ST7-mediated suppression of tumorigenicity of prostate cancer cells is characterized by remodeling of the extracellular matrix View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2006-06

AUTHORS

Cs-F Hooi, C Blancher, W Qiu, I M Revet, L H Williams, M L Ciavarella, R L Anderson, E W Thompson, A Connor, W A Phillips, I G Campbell

ABSTRACT

Multiple lines of evidence have provided compelling evidence for the existence of a tumor suppressor gene (TSG) on chromosome 7q31.1. ST7 may be the target of this genetic instability but its designation as a TSG is controversial. In this study, we show that, functionally, ST7 behaves as a tumor suppressor in human cancer. ST7 suppressed growth of PC-3 prostate cancer cells inoculated subcutaneously into severe combined immunodeficient mice, and increased the latency of tumor detection from 13 days in control tumors to 23 days. Re-expression of ST7 was also associated with suppression of colony formation under anchorage-independent conditions in MDA-MB-231 breast cancer cells and ST7 mRNA expression was downregulated in 44% of primary breast cancers. Expression profiling of PC-3 cells revealed that ST7 predominantly induces changes in genes involved in re-modeling the extracellular matrix such as SPARC, IGFBP5 and several matrix metalloproteinases. These data indicate that ST7 may mediate tumor suppression through modification of the tumor microenvironment. More... »

PAGES

3924

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/sj.onc.1209418

DOI

http://dx.doi.org/10.1038/sj.onc.1209418

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1004178931

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/16474848


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