Molecular characterization of early-stage bladder carcinomas by expression profiles, FGFR3 mutation status, and loss of 9q View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2006-04

AUTHORS

D Lindgren, F Liedberg, A Andersson, G Chebil, S Gudjonsson, Å Borg, W Månsson, T Fioretos, M Höglund

ABSTRACT

We used gene expression profiling, mutation analyses of FGFR3 and TP53, and LOH analyses of chromosome 9 and the TP53 region on chromosome arm 17p, to molecularly characterize 75 Ta and T1 bladder carcinomas. We identified four major cellular processes related to cell cycle, protein synthesis, immune response, and extra cellular components that contribute to the expressional heterogeneity of early-stage urothelial cell carcinoma (UCC). Activating FGFR3 mutations were found at the highest frequency in G1 tumors (80%), and showed a strong correlation with FGFR3 expression. In contrast, G3 tumors displayed mutations in less than 10% of the cases and a low level of FGFR3 expression. Even though LOH on chromosome 9 was not associated with any specific expression pattern, our data indicate that loss of chromosome 9 is associated with tumor development rather than initiation. The combined analyses suggest the existence of two types of UCC tumors, one which is characterized by FGFR3 mutation or expression, high expression of protein synthesis genes, and low expression of cell cycle genes. Furthermore, the presented data underscore FGFR3 receptor involvement in urothelial cell transformation as the presence of FGFR3 mutations has a major impact on the global gene expression profile of bladder carcinomas. More... »

PAGES

2685

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/sj.onc.1209249

DOI

http://dx.doi.org/10.1038/sj.onc.1209249

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1000190672

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/16532037


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Genetics", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chromosomes, Human, Pair 17", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chromosomes, Human, Pair 9", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA Mutational Analysis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA, Neoplasm", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Disease Progression", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Expression Profiling", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Loss of Heterozygosity", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Microsatellite Repeats", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mutation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasm Recurrence, Local", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Oligonucleotide Array Sequence Analysis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Receptor, Fibroblast Growth Factor, Type 3", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tumor Suppressor Protein p53", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Urinary Bladder Neoplasms", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Sk\u00e5ne University Hospital", 
          "id": "https://www.grid.ac/institutes/grid.411843.b", 
          "name": [
            "Department of Clinical Genetics, Lund University Hospital, Lund, Sweden"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lindgren", 
        "givenName": "D", 
        "id": "sg:person.01044632347.28", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01044632347.28"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Sk\u00e5ne University Hospital", 
          "id": "https://www.grid.ac/institutes/grid.411843.b", 
          "name": [
            "Department of Urology, Lund University Hospital, Lund, Sweden"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Liedberg", 
        "givenName": "F", 
        "id": "sg:person.0730403747.56", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0730403747.56"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Sk\u00e5ne University Hospital", 
          "id": "https://www.grid.ac/institutes/grid.411843.b", 
          "name": [
            "Department of Clinical Genetics, Lund University Hospital, Lund, Sweden"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Andersson", 
        "givenName": "A", 
        "id": "sg:person.01245212001.85", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01245212001.85"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Pathology and Cytology, Helsingborg Hospital AB, Helsingborg, Sweden"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chebil", 
        "givenName": "G", 
        "id": "sg:person.01015620300.32", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01015620300.32"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Sk\u00e5ne University Hospital", 
          "id": "https://www.grid.ac/institutes/grid.411843.b", 
          "name": [
            "Department of Urology, Lund University Hospital, Lund, Sweden"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gudjonsson", 
        "givenName": "S", 
        "id": "sg:person.01063733500.66", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01063733500.66"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Sk\u00e5ne University Hospital", 
          "id": "https://www.grid.ac/institutes/grid.411843.b", 
          "name": [
            "Department of Oncology, Lund University Hospital, Lund, Sweden"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Borg", 
        "givenName": "\u00c5", 
        "id": "sg:person.0601121013.45", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0601121013.45"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Sk\u00e5ne University Hospital", 
          "id": "https://www.grid.ac/institutes/grid.411843.b", 
          "name": [
            "Department of Urology, Lund University Hospital, Lund, Sweden"
          ], 
          "type": "Organization"
        }, 
        "familyName": "M\u00e5nsson", 
        "givenName": "W", 
        "id": "sg:person.01002437204.91", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01002437204.91"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Sk\u00e5ne University Hospital", 
          "id": "https://www.grid.ac/institutes/grid.411843.b", 
          "name": [
            "Department of Clinical Genetics, Lund University Hospital, Lund, Sweden"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fioretos", 
        "givenName": "T", 
        "id": "sg:person.01132332604.70", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01132332604.70"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Sk\u00e5ne University Hospital", 
          "id": "https://www.grid.ac/institutes/grid.411843.b", 
          "name": [
            "Department of Clinical Genetics, Lund University Hospital, Lund, Sweden"
          ], 
          "type": "Organization"
        }, 
        "familyName": "H\u00f6glund", 
        "givenName": "M", 
        "id": "sg:person.01233405147.34", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01233405147.34"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/s0092-8674(00)81604-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000618723"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-03-0134", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001531204"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.091062498", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001631710"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0302-2838(02)00068-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004961165"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-03-3620", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005461901"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-04-2409", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006822742"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1007403503", 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-3-642-59871-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007403503", 
          "https://doi.org/10.1007/978-3-642-59871-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-3-642-59871-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007403503", 
          "https://doi.org/10.1007/978-3-642-59871-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2004-10-3913", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008178522"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0022-5347(05)67972-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008602535"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0022-5347(05)67972-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008602535"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0002-9440(10)64665-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010814816"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.ejhg.5200883", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012462198", 
          "https://doi.org/10.1038/sj.ejhg.5200883"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.ejhg.5200883", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012462198", 
          "https://doi.org/10.1038/sj.ejhg.5200883"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/1097-0142(20010715)92:2<452::aid-cncr1342>3.0.co;2-b", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014111417"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/labinvest.3700250", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017472931", 
          "https://doi.org/10.1038/labinvest.3700250"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/labinvest.3700250", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017472931", 
          "https://doi.org/10.1038/labinvest.3700250"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/labinvest.3700250", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017472931", 
          "https://doi.org/10.1038/labinvest.3700250"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00042307-200409000-00006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018211129"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00042307-200409000-00006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018211129"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gr.9.11.1106", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018456662"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/1097-0029(20001101)51:3<280::aid-jemt7>3.0.co;2-o", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020636210"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-04-2095", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025035759"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0002-9440(10)65750-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029315385"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/14234", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036812315", 
          "https://doi.org/10.1038/14234"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/14234", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036812315", 
          "https://doi.org/10.1038/14234"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1464-410x.1999.00078.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042800724"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1207039", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044144627", 
          "https://doi.org/10.1038/sj.onc.1207039"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1207039", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044144627", 
          "https://doi.org/10.1038/sj.onc.1207039"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0002-9440(10)63679-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044171276"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng1061", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044852770", 
          "https://doi.org/10.1038/ng1061"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng1061", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044852770", 
          "https://doi.org/10.1038/ng1061"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/30.4.e15", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045723576"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-05-0259", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046447488"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ijc.10544", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046933445"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-03-2421", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053261331"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2003.05.073", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064203596"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/er.21.1.23", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064286129"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3892/ijo.14.3.441", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071510957"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074522355", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074795158", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074957460", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2144/03342mt01", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1075245738"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0022-5347(17)36924-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1076435142"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1076613541", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082749026", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2006-04", 
    "datePublishedReg": "2006-04-01", 
    "description": "We used gene expression profiling, mutation analyses of FGFR3 and TP53, and LOH analyses of chromosome 9 and the TP53 region on chromosome arm 17p, to molecularly characterize 75 Ta and T1 bladder carcinomas. We identified four major cellular processes related to cell cycle, protein synthesis, immune response, and extra cellular components that contribute to the expressional heterogeneity of early-stage urothelial cell carcinoma (UCC). Activating FGFR3 mutations were found at the highest frequency in G1 tumors (80%), and showed a strong correlation with FGFR3 expression. In contrast, G3 tumors displayed mutations in less than 10% of the cases and a low level of FGFR3 expression. Even though LOH on chromosome 9 was not associated with any specific expression pattern, our data indicate that loss of chromosome 9 is associated with tumor development rather than initiation. The combined analyses suggest the existence of two types of UCC tumors, one which is characterized by FGFR3 mutation or expression, high expression of protein synthesis genes, and low expression of cell cycle genes. Furthermore, the presented data underscore FGFR3 receptor involvement in urothelial cell transformation as the presence of FGFR3 mutations has a major impact on the global gene expression profile of bladder carcinomas.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/sj.onc.1209249", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1097543", 
        "issn": [
          "0950-9232", 
          "1476-5594"
        ], 
        "name": "Oncogene", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "18", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "25"
      }
    ], 
    "name": "Molecular characterization of early-stage bladder carcinomas by expression profiles, FGFR3 mutation status, and loss of 9q", 
    "pagination": "2685", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "00e80818ae5ed52853986f4d1c1a9efe7707b81d3e0ac70bd9ad26f9867d3269"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "16532037"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "8711562"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/sj.onc.1209249"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1000190672"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/sj.onc.1209249", 
      "https://app.dimensions.ai/details/publication/pub.1000190672"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T12:23", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000362_0000000362/records_87091_00000000.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/1209249"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/sj.onc.1209249'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/sj.onc.1209249'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/sj.onc.1209249'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/sj.onc.1209249'


 

This table displays all metadata directly associated to this object as RDF triples.

303 TRIPLES      21 PREDICATES      82 URIs      36 LITERALS      24 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/sj.onc.1209249 schema:about N0c9fe97813d44ec8af15b21d5b6a2816
2 N0e17c8febf99428bae4ac96e885bff7d
3 N1b3a44c62f4747048f2b4c6f1831b513
4 N1d66c88e383d49dfa094e6a96d910ec0
5 N31a42e7456454a2fb69c61135d879661
6 N3d76e462b39c409b91b91db1bcac6372
7 N44c7ef90576049d0857cf4ba2130fd6d
8 N59dc9d9e1531419b8a4594ca3e1078fe
9 N5aa1df9898d642829adbcf0e2387a58a
10 N7198041d901749139dd2a188d38078d0
11 N98e425f84e5a4f08893f939dc3b48ef2
12 Nd396477bab574762bf877d5220207bda
13 Ne0d1455858794cd29cb645f45400ee7b
14 Nee4163ba3cb74855b3e41ecd9d21a56f
15 Nf867cb6b01f349c0970835cdf55a7bc7
16 anzsrc-for:06
17 anzsrc-for:0604
18 schema:author Ncec28b5dbf814da9bbdb1eb296988909
19 schema:citation sg:pub.10.1007/978-3-642-59871-5
20 sg:pub.10.1038/14234
21 sg:pub.10.1038/labinvest.3700250
22 sg:pub.10.1038/ng1061
23 sg:pub.10.1038/sj.ejhg.5200883
24 sg:pub.10.1038/sj.onc.1207039
25 https://app.dimensions.ai/details/publication/pub.1007403503
26 https://app.dimensions.ai/details/publication/pub.1074522355
27 https://app.dimensions.ai/details/publication/pub.1074795158
28 https://app.dimensions.ai/details/publication/pub.1074957460
29 https://app.dimensions.ai/details/publication/pub.1076613541
30 https://app.dimensions.ai/details/publication/pub.1082749026
31 https://doi.org/10.1002/1097-0029(20001101)51:3<280::aid-jemt7>3.0.co;2-o
32 https://doi.org/10.1002/1097-0142(20010715)92:2<452::aid-cncr1342>3.0.co;2-b
33 https://doi.org/10.1002/ijc.10544
34 https://doi.org/10.1016/s0002-9440(10)63679-6
35 https://doi.org/10.1016/s0002-9440(10)64665-2
36 https://doi.org/10.1016/s0002-9440(10)65750-1
37 https://doi.org/10.1016/s0022-5347(05)67972-4
38 https://doi.org/10.1016/s0022-5347(17)36924-0
39 https://doi.org/10.1016/s0092-8674(00)81604-9
40 https://doi.org/10.1016/s0302-2838(02)00068-4
41 https://doi.org/10.1046/j.1464-410x.1999.00078.x
42 https://doi.org/10.1073/pnas.091062498
43 https://doi.org/10.1093/nar/30.4.e15
44 https://doi.org/10.1097/00042307-200409000-00006
45 https://doi.org/10.1101/gr.9.11.1106
46 https://doi.org/10.1158/0008-5472.can-03-2421
47 https://doi.org/10.1158/0008-5472.can-03-3620
48 https://doi.org/10.1158/1078-0432.ccr-03-0134
49 https://doi.org/10.1158/1078-0432.ccr-04-2095
50 https://doi.org/10.1158/1078-0432.ccr-04-2409
51 https://doi.org/10.1158/1078-0432.ccr-05-0259
52 https://doi.org/10.1182/blood-2004-10-3913
53 https://doi.org/10.1200/jco.2003.05.073
54 https://doi.org/10.1210/er.21.1.23
55 https://doi.org/10.2144/03342mt01
56 https://doi.org/10.3892/ijo.14.3.441
57 schema:datePublished 2006-04
58 schema:datePublishedReg 2006-04-01
59 schema:description We used gene expression profiling, mutation analyses of FGFR3 and TP53, and LOH analyses of chromosome 9 and the TP53 region on chromosome arm 17p, to molecularly characterize 75 Ta and T1 bladder carcinomas. We identified four major cellular processes related to cell cycle, protein synthesis, immune response, and extra cellular components that contribute to the expressional heterogeneity of early-stage urothelial cell carcinoma (UCC). Activating FGFR3 mutations were found at the highest frequency in G1 tumors (80%), and showed a strong correlation with FGFR3 expression. In contrast, G3 tumors displayed mutations in less than 10% of the cases and a low level of FGFR3 expression. Even though LOH on chromosome 9 was not associated with any specific expression pattern, our data indicate that loss of chromosome 9 is associated with tumor development rather than initiation. The combined analyses suggest the existence of two types of UCC tumors, one which is characterized by FGFR3 mutation or expression, high expression of protein synthesis genes, and low expression of cell cycle genes. Furthermore, the presented data underscore FGFR3 receptor involvement in urothelial cell transformation as the presence of FGFR3 mutations has a major impact on the global gene expression profile of bladder carcinomas.
60 schema:genre research_article
61 schema:inLanguage en
62 schema:isAccessibleForFree true
63 schema:isPartOf Ndb62120a114d4d82b541587e65c8bc98
64 Neac2b256581349f7a813a2c5bb9da235
65 sg:journal.1097543
66 schema:name Molecular characterization of early-stage bladder carcinomas by expression profiles, FGFR3 mutation status, and loss of 9q
67 schema:pagination 2685
68 schema:productId N1bec33e5c53c46928d9330d66ad2a902
69 N3bd54b935c78409f82c130da030ad785
70 N7aaef09d62c14a93b7624945653d650c
71 Nd587f41692a84c009d80ee0653697377
72 Nfb5b1ac123b4430db0756a709843561a
73 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000190672
74 https://doi.org/10.1038/sj.onc.1209249
75 schema:sdDatePublished 2019-04-11T12:23
76 schema:sdLicense https://scigraph.springernature.com/explorer/license/
77 schema:sdPublisher N9bd36c2627c044a6a5c212f48b032af8
78 schema:url https://www.nature.com/articles/1209249
79 sgo:license sg:explorer/license/
80 sgo:sdDataset articles
81 rdf:type schema:ScholarlyArticle
82 N005ff13174ea47eeb1ca56a3eefd1416 rdf:first sg:person.01245212001.85
83 rdf:rest N31172b53eeb045d78d4410b1b91aa2b4
84 N0c9fe97813d44ec8af15b21d5b6a2816 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
85 schema:name Loss of Heterozygosity
86 rdf:type schema:DefinedTerm
87 N0e17c8febf99428bae4ac96e885bff7d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
88 schema:name Mutation
89 rdf:type schema:DefinedTerm
90 N1b3a44c62f4747048f2b4c6f1831b513 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
91 schema:name Humans
92 rdf:type schema:DefinedTerm
93 N1bec33e5c53c46928d9330d66ad2a902 schema:name dimensions_id
94 schema:value pub.1000190672
95 rdf:type schema:PropertyValue
96 N1d66c88e383d49dfa094e6a96d910ec0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
97 schema:name Neoplasm Recurrence, Local
98 rdf:type schema:DefinedTerm
99 N304d83ce8500402aa8e998e2d90498b6 rdf:first sg:person.01233405147.34
100 rdf:rest rdf:nil
101 N31172b53eeb045d78d4410b1b91aa2b4 rdf:first sg:person.01015620300.32
102 rdf:rest Nfea0ee0c08274138a33d7656c43f0602
103 N31a42e7456454a2fb69c61135d879661 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
104 schema:name Disease Progression
105 rdf:type schema:DefinedTerm
106 N37d0b3279df647e68d83fe545c9fee22 rdf:first sg:person.0730403747.56
107 rdf:rest N005ff13174ea47eeb1ca56a3eefd1416
108 N38fbc0ccb834444caff12395fbdedbae rdf:first sg:person.01132332604.70
109 rdf:rest N304d83ce8500402aa8e998e2d90498b6
110 N3bd54b935c78409f82c130da030ad785 schema:name nlm_unique_id
111 schema:value 8711562
112 rdf:type schema:PropertyValue
113 N3d76e462b39c409b91b91db1bcac6372 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
114 schema:name Tumor Suppressor Protein p53
115 rdf:type schema:DefinedTerm
116 N44c7ef90576049d0857cf4ba2130fd6d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
117 schema:name Gene Expression Profiling
118 rdf:type schema:DefinedTerm
119 N59dc9d9e1531419b8a4594ca3e1078fe schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
120 schema:name Urinary Bladder Neoplasms
121 rdf:type schema:DefinedTerm
122 N5aa1df9898d642829adbcf0e2387a58a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
123 schema:name Microsatellite Repeats
124 rdf:type schema:DefinedTerm
125 N7198041d901749139dd2a188d38078d0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
126 schema:name DNA, Neoplasm
127 rdf:type schema:DefinedTerm
128 N7aaef09d62c14a93b7624945653d650c schema:name pubmed_id
129 schema:value 16532037
130 rdf:type schema:PropertyValue
131 N98e425f84e5a4f08893f939dc3b48ef2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
132 schema:name Chromosomes, Human, Pair 9
133 rdf:type schema:DefinedTerm
134 N9bd36c2627c044a6a5c212f48b032af8 schema:name Springer Nature - SN SciGraph project
135 rdf:type schema:Organization
136 Ncec28b5dbf814da9bbdb1eb296988909 rdf:first sg:person.01044632347.28
137 rdf:rest N37d0b3279df647e68d83fe545c9fee22
138 Nd0f12edf641b4801afc71b3334cca3d4 rdf:first sg:person.0601121013.45
139 rdf:rest Nef893efc78884279b45a058a025eb846
140 Nd396477bab574762bf877d5220207bda schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
141 schema:name Chromosomes, Human, Pair 17
142 rdf:type schema:DefinedTerm
143 Nd587f41692a84c009d80ee0653697377 schema:name readcube_id
144 schema:value 00e80818ae5ed52853986f4d1c1a9efe7707b81d3e0ac70bd9ad26f9867d3269
145 rdf:type schema:PropertyValue
146 Ndb62120a114d4d82b541587e65c8bc98 schema:volumeNumber 25
147 rdf:type schema:PublicationVolume
148 Ndf0da0dec5a1419cbba199350fb95e0e schema:name Department of Pathology and Cytology, Helsingborg Hospital AB, Helsingborg, Sweden
149 rdf:type schema:Organization
150 Ne0d1455858794cd29cb645f45400ee7b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
151 schema:name Oligonucleotide Array Sequence Analysis
152 rdf:type schema:DefinedTerm
153 Neac2b256581349f7a813a2c5bb9da235 schema:issueNumber 18
154 rdf:type schema:PublicationIssue
155 Nee4163ba3cb74855b3e41ecd9d21a56f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
156 schema:name DNA Mutational Analysis
157 rdf:type schema:DefinedTerm
158 Nef893efc78884279b45a058a025eb846 rdf:first sg:person.01002437204.91
159 rdf:rest N38fbc0ccb834444caff12395fbdedbae
160 Nf867cb6b01f349c0970835cdf55a7bc7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
161 schema:name Receptor, Fibroblast Growth Factor, Type 3
162 rdf:type schema:DefinedTerm
163 Nfb5b1ac123b4430db0756a709843561a schema:name doi
164 schema:value 10.1038/sj.onc.1209249
165 rdf:type schema:PropertyValue
166 Nfea0ee0c08274138a33d7656c43f0602 rdf:first sg:person.01063733500.66
167 rdf:rest Nd0f12edf641b4801afc71b3334cca3d4
168 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
169 schema:name Biological Sciences
170 rdf:type schema:DefinedTerm
171 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
172 schema:name Genetics
173 rdf:type schema:DefinedTerm
174 sg:journal.1097543 schema:issn 0950-9232
175 1476-5594
176 schema:name Oncogene
177 rdf:type schema:Periodical
178 sg:person.01002437204.91 schema:affiliation https://www.grid.ac/institutes/grid.411843.b
179 schema:familyName Månsson
180 schema:givenName W
181 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01002437204.91
182 rdf:type schema:Person
183 sg:person.01015620300.32 schema:affiliation Ndf0da0dec5a1419cbba199350fb95e0e
184 schema:familyName Chebil
185 schema:givenName G
186 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01015620300.32
187 rdf:type schema:Person
188 sg:person.01044632347.28 schema:affiliation https://www.grid.ac/institutes/grid.411843.b
189 schema:familyName Lindgren
190 schema:givenName D
191 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01044632347.28
192 rdf:type schema:Person
193 sg:person.01063733500.66 schema:affiliation https://www.grid.ac/institutes/grid.411843.b
194 schema:familyName Gudjonsson
195 schema:givenName S
196 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01063733500.66
197 rdf:type schema:Person
198 sg:person.01132332604.70 schema:affiliation https://www.grid.ac/institutes/grid.411843.b
199 schema:familyName Fioretos
200 schema:givenName T
201 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01132332604.70
202 rdf:type schema:Person
203 sg:person.01233405147.34 schema:affiliation https://www.grid.ac/institutes/grid.411843.b
204 schema:familyName Höglund
205 schema:givenName M
206 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01233405147.34
207 rdf:type schema:Person
208 sg:person.01245212001.85 schema:affiliation https://www.grid.ac/institutes/grid.411843.b
209 schema:familyName Andersson
210 schema:givenName A
211 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01245212001.85
212 rdf:type schema:Person
213 sg:person.0601121013.45 schema:affiliation https://www.grid.ac/institutes/grid.411843.b
214 schema:familyName Borg
215 schema:givenName Å
216 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0601121013.45
217 rdf:type schema:Person
218 sg:person.0730403747.56 schema:affiliation https://www.grid.ac/institutes/grid.411843.b
219 schema:familyName Liedberg
220 schema:givenName F
221 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0730403747.56
222 rdf:type schema:Person
223 sg:pub.10.1007/978-3-642-59871-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007403503
224 https://doi.org/10.1007/978-3-642-59871-5
225 rdf:type schema:CreativeWork
226 sg:pub.10.1038/14234 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036812315
227 https://doi.org/10.1038/14234
228 rdf:type schema:CreativeWork
229 sg:pub.10.1038/labinvest.3700250 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017472931
230 https://doi.org/10.1038/labinvest.3700250
231 rdf:type schema:CreativeWork
232 sg:pub.10.1038/ng1061 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044852770
233 https://doi.org/10.1038/ng1061
234 rdf:type schema:CreativeWork
235 sg:pub.10.1038/sj.ejhg.5200883 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012462198
236 https://doi.org/10.1038/sj.ejhg.5200883
237 rdf:type schema:CreativeWork
238 sg:pub.10.1038/sj.onc.1207039 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044144627
239 https://doi.org/10.1038/sj.onc.1207039
240 rdf:type schema:CreativeWork
241 https://app.dimensions.ai/details/publication/pub.1007403503 schema:CreativeWork
242 https://app.dimensions.ai/details/publication/pub.1074522355 schema:CreativeWork
243 https://app.dimensions.ai/details/publication/pub.1074795158 schema:CreativeWork
244 https://app.dimensions.ai/details/publication/pub.1074957460 schema:CreativeWork
245 https://app.dimensions.ai/details/publication/pub.1076613541 schema:CreativeWork
246 https://app.dimensions.ai/details/publication/pub.1082749026 schema:CreativeWork
247 https://doi.org/10.1002/1097-0029(20001101)51:3<280::aid-jemt7>3.0.co;2-o schema:sameAs https://app.dimensions.ai/details/publication/pub.1020636210
248 rdf:type schema:CreativeWork
249 https://doi.org/10.1002/1097-0142(20010715)92:2<452::aid-cncr1342>3.0.co;2-b schema:sameAs https://app.dimensions.ai/details/publication/pub.1014111417
250 rdf:type schema:CreativeWork
251 https://doi.org/10.1002/ijc.10544 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046933445
252 rdf:type schema:CreativeWork
253 https://doi.org/10.1016/s0002-9440(10)63679-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044171276
254 rdf:type schema:CreativeWork
255 https://doi.org/10.1016/s0002-9440(10)64665-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010814816
256 rdf:type schema:CreativeWork
257 https://doi.org/10.1016/s0002-9440(10)65750-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029315385
258 rdf:type schema:CreativeWork
259 https://doi.org/10.1016/s0022-5347(05)67972-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008602535
260 rdf:type schema:CreativeWork
261 https://doi.org/10.1016/s0022-5347(17)36924-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1076435142
262 rdf:type schema:CreativeWork
263 https://doi.org/10.1016/s0092-8674(00)81604-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000618723
264 rdf:type schema:CreativeWork
265 https://doi.org/10.1016/s0302-2838(02)00068-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004961165
266 rdf:type schema:CreativeWork
267 https://doi.org/10.1046/j.1464-410x.1999.00078.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1042800724
268 rdf:type schema:CreativeWork
269 https://doi.org/10.1073/pnas.091062498 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001631710
270 rdf:type schema:CreativeWork
271 https://doi.org/10.1093/nar/30.4.e15 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045723576
272 rdf:type schema:CreativeWork
273 https://doi.org/10.1097/00042307-200409000-00006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018211129
274 rdf:type schema:CreativeWork
275 https://doi.org/10.1101/gr.9.11.1106 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018456662
276 rdf:type schema:CreativeWork
277 https://doi.org/10.1158/0008-5472.can-03-2421 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053261331
278 rdf:type schema:CreativeWork
279 https://doi.org/10.1158/0008-5472.can-03-3620 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005461901
280 rdf:type schema:CreativeWork
281 https://doi.org/10.1158/1078-0432.ccr-03-0134 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001531204
282 rdf:type schema:CreativeWork
283 https://doi.org/10.1158/1078-0432.ccr-04-2095 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025035759
284 rdf:type schema:CreativeWork
285 https://doi.org/10.1158/1078-0432.ccr-04-2409 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006822742
286 rdf:type schema:CreativeWork
287 https://doi.org/10.1158/1078-0432.ccr-05-0259 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046447488
288 rdf:type schema:CreativeWork
289 https://doi.org/10.1182/blood-2004-10-3913 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008178522
290 rdf:type schema:CreativeWork
291 https://doi.org/10.1200/jco.2003.05.073 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064203596
292 rdf:type schema:CreativeWork
293 https://doi.org/10.1210/er.21.1.23 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064286129
294 rdf:type schema:CreativeWork
295 https://doi.org/10.2144/03342mt01 schema:sameAs https://app.dimensions.ai/details/publication/pub.1075245738
296 rdf:type schema:CreativeWork
297 https://doi.org/10.3892/ijo.14.3.441 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071510957
298 rdf:type schema:CreativeWork
299 https://www.grid.ac/institutes/grid.411843.b schema:alternateName Skåne University Hospital
300 schema:name Department of Clinical Genetics, Lund University Hospital, Lund, Sweden
301 Department of Oncology, Lund University Hospital, Lund, Sweden
302 Department of Urology, Lund University Hospital, Lund, Sweden
303 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...