Identification of tumor markers and differentiation markers for molecular diagnosis of lung adenocarcinoma View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2006-02-20

AUTHORS

N Nakamura, K Kobayashi, M Nakamoto, T Kohno, H Sasaki, Y Matsuno, J Yokota

ABSTRACT

To identify tumor markers and differentiation markers for lung adenocarcinoma (AdC), we analysed expression profiles of 14 500 genes against three cases of type II alveolar epithelial cells, bronchiolar epithelial cells, and bronchial epithelial cells, respectively, and 10 cases of AdC cells isolated by laser capture microdissection. Hierarchical clustering analysis indicated that AdC cells and noncancerous lung epithelial cells are significantly different in their expression profiles, and that different sets of differentiation markers are expressed among alveolar, bronchiolar and bronchial epithelial cells. Nine genes were identified as being highly expressed in AdC cells, but not expressed in noncancerous lung epithelial cells. Sixteen genes were identified as differentiation markers for lung epithelial cells. Real-time RT–PCR analysis of 45 lung AdC cases further revealed that expression of four tumor markers in AdC cells was significantly higher than that in noncancerous lung cells and that expression of ten differentiation markers was retained in a considerable fraction of lung AdC cases. Five tumor markers and seven differentiation markers were not expressed in peripheral blood cells. Similarities and differences in expression profiles between normal epithelial cells from different lung respiratory compartments and AdC cells demonstrated in this study will be informative for the molecular diagnosis of lung AdC. More... »

PAGES

4245-4255

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/sj.onc.1209442

DOI

http://dx.doi.org/10.1038/sj.onc.1209442

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1048106669

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/16491115


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