Genetic dissection of the role of p21Cip1/Waf1 in p53-mediated tumour suppression View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2007-03

AUTHORS

A Efeyan, M Collado, S Velasco-Miguel, M Serrano

ABSTRACT

Protein p21Cip1/Waf1 is transcriptionally activated by the tumour suppressor p53 and previous studies have shown that p21 plays a role in tumour suppression. However, the involvement of p21 in p53-mediated tumour suppression remains to be directly demonstrated in vivo. Tumour suppression mediated by p53 can be measured by comparing tumour susceptibility in animals carrying two (wild-type mice) or three (super-p53 mice) copies of the p53 gene. We have taken advantage of this genetically defined system to measure p53-mediated cell-cycle arrest, apoptosis and tumorigenesis, in a p21 wild-type and in a p21-null context. The absence of p21 significantly impaired the enhanced p53-mediated cell-cycle arrest characteristic of super-p53 cells, but did not affect the enhanced apoptosis. Importantly, in an experimental model of fibrosarcoma induction, the absence of p21 significantly decreased the tumour suppression benefit of super-p53 mice. We conclude that cell-cycle arrest through p21 plays a significant role in mediating p53-dependent cancer protection. More... »

PAGES

1209972

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/sj.onc.1209972

DOI

http://dx.doi.org/10.1038/sj.onc.1209972

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1014683131

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/16964282


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Apoptosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Cycle", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cyclin-Dependent Kinase Inhibitor p21", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tumor Suppressor Protein p53", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Spanish National Cancer Research Centre", 
          "id": "https://www.grid.ac/institutes/grid.7719.8", 
          "name": [
            "Molecular Oncology Program, Spanish National Cancer Centre (CNIO), Madrid, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Efeyan", 
        "givenName": "A", 
        "id": "sg:person.01276434177.74", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01276434177.74"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Spanish National Cancer Research Centre", 
          "id": "https://www.grid.ac/institutes/grid.7719.8", 
          "name": [
            "Molecular Oncology Program, Spanish National Cancer Centre (CNIO), Madrid, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Collado", 
        "givenName": "M", 
        "id": "sg:person.01147153635.56", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01147153635.56"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Spanish National Cancer Research Centre", 
          "id": "https://www.grid.ac/institutes/grid.7719.8", 
          "name": [
            "Molecular Oncology Program, Spanish National Cancer Centre (CNIO), Madrid, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Velasco-Miguel", 
        "givenName": "S", 
        "id": "sg:person.01004647243.35", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01004647243.35"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Spanish National Cancer Research Centre", 
          "id": "https://www.grid.ac/institutes/grid.7719.8", 
          "name": [
            "Molecular Oncology Program, Spanish National Cancer Centre (CNIO), Madrid, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Serrano", 
        "givenName": "M", 
        "id": "sg:person.013110175140.37", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013110175140.37"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/sj.onc.1205946", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001462636", 
          "https://doi.org/10.1038/sj.onc.1205946"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1205946", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001462636", 
          "https://doi.org/10.1038/sj.onc.1205946"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1201052", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001501834", 
          "https://doi.org/10.1038/sj.onc.1201052"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1201052", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001501834", 
          "https://doi.org/10.1038/sj.onc.1201052"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.20.16.6147-6158.2000", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002186098"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1204276", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004857908", 
          "https://doi.org/10.1038/sj.onc.1204276"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1204276", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004857908", 
          "https://doi.org/10.1038/sj.onc.1204276"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1203956", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011002808", 
          "https://doi.org/10.1038/sj.onc.1203956"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1203956", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011002808", 
          "https://doi.org/10.1038/sj.onc.1203956"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.7.4.535", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013372391"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1207994", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018636893", 
          "https://doi.org/10.1038/sj.onc.1207994"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1207994", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018636893", 
          "https://doi.org/10.1038/sj.onc.1207994"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc864", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018869258", 
          "https://doi.org/10.1038/nrc864"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc864", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018869258", 
          "https://doi.org/10.1038/nrc864"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/366701a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020218634", 
          "https://doi.org/10.1038/366701a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1209432", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023061383", 
          "https://doi.org/10.1038/sj.onc.1209432"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1209432", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023061383", 
          "https://doi.org/10.1038/sj.onc.1209432"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1201899", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024298808", 
          "https://doi.org/10.1038/sj.onc.1201899"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1201899", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024298808", 
          "https://doi.org/10.1038/sj.onc.1201899"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.141.2.503", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024342136"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1202840", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029385532", 
          "https://doi.org/10.1038/sj.onc.1202840"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1202840", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029385532", 
          "https://doi.org/10.1038/sj.onc.1202840"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.96.16.9089", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030304279"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/362847a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032575717", 
          "https://doi.org/10.1038/362847a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/emboj/cdf595", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033235876"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(93)90499-g", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034836400"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2004.12.027", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037368228"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(93)90500-p", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038576682"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0076-6879(01)33060-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039428546"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1207863", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044751771", 
          "https://doi.org/10.1038/sj.onc.1207863"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1207863", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044751771", 
          "https://doi.org/10.1038/sj.onc.1207863"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1207494", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045991567", 
          "https://doi.org/10.1038/sj.onc.1207494"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1207494", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045991567", 
          "https://doi.org/10.1038/sj.onc.1207494"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0002-9440(10)62342-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048280099"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/377552a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050160413", 
          "https://doi.org/10.1038/377552a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(95)90039-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051937826"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4161/cc.1.3.118", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1072295791"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4161/cc.3.2.658", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1072297833"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074369198", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074769883", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074865720", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1075025307", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1075301773", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2007-03", 
    "datePublishedReg": "2007-03-01", 
    "description": "Protein p21Cip1/Waf1 is transcriptionally activated by the tumour suppressor p53 and previous studies have shown that p21 plays a role in tumour suppression. However, the involvement of p21 in p53-mediated tumour suppression remains to be directly demonstrated in vivo. Tumour suppression mediated by p53 can be measured by comparing tumour susceptibility in animals carrying two (wild-type mice) or three (super-p53 mice) copies of the p53 gene. We have taken advantage of this genetically defined system to measure p53-mediated cell-cycle arrest, apoptosis and tumorigenesis, in a p21 wild-type and in a p21-null context. The absence of p21 significantly impaired the enhanced p53-mediated cell-cycle arrest characteristic of super-p53 cells, but did not affect the enhanced apoptosis. Importantly, in an experimental model of fibrosarcoma induction, the absence of p21 significantly decreased the tumour suppression benefit of super-p53 mice. We conclude that cell-cycle arrest through p21 plays a significant role in mediating p53-dependent cancer protection.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/sj.onc.1209972", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1097543", 
        "issn": [
          "0950-9232", 
          "1476-5594"
        ], 
        "name": "Oncogene", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "11", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "26"
      }
    ], 
    "name": "Genetic dissection of the role of p21Cip1/Waf1 in p53-mediated tumour suppression", 
    "pagination": "1209972", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "45f430e7c94734c4163b189e860f2775bb26aa7f13e00beda3f864eba09e2719"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "16964282"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "8711562"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/sj.onc.1209972"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1014683131"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/sj.onc.1209972", 
      "https://app.dimensions.ai/details/publication/pub.1014683131"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T12:03", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000360_0000000360/records_118306_00000000.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://www.nature.com/articles/1209972"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/sj.onc.1209972'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/sj.onc.1209972'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/sj.onc.1209972'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/sj.onc.1209972'


 

This table displays all metadata directly associated to this object as RDF triples.

219 TRIPLES      21 PREDICATES      67 URIs      27 LITERALS      15 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/sj.onc.1209972 schema:about N1ed6a215edde4c6fa97613dd43edd784
2 N31c6ab4b58c8488983e659656dba5c50
3 N5c69cdedd59c49658cb607d5770c8448
4 N744bbd85a0ff40cd8ea097836c121988
5 N77ed06bcf5bd4695887babd2f0066e6b
6 N9b9ee6c7c8c440efa37bd8bc1ee6aaca
7 anzsrc-for:11
8 anzsrc-for:1112
9 schema:author N0ebca8fbc4bc4479a4b404caa874cc6f
10 schema:citation sg:pub.10.1038/362847a0
11 sg:pub.10.1038/366701a0
12 sg:pub.10.1038/377552a0
13 sg:pub.10.1038/nrc864
14 sg:pub.10.1038/sj.onc.1201052
15 sg:pub.10.1038/sj.onc.1201899
16 sg:pub.10.1038/sj.onc.1202840
17 sg:pub.10.1038/sj.onc.1203956
18 sg:pub.10.1038/sj.onc.1204276
19 sg:pub.10.1038/sj.onc.1205946
20 sg:pub.10.1038/sj.onc.1207494
21 sg:pub.10.1038/sj.onc.1207863
22 sg:pub.10.1038/sj.onc.1207994
23 sg:pub.10.1038/sj.onc.1209432
24 https://app.dimensions.ai/details/publication/pub.1074369198
25 https://app.dimensions.ai/details/publication/pub.1074769883
26 https://app.dimensions.ai/details/publication/pub.1074865720
27 https://app.dimensions.ai/details/publication/pub.1075025307
28 https://app.dimensions.ai/details/publication/pub.1075301773
29 https://doi.org/10.1016/0092-8674(93)90499-g
30 https://doi.org/10.1016/0092-8674(93)90500-p
31 https://doi.org/10.1016/0092-8674(95)90039-x
32 https://doi.org/10.1016/j.cell.2004.12.027
33 https://doi.org/10.1016/s0002-9440(10)62342-5
34 https://doi.org/10.1016/s0076-6879(01)33060-4
35 https://doi.org/10.1073/pnas.96.16.9089
36 https://doi.org/10.1083/jcb.141.2.503
37 https://doi.org/10.1093/emboj/cdf595
38 https://doi.org/10.1101/gad.7.4.535
39 https://doi.org/10.1128/mcb.20.16.6147-6158.2000
40 https://doi.org/10.4161/cc.1.3.118
41 https://doi.org/10.4161/cc.3.2.658
42 schema:datePublished 2007-03
43 schema:datePublishedReg 2007-03-01
44 schema:description Protein p21Cip1/Waf1 is transcriptionally activated by the tumour suppressor p53 and previous studies have shown that p21 plays a role in tumour suppression. However, the involvement of p21 in p53-mediated tumour suppression remains to be directly demonstrated in vivo. Tumour suppression mediated by p53 can be measured by comparing tumour susceptibility in animals carrying two (wild-type mice) or three (super-p53 mice) copies of the p53 gene. We have taken advantage of this genetically defined system to measure p53-mediated cell-cycle arrest, apoptosis and tumorigenesis, in a p21 wild-type and in a p21-null context. The absence of p21 significantly impaired the enhanced p53-mediated cell-cycle arrest characteristic of super-p53 cells, but did not affect the enhanced apoptosis. Importantly, in an experimental model of fibrosarcoma induction, the absence of p21 significantly decreased the tumour suppression benefit of super-p53 mice. We conclude that cell-cycle arrest through p21 plays a significant role in mediating p53-dependent cancer protection.
45 schema:genre research_article
46 schema:inLanguage en
47 schema:isAccessibleForFree true
48 schema:isPartOf N2663e378486b43938ec7afcd2e9c3935
49 N3e46c35abcb04357bba13c852c7df9e8
50 sg:journal.1097543
51 schema:name Genetic dissection of the role of p21Cip1/Waf1 in p53-mediated tumour suppression
52 schema:pagination 1209972
53 schema:productId N0f7c38fe0bda4400bdaa8b52bf79d458
54 N2cb042f23a4c4b97a30ef033ce34fb45
55 N391cbbb366814350a0ba907d59481904
56 N68c4670cb9624e2fae15c6ebfe53fa90
57 N72103369a76c492cb5b7fd30fe19b972
58 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014683131
59 https://doi.org/10.1038/sj.onc.1209972
60 schema:sdDatePublished 2019-04-11T12:03
61 schema:sdLicense https://scigraph.springernature.com/explorer/license/
62 schema:sdPublisher N286143570ee74613a11160fdcce95689
63 schema:url http://www.nature.com/articles/1209972
64 sgo:license sg:explorer/license/
65 sgo:sdDataset articles
66 rdf:type schema:ScholarlyArticle
67 N0ebca8fbc4bc4479a4b404caa874cc6f rdf:first sg:person.01276434177.74
68 rdf:rest Nf0582e2e33554a769c901a0d2334a13c
69 N0f7c38fe0bda4400bdaa8b52bf79d458 schema:name nlm_unique_id
70 schema:value 8711562
71 rdf:type schema:PropertyValue
72 N1ed6a215edde4c6fa97613dd43edd784 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
73 schema:name Mice
74 rdf:type schema:DefinedTerm
75 N2663e378486b43938ec7afcd2e9c3935 schema:volumeNumber 26
76 rdf:type schema:PublicationVolume
77 N286143570ee74613a11160fdcce95689 schema:name Springer Nature - SN SciGraph project
78 rdf:type schema:Organization
79 N2cb042f23a4c4b97a30ef033ce34fb45 schema:name doi
80 schema:value 10.1038/sj.onc.1209972
81 rdf:type schema:PropertyValue
82 N31c6ab4b58c8488983e659656dba5c50 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
83 schema:name Cyclin-Dependent Kinase Inhibitor p21
84 rdf:type schema:DefinedTerm
85 N391cbbb366814350a0ba907d59481904 schema:name readcube_id
86 schema:value 45f430e7c94734c4163b189e860f2775bb26aa7f13e00beda3f864eba09e2719
87 rdf:type schema:PropertyValue
88 N3e46c35abcb04357bba13c852c7df9e8 schema:issueNumber 11
89 rdf:type schema:PublicationIssue
90 N5c69cdedd59c49658cb607d5770c8448 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
91 schema:name Animals
92 rdf:type schema:DefinedTerm
93 N68c4670cb9624e2fae15c6ebfe53fa90 schema:name pubmed_id
94 schema:value 16964282
95 rdf:type schema:PropertyValue
96 N6a9e014daddd447faf4e5e0c6cc518b5 rdf:first sg:person.013110175140.37
97 rdf:rest rdf:nil
98 N72103369a76c492cb5b7fd30fe19b972 schema:name dimensions_id
99 schema:value pub.1014683131
100 rdf:type schema:PropertyValue
101 N744bbd85a0ff40cd8ea097836c121988 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
102 schema:name Cell Cycle
103 rdf:type schema:DefinedTerm
104 N77ed06bcf5bd4695887babd2f0066e6b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
105 schema:name Apoptosis
106 rdf:type schema:DefinedTerm
107 N9b9ee6c7c8c440efa37bd8bc1ee6aaca schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
108 schema:name Tumor Suppressor Protein p53
109 rdf:type schema:DefinedTerm
110 Nc9c0dbd57f58489abbf1b00ef74584e0 rdf:first sg:person.01004647243.35
111 rdf:rest N6a9e014daddd447faf4e5e0c6cc518b5
112 Nf0582e2e33554a769c901a0d2334a13c rdf:first sg:person.01147153635.56
113 rdf:rest Nc9c0dbd57f58489abbf1b00ef74584e0
114 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
115 schema:name Medical and Health Sciences
116 rdf:type schema:DefinedTerm
117 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
118 schema:name Oncology and Carcinogenesis
119 rdf:type schema:DefinedTerm
120 sg:journal.1097543 schema:issn 0950-9232
121 1476-5594
122 schema:name Oncogene
123 rdf:type schema:Periodical
124 sg:person.01004647243.35 schema:affiliation https://www.grid.ac/institutes/grid.7719.8
125 schema:familyName Velasco-Miguel
126 schema:givenName S
127 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01004647243.35
128 rdf:type schema:Person
129 sg:person.01147153635.56 schema:affiliation https://www.grid.ac/institutes/grid.7719.8
130 schema:familyName Collado
131 schema:givenName M
132 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01147153635.56
133 rdf:type schema:Person
134 sg:person.01276434177.74 schema:affiliation https://www.grid.ac/institutes/grid.7719.8
135 schema:familyName Efeyan
136 schema:givenName A
137 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01276434177.74
138 rdf:type schema:Person
139 sg:person.013110175140.37 schema:affiliation https://www.grid.ac/institutes/grid.7719.8
140 schema:familyName Serrano
141 schema:givenName M
142 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013110175140.37
143 rdf:type schema:Person
144 sg:pub.10.1038/362847a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032575717
145 https://doi.org/10.1038/362847a0
146 rdf:type schema:CreativeWork
147 sg:pub.10.1038/366701a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020218634
148 https://doi.org/10.1038/366701a0
149 rdf:type schema:CreativeWork
150 sg:pub.10.1038/377552a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050160413
151 https://doi.org/10.1038/377552a0
152 rdf:type schema:CreativeWork
153 sg:pub.10.1038/nrc864 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018869258
154 https://doi.org/10.1038/nrc864
155 rdf:type schema:CreativeWork
156 sg:pub.10.1038/sj.onc.1201052 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001501834
157 https://doi.org/10.1038/sj.onc.1201052
158 rdf:type schema:CreativeWork
159 sg:pub.10.1038/sj.onc.1201899 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024298808
160 https://doi.org/10.1038/sj.onc.1201899
161 rdf:type schema:CreativeWork
162 sg:pub.10.1038/sj.onc.1202840 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029385532
163 https://doi.org/10.1038/sj.onc.1202840
164 rdf:type schema:CreativeWork
165 sg:pub.10.1038/sj.onc.1203956 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011002808
166 https://doi.org/10.1038/sj.onc.1203956
167 rdf:type schema:CreativeWork
168 sg:pub.10.1038/sj.onc.1204276 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004857908
169 https://doi.org/10.1038/sj.onc.1204276
170 rdf:type schema:CreativeWork
171 sg:pub.10.1038/sj.onc.1205946 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001462636
172 https://doi.org/10.1038/sj.onc.1205946
173 rdf:type schema:CreativeWork
174 sg:pub.10.1038/sj.onc.1207494 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045991567
175 https://doi.org/10.1038/sj.onc.1207494
176 rdf:type schema:CreativeWork
177 sg:pub.10.1038/sj.onc.1207863 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044751771
178 https://doi.org/10.1038/sj.onc.1207863
179 rdf:type schema:CreativeWork
180 sg:pub.10.1038/sj.onc.1207994 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018636893
181 https://doi.org/10.1038/sj.onc.1207994
182 rdf:type schema:CreativeWork
183 sg:pub.10.1038/sj.onc.1209432 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023061383
184 https://doi.org/10.1038/sj.onc.1209432
185 rdf:type schema:CreativeWork
186 https://app.dimensions.ai/details/publication/pub.1074369198 schema:CreativeWork
187 https://app.dimensions.ai/details/publication/pub.1074769883 schema:CreativeWork
188 https://app.dimensions.ai/details/publication/pub.1074865720 schema:CreativeWork
189 https://app.dimensions.ai/details/publication/pub.1075025307 schema:CreativeWork
190 https://app.dimensions.ai/details/publication/pub.1075301773 schema:CreativeWork
191 https://doi.org/10.1016/0092-8674(93)90499-g schema:sameAs https://app.dimensions.ai/details/publication/pub.1034836400
192 rdf:type schema:CreativeWork
193 https://doi.org/10.1016/0092-8674(93)90500-p schema:sameAs https://app.dimensions.ai/details/publication/pub.1038576682
194 rdf:type schema:CreativeWork
195 https://doi.org/10.1016/0092-8674(95)90039-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1051937826
196 rdf:type schema:CreativeWork
197 https://doi.org/10.1016/j.cell.2004.12.027 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037368228
198 rdf:type schema:CreativeWork
199 https://doi.org/10.1016/s0002-9440(10)62342-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048280099
200 rdf:type schema:CreativeWork
201 https://doi.org/10.1016/s0076-6879(01)33060-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039428546
202 rdf:type schema:CreativeWork
203 https://doi.org/10.1073/pnas.96.16.9089 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030304279
204 rdf:type schema:CreativeWork
205 https://doi.org/10.1083/jcb.141.2.503 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024342136
206 rdf:type schema:CreativeWork
207 https://doi.org/10.1093/emboj/cdf595 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033235876
208 rdf:type schema:CreativeWork
209 https://doi.org/10.1101/gad.7.4.535 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013372391
210 rdf:type schema:CreativeWork
211 https://doi.org/10.1128/mcb.20.16.6147-6158.2000 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002186098
212 rdf:type schema:CreativeWork
213 https://doi.org/10.4161/cc.1.3.118 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072295791
214 rdf:type schema:CreativeWork
215 https://doi.org/10.4161/cc.3.2.658 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072297833
216 rdf:type schema:CreativeWork
217 https://www.grid.ac/institutes/grid.7719.8 schema:alternateName Spanish National Cancer Research Centre
218 schema:name Molecular Oncology Program, Spanish National Cancer Centre (CNIO), Madrid, Spain
219 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...