Hec1 sequentially recruits Zwint-1 and ZW10 to kinetochores for faithful chromosome segregation and spindle checkpoint control View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2006-11

AUTHORS

Y-T Lin, Y Chen, G Wu, W-H Lee

ABSTRACT

Faithful chromosome segregation is essential for maintaining the genomic integrity, which requires coordination among chromosomes, kinetochores, centrosomes and spindles during mitosis. Previously, we discovered a novel coiled-coil protein, highly expressed in cancer 1 (Hec1), which is indispensable for this process. However, the precise underlying mechanism remains unclear. Here, we show that Hec1 directly interacts with human ZW10 interacting protein (Zwint-1), a binding partner of Zeste White 10 (ZW10) that is required for chromosome motility and spindle checkpoint control. In mitotic cells, Hec1 transiently forms complexes with Zwint-1 and ZW10 in a temporal and spatial manner. Although the three proteins have variable cell cycle-dependent expression profiles, they can only be co-immunoprecipitated during M phase. Immunofluorescent study showed that Hec1 and Zwint-1 co-localize at kinetochores beginning at prophase and that ZW10 joins them later at prometaphase. Depletion of Hec1 impairs the recruitment of both Zwint-1 and ZW10 to kinetochores, while depletion of Zwint-1 abrogates the kinetochore localization of ZW10 but not Hec1. The results suggest that the localization of Hec1 at kinetochores is required for the sequential recruitment of Zwint-1 and ZW10. Disrupting this recruitment by inhibiting the expression of Hec1 or Zwint-1 causes chromosome missegregation, spindle checkpoint failure, and eventually cell death upon cytokinesis. Taken together, these results, at least in part, provide a molecular basis to explain how Hec1 plays a crucial role for spindle checkpoint control and faithful chromosome segregation. More... »

PAGES

1209687

References to SciGraph publications

  • 2001-09. Evolutionary conservation between budding yeast and human kinetochores in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 2001-04. A role for the Adenomatous Polyposis Coli protein in chromosome segregation in NATURE CELL BIOLOGY
  • 2001-01. Cell division: Mitotic kinases as regulators of cell division and its checkpoints in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 1998-12. A new look at kinetochore structure in vertebrate somatic cells using high-pressure freezing and freeze substitution in CHROMOSOMA
  • 1997-04. Genetic instability in colorectal cancers in NATURE
  • 2001-05. Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells in NATURE
  • 2001-01. MAD2 haplo-insufficiency causes premature anaphase and chromosome instability in mammalian cells in NATURE
  • 1966-03. The fine structure of the kinetochore of a mammalian cell in vitro in CHROMOSOMA
  • 1995-02. Mitotic forces control a cell-cycle checkpoint in NATURE
  • 2000-12. Human Zw10 and ROD are mitotic checkpoint proteins that bind to kinetochores in NATURE CELL BIOLOGY
  • 2001-04. Mutations in the APC tumour suppressor gene cause chromosomal instability in NATURE CELL BIOLOGY
  • 2000-12. Cytoplasmic dynein is required for poleward chromosome movement during mitosis in Drosophila embryos in NATURE CELL BIOLOGY
  • 1999-07. Identification of frequent impairment of the mitotic checkpoint and molecular analysis of the mitotic checkpoint genes, hsMAD2 and p55CDC, in human lung cancers in ONCOGENE
  • 1985-01. Identification of a family of human centromere proteins using autoimmune sera from patients with scleroderma in CHROMOSOMA
  • 2000-12. The rate of poleward chromosome motion is attenuated in Drosophila zw10 and rod mutants in NATURE CELL BIOLOGY
  • 1998-10. Tumour amplified kinase STK15/BTAK induces centrosome amplification, aneuploidy and transformation in NATURE GENETICS
  • 2000-12. Rough Deal and Zw10 are required for the metaphase checkpoint in Drosophila in NATURE CELL BIOLOGY
  • 2004-11. A conserved Mis12 centromere complex is linked to heterochromatic HP1 and outer kinetochore protein Zwint-1 in NATURE CELL BIOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/sj.onc.1209687

    DOI

    http://dx.doi.org/10.1038/sj.onc.1209687

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1025342268

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/16732327


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biochemistry and Cell Biology", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biological Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cell Cycle Proteins", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cell Line, Tumor", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Chromosomal Proteins, Non-Histone", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Chromosome Segregation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Electrophoresis, Polyacrylamide Gel", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Fluorescent Antibody Technique", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Gene Expression", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "HeLa Cells", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Intracellular Signaling Peptides and Proteins", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Kinetochores", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Microtubule-Associated Proteins", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mitosis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Nuclear Proteins", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "RNA, Small Interfering", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Spindle Apparatus", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Transfection", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "The University of Texas Health Science Center at San Antonio", 
              "id": "https://www.grid.ac/institutes/grid.267309.9", 
              "name": [
                "Department of Biological Chemistry, University of California, Irvine, CA, USA", 
                "Department of Molecular Medicine, University of Texas Health Science Center, San Antonio, TX, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lin", 
            "givenName": "Y-T", 
            "id": "sg:person.01071211363.40", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01071211363.40"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "The University of Texas Health Science Center at San Antonio", 
              "id": "https://www.grid.ac/institutes/grid.267309.9", 
              "name": [
                "Department of Molecular Medicine, University of Texas Health Science Center, San Antonio, TX, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Chen", 
            "givenName": "Y", 
            "id": "sg:person.011163226074.51", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011163226074.51"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of California, Irvine", 
              "id": "https://www.grid.ac/institutes/grid.266093.8", 
              "name": [
                "Department of Biological Chemistry, University of California, Irvine, CA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Wu", 
            "givenName": "G", 
            "id": "sg:person.01302416345.76", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01302416345.76"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of California, Irvine", 
              "id": "https://www.grid.ac/institutes/grid.266093.8", 
              "name": [
                "Department of Biological Chemistry, University of California, Irvine, CA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lee", 
            "givenName": "W-H", 
            "id": "sg:person.015676051444.00", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015676051444.00"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1074/jbc.m407588200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000479055"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35089568", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001059843", 
              "https://doi.org/10.1038/35089568"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35089568", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001059843", 
              "https://doi.org/10.1038/35089568"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35089568", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001059843", 
              "https://doi.org/10.1038/35089568"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1083/jcb.152.2.349", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001150403"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1091/mbc.e02-09-0624", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001240702"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35046598", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002885997", 
              "https://doi.org/10.1038/35046598"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35046598", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002885997", 
              "https://doi.org/10.1038/35046598"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1091/mbc.e04-09-0852", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004459763"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1534-5807(01)00019-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005182624"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.tcb.2005.09.010", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005784990"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m314205200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005958831"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1083/jcb.200201052", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008186436"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncb1187", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008247795", 
              "https://doi.org/10.1038/ncb1187"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncb1187", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008247795", 
              "https://doi.org/10.1038/ncb1187"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.1144403", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008455482"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/mcb.19.8.5417", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008521026"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.934801", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009213855"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.1040903", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010897721"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0092-8674(02)00633-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012559680"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m310224200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013835039"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0092-8674(02)00973-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013918707"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1083/jcb.146.5.941", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016416884"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1083/jcb.146.5.941", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016416884"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/2496", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016917923", 
              "https://doi.org/10.1038/2496"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/2496", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016917923", 
              "https://doi.org/10.1038/2496"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m008893200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016972927"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35046574", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017450371", 
              "https://doi.org/10.1038/35046574"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35046574", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017450371", 
              "https://doi.org/10.1038/35046574"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/mcb.25.5.1958-1970.2005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017878719"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.272.38.24081", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022152464"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/mcb.17.10.6049", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022969599"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.1126303", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024261476"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00328227", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024608514", 
              "https://doi.org/10.1007/bf00328227"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0501168102", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026075279"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0092-8674(00)80875-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026929574"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35070123", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027104291", 
              "https://doi.org/10.1038/35070123"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35070123", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027104291", 
              "https://doi.org/10.1038/35070123"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1083/jcb.104.4.805", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027129655"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35078107", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028423924", 
              "https://doi.org/10.1038/35078107"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35078107", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028423924", 
              "https://doi.org/10.1038/35078107"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0092-8674(03)00115-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028608160"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1083/jcb.104.4.817", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028740380"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35046592", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028881813", 
              "https://doi.org/10.1038/35046592"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35046592", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028881813", 
              "https://doi.org/10.1038/35046592"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1242/jcs.00645", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029850373"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0092-8674(89)90517-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030112583"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1083/jcb.141.4.967", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032117458"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1083/jcb.138.6.1289", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032557600"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1091/mbc.12.9.2767", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032748284"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1083/jcb.130.4.941", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033379510"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.12.12.1871", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034484559"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35053094", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035074433", 
              "https://doi.org/10.1038/35053094"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35053094", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035074433", 
              "https://doi.org/10.1038/35053094"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0960-9822(98)70156-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035164628"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m207069200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035559622"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/386623a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036879517", 
              "https://doi.org/10.1038/386623a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35070129", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036988128", 
              "https://doi.org/10.1038/35070129"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35070129", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036988128", 
              "https://doi.org/10.1038/35070129"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s004120050320", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037201783", 
              "https://doi.org/10.1007/s004120050320"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1083/jcb.113.5.1091", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037650226"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1083/jcb.118.4.759", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038661272"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cub.2003.12.058", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038889208"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0092-8674(81)90014-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039144913"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00332792", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040023552", 
              "https://doi.org/10.1007/bf00332792"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1083/jcb.200411118", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041503453"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0959-437x(99)80010-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042224462"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35046605", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042520451", 
              "https://doi.org/10.1038/35046605"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35046605", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042520451", 
              "https://doi.org/10.1038/35046605"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0092-8674(01)00438-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042720385"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0092-8674(00)80718-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044824643"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/emboj/20.4.777", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044862972"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1006/excr.1998.4278", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045691020"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1091/mbc.e05-03-0239", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046695692"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0092-8674(81)90015-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047443381"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/373630a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047665292", 
              "https://doi.org/10.1038/373630a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1202807", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049366469", 
              "https://doi.org/10.1038/sj.onc.1202807"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1202807", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049366469", 
              "https://doi.org/10.1038/sj.onc.1202807"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1083/jcb.132.1.111", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050214236"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.devcel.2004.06.006", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050654199"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0092-8674(00)00034-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051341500"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35048096", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051541099", 
              "https://doi.org/10.1038/35048096"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35048096", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051541099", 
              "https://doi.org/10.1038/35048096"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1075596", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052099452"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m504070200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052309565"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1083/jcb.142.3.763", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053727072"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074638185", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082563109", 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2006-11", 
        "datePublishedReg": "2006-11-01", 
        "description": "Faithful chromosome segregation is essential for maintaining the genomic integrity, which requires coordination among chromosomes, kinetochores, centrosomes and spindles during mitosis. Previously, we discovered a novel coiled-coil protein, highly expressed in cancer 1 (Hec1), which is indispensable for this process. However, the precise underlying mechanism remains unclear. Here, we show that Hec1 directly interacts with human ZW10 interacting protein (Zwint-1), a binding partner of Zeste White 10 (ZW10) that is required for chromosome motility and spindle checkpoint control. In mitotic cells, Hec1 transiently forms complexes with Zwint-1 and ZW10 in a temporal and spatial manner. Although the three proteins have variable cell cycle-dependent expression profiles, they can only be co-immunoprecipitated during M phase. Immunofluorescent study showed that Hec1 and Zwint-1 co-localize at kinetochores beginning at prophase and that ZW10 joins them later at prometaphase. Depletion of Hec1 impairs the recruitment of both Zwint-1 and ZW10 to kinetochores, while depletion of Zwint-1 abrogates the kinetochore localization of ZW10 but not Hec1. The results suggest that the localization of Hec1 at kinetochores is required for the sequential recruitment of Zwint-1 and ZW10. Disrupting this recruitment by inhibiting the expression of Hec1 or Zwint-1 causes chromosome missegregation, spindle checkpoint failure, and eventually cell death upon cytokinesis. Taken together, these results, at least in part, provide a molecular basis to explain how Hec1 plays a crucial role for spindle checkpoint control and faithful chromosome segregation.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1038/sj.onc.1209687", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": true, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.2477454", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1097543", 
            "issn": [
              "0950-9232", 
              "1476-5594"
            ], 
            "name": "Oncogene", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "52", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "25"
          }
        ], 
        "name": "Hec1 sequentially recruits Zwint-1 and ZW10 to kinetochores for faithful chromosome segregation and spindle checkpoint control", 
        "pagination": "1209687", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "78bb537c9de083b097356292e6d4eaeb2dbd3ef31bad5151c0403d1557c69485"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "16732327"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "8711562"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/sj.onc.1209687"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1025342268"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/sj.onc.1209687", 
          "https://app.dimensions.ai/details/publication/pub.1025342268"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-11T12:07", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000360_0000000360/records_118344_00000000.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "http://www.nature.com/articles/1209687"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/sj.onc.1209687'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/sj.onc.1209687'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/sj.onc.1209687'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/sj.onc.1209687'


     

    This table displays all metadata directly associated to this object as RDF triples.

    399 TRIPLES      21 PREDICATES      119 URIs      38 LITERALS      26 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/sj.onc.1209687 schema:about N004ca71d264a48a5a5bb531c665360fe
    2 N06d5a5dbd2534c1f815724e73a61c465
    3 N08966c8c25d7410f99a505904a070343
    4 N10f300ec54504f899d276ce561553ee3
    5 N34a325fb5eb841f49069d254f13f9ef4
    6 N6b45df95c82948ce847895152a6debc4
    7 N7b0cf9ede0d944d6bb182c1e413c13fb
    8 N7e8072c33d6f467dba5ea2d5ec17bd30
    9 N84ba58dc35a546cba80f8fbc1d386256
    10 Na87acbad8e594c748636f07c212f52cf
    11 Ncbaf8870d71d4baeae0e2fccf4c5fdfa
    12 Ncc376bd844464adf9a4c1f9c81ca6c7a
    13 Ndb2c4cf6ea89485296b21720cad7c3a6
    14 Ndd3b5a0254474e2ea04b08a5a167e09d
    15 Ne0903d6d839a408f9cc6b37b3fd89b40
    16 Nebd9461859b843e3be63a5c6280d0703
    17 Nedf264b580b149eab933f04258ed2003
    18 anzsrc-for:06
    19 anzsrc-for:0601
    20 schema:author N9b864439963b4e4ea8a80abca45ed583
    21 schema:citation sg:pub.10.1007/bf00328227
    22 sg:pub.10.1007/bf00332792
    23 sg:pub.10.1007/s004120050320
    24 sg:pub.10.1038/2496
    25 sg:pub.10.1038/35046574
    26 sg:pub.10.1038/35046592
    27 sg:pub.10.1038/35046598
    28 sg:pub.10.1038/35046605
    29 sg:pub.10.1038/35048096
    30 sg:pub.10.1038/35053094
    31 sg:pub.10.1038/35070123
    32 sg:pub.10.1038/35070129
    33 sg:pub.10.1038/35078107
    34 sg:pub.10.1038/35089568
    35 sg:pub.10.1038/373630a0
    36 sg:pub.10.1038/386623a0
    37 sg:pub.10.1038/ncb1187
    38 sg:pub.10.1038/sj.onc.1202807
    39 https://app.dimensions.ai/details/publication/pub.1074638185
    40 https://app.dimensions.ai/details/publication/pub.1082563109
    41 https://doi.org/10.1006/excr.1998.4278
    42 https://doi.org/10.1016/0092-8674(81)90014-3
    43 https://doi.org/10.1016/0092-8674(81)90015-5
    44 https://doi.org/10.1016/0092-8674(89)90517-5
    45 https://doi.org/10.1016/j.cub.2003.12.058
    46 https://doi.org/10.1016/j.devcel.2004.06.006
    47 https://doi.org/10.1016/j.tcb.2005.09.010
    48 https://doi.org/10.1016/s0092-8674(00)00034-9
    49 https://doi.org/10.1016/s0092-8674(00)80718-7
    50 https://doi.org/10.1016/s0092-8674(00)80875-2
    51 https://doi.org/10.1016/s0092-8674(01)00438-x
    52 https://doi.org/10.1016/s0092-8674(02)00633-5
    53 https://doi.org/10.1016/s0092-8674(02)00973-x
    54 https://doi.org/10.1016/s0092-8674(03)00115-6
    55 https://doi.org/10.1016/s0959-437x(99)80010-0
    56 https://doi.org/10.1016/s0960-9822(98)70156-3
    57 https://doi.org/10.1016/s1534-5807(01)00019-3
    58 https://doi.org/10.1073/pnas.0501168102
    59 https://doi.org/10.1074/jbc.272.38.24081
    60 https://doi.org/10.1074/jbc.m008893200
    61 https://doi.org/10.1074/jbc.m207069200
    62 https://doi.org/10.1074/jbc.m310224200
    63 https://doi.org/10.1074/jbc.m314205200
    64 https://doi.org/10.1074/jbc.m407588200
    65 https://doi.org/10.1074/jbc.m504070200
    66 https://doi.org/10.1083/jcb.104.4.805
    67 https://doi.org/10.1083/jcb.104.4.817
    68 https://doi.org/10.1083/jcb.113.5.1091
    69 https://doi.org/10.1083/jcb.118.4.759
    70 https://doi.org/10.1083/jcb.130.4.941
    71 https://doi.org/10.1083/jcb.132.1.111
    72 https://doi.org/10.1083/jcb.138.6.1289
    73 https://doi.org/10.1083/jcb.141.4.967
    74 https://doi.org/10.1083/jcb.142.3.763
    75 https://doi.org/10.1083/jcb.146.5.941
    76 https://doi.org/10.1083/jcb.152.2.349
    77 https://doi.org/10.1083/jcb.200201052
    78 https://doi.org/10.1083/jcb.200411118
    79 https://doi.org/10.1091/mbc.12.9.2767
    80 https://doi.org/10.1091/mbc.e02-09-0624
    81 https://doi.org/10.1091/mbc.e04-09-0852
    82 https://doi.org/10.1091/mbc.e05-03-0239
    83 https://doi.org/10.1093/emboj/20.4.777
    84 https://doi.org/10.1101/gad.1040903
    85 https://doi.org/10.1101/gad.1126303
    86 https://doi.org/10.1101/gad.1144403
    87 https://doi.org/10.1101/gad.12.12.1871
    88 https://doi.org/10.1101/gad.934801
    89 https://doi.org/10.1126/science.1075596
    90 https://doi.org/10.1128/mcb.17.10.6049
    91 https://doi.org/10.1128/mcb.19.8.5417
    92 https://doi.org/10.1128/mcb.25.5.1958-1970.2005
    93 https://doi.org/10.1242/jcs.00645
    94 schema:datePublished 2006-11
    95 schema:datePublishedReg 2006-11-01
    96 schema:description Faithful chromosome segregation is essential for maintaining the genomic integrity, which requires coordination among chromosomes, kinetochores, centrosomes and spindles during mitosis. Previously, we discovered a novel coiled-coil protein, highly expressed in cancer 1 (Hec1), which is indispensable for this process. However, the precise underlying mechanism remains unclear. Here, we show that Hec1 directly interacts with human ZW10 interacting protein (Zwint-1), a binding partner of Zeste White 10 (ZW10) that is required for chromosome motility and spindle checkpoint control. In mitotic cells, Hec1 transiently forms complexes with Zwint-1 and ZW10 in a temporal and spatial manner. Although the three proteins have variable cell cycle-dependent expression profiles, they can only be co-immunoprecipitated during M phase. Immunofluorescent study showed that Hec1 and Zwint-1 co-localize at kinetochores beginning at prophase and that ZW10 joins them later at prometaphase. Depletion of Hec1 impairs the recruitment of both Zwint-1 and ZW10 to kinetochores, while depletion of Zwint-1 abrogates the kinetochore localization of ZW10 but not Hec1. The results suggest that the localization of Hec1 at kinetochores is required for the sequential recruitment of Zwint-1 and ZW10. Disrupting this recruitment by inhibiting the expression of Hec1 or Zwint-1 causes chromosome missegregation, spindle checkpoint failure, and eventually cell death upon cytokinesis. Taken together, these results, at least in part, provide a molecular basis to explain how Hec1 plays a crucial role for spindle checkpoint control and faithful chromosome segregation.
    97 schema:genre research_article
    98 schema:inLanguage en
    99 schema:isAccessibleForFree true
    100 schema:isPartOf N19448706c7624ecc8e33a96f5d219416
    101 N76a532d742b345eea0aa3d5429fb44af
    102 sg:journal.1097543
    103 schema:name Hec1 sequentially recruits Zwint-1 and ZW10 to kinetochores for faithful chromosome segregation and spindle checkpoint control
    104 schema:pagination 1209687
    105 schema:productId N24cb82fe8beb420aa701635de0677658
    106 N308a5fc9a1f84d2d8cb40760126e54cd
    107 N3c6fb3e3a53b4d39a738a2737d744a1c
    108 N768de9f3a892490685e9515359388b0f
    109 Nc7dc8dd73a404d3aa58246a900534389
    110 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025342268
    111 https://doi.org/10.1038/sj.onc.1209687
    112 schema:sdDatePublished 2019-04-11T12:07
    113 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    114 schema:sdPublisher Nb2cf4ed069d2489da42e29989c2eac67
    115 schema:url http://www.nature.com/articles/1209687
    116 sgo:license sg:explorer/license/
    117 sgo:sdDataset articles
    118 rdf:type schema:ScholarlyArticle
    119 N004ca71d264a48a5a5bb531c665360fe schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    120 schema:name Gene Expression
    121 rdf:type schema:DefinedTerm
    122 N06d5a5dbd2534c1f815724e73a61c465 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    123 schema:name Cell Cycle Proteins
    124 rdf:type schema:DefinedTerm
    125 N08966c8c25d7410f99a505904a070343 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    126 schema:name Humans
    127 rdf:type schema:DefinedTerm
    128 N10f300ec54504f899d276ce561553ee3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    129 schema:name Chromosome Segregation
    130 rdf:type schema:DefinedTerm
    131 N19448706c7624ecc8e33a96f5d219416 schema:issueNumber 52
    132 rdf:type schema:PublicationIssue
    133 N24cb82fe8beb420aa701635de0677658 schema:name nlm_unique_id
    134 schema:value 8711562
    135 rdf:type schema:PropertyValue
    136 N308a5fc9a1f84d2d8cb40760126e54cd schema:name readcube_id
    137 schema:value 78bb537c9de083b097356292e6d4eaeb2dbd3ef31bad5151c0403d1557c69485
    138 rdf:type schema:PropertyValue
    139 N34a325fb5eb841f49069d254f13f9ef4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    140 schema:name Kinetochores
    141 rdf:type schema:DefinedTerm
    142 N3c6fb3e3a53b4d39a738a2737d744a1c schema:name doi
    143 schema:value 10.1038/sj.onc.1209687
    144 rdf:type schema:PropertyValue
    145 N6b45df95c82948ce847895152a6debc4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    146 schema:name Fluorescent Antibody Technique
    147 rdf:type schema:DefinedTerm
    148 N704f32b2f9154e44862d9d68c0432a5c rdf:first sg:person.01302416345.76
    149 rdf:rest Ndbe693f0c7bb465b8ad0db9aaafe89ad
    150 N768de9f3a892490685e9515359388b0f schema:name pubmed_id
    151 schema:value 16732327
    152 rdf:type schema:PropertyValue
    153 N76a532d742b345eea0aa3d5429fb44af schema:volumeNumber 25
    154 rdf:type schema:PublicationVolume
    155 N7b0cf9ede0d944d6bb182c1e413c13fb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    156 schema:name Nuclear Proteins
    157 rdf:type schema:DefinedTerm
    158 N7e8072c33d6f467dba5ea2d5ec17bd30 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    159 schema:name Mitosis
    160 rdf:type schema:DefinedTerm
    161 N84ba58dc35a546cba80f8fbc1d386256 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    162 schema:name HeLa Cells
    163 rdf:type schema:DefinedTerm
    164 N9b864439963b4e4ea8a80abca45ed583 rdf:first sg:person.01071211363.40
    165 rdf:rest Nab01b8fc19b24c69ac5d0b5e5c387b85
    166 Na87acbad8e594c748636f07c212f52cf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    167 schema:name Chromosomal Proteins, Non-Histone
    168 rdf:type schema:DefinedTerm
    169 Nab01b8fc19b24c69ac5d0b5e5c387b85 rdf:first sg:person.011163226074.51
    170 rdf:rest N704f32b2f9154e44862d9d68c0432a5c
    171 Nb2cf4ed069d2489da42e29989c2eac67 schema:name Springer Nature - SN SciGraph project
    172 rdf:type schema:Organization
    173 Nc7dc8dd73a404d3aa58246a900534389 schema:name dimensions_id
    174 schema:value pub.1025342268
    175 rdf:type schema:PropertyValue
    176 Ncbaf8870d71d4baeae0e2fccf4c5fdfa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    177 schema:name RNA, Small Interfering
    178 rdf:type schema:DefinedTerm
    179 Ncc376bd844464adf9a4c1f9c81ca6c7a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    180 schema:name Electrophoresis, Polyacrylamide Gel
    181 rdf:type schema:DefinedTerm
    182 Ndb2c4cf6ea89485296b21720cad7c3a6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    183 schema:name Microtubule-Associated Proteins
    184 rdf:type schema:DefinedTerm
    185 Ndbe693f0c7bb465b8ad0db9aaafe89ad rdf:first sg:person.015676051444.00
    186 rdf:rest rdf:nil
    187 Ndd3b5a0254474e2ea04b08a5a167e09d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    188 schema:name Intracellular Signaling Peptides and Proteins
    189 rdf:type schema:DefinedTerm
    190 Ne0903d6d839a408f9cc6b37b3fd89b40 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    191 schema:name Spindle Apparatus
    192 rdf:type schema:DefinedTerm
    193 Nebd9461859b843e3be63a5c6280d0703 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    194 schema:name Transfection
    195 rdf:type schema:DefinedTerm
    196 Nedf264b580b149eab933f04258ed2003 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    197 schema:name Cell Line, Tumor
    198 rdf:type schema:DefinedTerm
    199 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
    200 schema:name Biological Sciences
    201 rdf:type schema:DefinedTerm
    202 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
    203 schema:name Biochemistry and Cell Biology
    204 rdf:type schema:DefinedTerm
    205 sg:grant.2477454 http://pending.schema.org/fundedItem sg:pub.10.1038/sj.onc.1209687
    206 rdf:type schema:MonetaryGrant
    207 sg:journal.1097543 schema:issn 0950-9232
    208 1476-5594
    209 schema:name Oncogene
    210 rdf:type schema:Periodical
    211 sg:person.01071211363.40 schema:affiliation https://www.grid.ac/institutes/grid.267309.9
    212 schema:familyName Lin
    213 schema:givenName Y-T
    214 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01071211363.40
    215 rdf:type schema:Person
    216 sg:person.011163226074.51 schema:affiliation https://www.grid.ac/institutes/grid.267309.9
    217 schema:familyName Chen
    218 schema:givenName Y
    219 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011163226074.51
    220 rdf:type schema:Person
    221 sg:person.01302416345.76 schema:affiliation https://www.grid.ac/institutes/grid.266093.8
    222 schema:familyName Wu
    223 schema:givenName G
    224 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01302416345.76
    225 rdf:type schema:Person
    226 sg:person.015676051444.00 schema:affiliation https://www.grid.ac/institutes/grid.266093.8
    227 schema:familyName Lee
    228 schema:givenName W-H
    229 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015676051444.00
    230 rdf:type schema:Person
    231 sg:pub.10.1007/bf00328227 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024608514
    232 https://doi.org/10.1007/bf00328227
    233 rdf:type schema:CreativeWork
    234 sg:pub.10.1007/bf00332792 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040023552
    235 https://doi.org/10.1007/bf00332792
    236 rdf:type schema:CreativeWork
    237 sg:pub.10.1007/s004120050320 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037201783
    238 https://doi.org/10.1007/s004120050320
    239 rdf:type schema:CreativeWork
    240 sg:pub.10.1038/2496 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016917923
    241 https://doi.org/10.1038/2496
    242 rdf:type schema:CreativeWork
    243 sg:pub.10.1038/35046574 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017450371
    244 https://doi.org/10.1038/35046574
    245 rdf:type schema:CreativeWork
    246 sg:pub.10.1038/35046592 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028881813
    247 https://doi.org/10.1038/35046592
    248 rdf:type schema:CreativeWork
    249 sg:pub.10.1038/35046598 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002885997
    250 https://doi.org/10.1038/35046598
    251 rdf:type schema:CreativeWork
    252 sg:pub.10.1038/35046605 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042520451
    253 https://doi.org/10.1038/35046605
    254 rdf:type schema:CreativeWork
    255 sg:pub.10.1038/35048096 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051541099
    256 https://doi.org/10.1038/35048096
    257 rdf:type schema:CreativeWork
    258 sg:pub.10.1038/35053094 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035074433
    259 https://doi.org/10.1038/35053094
    260 rdf:type schema:CreativeWork
    261 sg:pub.10.1038/35070123 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027104291
    262 https://doi.org/10.1038/35070123
    263 rdf:type schema:CreativeWork
    264 sg:pub.10.1038/35070129 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036988128
    265 https://doi.org/10.1038/35070129
    266 rdf:type schema:CreativeWork
    267 sg:pub.10.1038/35078107 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028423924
    268 https://doi.org/10.1038/35078107
    269 rdf:type schema:CreativeWork
    270 sg:pub.10.1038/35089568 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001059843
    271 https://doi.org/10.1038/35089568
    272 rdf:type schema:CreativeWork
    273 sg:pub.10.1038/373630a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047665292
    274 https://doi.org/10.1038/373630a0
    275 rdf:type schema:CreativeWork
    276 sg:pub.10.1038/386623a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036879517
    277 https://doi.org/10.1038/386623a0
    278 rdf:type schema:CreativeWork
    279 sg:pub.10.1038/ncb1187 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008247795
    280 https://doi.org/10.1038/ncb1187
    281 rdf:type schema:CreativeWork
    282 sg:pub.10.1038/sj.onc.1202807 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049366469
    283 https://doi.org/10.1038/sj.onc.1202807
    284 rdf:type schema:CreativeWork
    285 https://app.dimensions.ai/details/publication/pub.1074638185 schema:CreativeWork
    286 https://app.dimensions.ai/details/publication/pub.1082563109 schema:CreativeWork
    287 https://doi.org/10.1006/excr.1998.4278 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045691020
    288 rdf:type schema:CreativeWork
    289 https://doi.org/10.1016/0092-8674(81)90014-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039144913
    290 rdf:type schema:CreativeWork
    291 https://doi.org/10.1016/0092-8674(81)90015-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047443381
    292 rdf:type schema:CreativeWork
    293 https://doi.org/10.1016/0092-8674(89)90517-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030112583
    294 rdf:type schema:CreativeWork
    295 https://doi.org/10.1016/j.cub.2003.12.058 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038889208
    296 rdf:type schema:CreativeWork
    297 https://doi.org/10.1016/j.devcel.2004.06.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050654199
    298 rdf:type schema:CreativeWork
    299 https://doi.org/10.1016/j.tcb.2005.09.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005784990
    300 rdf:type schema:CreativeWork
    301 https://doi.org/10.1016/s0092-8674(00)00034-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051341500
    302 rdf:type schema:CreativeWork
    303 https://doi.org/10.1016/s0092-8674(00)80718-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044824643
    304 rdf:type schema:CreativeWork
    305 https://doi.org/10.1016/s0092-8674(00)80875-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026929574
    306 rdf:type schema:CreativeWork
    307 https://doi.org/10.1016/s0092-8674(01)00438-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1042720385
    308 rdf:type schema:CreativeWork
    309 https://doi.org/10.1016/s0092-8674(02)00633-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012559680
    310 rdf:type schema:CreativeWork
    311 https://doi.org/10.1016/s0092-8674(02)00973-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1013918707
    312 rdf:type schema:CreativeWork
    313 https://doi.org/10.1016/s0092-8674(03)00115-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028608160
    314 rdf:type schema:CreativeWork
    315 https://doi.org/10.1016/s0959-437x(99)80010-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042224462
    316 rdf:type schema:CreativeWork
    317 https://doi.org/10.1016/s0960-9822(98)70156-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035164628
    318 rdf:type schema:CreativeWork
    319 https://doi.org/10.1016/s1534-5807(01)00019-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005182624
    320 rdf:type schema:CreativeWork
    321 https://doi.org/10.1073/pnas.0501168102 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026075279
    322 rdf:type schema:CreativeWork
    323 https://doi.org/10.1074/jbc.272.38.24081 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022152464
    324 rdf:type schema:CreativeWork
    325 https://doi.org/10.1074/jbc.m008893200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016972927
    326 rdf:type schema:CreativeWork
    327 https://doi.org/10.1074/jbc.m207069200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035559622
    328 rdf:type schema:CreativeWork
    329 https://doi.org/10.1074/jbc.m310224200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013835039
    330 rdf:type schema:CreativeWork
    331 https://doi.org/10.1074/jbc.m314205200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005958831
    332 rdf:type schema:CreativeWork
    333 https://doi.org/10.1074/jbc.m407588200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000479055
    334 rdf:type schema:CreativeWork
    335 https://doi.org/10.1074/jbc.m504070200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052309565
    336 rdf:type schema:CreativeWork
    337 https://doi.org/10.1083/jcb.104.4.805 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027129655
    338 rdf:type schema:CreativeWork
    339 https://doi.org/10.1083/jcb.104.4.817 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028740380
    340 rdf:type schema:CreativeWork
    341 https://doi.org/10.1083/jcb.113.5.1091 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037650226
    342 rdf:type schema:CreativeWork
    343 https://doi.org/10.1083/jcb.118.4.759 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038661272
    344 rdf:type schema:CreativeWork
    345 https://doi.org/10.1083/jcb.130.4.941 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033379510
    346 rdf:type schema:CreativeWork
    347 https://doi.org/10.1083/jcb.132.1.111 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050214236
    348 rdf:type schema:CreativeWork
    349 https://doi.org/10.1083/jcb.138.6.1289 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032557600
    350 rdf:type schema:CreativeWork
    351 https://doi.org/10.1083/jcb.141.4.967 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032117458
    352 rdf:type schema:CreativeWork
    353 https://doi.org/10.1083/jcb.142.3.763 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053727072
    354 rdf:type schema:CreativeWork
    355 https://doi.org/10.1083/jcb.146.5.941 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016416884
    356 rdf:type schema:CreativeWork
    357 https://doi.org/10.1083/jcb.152.2.349 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001150403
    358 rdf:type schema:CreativeWork
    359 https://doi.org/10.1083/jcb.200201052 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008186436
    360 rdf:type schema:CreativeWork
    361 https://doi.org/10.1083/jcb.200411118 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041503453
    362 rdf:type schema:CreativeWork
    363 https://doi.org/10.1091/mbc.12.9.2767 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032748284
    364 rdf:type schema:CreativeWork
    365 https://doi.org/10.1091/mbc.e02-09-0624 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001240702
    366 rdf:type schema:CreativeWork
    367 https://doi.org/10.1091/mbc.e04-09-0852 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004459763
    368 rdf:type schema:CreativeWork
    369 https://doi.org/10.1091/mbc.e05-03-0239 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046695692
    370 rdf:type schema:CreativeWork
    371 https://doi.org/10.1093/emboj/20.4.777 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044862972
    372 rdf:type schema:CreativeWork
    373 https://doi.org/10.1101/gad.1040903 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010897721
    374 rdf:type schema:CreativeWork
    375 https://doi.org/10.1101/gad.1126303 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024261476
    376 rdf:type schema:CreativeWork
    377 https://doi.org/10.1101/gad.1144403 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008455482
    378 rdf:type schema:CreativeWork
    379 https://doi.org/10.1101/gad.12.12.1871 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034484559
    380 rdf:type schema:CreativeWork
    381 https://doi.org/10.1101/gad.934801 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009213855
    382 rdf:type schema:CreativeWork
    383 https://doi.org/10.1126/science.1075596 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052099452
    384 rdf:type schema:CreativeWork
    385 https://doi.org/10.1128/mcb.17.10.6049 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022969599
    386 rdf:type schema:CreativeWork
    387 https://doi.org/10.1128/mcb.19.8.5417 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008521026
    388 rdf:type schema:CreativeWork
    389 https://doi.org/10.1128/mcb.25.5.1958-1970.2005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017878719
    390 rdf:type schema:CreativeWork
    391 https://doi.org/10.1242/jcs.00645 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029850373
    392 rdf:type schema:CreativeWork
    393 https://www.grid.ac/institutes/grid.266093.8 schema:alternateName University of California, Irvine
    394 schema:name Department of Biological Chemistry, University of California, Irvine, CA, USA
    395 rdf:type schema:Organization
    396 https://www.grid.ac/institutes/grid.267309.9 schema:alternateName The University of Texas Health Science Center at San Antonio
    397 schema:name Department of Biological Chemistry, University of California, Irvine, CA, USA
    398 Department of Molecular Medicine, University of Texas Health Science Center, San Antonio, TX, USA
    399 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...