Recruitment of ATR to sites of ionising radiation-induced DNA damage requires ATM and components of the MRN protein complex View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2006-06

AUTHORS

K E Adams, A L Medhurst, D A Dart, N D Lakin

ABSTRACT

ATM and ATR are two related kinases essential for signalling DNA damage. Although ATM is thought to be the principle kinase responsible for signalling ionising radiation (IR)-induced DNA damage, ATR also contributes to signalling this form of genotoxic stress. However, the molecular basis of differential ATM and ATR activation in response to IR remains unclear. Here, we report that ATR is recruited to sites of IR-induced DNA damage significantly later than activation of ATM. We show that ATR is recruited to IR-induced nuclear foci in G(1) and S phase of the cell cycle, supporting a role for ATR in detecting DNA damage outside of S phase. In addition, we report that recruitment of ATR to sites of IR-induced DNA damage is concomitant with appearance of large tracts of single-stranded DNA (ssDNA) and that this event is dependent on ATM and components of the Mre11/Rad50/Nbs1 (MRN) protein complex. More... »

PAGES

3894

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/sj.onc.1209426

DOI

http://dx.doi.org/10.1038/sj.onc.1209426

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1027338899

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/16474843


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