Unravelling the complexities of the NF-κB signalling pathway using mouse knockout and transgenic models View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2006-10

AUTHORS

S Gerondakis, R Grumont, R Gugasyan, L Wong, I Isomura, W Ho, A Banerjee

ABSTRACT

The nuclear factor-kappaB (NF-kappaB) signalling pathway serves a crucial role in regulating the transcriptional responses of physiological processes that include cell division, cell survival, differentiation, immunity and inflammation. Here we outline studies using mouse models in which the core components of the NF-kappaB pathway, namely the IkappaB kinase subunits (IKKalpha, IKKbeta and NEMO), the IkappaB proteins (IkappaBalpha, IkappaBbeta, IkappaBvarepsilon and Bcl-3) and the five NF-kappaB transcription factors (NF-kappaB1, NF-kappaB2, c-Rel, RelA and RelB), have been genetically manipulated using transgenic and knockout technology. More... »

PAGES

1209944

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/sj.onc.1209944

    DOI

    http://dx.doi.org/10.1038/sj.onc.1209944

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1044003474

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/17072328


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