IκB kinase complexes: gateways to NF-κB activation and transcription View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2006-10

AUTHORS

Claus Scheidereit

ABSTRACT

Transcription factors of the NF-kappaB family regulate hundreds of genes in the context of multiple important physiological and pathological processes. NF-kappaB activation depends on phosphorylation-induced proteolysis of inhibitory IkappaB molecules and NF-kappaB precursors by the ubiquitin-proteasome system. Most of the diverse signaling pathways that activate NF-kappaB converge on IkappaB kinases (IKK), which are essential for signal transmission. Many important details of the composition, regulation and biological function of IKK have been revealed in the last years. This review summarizes current aspects of structure and function of the regular stoichiometric components, the regulatory transient protein interactions of IKK and the mechanisms that contribute to its activation, deactivation and homeostasis. Both phosphorylation and ubiquitinatin (destructive as well as non-destructive) are crucial post-translational events in these processes. In addition to controlling induced IkappaB degradation in the cytoplasm and processing of the NF-kappaB precursor p100, nuclear IKK components have been found to act directly at the chromatin level of induced genes and to mediate responses to DNA damage. Finally, IKK is engaged in cross talk with other pathways and confers functions independently of NF-kappaB. More... »

PAGES

1209934

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/sj.onc.1209934

    DOI

    http://dx.doi.org/10.1038/sj.onc.1209934

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1005692728

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/17072322


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