Transcriptional profiling suggests that Barrett's metaplasia is an early intermediate stage in esophageal adenocarcinogenesis View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2006-06

AUTHORS

S Wang, M Zhan, J Yin, J M Abraham, Y Mori, F Sato, Y Xu, A Olaru, A T Berki, H Li, K Schulmann, T Kan, J P Hamilton, B Paun, M M Yu, Z Jin, Y Cheng, T Ito, C Mantzur, B D Greenwald, S J Meltzer

ABSTRACT

To investigate the relationship between Barrett's esophagus (BE) and esophageal adenocarcinoma (EAC), we determined gene expression profiles of discrete pathological stages of esophageal neoplasia using a sequence-verified human cDNA microarray. Fifty one RNAs, comprising 24 normal esophagi (NE), 18 BEs, and nine EACs were hybridized to cDNA microarrays. Five statistical analyses were used for the data analysis. Genes showing significantly different expression levels among the three sample groups were identified. Genes were grouped into functional categories based on the Gene Ontology Consortium. Surprisingly, the expression pattern of BE was significantly more similar to EAC than to NE, notwithstanding the known histopathologic differences between BE and EAC. The pattern of NE was clearly distinct from that of EAC. Thirty-six genes were the most differentially modulated, according to these microarray data, in BE-associated neoplastic progression. Twelve genes were significantly differentially expressed in cancer-associated BE's plus EAC (as a single combined tissue group) vs noncancer-associated BE's. These genes represent potential biomarkers to diagnose EAC at its early stages. Our results demonstrate that molecular events at the transcriptional level in BE are remarkably similar to BE's-associated adenocarcinoma of the esophagus. This finding alarmingly implies that BE is biologically closer to cancer than to normal esophagus, and that the cancer risk of BE is perhaps higher than we had imagined. These findings suggest that changes modulated at the molecular biologic level supervene earlier than histologic changes, and that BE is an early intermediate stage in the process of EAC. More... »

PAGES

3346

References to SciGraph publications

  • 2002-02. Long-term survival after esophagectomy for Barrett’s adenocarcinoma in endoscopically surveyed and nonsurveyed patients in JOURNAL OF GASTROINTESTINAL SURGERY
  • 2003-04. Losses of Heterozygosity on Chromosomes 9p and 17p Are Frequent Events in Barrett’s Metaplasia Not Associated With Dysplasia or Adenocarcinoma in THE AMERICAN JOURNAL OF GASTROENTEROLOGY
  • 2003-10. Identifying biological themes within lists of genes with EASE in GENOME BIOLOGY
  • 2001-11. Proton pump inhibitors reduce cell cycle abnormalities in Barrett's esophagus in ONCOGENE
  • 2003-06. Barrett’s esophagus and Barrett’s carcinoma in CURRENT ONCOLOGY REPORTS
  • 2003-01. An LOH and mutational investigation of the ST7 gene locus in human esophageal carcinoma in ONCOGENE
  • 2001-05. β-catenin–sensitive isoforms of lymphoid enhancer factor-1 are selectively expressed in colon cancer in NATURE GENETICS
  • 2005-02. Constitutive expression of growth regulated oncogene (gro) in human colon carcinoma cells with different metastatic potential and its role in regulating their metastatic phenotype in CLINICAL & EXPERIMENTAL METASTASIS
  • 2002-01. Global gene expression profiling in Barrett's esophagus and esophageal cancer: a comparative analysis using cDNA microarrays in ONCOGENE
  • 2004-09. Bioconductor: open software development for computational biology and bioinformatics in GENOME BIOLOGY
  • 2004-06. A multigene expression panel for the molecular diagnosis of Barrett's esophagus and Barrett's adenocarcinoma of the esophagus in ONCOGENE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/sj.onc.1209357

    DOI

    http://dx.doi.org/10.1038/sj.onc.1209357

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1026622123

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/16449976


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Genetics", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biological Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Adenocarcinoma", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Barrett Esophagus", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Biomarkers, Tumor", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cell Transformation, Neoplastic", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Esophageal Neoplasms", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Gene Expression Profiling", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Metaplasia", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Neoplasm Staging", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Oligonucleotide Array Sequence Analysis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Transcription, Genetic", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "name": [
                "Division of Gastroenterology, Department of Medicine, Baltimore, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Wang", 
            "givenName": "S", 
            "id": "sg:person.013145713227.92", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013145713227.92"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "National Institute on Aging", 
              "id": "https://www.grid.ac/institutes/grid.419475.a", 
              "name": [
                "Bioinformatics Unit, National Institute on Aging, NIH, Baltimore, MD, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Zhan", 
            "givenName": "M", 
            "id": "sg:person.01274611657.79", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01274611657.79"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Division of Gastroenterology, Department of Medicine, Baltimore, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Yin", 
            "givenName": "J", 
            "id": "sg:person.0631337337.03", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0631337337.03"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Division of Gastroenterology, Department of Medicine, Baltimore, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Abraham", 
            "givenName": "J M", 
            "id": "sg:person.016402121412.69", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016402121412.69"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Division of Gastroenterology, Department of Medicine, Baltimore, USA", 
                "Marlene and Stewart Greenebaum Cancer Center, University of Maryland, Baltimore, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Mori", 
            "givenName": "Y", 
            "id": "sg:person.0622613100.94", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0622613100.94"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Maryland, Baltimore", 
              "id": "https://www.grid.ac/institutes/grid.411024.2", 
              "name": [
                "Division of Gastroenterology, Department of Medicine, Baltimore, USA", 
                "Department of Pathology, University of Maryland School of Medicine, Baltimore, USA", 
                "Marlene and Stewart Greenebaum Cancer Center, University of Maryland, Baltimore, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Sato", 
            "givenName": "F", 
            "id": "sg:person.012537270251.68", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012537270251.68"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Division of Gastroenterology, Department of Medicine, Baltimore, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Xu", 
            "givenName": "Y", 
            "id": "sg:person.0745565737.45", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0745565737.45"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Division of Gastroenterology, Department of Medicine, Baltimore, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Olaru", 
            "givenName": "A", 
            "id": "sg:person.014223417067.93", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014223417067.93"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Division of Gastroenterology, Department of Medicine, Baltimore, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Berki", 
            "givenName": "A T", 
            "id": "sg:person.01367351341.20", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01367351341.20"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Maryland, Baltimore", 
              "id": "https://www.grid.ac/institutes/grid.411024.2", 
              "name": [
                "Department of Pathology, University of Maryland School of Medicine, Baltimore, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Li", 
            "givenName": "H", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Division of Gastroenterology, Department of Medicine, Baltimore, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Schulmann", 
            "givenName": "K", 
            "id": "sg:person.0763151404.83", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0763151404.83"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Division of Gastroenterology, Department of Medicine, Baltimore, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kan", 
            "givenName": "T", 
            "id": "sg:person.0742762363.63", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0742762363.63"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Division of Gastroenterology, Department of Medicine, Baltimore, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hamilton", 
            "givenName": "J P", 
            "id": "sg:person.0745315065.15", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0745315065.15"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Division of Gastroenterology, Department of Medicine, Baltimore, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Paun", 
            "givenName": "B", 
            "id": "sg:person.01167516500.35", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01167516500.35"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Division of Gastroenterology, Department of Medicine, Baltimore, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Yu", 
            "givenName": "M M", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Division of Gastroenterology, Department of Medicine, Baltimore, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Jin", 
            "givenName": "Z", 
            "id": "sg:person.01055305265.97", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01055305265.97"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Division of Gastroenterology, Department of Medicine, Baltimore, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Cheng", 
            "givenName": "Y", 
            "id": "sg:person.01247134351.71", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01247134351.71"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Division of Gastroenterology, Department of Medicine, Baltimore, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ito", 
            "givenName": "T", 
            "id": "sg:person.01012616251.96", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01012616251.96"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Division of Gastroenterology, Department of Medicine, Baltimore, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Mantzur", 
            "givenName": "C", 
            "id": "sg:person.01013557467.96", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01013557467.96"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Division of Gastroenterology, Department of Medicine, Baltimore, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Greenwald", 
            "givenName": "B D", 
            "id": "sg:person.0616072747.09", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0616072747.09"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Division of Gastroenterology, Department of Medicine, Baltimore, USA", 
                "Marlene and Stewart Greenebaum Cancer Center, University of Maryland, Baltimore, USA", 
                "Baltimore VA Hospital, Baltimore, MD, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Meltzer", 
            "givenName": "S J", 
            "id": "sg:person.01033746104.09", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01033746104.09"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1093/carcin/21.2.257", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000603940"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-04-0048", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000633292"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1067/msy.2002.119292", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001224063"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/gb-2003-4-10-r70", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001293245", 
              "https://doi.org/10.1186/gb-2003-4-10-r70"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/carcin/22.8.1119", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001383948"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.091062498", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001631710"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1359-6101(03)00019-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009382264"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1359-6101(03)00019-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009382264"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1207663", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013051206", 
              "https://doi.org/10.1038/sj.onc.1207663"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1207663", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013051206", 
              "https://doi.org/10.1038/sj.onc.1207663"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/cncr.20232", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013602855"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0025-7125(02)00082-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015093779"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ijc.20267", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016913970"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1053/gast.2002.32371", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018418301"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/gb-2004-5-10-r80", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018457673", 
              "https://doi.org/10.1186/gb-2004-5-10-r80"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1206125", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018616177", 
              "https://doi.org/10.1038/sj.onc.1206125"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1206125", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018616177", 
              "https://doi.org/10.1038/sj.onc.1206125"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11912-003-0111-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022561281", 
              "https://doi.org/10.1007/s11912-003-0111-x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0046-8177(96)90213-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024033133"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/carcin/bgh011", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027139292"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00008469-199204000-00008", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029881392"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00008469-199204000-00008", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029881392"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cancergencyto.2004.01.017", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030994899"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0016-5085(00)70254-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034324415"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0016-5085(00)70254-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034324415"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng0501-53", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034643939", 
              "https://doi.org/10.1038/ng0501-53"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng0501-53", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034643939", 
              "https://doi.org/10.1038/ng0501-53"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/carcin/23.12.2095", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035059134"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0002-9440(10)62550-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035365566"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1016/s1091-255x(01)00052-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035690690", 
              "https://doi.org/10.1016/s1091-255x(01)00052-x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1205111", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037814003", 
              "https://doi.org/10.1038/sj.onc.1205111"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1205111", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037814003", 
              "https://doi.org/10.1038/sj.onc.1205111"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-03-2438", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037887215"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.082099299", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037994416"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1111/j.1572-0241.2003.07411.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039906212", 
              "https://doi.org/10.1111/j.1572-0241.2003.07411.x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/gkh036", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040530060"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1046/j.1442-2050.2002.00216.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041201365"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1204947", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042293512", 
              "https://doi.org/10.1038/sj.onc.1204947"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1204947", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042293512", 
              "https://doi.org/10.1038/sj.onc.1204947"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.274.46.33166", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046066831"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0016-5085(87)90306-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048993111"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/gut.50.3.373", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049278506"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10585-004-5458-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049958883", 
              "https://doi.org/10.1007/s10585-004-5458-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10585-004-5458-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049958883", 
              "https://doi.org/10.1007/s10585-004-5458-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1471-4159.2004.02493.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050314868"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3748/wjg.v10.i21.3194", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1071362590"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3892/or.10.2.427", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1071528808"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3892/or.5.1.73", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1071535604"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4067/s0034-98872003000600001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1072187295"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074552215", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1075070908", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1075286774", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1075295419", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1075329275", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1076573800", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1076606930", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1077035968", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1077833330", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082609021", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082750996", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082961924", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1083296803", 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2006-06", 
        "datePublishedReg": "2006-06-01", 
        "description": "To investigate the relationship between Barrett's esophagus (BE) and esophageal adenocarcinoma (EAC), we determined gene expression profiles of discrete pathological stages of esophageal neoplasia using a sequence-verified human cDNA microarray. Fifty one RNAs, comprising 24 normal esophagi (NE), 18 BEs, and nine EACs were hybridized to cDNA microarrays. Five statistical analyses were used for the data analysis. Genes showing significantly different expression levels among the three sample groups were identified. Genes were grouped into functional categories based on the Gene Ontology Consortium. Surprisingly, the expression pattern of BE was significantly more similar to EAC than to NE, notwithstanding the known histopathologic differences between BE and EAC. The pattern of NE was clearly distinct from that of EAC. Thirty-six genes were the most differentially modulated, according to these microarray data, in BE-associated neoplastic progression. Twelve genes were significantly differentially expressed in cancer-associated BE's plus EAC (as a single combined tissue group) vs noncancer-associated BE's. These genes represent potential biomarkers to diagnose EAC at its early stages. Our results demonstrate that molecular events at the transcriptional level in BE are remarkably similar to BE's-associated adenocarcinoma of the esophagus. This finding alarmingly implies that BE is biologically closer to cancer than to normal esophagus, and that the cancer risk of BE is perhaps higher than we had imagined. These findings suggest that changes modulated at the molecular biologic level supervene earlier than histologic changes, and that BE is an early intermediate stage in the process of EAC.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1038/sj.onc.1209357", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": true, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.2465811", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2476033", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2683382", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2688895", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1097543", 
            "issn": [
              "0950-9232", 
              "1476-5594"
            ], 
            "name": "Oncogene", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "23", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "25"
          }
        ], 
        "name": "Transcriptional profiling suggests that Barrett's metaplasia is an early intermediate stage in esophageal adenocarcinogenesis", 
        "pagination": "3346", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "7ed33b177bb5374136e8dc9e8fc5cbd7d93b9ba1d4b712dcb2e7da0584da74a6"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "16449976"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "8711562"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/sj.onc.1209357"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1026622123"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/sj.onc.1209357", 
          "https://app.dimensions.ai/details/publication/pub.1026622123"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-11T12:26", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000362_0000000362/records_87109_00000000.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://www.nature.com/articles/1209357"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/sj.onc.1209357'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/sj.onc.1209357'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/sj.onc.1209357'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/sj.onc.1209357'


     

    This table displays all metadata directly associated to this object as RDF triples.

    460 TRIPLES      21 PREDICATES      93 URIs      32 LITERALS      20 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/sj.onc.1209357 schema:about N078d84305a624fc69ebd9ee82c544f84
    2 N4949c6e7933d4ae285d07db9e9350f02
    3 N57edd52a35c9468a9488a71aaa5b2311
    4 N5fae2d4286694b66a7e707c153a35759
    5 N5fe646b1f5bd4fd49c52800ddc78484d
    6 N6039a28a0fca4874b7feb328a5cb7f5f
    7 N81a1d929e9fe48fdaf1b70f1b68cecb0
    8 N878ef2a035ae4ba9ac8d20bcd76628f6
    9 Ne319ebcafc4d48ee8a145353cd7d1e57
    10 Ne3dc7ef26d794360bd0137fe3b5550cf
    11 Nfa2208e7898d47d58b5c25d177cb7fa0
    12 anzsrc-for:06
    13 anzsrc-for:0604
    14 schema:author N67cfe099479a489c812211f56ba980d7
    15 schema:citation sg:pub.10.1007/s10585-004-5458-3
    16 sg:pub.10.1007/s11912-003-0111-x
    17 sg:pub.10.1016/s1091-255x(01)00052-x
    18 sg:pub.10.1038/ng0501-53
    19 sg:pub.10.1038/sj.onc.1204947
    20 sg:pub.10.1038/sj.onc.1205111
    21 sg:pub.10.1038/sj.onc.1206125
    22 sg:pub.10.1038/sj.onc.1207663
    23 sg:pub.10.1111/j.1572-0241.2003.07411.x
    24 sg:pub.10.1186/gb-2003-4-10-r70
    25 sg:pub.10.1186/gb-2004-5-10-r80
    26 https://app.dimensions.ai/details/publication/pub.1074552215
    27 https://app.dimensions.ai/details/publication/pub.1075070908
    28 https://app.dimensions.ai/details/publication/pub.1075286774
    29 https://app.dimensions.ai/details/publication/pub.1075295419
    30 https://app.dimensions.ai/details/publication/pub.1075329275
    31 https://app.dimensions.ai/details/publication/pub.1076573800
    32 https://app.dimensions.ai/details/publication/pub.1076606930
    33 https://app.dimensions.ai/details/publication/pub.1077035968
    34 https://app.dimensions.ai/details/publication/pub.1077833330
    35 https://app.dimensions.ai/details/publication/pub.1082609021
    36 https://app.dimensions.ai/details/publication/pub.1082750996
    37 https://app.dimensions.ai/details/publication/pub.1082961924
    38 https://app.dimensions.ai/details/publication/pub.1083296803
    39 https://doi.org/10.1002/cncr.20232
    40 https://doi.org/10.1002/ijc.20267
    41 https://doi.org/10.1016/0016-5085(87)90306-4
    42 https://doi.org/10.1016/j.cancergencyto.2004.01.017
    43 https://doi.org/10.1016/s0002-9440(10)62550-3
    44 https://doi.org/10.1016/s0016-5085(00)70254-x
    45 https://doi.org/10.1016/s0025-7125(02)00082-2
    46 https://doi.org/10.1016/s0046-8177(96)90213-0
    47 https://doi.org/10.1016/s1359-6101(03)00019-4
    48 https://doi.org/10.1046/j.1442-2050.2002.00216.x
    49 https://doi.org/10.1053/gast.2002.32371
    50 https://doi.org/10.1067/msy.2002.119292
    51 https://doi.org/10.1073/pnas.082099299
    52 https://doi.org/10.1073/pnas.091062498
    53 https://doi.org/10.1074/jbc.274.46.33166
    54 https://doi.org/10.1093/carcin/21.2.257
    55 https://doi.org/10.1093/carcin/22.8.1119
    56 https://doi.org/10.1093/carcin/23.12.2095
    57 https://doi.org/10.1093/carcin/bgh011
    58 https://doi.org/10.1093/nar/gkh036
    59 https://doi.org/10.1097/00008469-199204000-00008
    60 https://doi.org/10.1111/j.1471-4159.2004.02493.x
    61 https://doi.org/10.1136/gut.50.3.373
    62 https://doi.org/10.1158/0008-5472.can-03-2438
    63 https://doi.org/10.1158/1078-0432.ccr-04-0048
    64 https://doi.org/10.3748/wjg.v10.i21.3194
    65 https://doi.org/10.3892/or.10.2.427
    66 https://doi.org/10.3892/or.5.1.73
    67 https://doi.org/10.4067/s0034-98872003000600001
    68 schema:datePublished 2006-06
    69 schema:datePublishedReg 2006-06-01
    70 schema:description To investigate the relationship between Barrett's esophagus (BE) and esophageal adenocarcinoma (EAC), we determined gene expression profiles of discrete pathological stages of esophageal neoplasia using a sequence-verified human cDNA microarray. Fifty one RNAs, comprising 24 normal esophagi (NE), 18 BEs, and nine EACs were hybridized to cDNA microarrays. Five statistical analyses were used for the data analysis. Genes showing significantly different expression levels among the three sample groups were identified. Genes were grouped into functional categories based on the Gene Ontology Consortium. Surprisingly, the expression pattern of BE was significantly more similar to EAC than to NE, notwithstanding the known histopathologic differences between BE and EAC. The pattern of NE was clearly distinct from that of EAC. Thirty-six genes were the most differentially modulated, according to these microarray data, in BE-associated neoplastic progression. Twelve genes were significantly differentially expressed in cancer-associated BE's plus EAC (as a single combined tissue group) vs noncancer-associated BE's. These genes represent potential biomarkers to diagnose EAC at its early stages. Our results demonstrate that molecular events at the transcriptional level in BE are remarkably similar to BE's-associated adenocarcinoma of the esophagus. This finding alarmingly implies that BE is biologically closer to cancer than to normal esophagus, and that the cancer risk of BE is perhaps higher than we had imagined. These findings suggest that changes modulated at the molecular biologic level supervene earlier than histologic changes, and that BE is an early intermediate stage in the process of EAC.
    71 schema:genre research_article
    72 schema:inLanguage en
    73 schema:isAccessibleForFree true
    74 schema:isPartOf N24e096aec7f94a3eb90b42a36da02fad
    75 Nc5b3d3f10f8a4d0ca1ef14c202a6e531
    76 sg:journal.1097543
    77 schema:name Transcriptional profiling suggests that Barrett's metaplasia is an early intermediate stage in esophageal adenocarcinogenesis
    78 schema:pagination 3346
    79 schema:productId N26ea80af09da4967bf3cadb3bed4c931
    80 N4b2e5ffb81224b05a7ccc1272f59c2d5
    81 N86cce19439304e668f100560e8e7c1fa
    82 N8dd4f59ae72d4849848a45a9a093afa7
    83 Nbec973e68a6243b8836fdc55306ee861
    84 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026622123
    85 https://doi.org/10.1038/sj.onc.1209357
    86 schema:sdDatePublished 2019-04-11T12:26
    87 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    88 schema:sdPublisher N95b2c277b02d4f249f120d1f8be1a63e
    89 schema:url https://www.nature.com/articles/1209357
    90 sgo:license sg:explorer/license/
    91 sgo:sdDataset articles
    92 rdf:type schema:ScholarlyArticle
    93 N078d84305a624fc69ebd9ee82c544f84 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    94 schema:name Humans
    95 rdf:type schema:DefinedTerm
    96 N246b2c5ed8024eadb6fc80f86e3d9695 schema:name Division of Gastroenterology, Department of Medicine, Baltimore, USA
    97 rdf:type schema:Organization
    98 N24e096aec7f94a3eb90b42a36da02fad schema:volumeNumber 25
    99 rdf:type schema:PublicationVolume
    100 N26ea80af09da4967bf3cadb3bed4c931 schema:name nlm_unique_id
    101 schema:value 8711562
    102 rdf:type schema:PropertyValue
    103 N2a6dba47be264b21b3e326b14111eec1 rdf:first sg:person.0763151404.83
    104 rdf:rest N497948ec1297487e85d02952774220bf
    105 N2f1a4aa9f785405bb5de6cc9e41512f1 schema:name Division of Gastroenterology, Department of Medicine, Baltimore, USA
    106 rdf:type schema:Organization
    107 N45d37e6f384e43caac236b28056ffa1d rdf:first N9734a9947e974b90bec857a4921489bd
    108 rdf:rest Nf677cf2a89a6453cb4515ad4cd23c665
    109 N4949c6e7933d4ae285d07db9e9350f02 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    110 schema:name Metaplasia
    111 rdf:type schema:DefinedTerm
    112 N497948ec1297487e85d02952774220bf rdf:first sg:person.0742762363.63
    113 rdf:rest Na60e05286e6646a2a40c5b9f59b14728
    114 N4aa5977eac1b4f6b99c617cf71c7cd9c rdf:first sg:person.012537270251.68
    115 rdf:rest Na2b4112c1ce144b4ae3db30bdeba63a5
    116 N4b2e5ffb81224b05a7ccc1272f59c2d5 schema:name doi
    117 schema:value 10.1038/sj.onc.1209357
    118 rdf:type schema:PropertyValue
    119 N4f00f394f8994b9ebc4c3f713848bfdb schema:name Division of Gastroenterology, Department of Medicine, Baltimore, USA
    120 rdf:type schema:Organization
    121 N57edd52a35c9468a9488a71aaa5b2311 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    122 schema:name Esophageal Neoplasms
    123 rdf:type schema:DefinedTerm
    124 N58b248e25b7f43b8adbd2fef896f41b9 schema:name Division of Gastroenterology, Department of Medicine, Baltimore, USA
    125 rdf:type schema:Organization
    126 N5b28f067928a450c816af78e63848e37 rdf:first N65909eeb5c13482494fb78752b8e9f44
    127 rdf:rest N2a6dba47be264b21b3e326b14111eec1
    128 N5c751d2e1f1b4363baf3e14a17e533db schema:name Baltimore VA Hospital, Baltimore, MD, USA
    129 Division of Gastroenterology, Department of Medicine, Baltimore, USA
    130 Marlene and Stewart Greenebaum Cancer Center, University of Maryland, Baltimore, USA
    131 rdf:type schema:Organization
    132 N5dfe9e34e60445a7810ee9460543ba6f schema:name Division of Gastroenterology, Department of Medicine, Baltimore, USA
    133 Marlene and Stewart Greenebaum Cancer Center, University of Maryland, Baltimore, USA
    134 rdf:type schema:Organization
    135 N5e7968fc5fb14e3e8557a15fffc18c29 rdf:first sg:person.0616072747.09
    136 rdf:rest Nd9d0842c16fb4849af92b00df10998b7
    137 N5fae2d4286694b66a7e707c153a35759 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    138 schema:name Biomarkers, Tumor
    139 rdf:type schema:DefinedTerm
    140 N5fe646b1f5bd4fd49c52800ddc78484d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    141 schema:name Cell Transformation, Neoplastic
    142 rdf:type schema:DefinedTerm
    143 N6039a28a0fca4874b7feb328a5cb7f5f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    144 schema:name Adenocarcinoma
    145 rdf:type schema:DefinedTerm
    146 N616e87fb88b248fe940f7c1dc65f5eef rdf:first sg:person.01012616251.96
    147 rdf:rest N718143239a2346a880a008d0abc87c03
    148 N65909eeb5c13482494fb78752b8e9f44 schema:affiliation https://www.grid.ac/institutes/grid.411024.2
    149 schema:familyName Li
    150 schema:givenName H
    151 rdf:type schema:Person
    152 N669f2c40e53f478ba025547e65d264d3 rdf:first sg:person.0622613100.94
    153 rdf:rest N4aa5977eac1b4f6b99c617cf71c7cd9c
    154 N6756e22852144d1c8e9f7e1e9cbac526 schema:name Division of Gastroenterology, Department of Medicine, Baltimore, USA
    155 rdf:type schema:Organization
    156 N67cfe099479a489c812211f56ba980d7 rdf:first sg:person.013145713227.92
    157 rdf:rest Nbc3292060e314c38af861de84c16708b
    158 N693716896152460294be9a9637c8bfe8 rdf:first sg:person.0631337337.03
    159 rdf:rest N8b5fa7e907b8487292e03f01c6986a5b
    160 N718143239a2346a880a008d0abc87c03 rdf:first sg:person.01013557467.96
    161 rdf:rest N5e7968fc5fb14e3e8557a15fffc18c29
    162 N81a1d929e9fe48fdaf1b70f1b68cecb0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    163 schema:name Barrett Esophagus
    164 rdf:type schema:DefinedTerm
    165 N86cce19439304e668f100560e8e7c1fa schema:name readcube_id
    166 schema:value 7ed33b177bb5374136e8dc9e8fc5cbd7d93b9ba1d4b712dcb2e7da0584da74a6
    167 rdf:type schema:PropertyValue
    168 N878ef2a035ae4ba9ac8d20bcd76628f6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    169 schema:name Oligonucleotide Array Sequence Analysis
    170 rdf:type schema:DefinedTerm
    171 N8b5fa7e907b8487292e03f01c6986a5b rdf:first sg:person.016402121412.69
    172 rdf:rest N669f2c40e53f478ba025547e65d264d3
    173 N8dd4f59ae72d4849848a45a9a093afa7 schema:name pubmed_id
    174 schema:value 16449976
    175 rdf:type schema:PropertyValue
    176 N907752c3c43f4df29f676c64237a903d rdf:first sg:person.01247134351.71
    177 rdf:rest N616e87fb88b248fe940f7c1dc65f5eef
    178 N939224d0a2624b2690a57df6901f878c schema:name Division of Gastroenterology, Department of Medicine, Baltimore, USA
    179 rdf:type schema:Organization
    180 N95b2c277b02d4f249f120d1f8be1a63e schema:name Springer Nature - SN SciGraph project
    181 rdf:type schema:Organization
    182 N9734a9947e974b90bec857a4921489bd schema:affiliation Nf4ec8f80e48f422f8d9f5cc4bd4e98db
    183 schema:familyName Yu
    184 schema:givenName M M
    185 rdf:type schema:Person
    186 N98fb1d26f7354f5dbfa0602d869a8327 rdf:first sg:person.01167516500.35
    187 rdf:rest N45d37e6f384e43caac236b28056ffa1d
    188 Na2b4112c1ce144b4ae3db30bdeba63a5 rdf:first sg:person.0745565737.45
    189 rdf:rest Nfa89821ff8bd406f9d465c4420b53bae
    190 Na5b25d68d3c840259a7740e0d35484ab schema:name Division of Gastroenterology, Department of Medicine, Baltimore, USA
    191 rdf:type schema:Organization
    192 Na60e05286e6646a2a40c5b9f59b14728 rdf:first sg:person.0745315065.15
    193 rdf:rest N98fb1d26f7354f5dbfa0602d869a8327
    194 Nad6849a0f0a348d0a037b4e02329b7f8 schema:name Division of Gastroenterology, Department of Medicine, Baltimore, USA
    195 rdf:type schema:Organization
    196 Nb348125356e946ae9582e7b401067802 schema:name Division of Gastroenterology, Department of Medicine, Baltimore, USA
    197 rdf:type schema:Organization
    198 Nb5e814f22d4246e18131fe32d4671341 schema:name Division of Gastroenterology, Department of Medicine, Baltimore, USA
    199 rdf:type schema:Organization
    200 Nbc3292060e314c38af861de84c16708b rdf:first sg:person.01274611657.79
    201 rdf:rest N693716896152460294be9a9637c8bfe8
    202 Nbec973e68a6243b8836fdc55306ee861 schema:name dimensions_id
    203 schema:value pub.1026622123
    204 rdf:type schema:PropertyValue
    205 Nc5b3d3f10f8a4d0ca1ef14c202a6e531 schema:issueNumber 23
    206 rdf:type schema:PublicationIssue
    207 Nd9d0842c16fb4849af92b00df10998b7 rdf:first sg:person.01033746104.09
    208 rdf:rest rdf:nil
    209 Ndc2369bee9e244b0891527f5f475e1d7 schema:name Division of Gastroenterology, Department of Medicine, Baltimore, USA
    210 rdf:type schema:Organization
    211 Ndee6cf7499ed460a93d6e0f3ef1f73fe schema:name Division of Gastroenterology, Department of Medicine, Baltimore, USA
    212 rdf:type schema:Organization
    213 Ne319ebcafc4d48ee8a145353cd7d1e57 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    214 schema:name Neoplasm Staging
    215 rdf:type schema:DefinedTerm
    216 Ne3dc7ef26d794360bd0137fe3b5550cf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    217 schema:name Gene Expression Profiling
    218 rdf:type schema:DefinedTerm
    219 Nec1cab2a738545fe9a9f89eb08e41c10 schema:name Division of Gastroenterology, Department of Medicine, Baltimore, USA
    220 rdf:type schema:Organization
    221 Nf4ec8f80e48f422f8d9f5cc4bd4e98db schema:name Division of Gastroenterology, Department of Medicine, Baltimore, USA
    222 rdf:type schema:Organization
    223 Nf677cf2a89a6453cb4515ad4cd23c665 rdf:first sg:person.01055305265.97
    224 rdf:rest N907752c3c43f4df29f676c64237a903d
    225 Nf6a65de6161e4c3eab5a0d5f45611018 rdf:first sg:person.01367351341.20
    226 rdf:rest N5b28f067928a450c816af78e63848e37
    227 Nfa2208e7898d47d58b5c25d177cb7fa0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    228 schema:name Transcription, Genetic
    229 rdf:type schema:DefinedTerm
    230 Nfa89821ff8bd406f9d465c4420b53bae rdf:first sg:person.014223417067.93
    231 rdf:rest Nf6a65de6161e4c3eab5a0d5f45611018
    232 Nfd87a9f5555e470ea3e6643bce4ef4ad schema:name Division of Gastroenterology, Department of Medicine, Baltimore, USA
    233 rdf:type schema:Organization
    234 Nfe656ebe82e24801a0e76840ce65a8c2 schema:name Division of Gastroenterology, Department of Medicine, Baltimore, USA
    235 rdf:type schema:Organization
    236 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
    237 schema:name Biological Sciences
    238 rdf:type schema:DefinedTerm
    239 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
    240 schema:name Genetics
    241 rdf:type schema:DefinedTerm
    242 sg:grant.2465811 http://pending.schema.org/fundedItem sg:pub.10.1038/sj.onc.1209357
    243 rdf:type schema:MonetaryGrant
    244 sg:grant.2476033 http://pending.schema.org/fundedItem sg:pub.10.1038/sj.onc.1209357
    245 rdf:type schema:MonetaryGrant
    246 sg:grant.2683382 http://pending.schema.org/fundedItem sg:pub.10.1038/sj.onc.1209357
    247 rdf:type schema:MonetaryGrant
    248 sg:grant.2688895 http://pending.schema.org/fundedItem sg:pub.10.1038/sj.onc.1209357
    249 rdf:type schema:MonetaryGrant
    250 sg:journal.1097543 schema:issn 0950-9232
    251 1476-5594
    252 schema:name Oncogene
    253 rdf:type schema:Periodical
    254 sg:person.01012616251.96 schema:affiliation Nad6849a0f0a348d0a037b4e02329b7f8
    255 schema:familyName Ito
    256 schema:givenName T
    257 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01012616251.96
    258 rdf:type schema:Person
    259 sg:person.01013557467.96 schema:affiliation N4f00f394f8994b9ebc4c3f713848bfdb
    260 schema:familyName Mantzur
    261 schema:givenName C
    262 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01013557467.96
    263 rdf:type schema:Person
    264 sg:person.01033746104.09 schema:affiliation N5c751d2e1f1b4363baf3e14a17e533db
    265 schema:familyName Meltzer
    266 schema:givenName S J
    267 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01033746104.09
    268 rdf:type schema:Person
    269 sg:person.01055305265.97 schema:affiliation N2f1a4aa9f785405bb5de6cc9e41512f1
    270 schema:familyName Jin
    271 schema:givenName Z
    272 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01055305265.97
    273 rdf:type schema:Person
    274 sg:person.01167516500.35 schema:affiliation Nb348125356e946ae9582e7b401067802
    275 schema:familyName Paun
    276 schema:givenName B
    277 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01167516500.35
    278 rdf:type schema:Person
    279 sg:person.01247134351.71 schema:affiliation Nfe656ebe82e24801a0e76840ce65a8c2
    280 schema:familyName Cheng
    281 schema:givenName Y
    282 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01247134351.71
    283 rdf:type schema:Person
    284 sg:person.012537270251.68 schema:affiliation https://www.grid.ac/institutes/grid.411024.2
    285 schema:familyName Sato
    286 schema:givenName F
    287 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012537270251.68
    288 rdf:type schema:Person
    289 sg:person.01274611657.79 schema:affiliation https://www.grid.ac/institutes/grid.419475.a
    290 schema:familyName Zhan
    291 schema:givenName M
    292 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01274611657.79
    293 rdf:type schema:Person
    294 sg:person.013145713227.92 schema:affiliation N246b2c5ed8024eadb6fc80f86e3d9695
    295 schema:familyName Wang
    296 schema:givenName S
    297 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013145713227.92
    298 rdf:type schema:Person
    299 sg:person.01367351341.20 schema:affiliation Ndc2369bee9e244b0891527f5f475e1d7
    300 schema:familyName Berki
    301 schema:givenName A T
    302 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01367351341.20
    303 rdf:type schema:Person
    304 sg:person.014223417067.93 schema:affiliation N58b248e25b7f43b8adbd2fef896f41b9
    305 schema:familyName Olaru
    306 schema:givenName A
    307 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014223417067.93
    308 rdf:type schema:Person
    309 sg:person.016402121412.69 schema:affiliation Nfd87a9f5555e470ea3e6643bce4ef4ad
    310 schema:familyName Abraham
    311 schema:givenName J M
    312 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016402121412.69
    313 rdf:type schema:Person
    314 sg:person.0616072747.09 schema:affiliation Nec1cab2a738545fe9a9f89eb08e41c10
    315 schema:familyName Greenwald
    316 schema:givenName B D
    317 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0616072747.09
    318 rdf:type schema:Person
    319 sg:person.0622613100.94 schema:affiliation N5dfe9e34e60445a7810ee9460543ba6f
    320 schema:familyName Mori
    321 schema:givenName Y
    322 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0622613100.94
    323 rdf:type schema:Person
    324 sg:person.0631337337.03 schema:affiliation N939224d0a2624b2690a57df6901f878c
    325 schema:familyName Yin
    326 schema:givenName J
    327 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0631337337.03
    328 rdf:type schema:Person
    329 sg:person.0742762363.63 schema:affiliation N6756e22852144d1c8e9f7e1e9cbac526
    330 schema:familyName Kan
    331 schema:givenName T
    332 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0742762363.63
    333 rdf:type schema:Person
    334 sg:person.0745315065.15 schema:affiliation Na5b25d68d3c840259a7740e0d35484ab
    335 schema:familyName Hamilton
    336 schema:givenName J P
    337 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0745315065.15
    338 rdf:type schema:Person
    339 sg:person.0745565737.45 schema:affiliation Ndee6cf7499ed460a93d6e0f3ef1f73fe
    340 schema:familyName Xu
    341 schema:givenName Y
    342 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0745565737.45
    343 rdf:type schema:Person
    344 sg:person.0763151404.83 schema:affiliation Nb5e814f22d4246e18131fe32d4671341
    345 schema:familyName Schulmann
    346 schema:givenName K
    347 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0763151404.83
    348 rdf:type schema:Person
    349 sg:pub.10.1007/s10585-004-5458-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049958883
    350 https://doi.org/10.1007/s10585-004-5458-3
    351 rdf:type schema:CreativeWork
    352 sg:pub.10.1007/s11912-003-0111-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1022561281
    353 https://doi.org/10.1007/s11912-003-0111-x
    354 rdf:type schema:CreativeWork
    355 sg:pub.10.1016/s1091-255x(01)00052-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1035690690
    356 https://doi.org/10.1016/s1091-255x(01)00052-x
    357 rdf:type schema:CreativeWork
    358 sg:pub.10.1038/ng0501-53 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034643939
    359 https://doi.org/10.1038/ng0501-53
    360 rdf:type schema:CreativeWork
    361 sg:pub.10.1038/sj.onc.1204947 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042293512
    362 https://doi.org/10.1038/sj.onc.1204947
    363 rdf:type schema:CreativeWork
    364 sg:pub.10.1038/sj.onc.1205111 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037814003
    365 https://doi.org/10.1038/sj.onc.1205111
    366 rdf:type schema:CreativeWork
    367 sg:pub.10.1038/sj.onc.1206125 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018616177
    368 https://doi.org/10.1038/sj.onc.1206125
    369 rdf:type schema:CreativeWork
    370 sg:pub.10.1038/sj.onc.1207663 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013051206
    371 https://doi.org/10.1038/sj.onc.1207663
    372 rdf:type schema:CreativeWork
    373 sg:pub.10.1111/j.1572-0241.2003.07411.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1039906212
    374 https://doi.org/10.1111/j.1572-0241.2003.07411.x
    375 rdf:type schema:CreativeWork
    376 sg:pub.10.1186/gb-2003-4-10-r70 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001293245
    377 https://doi.org/10.1186/gb-2003-4-10-r70
    378 rdf:type schema:CreativeWork
    379 sg:pub.10.1186/gb-2004-5-10-r80 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018457673
    380 https://doi.org/10.1186/gb-2004-5-10-r80
    381 rdf:type schema:CreativeWork
    382 https://app.dimensions.ai/details/publication/pub.1074552215 schema:CreativeWork
    383 https://app.dimensions.ai/details/publication/pub.1075070908 schema:CreativeWork
    384 https://app.dimensions.ai/details/publication/pub.1075286774 schema:CreativeWork
    385 https://app.dimensions.ai/details/publication/pub.1075295419 schema:CreativeWork
    386 https://app.dimensions.ai/details/publication/pub.1075329275 schema:CreativeWork
    387 https://app.dimensions.ai/details/publication/pub.1076573800 schema:CreativeWork
    388 https://app.dimensions.ai/details/publication/pub.1076606930 schema:CreativeWork
    389 https://app.dimensions.ai/details/publication/pub.1077035968 schema:CreativeWork
    390 https://app.dimensions.ai/details/publication/pub.1077833330 schema:CreativeWork
    391 https://app.dimensions.ai/details/publication/pub.1082609021 schema:CreativeWork
    392 https://app.dimensions.ai/details/publication/pub.1082750996 schema:CreativeWork
    393 https://app.dimensions.ai/details/publication/pub.1082961924 schema:CreativeWork
    394 https://app.dimensions.ai/details/publication/pub.1083296803 schema:CreativeWork
    395 https://doi.org/10.1002/cncr.20232 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013602855
    396 rdf:type schema:CreativeWork
    397 https://doi.org/10.1002/ijc.20267 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016913970
    398 rdf:type schema:CreativeWork
    399 https://doi.org/10.1016/0016-5085(87)90306-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048993111
    400 rdf:type schema:CreativeWork
    401 https://doi.org/10.1016/j.cancergencyto.2004.01.017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030994899
    402 rdf:type schema:CreativeWork
    403 https://doi.org/10.1016/s0002-9440(10)62550-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035365566
    404 rdf:type schema:CreativeWork
    405 https://doi.org/10.1016/s0016-5085(00)70254-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1034324415
    406 rdf:type schema:CreativeWork
    407 https://doi.org/10.1016/s0025-7125(02)00082-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015093779
    408 rdf:type schema:CreativeWork
    409 https://doi.org/10.1016/s0046-8177(96)90213-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024033133
    410 rdf:type schema:CreativeWork
    411 https://doi.org/10.1016/s1359-6101(03)00019-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009382264
    412 rdf:type schema:CreativeWork
    413 https://doi.org/10.1046/j.1442-2050.2002.00216.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1041201365
    414 rdf:type schema:CreativeWork
    415 https://doi.org/10.1053/gast.2002.32371 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018418301
    416 rdf:type schema:CreativeWork
    417 https://doi.org/10.1067/msy.2002.119292 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001224063
    418 rdf:type schema:CreativeWork
    419 https://doi.org/10.1073/pnas.082099299 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037994416
    420 rdf:type schema:CreativeWork
    421 https://doi.org/10.1073/pnas.091062498 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001631710
    422 rdf:type schema:CreativeWork
    423 https://doi.org/10.1074/jbc.274.46.33166 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046066831
    424 rdf:type schema:CreativeWork
    425 https://doi.org/10.1093/carcin/21.2.257 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000603940
    426 rdf:type schema:CreativeWork
    427 https://doi.org/10.1093/carcin/22.8.1119 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001383948
    428 rdf:type schema:CreativeWork
    429 https://doi.org/10.1093/carcin/23.12.2095 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035059134
    430 rdf:type schema:CreativeWork
    431 https://doi.org/10.1093/carcin/bgh011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027139292
    432 rdf:type schema:CreativeWork
    433 https://doi.org/10.1093/nar/gkh036 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040530060
    434 rdf:type schema:CreativeWork
    435 https://doi.org/10.1097/00008469-199204000-00008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029881392
    436 rdf:type schema:CreativeWork
    437 https://doi.org/10.1111/j.1471-4159.2004.02493.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1050314868
    438 rdf:type schema:CreativeWork
    439 https://doi.org/10.1136/gut.50.3.373 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049278506
    440 rdf:type schema:CreativeWork
    441 https://doi.org/10.1158/0008-5472.can-03-2438 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037887215
    442 rdf:type schema:CreativeWork
    443 https://doi.org/10.1158/1078-0432.ccr-04-0048 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000633292
    444 rdf:type schema:CreativeWork
    445 https://doi.org/10.3748/wjg.v10.i21.3194 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071362590
    446 rdf:type schema:CreativeWork
    447 https://doi.org/10.3892/or.10.2.427 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071528808
    448 rdf:type schema:CreativeWork
    449 https://doi.org/10.3892/or.5.1.73 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071535604
    450 rdf:type schema:CreativeWork
    451 https://doi.org/10.4067/s0034-98872003000600001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072187295
    452 rdf:type schema:CreativeWork
    453 https://www.grid.ac/institutes/grid.411024.2 schema:alternateName University of Maryland, Baltimore
    454 schema:name Department of Pathology, University of Maryland School of Medicine, Baltimore, USA
    455 Division of Gastroenterology, Department of Medicine, Baltimore, USA
    456 Marlene and Stewart Greenebaum Cancer Center, University of Maryland, Baltimore, USA
    457 rdf:type schema:Organization
    458 https://www.grid.ac/institutes/grid.419475.a schema:alternateName National Institute on Aging
    459 schema:name Bioinformatics Unit, National Institute on Aging, NIH, Baltimore, MD, USA
    460 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...