ADAM23, a possible tumor suppressor gene, is frequently silenced in gastric cancers by homozygous deletion or aberrant promoter hypermethylation View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2005-08-15

AUTHORS

Hisashi Takada, Issei Imoto, Hitoshi Tsuda, Yukihiro Nakanishi, Takashi Ichikura, Hidetaka Mochizuki, Shoji Mitsufuji, Fumie Hosoda, Setsuo Hirohashi, Misao Ohki, Johji Inazawa

ABSTRACT

Array-based comparative genomic hybridization (CGH-array) has a powerful potential for high-throughput identification of genetic aberrations in cell genomes. We identified a homozygous loss of ADAM23 (2q33.3) in the course of a program to screen a panel of gastric cancer (GC) cell lines (1/32, 3.1%) for genomic copy-number aberrations using our custom-made CGH-array. Infrequent homozygous deletion of ADAM23 was also seen in primary gastric tumors (1/39, 2.6%). ADAM23 mRNA was expressed in normal stomach tissue, but not in the majority of GC cell lines without homozygous deletion of this gene. Expression of ADAM23 mRNA was restored to gene-silenced GC cells after treatment with 5-aza 2′-deoxycytidine. The methylation status of the ADAM23 CpG island, which showed promoter activity, correlated inversely with its expression. Methylation of this CpG island was observed both in GC cell lines and in primary GC tissues; in primary tumors with a hypermethylated CpG island, expression of ADAM23 was lower than in adjacent noncancerous tissues. Moreover, restoration of ADAM23 in GC cells reduced their numbers in colony-formation assays. These results suggest that genetic or epigenetic silencing by hypermethylation of the ADAM23 CpG-rich promoter region leads to loss of ADAM23 function, which may be a factor in gastric carcinogenesis. More... »

PAGES

8051-8060

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/sj.onc.1208952

DOI

http://dx.doi.org/10.1038/sj.onc.1208952

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1016286094

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/16103878


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "ADAM Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Line, Tumor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "CpG Islands", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA Methylation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Deletion", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Expression Regulation, Neoplastic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Silencing", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genes, Tumor Suppressor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Nucleic Acid Hybridization", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Promoter Regions, Genetic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Stomach Neoplasms", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Division of Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kawaramachi Hirokoji Kamigyo-ku, Kyoto, Japan", 
          "id": "http://www.grid.ac/institutes/grid.272458.e", 
          "name": [
            "Department of Molecular Cytogenetics, Medical Research Institute and School of Biomedical Science, Tokyo Medical and Dental University, Bunkyo-ku, Tokyo, Japan", 
            "Core Research for Evolutional Science and Technology (CREST) of Japan Science and Technology Corporation (JST), Hon-machi Kawaguchi, Saitama, Japan", 
            "Division of Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kawaramachi Hirokoji Kamigyo-ku, Kyoto, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Takada", 
        "givenName": "Hisashi", 
        "id": "sg:person.0652564305.15", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0652564305.15"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Core Research for Evolutional Science and Technology (CREST) of Japan Science and Technology Corporation (JST), Hon-machi Kawaguchi, Saitama, Japan", 
          "id": "http://www.grid.ac/institutes/grid.419082.6", 
          "name": [
            "Department of Molecular Cytogenetics, Medical Research Institute and School of Biomedical Science, Tokyo Medical and Dental University, Bunkyo-ku, Tokyo, Japan", 
            "Core Research for Evolutional Science and Technology (CREST) of Japan Science and Technology Corporation (JST), Hon-machi Kawaguchi, Saitama, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Imoto", 
        "givenName": "Issei", 
        "id": "sg:person.01264511401.47", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01264511401.47"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pathology II, National Defense Medical College, Namiki, Tokorozawa, Japan", 
          "id": "http://www.grid.ac/institutes/grid.416614.0", 
          "name": [
            "Core Research for Evolutional Science and Technology (CREST) of Japan Science and Technology Corporation (JST), Hon-machi Kawaguchi, Saitama, Japan", 
            "Department of Pathology II, National Defense Medical College, Namiki, Tokorozawa, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tsuda", 
        "givenName": "Hitoshi", 
        "id": "sg:person.07547136242.70", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07547136242.70"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Pathology Division, National Cancer Center Research Institute, Tsukiji Chuo-ku Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.272242.3", 
          "name": [
            "Pathology Division, National Cancer Center Research Institute, Tsukiji Chuo-ku Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nakanishi", 
        "givenName": "Yukihiro", 
        "id": "sg:person.01172752000.98", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01172752000.98"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Surgery I, National Defense Medical College, Namiki, Tokorozawa, Japan", 
          "id": "http://www.grid.ac/institutes/grid.416614.0", 
          "name": [
            "Department of Surgery I, National Defense Medical College, Namiki, Tokorozawa, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ichikura", 
        "givenName": "Takashi", 
        "id": "sg:person.0634231701.10", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0634231701.10"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Surgery I, National Defense Medical College, Namiki, Tokorozawa, Japan", 
          "id": "http://www.grid.ac/institutes/grid.416614.0", 
          "name": [
            "Department of Surgery I, National Defense Medical College, Namiki, Tokorozawa, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mochizuki", 
        "givenName": "Hidetaka", 
        "id": "sg:person.01207342056.64", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01207342056.64"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kawaramachi Hirokoji Kamigyo-ku, Kyoto, Japan", 
          "id": "http://www.grid.ac/institutes/grid.272458.e", 
          "name": [
            "Division of Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kawaramachi Hirokoji Kamigyo-ku, Kyoto, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mitsufuji", 
        "givenName": "Shoji", 
        "id": "sg:person.01306410101.35", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01306410101.35"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Cancer Genomics Project, National Cancer Center Research Institute, Tsukiji Chuo-ku Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.272242.3", 
          "name": [
            "Core Research for Evolutional Science and Technology (CREST) of Japan Science and Technology Corporation (JST), Hon-machi Kawaguchi, Saitama, Japan", 
            "Cancer Genomics Project, National Cancer Center Research Institute, Tsukiji Chuo-ku Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hosoda", 
        "givenName": "Fumie", 
        "id": "sg:person.0774504244.38", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0774504244.38"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Pathology Division, National Cancer Center Research Institute, Tsukiji Chuo-ku Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.272242.3", 
          "name": [
            "Pathology Division, National Cancer Center Research Institute, Tsukiji Chuo-ku Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hirohashi", 
        "givenName": "Setsuo", 
        "id": "sg:person.0771511462.11", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0771511462.11"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Cancer Genomics Project, National Cancer Center Research Institute, Tsukiji Chuo-ku Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.272242.3", 
          "name": [
            "Cancer Genomics Project, National Cancer Center Research Institute, Tsukiji Chuo-ku Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ohki", 
        "givenName": "Misao", 
        "id": "sg:person.01025357363.39", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01025357363.39"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "COE program for Frontier Research on Molecular Destruction and Reconstitution of Tooth and Bone, Tokyo Medical and Dental University, Bunkyo-ku, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.265073.5", 
          "name": [
            "Department of Molecular Cytogenetics, Medical Research Institute and School of Biomedical Science, Tokyo Medical and Dental University, Bunkyo-ku, Tokyo, Japan", 
            "Core Research for Evolutional Science and Technology (CREST) of Japan Science and Technology Corporation (JST), Hon-machi Kawaguchi, Saitama, Japan", 
            "COE program for Frontier Research on Molecular Destruction and Reconstitution of Tooth and Bone, Tokyo Medical and Dental University, Bunkyo-ku, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Inazawa", 
        "givenName": "Johji", 
        "id": "sg:person.01012503077.62", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01012503077.62"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/modpathol.3800180", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012160702", 
          "https://doi.org/10.1038/modpathol.3800180"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00294705", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000889218", 
          "https://doi.org/10.1007/bf00294705"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng754", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010978328", 
          "https://doi.org/10.1038/ng754"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1207263", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007151627", 
          "https://doi.org/10.1038/sj.onc.1207263"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2005-08-15", 
    "datePublishedReg": "2005-08-15", 
    "description": "Array-based comparative genomic hybridization (CGH-array) has a powerful potential for high-throughput identification of genetic aberrations in cell genomes. We identified a homozygous loss of ADAM23 (2q33.3) in the course of a program to screen a panel of gastric cancer (GC) cell lines (1/32, 3.1%) for genomic copy-number aberrations using our custom-made CGH-array. Infrequent homozygous deletion of ADAM23 was also seen in primary gastric tumors (1/39, 2.6%). ADAM23 mRNA was expressed in normal stomach tissue, but not in the majority of GC cell lines without homozygous deletion of this gene. Expression of ADAM23 mRNA was restored to gene-silenced GC cells after treatment with 5-aza 2\u2032-deoxycytidine. The methylation status of the ADAM23 CpG island, which showed promoter activity, correlated inversely with its expression. Methylation of this CpG island was observed both in GC cell lines and in primary GC tissues; in primary tumors with a hypermethylated CpG island, expression of ADAM23 was lower than in adjacent noncancerous tissues. Moreover, restoration of ADAM23 in GC cells reduced their numbers in colony-formation assays. These results suggest that genetic or epigenetic silencing by hypermethylation of the ADAM23 CpG-rich promoter region leads to loss of ADAM23 function, which may be a factor in gastric carcinogenesis.", 
    "genre": "article", 
    "id": "sg:pub.10.1038/sj.onc.1208952", 
    "inLanguage": "en", 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1097543", 
        "issn": [
          "0950-9232", 
          "1476-5594"
        ], 
        "name": "Oncogene", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "54", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "24"
      }
    ], 
    "keywords": [
      "CpG islands", 
      "GC cell lines", 
      "CpG-rich promoter region", 
      "cell lines", 
      "hypermethylated CpG islands", 
      "homozygous deletion", 
      "high-throughput identification", 
      "GC cells", 
      "tumor suppressor gene", 
      "aberrant promoter hypermethylation", 
      "colony formation assays", 
      "possible tumor suppressor gene", 
      "genomic copy number aberrations", 
      "epigenetic silencing", 
      "comparative genomic hybridization", 
      "gastric cancer cell lines", 
      "copy number aberrations", 
      "cell genome", 
      "promoter activity", 
      "promoter region", 
      "primary GC tissues", 
      "suppressor gene", 
      "methylation status", 
      "ADAM23", 
      "cancer cell lines", 
      "normal stomach tissues", 
      "promoter hypermethylation", 
      "genomic hybridization", 
      "homozygous loss", 
      "CGH array", 
      "genetic aberrations", 
      "deletion", 
      "GC tissues", 
      "genes", 
      "hypermethylation", 
      "expression", 
      "primary gastric tumors", 
      "mRNA", 
      "islands", 
      "gastric carcinogenesis", 
      "genome", 
      "cells", 
      "adjacent noncancerous tissues", 
      "silencing", 
      "methylation", 
      "tissue", 
      "noncancerous tissues", 
      "lines", 
      "hybridization", 
      "aberrations", 
      "stomach tissue", 
      "assays", 
      "carcinogenesis", 
      "gastric cancer", 
      "identification", 
      "loss", 
      "gastric tumors", 
      "powerful potential", 
      "activity", 
      "region", 
      "function", 
      "restoration", 
      "primary tumor", 
      "cancer", 
      "tumors", 
      "factors", 
      "potential", 
      "array", 
      "number", 
      "majority", 
      "panel", 
      "status", 
      "results", 
      "treatment", 
      "program", 
      "course", 
      "custom-made CGH-array", 
      "Infrequent homozygous deletion", 
      "ADAM23 mRNA", 
      "gene-silenced GC cells", 
      "ADAM23 CpG island", 
      "expression of ADAM23", 
      "restoration of ADAM23", 
      "ADAM23 CpG-rich promoter region", 
      "ADAM23 function"
    ], 
    "name": "ADAM23, a possible tumor suppressor gene, is frequently silenced in gastric cancers by homozygous deletion or aberrant promoter hypermethylation", 
    "pagination": "8051-8060", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1016286094"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/sj.onc.1208952"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "16103878"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/sj.onc.1208952", 
      "https://app.dimensions.ai/details/publication/pub.1016286094"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-01-01T18:15", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220101/entities/gbq_results/article/article_410.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1038/sj.onc.1208952"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/sj.onc.1208952'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/sj.onc.1208952'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/sj.onc.1208952'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/sj.onc.1208952'


 

This table displays all metadata directly associated to this object as RDF triples.

308 TRIPLES      22 PREDICATES      128 URIs      115 LITERALS      19 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/sj.onc.1208952 schema:about N15c7903415684e81aa7b4ec765986261
2 N42a6ac4413054691a5f90251e5348e23
3 N5e33121adba4450f820cdd595f30160d
4 N6d8f444b267344028fa72a4b029699b2
5 N72edae70db654eafa2cb1432da6bc874
6 N73eec76ab41e46b1be309a61a5041ff4
7 N86cc0255cacc4f989d3776a05a8c2221
8 Na349d7dd741c478695108a25eb5e24c5
9 Ncfe8e3364a9944b8b3ac71441effca99
10 Ndde343dd9d644d5ab2c365dbb9941329
11 Nf69aa83ad26e452ab742bcd94fbfa658
12 Nf92b083bfb4546c68aacc4f9aa33bd54
13 anzsrc-for:11
14 anzsrc-for:1103
15 anzsrc-for:1112
16 schema:author N47a54ae8aa3a4ef8adecae22ae021120
17 schema:citation sg:pub.10.1007/bf00294705
18 sg:pub.10.1038/modpathol.3800180
19 sg:pub.10.1038/ng754
20 sg:pub.10.1038/sj.onc.1207263
21 schema:datePublished 2005-08-15
22 schema:datePublishedReg 2005-08-15
23 schema:description Array-based comparative genomic hybridization (CGH-array) has a powerful potential for high-throughput identification of genetic aberrations in cell genomes. We identified a homozygous loss of ADAM23 (2q33.3) in the course of a program to screen a panel of gastric cancer (GC) cell lines (1/32, 3.1%) for genomic copy-number aberrations using our custom-made CGH-array. Infrequent homozygous deletion of ADAM23 was also seen in primary gastric tumors (1/39, 2.6%). ADAM23 mRNA was expressed in normal stomach tissue, but not in the majority of GC cell lines without homozygous deletion of this gene. Expression of ADAM23 mRNA was restored to gene-silenced GC cells after treatment with 5-aza 2′-deoxycytidine. The methylation status of the ADAM23 CpG island, which showed promoter activity, correlated inversely with its expression. Methylation of this CpG island was observed both in GC cell lines and in primary GC tissues; in primary tumors with a hypermethylated CpG island, expression of ADAM23 was lower than in adjacent noncancerous tissues. Moreover, restoration of ADAM23 in GC cells reduced their numbers in colony-formation assays. These results suggest that genetic or epigenetic silencing by hypermethylation of the ADAM23 CpG-rich promoter region leads to loss of ADAM23 function, which may be a factor in gastric carcinogenesis.
24 schema:genre article
25 schema:inLanguage en
26 schema:isAccessibleForFree true
27 schema:isPartOf N2274adc4e21d4119bcf7922c15c79c59
28 N4842ca6d5f0e49cdb9b78141d1c2d816
29 sg:journal.1097543
30 schema:keywords ADAM23
31 ADAM23 CpG island
32 ADAM23 CpG-rich promoter region
33 ADAM23 function
34 ADAM23 mRNA
35 CGH array
36 CpG islands
37 CpG-rich promoter region
38 GC cell lines
39 GC cells
40 GC tissues
41 Infrequent homozygous deletion
42 aberrant promoter hypermethylation
43 aberrations
44 activity
45 adjacent noncancerous tissues
46 array
47 assays
48 cancer
49 cancer cell lines
50 carcinogenesis
51 cell genome
52 cell lines
53 cells
54 colony formation assays
55 comparative genomic hybridization
56 copy number aberrations
57 course
58 custom-made CGH-array
59 deletion
60 epigenetic silencing
61 expression
62 expression of ADAM23
63 factors
64 function
65 gastric cancer
66 gastric cancer cell lines
67 gastric carcinogenesis
68 gastric tumors
69 gene-silenced GC cells
70 genes
71 genetic aberrations
72 genome
73 genomic copy number aberrations
74 genomic hybridization
75 high-throughput identification
76 homozygous deletion
77 homozygous loss
78 hybridization
79 hypermethylated CpG islands
80 hypermethylation
81 identification
82 islands
83 lines
84 loss
85 mRNA
86 majority
87 methylation
88 methylation status
89 noncancerous tissues
90 normal stomach tissues
91 number
92 panel
93 possible tumor suppressor gene
94 potential
95 powerful potential
96 primary GC tissues
97 primary gastric tumors
98 primary tumor
99 program
100 promoter activity
101 promoter hypermethylation
102 promoter region
103 region
104 restoration
105 restoration of ADAM23
106 results
107 silencing
108 status
109 stomach tissue
110 suppressor gene
111 tissue
112 treatment
113 tumor suppressor gene
114 tumors
115 schema:name ADAM23, a possible tumor suppressor gene, is frequently silenced in gastric cancers by homozygous deletion or aberrant promoter hypermethylation
116 schema:pagination 8051-8060
117 schema:productId N5fb1c99b2beb4a64b01937b89f3384b3
118 N764340f25e6e42c6b4eef6ce68a1b5dc
119 N7739ab3689454064a531b507fcf780fb
120 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016286094
121 https://doi.org/10.1038/sj.onc.1208952
122 schema:sdDatePublished 2022-01-01T18:15
123 schema:sdLicense https://scigraph.springernature.com/explorer/license/
124 schema:sdPublisher N1f522066d8d3418e9c44121bc9a9934e
125 schema:url https://doi.org/10.1038/sj.onc.1208952
126 sgo:license sg:explorer/license/
127 sgo:sdDataset articles
128 rdf:type schema:ScholarlyArticle
129 N15afa30bfd014bbbb7aa0bde3e17ad28 rdf:first sg:person.01207342056.64
130 rdf:rest N52c3ac39baad44c9896de1a47f1e7237
131 N15c7903415684e81aa7b4ec765986261 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
132 schema:name Humans
133 rdf:type schema:DefinedTerm
134 N1f522066d8d3418e9c44121bc9a9934e schema:name Springer Nature - SN SciGraph project
135 rdf:type schema:Organization
136 N2274adc4e21d4119bcf7922c15c79c59 schema:issueNumber 54
137 rdf:type schema:PublicationIssue
138 N357a838845cd4c289d298de485624d2c rdf:first sg:person.01012503077.62
139 rdf:rest rdf:nil
140 N3cf08693d8264d509b2da4331ddf9cef rdf:first sg:person.01025357363.39
141 rdf:rest N357a838845cd4c289d298de485624d2c
142 N42a6ac4413054691a5f90251e5348e23 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
143 schema:name Nucleic Acid Hybridization
144 rdf:type schema:DefinedTerm
145 N469b6cd173bf44d595f64223f56ee49f rdf:first sg:person.0634231701.10
146 rdf:rest N15afa30bfd014bbbb7aa0bde3e17ad28
147 N47a54ae8aa3a4ef8adecae22ae021120 rdf:first sg:person.0652564305.15
148 rdf:rest Nbcf7a278a8a34f029c69fd2679d687be
149 N4842ca6d5f0e49cdb9b78141d1c2d816 schema:volumeNumber 24
150 rdf:type schema:PublicationVolume
151 N52c3ac39baad44c9896de1a47f1e7237 rdf:first sg:person.01306410101.35
152 rdf:rest N6e9a0f74647c4641810fce29460fc715
153 N5e33121adba4450f820cdd595f30160d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
154 schema:name Promoter Regions, Genetic
155 rdf:type schema:DefinedTerm
156 N5fb1c99b2beb4a64b01937b89f3384b3 schema:name dimensions_id
157 schema:value pub.1016286094
158 rdf:type schema:PropertyValue
159 N6d8f444b267344028fa72a4b029699b2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
160 schema:name DNA Methylation
161 rdf:type schema:DefinedTerm
162 N6e9a0f74647c4641810fce29460fc715 rdf:first sg:person.0774504244.38
163 rdf:rest N8049f48818654e9ba09911b6900b583b
164 N72edae70db654eafa2cb1432da6bc874 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
165 schema:name Cell Line, Tumor
166 rdf:type schema:DefinedTerm
167 N737a286a75924120ae5e4ff6c7484414 rdf:first sg:person.01172752000.98
168 rdf:rest N469b6cd173bf44d595f64223f56ee49f
169 N73eec76ab41e46b1be309a61a5041ff4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
170 schema:name CpG Islands
171 rdf:type schema:DefinedTerm
172 N764340f25e6e42c6b4eef6ce68a1b5dc schema:name pubmed_id
173 schema:value 16103878
174 rdf:type schema:PropertyValue
175 N7739ab3689454064a531b507fcf780fb schema:name doi
176 schema:value 10.1038/sj.onc.1208952
177 rdf:type schema:PropertyValue
178 N8049f48818654e9ba09911b6900b583b rdf:first sg:person.0771511462.11
179 rdf:rest N3cf08693d8264d509b2da4331ddf9cef
180 N86cc0255cacc4f989d3776a05a8c2221 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
181 schema:name Genes, Tumor Suppressor
182 rdf:type schema:DefinedTerm
183 N914a5b5f1f004375af5e286df859ef1f rdf:first sg:person.07547136242.70
184 rdf:rest N737a286a75924120ae5e4ff6c7484414
185 Na349d7dd741c478695108a25eb5e24c5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
186 schema:name ADAM Proteins
187 rdf:type schema:DefinedTerm
188 Nbcf7a278a8a34f029c69fd2679d687be rdf:first sg:person.01264511401.47
189 rdf:rest N914a5b5f1f004375af5e286df859ef1f
190 Ncfe8e3364a9944b8b3ac71441effca99 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
191 schema:name Gene Expression Regulation, Neoplastic
192 rdf:type schema:DefinedTerm
193 Ndde343dd9d644d5ab2c365dbb9941329 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
194 schema:name Gene Silencing
195 rdf:type schema:DefinedTerm
196 Nf69aa83ad26e452ab742bcd94fbfa658 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
197 schema:name Stomach Neoplasms
198 rdf:type schema:DefinedTerm
199 Nf92b083bfb4546c68aacc4f9aa33bd54 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
200 schema:name Gene Deletion
201 rdf:type schema:DefinedTerm
202 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
203 schema:name Medical and Health Sciences
204 rdf:type schema:DefinedTerm
205 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
206 schema:name Clinical Sciences
207 rdf:type schema:DefinedTerm
208 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
209 schema:name Oncology and Carcinogenesis
210 rdf:type schema:DefinedTerm
211 sg:journal.1097543 schema:issn 0950-9232
212 1476-5594
213 schema:name Oncogene
214 schema:publisher Springer Nature
215 rdf:type schema:Periodical
216 sg:person.01012503077.62 schema:affiliation grid-institutes:grid.265073.5
217 schema:familyName Inazawa
218 schema:givenName Johji
219 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01012503077.62
220 rdf:type schema:Person
221 sg:person.01025357363.39 schema:affiliation grid-institutes:grid.272242.3
222 schema:familyName Ohki
223 schema:givenName Misao
224 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01025357363.39
225 rdf:type schema:Person
226 sg:person.01172752000.98 schema:affiliation grid-institutes:grid.272242.3
227 schema:familyName Nakanishi
228 schema:givenName Yukihiro
229 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01172752000.98
230 rdf:type schema:Person
231 sg:person.01207342056.64 schema:affiliation grid-institutes:grid.416614.0
232 schema:familyName Mochizuki
233 schema:givenName Hidetaka
234 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01207342056.64
235 rdf:type schema:Person
236 sg:person.01264511401.47 schema:affiliation grid-institutes:grid.419082.6
237 schema:familyName Imoto
238 schema:givenName Issei
239 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01264511401.47
240 rdf:type schema:Person
241 sg:person.01306410101.35 schema:affiliation grid-institutes:grid.272458.e
242 schema:familyName Mitsufuji
243 schema:givenName Shoji
244 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01306410101.35
245 rdf:type schema:Person
246 sg:person.0634231701.10 schema:affiliation grid-institutes:grid.416614.0
247 schema:familyName Ichikura
248 schema:givenName Takashi
249 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0634231701.10
250 rdf:type schema:Person
251 sg:person.0652564305.15 schema:affiliation grid-institutes:grid.272458.e
252 schema:familyName Takada
253 schema:givenName Hisashi
254 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0652564305.15
255 rdf:type schema:Person
256 sg:person.07547136242.70 schema:affiliation grid-institutes:grid.416614.0
257 schema:familyName Tsuda
258 schema:givenName Hitoshi
259 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07547136242.70
260 rdf:type schema:Person
261 sg:person.0771511462.11 schema:affiliation grid-institutes:grid.272242.3
262 schema:familyName Hirohashi
263 schema:givenName Setsuo
264 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0771511462.11
265 rdf:type schema:Person
266 sg:person.0774504244.38 schema:affiliation grid-institutes:grid.272242.3
267 schema:familyName Hosoda
268 schema:givenName Fumie
269 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0774504244.38
270 rdf:type schema:Person
271 sg:pub.10.1007/bf00294705 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000889218
272 https://doi.org/10.1007/bf00294705
273 rdf:type schema:CreativeWork
274 sg:pub.10.1038/modpathol.3800180 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012160702
275 https://doi.org/10.1038/modpathol.3800180
276 rdf:type schema:CreativeWork
277 sg:pub.10.1038/ng754 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010978328
278 https://doi.org/10.1038/ng754
279 rdf:type schema:CreativeWork
280 sg:pub.10.1038/sj.onc.1207263 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007151627
281 https://doi.org/10.1038/sj.onc.1207263
282 rdf:type schema:CreativeWork
283 grid-institutes:grid.265073.5 schema:alternateName COE program for Frontier Research on Molecular Destruction and Reconstitution of Tooth and Bone, Tokyo Medical and Dental University, Bunkyo-ku, Tokyo, Japan
284 schema:name COE program for Frontier Research on Molecular Destruction and Reconstitution of Tooth and Bone, Tokyo Medical and Dental University, Bunkyo-ku, Tokyo, Japan
285 Core Research for Evolutional Science and Technology (CREST) of Japan Science and Technology Corporation (JST), Hon-machi Kawaguchi, Saitama, Japan
286 Department of Molecular Cytogenetics, Medical Research Institute and School of Biomedical Science, Tokyo Medical and Dental University, Bunkyo-ku, Tokyo, Japan
287 rdf:type schema:Organization
288 grid-institutes:grid.272242.3 schema:alternateName Cancer Genomics Project, National Cancer Center Research Institute, Tsukiji Chuo-ku Tokyo, Japan
289 Pathology Division, National Cancer Center Research Institute, Tsukiji Chuo-ku Tokyo, Japan
290 schema:name Cancer Genomics Project, National Cancer Center Research Institute, Tsukiji Chuo-ku Tokyo, Japan
291 Core Research for Evolutional Science and Technology (CREST) of Japan Science and Technology Corporation (JST), Hon-machi Kawaguchi, Saitama, Japan
292 Pathology Division, National Cancer Center Research Institute, Tsukiji Chuo-ku Tokyo, Japan
293 rdf:type schema:Organization
294 grid-institutes:grid.272458.e schema:alternateName Division of Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kawaramachi Hirokoji Kamigyo-ku, Kyoto, Japan
295 schema:name Core Research for Evolutional Science and Technology (CREST) of Japan Science and Technology Corporation (JST), Hon-machi Kawaguchi, Saitama, Japan
296 Department of Molecular Cytogenetics, Medical Research Institute and School of Biomedical Science, Tokyo Medical and Dental University, Bunkyo-ku, Tokyo, Japan
297 Division of Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kawaramachi Hirokoji Kamigyo-ku, Kyoto, Japan
298 rdf:type schema:Organization
299 grid-institutes:grid.416614.0 schema:alternateName Department of Pathology II, National Defense Medical College, Namiki, Tokorozawa, Japan
300 Department of Surgery I, National Defense Medical College, Namiki, Tokorozawa, Japan
301 schema:name Core Research for Evolutional Science and Technology (CREST) of Japan Science and Technology Corporation (JST), Hon-machi Kawaguchi, Saitama, Japan
302 Department of Pathology II, National Defense Medical College, Namiki, Tokorozawa, Japan
303 Department of Surgery I, National Defense Medical College, Namiki, Tokorozawa, Japan
304 rdf:type schema:Organization
305 grid-institutes:grid.419082.6 schema:alternateName Core Research for Evolutional Science and Technology (CREST) of Japan Science and Technology Corporation (JST), Hon-machi Kawaguchi, Saitama, Japan
306 schema:name Core Research for Evolutional Science and Technology (CREST) of Japan Science and Technology Corporation (JST), Hon-machi Kawaguchi, Saitama, Japan
307 Department of Molecular Cytogenetics, Medical Research Institute and School of Biomedical Science, Tokyo Medical and Dental University, Bunkyo-ku, Tokyo, Japan
308 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...