6f43dfbe425ec1c4a0aa08 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
181 schema:name Animals
182 rdf:type schema:DefinedTerm
183 Ne1df439e963f434bb51a3a06f7118800 schema:name doi
184 schema:value 10.1038/sj.onc.1210141
185 rdf:type schema:PropertyValue
186 Ne2c425f832c0446f9069d52123b180ee schema:name pubmed_id
187 schema:value 17160019
188 rdf:type schema:PropertyValue
189 Ne5982ab042e74c4fac3d4c6c4591b2da schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
190 schema:name Cell Division
191 rdf:type schema:DefinedTerm
192 Nf5a6a8fbd41548b484bb7618890cf03d rdf:first sg:person.01372474503.30
193 rdf:rest Nf90cf6a3a05d4b2e91efcba214d31ca4
194 Nf90cf6a3a05d4b2e91efcba214d31ca4 rdf:first sg:person.01252761467.85
195 rdf:rest N8535b62384954a258a008a9d46c2fc92
196 Nfa6a2cd753c0459ba56c9595eb324d01 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
197 schema:name beta Catenin
198 rdf:type schema:DefinedTerm
199 Nfd21bc18df63446c88fd6b3bf8ed53f5 rdf:first sg:person.011640603564.72
200 rdf:rest rdf:nil
201 Nfda78ea0a6484f709282e81f9622a7b9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
202 schema:name Microtubules
203 rdf:type schema:DefinedTerm
204 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
205 schema:name Biological Sciences
206 rdf:type schema:DefinedTerm
207 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
208 schema:name Biochemistry and Cell Biology
209 rdf:type schema:DefinedTerm
210 sg:journal.1097543 schema:issn 0950-9232
211 1476-5594
212 schema:name Oncogene
213 rdf:type schema:Periodical
214 sg:person.01004540071.38 schema:affiliation https://www.grid.ac/institutes/grid.473495.8
215 schema:familyName Harada
216 schema:givenName N
217 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01004540071.38
218 rdf:type schema:Person
219 sg:person.010144232201.38 schema:affiliation https://www.grid.ac/institutes/grid.258799.8
220 schema:familyName Aoki
221 schema:givenName K
222 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010144232201.38
223 rdf:type schema:Person
224 sg:person.01015162364.98 schema:affiliation https://www.grid.ac/institutes/grid.410800.d
225 schema:familyName Tatematsu
226 schema:givenName M
227 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01015162364.98
228 rdf:type schema:Person
229 sg:person.010162413401.73 schema:affiliation https://www.grid.ac/institutes/grid.258799.8
230 schema:familyName Sugai
231 schema:givenName M
232 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010162413401.73
233 rdf:type schema:Person
234 sg:person.01077750644.53 schema:affiliation https://www.grid.ac/institutes/grid.258799.8
235 schema:familyName Seno
236 schema:givenName H
237 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01077750644.53
238 rdf:type schema:Person
239 sg:person.01111330405.64 schema:affiliation https://www.grid.ac/institutes/grid.410800.d
240 schema:familyName Mizoshita
241 schema:givenName T
242 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01111330405.64
243 rdf:type schema:Person
244 sg:person.011640603564.72 schema:affiliation https://www.grid.ac/institutes/grid.258799.8
245 schema:familyName Taketo
246 schema:givenName M M
247 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011640603564.72
248 rdf:type schema:Person
249 sg:person.01252761467.85 schema:affiliation https://www.grid.ac/institutes/grid.410800.d
250 schema:familyName Tsukamoto
251 schema:givenName T
252 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01252761467.85
253 rdf:type schema:Person
254 sg:person.01320307366.35 schema:affiliation https://www.grid.ac/institutes/grid.258799.8
255 schema:familyName Oshima
256 schema:givenName M
257 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01320307366.35
258 rdf:type schema:Person
259 sg:person.01372474503.30 schema:affiliation https://www.grid.ac/institutes/grid.258799.8
260 schema:familyName Miyoshi
261 schema:givenName H
262 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01372474503.30
263 rdf:type schema:Person
264 sg:person.015663113665.59 schema:affiliation https://www.grid.ac/institutes/grid.258799.8
265 schema:familyName Chiba
266 schema:givenName T
267 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015663113665.59
268 rdf:type schema:Person
269 sg:person.016327170752.58 schema:affiliation https://www.grid.ac/institutes/grid.42505.36
270 schema:familyName Hsieh
271 schema:givenName C-L
272 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016327170752.58
273 rdf:type schema:Person
274 sg:person.0671034461.30 schema:affiliation https://www.grid.ac/institutes/grid.258799.8
275 schema:familyName Aoki
276 schema:givenName M
277 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0671034461.30
278 rdf:type schema:Person
279 sg:pub.10.1007/s00432-003-0499-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036429089
280 https://doi.org/10.1007/s00432-003-0499-6
281 rdf:type schema:CreativeWork
282 sg:pub.10.1038/18884 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037595361
283 https://doi.org/10.1038/18884
284 rdf:type schema:CreativeWork
285 sg:pub.10.1038/32688 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011887818
286 https://doi.org/10.1038/32688
287 rdf:type schema:CreativeWork
288 sg:pub.10.1038/35053094 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035074433
289 https://doi.org/10.1038/35053094
290 rdf:type schema:CreativeWork
291 sg:pub.10.1038/35070123 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027104291
292 https://doi.org/10.1038/35070123
293 rdf:type schema:CreativeWork
294 sg:pub.10.1038/35070129 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036988128
295 https://doi.org/10.1038/35070129
296 rdf:type schema:CreativeWork
297 sg:pub.10.1038/88871 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019751960
298 https://doi.org/10.1038/88871
299 rdf:type schema:CreativeWork
300 sg:pub.10.1038/nature02313 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016242812
301 https://doi.org/10.1038/nature02313
302 rdf:type schema:CreativeWork
303 sg:pub.10.1038/nature03099 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012218108
304 https://doi.org/10.1038/nature03099
305 rdf:type schema:CreativeWork
306 sg:pub.10.1038/ng1045 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038615904
307 https://doi.org/10.1038/ng1045
308 rdf:type schema:CreativeWork
309 sg:pub.10.1038/ng1265 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023759725
310 https://doi.org/10.1038/ng1265
311 rdf:type schema:CreativeWork
312 sg:pub.10.1038/nrc1170 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044830086
313 https://doi.org/10.1038/nrc1170
314 rdf:type schema:CreativeWork
315 https://app.dimensions.ai/details/publication/pub.1074775077 schema:CreativeWork
316 https://app.dimensions.ai/details/publication/pub.1075060952 schema:CreativeWork
317 https://doi.org/10.1002/(sici)1097-0320(20000215)42:1<27::aid-cyto5>3.0.co;2-n schema:sameAs https://app.dimensions.ai/details/publication/pub.1010809430
318 rdf:type schema:CreativeWork
319 https://doi.org/10.1002/(sici)1098-1004(1998)11:2<114::aid-humu3>3.0.co;2-j schema:sameAs https://app.dimensions.ai/details/publication/pub.1015242411
320 rdf:type schema:CreativeWork
321 https://doi.org/10.1016/j.molcel.2004.07.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043205288
322 rdf:type schema:CreativeWork
323 https://doi.org/10.1016/s0012-1606(02)00020-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029639694
324 rdf:type schema:CreativeWork
325 https://doi.org/10.1016/s0065-230x(03)87293-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006057816
326 rdf:type schema:CreativeWork
327 https://doi.org/10.1016/s0092-8674(02)01014-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029474411
328 rdf:type schema:CreativeWork
329 https://doi.org/10.1016/s1097-2765(02)00510-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024283825
330 rdf:type schema:CreativeWork
331 https://doi.org/10.1016/s1097-2765(02)00524-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009224712
332 rdf:type schema:CreativeWork
333 https://doi.org/10.1016/s1535-6108(03)00302-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031673155
334 rdf:type schema:CreativeWork
335 https://doi.org/10.1016/s1535-6108(04)00033-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009712886
336 rdf:type schema:CreativeWork
337 https://doi.org/10.1073/pnas.0408454102 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009836788
338 rdf:type schema:CreativeWork
339 https://doi.org/10.1073/pnas.090013497 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026747570
340 rdf:type schema:CreativeWork
341 https://doi.org/10.1073/pnas.92.10.4482 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015460383
342 rdf:type schema:CreativeWork
343 https://doi.org/10.1074/jbc.m310876200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041897132
344 rdf:type schema:CreativeWork
345 https://doi.org/10.1083/jcb.200307070 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019902363
346 rdf:type schema:CreativeWork
347 https://doi.org/10.1091/mbc.e03-08-0613 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036399145
348 rdf:type schema:CreativeWork
349 https://doi.org/10.1093/emboj/18.21.5931 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049664537
350 rdf:type schema:CreativeWork
351 https://doi.org/10.1101/gad.2.6.718 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005694212
352 rdf:type schema:CreativeWork
353 https://doi.org/10.1111/j.1349-7006.2006.00190.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1042514978
354 rdf:type schema:CreativeWork
355 https://doi.org/10.1126/science.1075277 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062446854
356 rdf:type schema:CreativeWork
357 https://doi.org/10.1126/science.275.5307.1784 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062556119
358 rdf:type schema:CreativeWork
359 https://doi.org/10.1126/science.281.5382.1509 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042662127
360 rdf:type schema:CreativeWork
361 https://doi.org/10.1158/0008-5472.can-05-2145 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026567961
362 rdf:type schema:CreativeWork
363 https://doi.org/10.1242/dev.02398 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011760806
364 rdf:type schema:CreativeWork
365 https://doi.org/10.1242/jcs.01556 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040731411
366 rdf:type schema:CreativeWork
367 https://doi.org/10.3892/ijo.21.4.769 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071514779
368 rdf:type schema:CreativeWork
369 https://www.grid.ac/institutes/grid.258799.8 schema:alternateName Kyoto University
370 schema:name Center for Molecular Biology and Genetics, Kyoto University, Kyoto, Japan
371 Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
372 Department of Pharmacology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
373 rdf:type schema:Organization
374 https://www.grid.ac/institutes/grid.410800.d schema:alternateName Aichi Cancer Center
375 schema:name Division of Oncological Pathology, Aichi Cancer Center Research Institute, Aichi, Japan
376 rdf:type schema:Organization
377 https://www.grid.ac/institutes/grid.42505.36 schema:alternateName University of Southern California
378 schema:name Department of Biochemistry and Molecular Biology, University of Southern California, Los Angeles, CA, USA
379 Department of Urology, University of Southern California, Los Angeles, CA, USA
380 rdf:type schema:Organization
381 https://www.grid.ac/institutes/grid.473495.8 schema:alternateName MSD (Japan)
382 schema:name Banyu Tsukuba Research Institute (Merck), Ibaraki, Japan
383 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...