Growth factors rescue cutaneous melanoma cells from apoptosis induced by knockdown of mutated (V600E) B-RAF View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2005-06-20

AUTHORS

Claus Christensen, Per Guldberg

ABSTRACT

Constitutive activation of the RAS-RAF-MEK-ERK signaling cascade is a hallmark of cutaneous malignant melanoma. A single activating mutation (c.1799T>A; p.V600E) in the gene encoding the serine/threonine kinase B-RAF occurs in >60% of the tumors. Previous work has shown that knockdown of V600EB-RAF by RNA interference induces a variety of phenotypic changes in cultured melanoma cells, including lower proliferation rates, reduced anchorage-independent growth and apoptosis. Here, we show that the majority of melanomas harboring the V600EB-RAF mutation have retained the wild-type (WT) B-RAF allele, and that these cells can be rescued from the effects of V600EB-RAF knockdown by stimulation with growth factors. Ectopic expression of short hairpin RNAs specifically suppressing V600EB-RAF in melanoma cell lines reduced colony formation by ∼80%. This response could be rescued by basic fibroblast growth factor, hepatocyte growth factor or, to a lesser extent, endothelin-1. Rescue with growth factors was not possible in cell lines lacking WTB-RAF. Single-cell clones with efficient knockdown of V600EB-RAF could be propagated in the presence of basic fibroblast growth factor but underwent apoptosis or senescence-like growth arrest upon withdrawal of this growth factor. The ability of growth factors to modulate the response of V600EB-RAF knockdown in melanoma cells may have both experimental and therapeutic implications. More... »

PAGES

6292-6302

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/sj.onc.1208758

DOI

http://dx.doi.org/10.1038/sj.onc.1208758

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1050930151

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/16007203


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Alleles", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Apoptosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Base Sequence", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Line, Tumor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA Primers", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Growth Substances", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Melanoma", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mutation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Proto-Oncogene Proteins B-raf", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Skin Neoplasms", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Institute of Cancer Biology, Danish Cancer Society, Strandboulevarden 49, DK-2100, Copenhagen, Denmark", 
          "id": "http://www.grid.ac/institutes/grid.5254.6", 
          "name": [
            "Institute of Cancer Biology, Danish Cancer Society, Strandboulevarden 49, DK-2100, Copenhagen, Denmark"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Christensen", 
        "givenName": "Claus", 
        "id": "sg:person.01130132302.52", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01130132302.52"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute of Cancer Biology, Danish Cancer Society, Strandboulevarden 49, DK-2100, Copenhagen, Denmark", 
          "id": "http://www.grid.ac/institutes/grid.5254.6", 
          "name": [
            "Institute of Cancer Biology, Danish Cancer Society, Strandboulevarden 49, DK-2100, Copenhagen, Denmark"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Guldberg", 
        "givenName": "Per", 
        "id": "sg:person.0760021664.46", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0760021664.46"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/sj.onc.1205101", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051023398", 
          "https://doi.org/10.1038/sj.onc.1205101"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1206427", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050315555", 
          "https://doi.org/10.1038/sj.onc.1206427"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1205034", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028697716", 
          "https://doi.org/10.1038/sj.onc.1205034"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1207812", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007188913", 
          "https://doi.org/10.1038/sj.onc.1207812"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1206455", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022694494", 
          "https://doi.org/10.1038/sj.onc.1206455"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1203066", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016220528", 
          "https://doi.org/10.1038/sj.onc.1203066"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature00766", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023536940", 
          "https://doi.org/10.1038/nature00766"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1207785", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041507679", 
          "https://doi.org/10.1038/sj.onc.1207785"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrm1498", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050758604", 
          "https://doi.org/10.1038/nrm1498"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2005-06-20", 
    "datePublishedReg": "2005-06-20", 
    "description": "Constitutive activation of the RAS-RAF-MEK-ERK signaling cascade is a hallmark of cutaneous malignant melanoma. A single activating mutation (c.1799T>A; p.V600E) in the gene encoding the serine/threonine kinase B-RAF occurs in >60% of the tumors. Previous work has shown that knockdown of V600EB-RAF by RNA interference induces a variety of phenotypic changes in cultured melanoma cells, including lower proliferation rates, reduced anchorage-independent growth and apoptosis. Here, we show that the majority of melanomas harboring the V600EB-RAF mutation have retained the wild-type (WT) B-RAF allele, and that these cells can be rescued from the effects of V600EB-RAF knockdown by stimulation with growth factors. Ectopic expression of short hairpin RNAs specifically suppressing V600EB-RAF in melanoma cell lines reduced colony formation by \u223c80%. This response could be rescued by basic fibroblast growth factor, hepatocyte growth factor or, to a lesser extent, endothelin-1. Rescue with growth factors was not possible in cell lines lacking WTB-RAF. Single-cell clones with efficient knockdown of V600EB-RAF could be propagated in the presence of basic fibroblast growth factor but underwent apoptosis or senescence-like growth arrest upon withdrawal of this growth factor. The ability of growth factors to modulate the response of V600EB-RAF knockdown in melanoma cells may have both experimental and therapeutic implications.", 
    "genre": "article", 
    "id": "sg:pub.10.1038/sj.onc.1208758", 
    "inLanguage": "en", 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1097543", 
        "issn": [
          "0950-9232", 
          "1476-5594"
        ], 
        "name": "Oncogene", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "41", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "24"
      }
    ], 
    "keywords": [
      "V600EB-RAF", 
      "serine/threonine kinase B", 
      "fibroblast growth factor", 
      "basic fibroblast growth factor", 
      "growth factor", 
      "single-cell clones", 
      "senescence-like growth arrest", 
      "anchorage-independent growth", 
      "MEK-ERK", 
      "melanoma cells", 
      "cell lines", 
      "RAS-RAF", 
      "short hairpin RNA", 
      "ectopic expression", 
      "RNA interference", 
      "kinase B", 
      "growth arrest", 
      "constitutive activation", 
      "phenotypic changes", 
      "RAF allele", 
      "hepatocyte growth factor", 
      "efficient knockdown", 
      "hairpin RNA", 
      "knockdown", 
      "melanoma cell lines", 
      "underwent apoptosis", 
      "cutaneous melanoma cells", 
      "majority of melanomas", 
      "colony formation", 
      "apoptosis", 
      "Raf", 
      "mutations", 
      "cultured melanoma cells", 
      "low proliferation rate", 
      "cells", 
      "proliferation rate", 
      "genes", 
      "lesser extent", 
      "RNA", 
      "clones", 
      "alleles", 
      "cascade", 
      "therapeutic implications", 
      "expression", 
      "lines", 
      "hallmark", 
      "activation", 
      "arrest", 
      "rescue", 
      "growth", 
      "factors", 
      "response", 
      "formation", 
      "melanoma", 
      "stimulation", 
      "variety", 
      "ability", 
      "presence", 
      "previous work", 
      "cutaneous malignant melanoma", 
      "changes", 
      "majority", 
      "malignant melanoma", 
      "extent", 
      "interference", 
      "implications", 
      "effect", 
      "tumors", 
      "endothelin-1", 
      "rate", 
      "work", 
      "withdrawal", 
      "threonine kinase B", 
      "V600EB-RAF mutation", 
      "V600EB-RAF knockdown", 
      "WTB-RAF"
    ], 
    "name": "Growth factors rescue cutaneous melanoma cells from apoptosis induced by knockdown of mutated (V600E) B-RAF", 
    "pagination": "6292-6302", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1050930151"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/sj.onc.1208758"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "16007203"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/sj.onc.1208758", 
      "https://app.dimensions.ai/details/publication/pub.1050930151"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2021-12-01T19:17", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20211201/entities/gbq_results/article/article_411.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1038/sj.onc.1208758"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/sj.onc.1208758'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/sj.onc.1208758'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/sj.onc.1208758'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/sj.onc.1208758'


 

This table displays all metadata directly associated to this object as RDF triples.

225 TRIPLES      22 PREDICATES      122 URIs      105 LITERALS      18 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/sj.onc.1208758 schema:about N0955f70a3edf428b8f066967819cb9cf
2 N28d41819ca474a25abe880688c51f0da
3 N2bf8409e220842968b9e6deb8bb48efe
4 N44d7e4168440458c889f238b25c07712
5 N762feb5a33ed47c59526c8d445d73a34
6 Na9b02f6d51ef436fa74fe7d2cd962db3
7 Nbef32ee5178b4037ba20206d16b1b727
8 Nd0b966d4b2dc43ac9df9df630b184837
9 Ne40a4cba0e7140e1930df1305b614939
10 Neae99f8abbc94a14b479f86e6683657f
11 Nec4e334327484196820506d1d1bcb17f
12 anzsrc-for:11
13 anzsrc-for:1112
14 schema:author N428c629574e8409c8c5c02a26e2e0ea9
15 schema:citation sg:pub.10.1038/nature00766
16 sg:pub.10.1038/nrm1498
17 sg:pub.10.1038/sj.onc.1203066
18 sg:pub.10.1038/sj.onc.1205034
19 sg:pub.10.1038/sj.onc.1205101
20 sg:pub.10.1038/sj.onc.1206427
21 sg:pub.10.1038/sj.onc.1206455
22 sg:pub.10.1038/sj.onc.1207785
23 sg:pub.10.1038/sj.onc.1207812
24 schema:datePublished 2005-06-20
25 schema:datePublishedReg 2005-06-20
26 schema:description Constitutive activation of the RAS-RAF-MEK-ERK signaling cascade is a hallmark of cutaneous malignant melanoma. A single activating mutation (c.1799T>A; p.V600E) in the gene encoding the serine/threonine kinase B-RAF occurs in >60% of the tumors. Previous work has shown that knockdown of V600EB-RAF by RNA interference induces a variety of phenotypic changes in cultured melanoma cells, including lower proliferation rates, reduced anchorage-independent growth and apoptosis. Here, we show that the majority of melanomas harboring the V600EB-RAF mutation have retained the wild-type (WT) B-RAF allele, and that these cells can be rescued from the effects of V600EB-RAF knockdown by stimulation with growth factors. Ectopic expression of short hairpin RNAs specifically suppressing V600EB-RAF in melanoma cell lines reduced colony formation by ∼80%. This response could be rescued by basic fibroblast growth factor, hepatocyte growth factor or, to a lesser extent, endothelin-1. Rescue with growth factors was not possible in cell lines lacking WTB-RAF. Single-cell clones with efficient knockdown of V600EB-RAF could be propagated in the presence of basic fibroblast growth factor but underwent apoptosis or senescence-like growth arrest upon withdrawal of this growth factor. The ability of growth factors to modulate the response of V600EB-RAF knockdown in melanoma cells may have both experimental and therapeutic implications.
27 schema:genre article
28 schema:inLanguage en
29 schema:isAccessibleForFree true
30 schema:isPartOf N28c4ca856cff45f3925e574b9ad51ab2
31 N6d90f40f728b4d6993c2ade65c52ae8c
32 sg:journal.1097543
33 schema:keywords MEK-ERK
34 RAF allele
35 RAS-RAF
36 RNA
37 RNA interference
38 Raf
39 V600EB-RAF
40 V600EB-RAF knockdown
41 V600EB-RAF mutation
42 WTB-RAF
43 ability
44 activation
45 alleles
46 anchorage-independent growth
47 apoptosis
48 arrest
49 basic fibroblast growth factor
50 cascade
51 cell lines
52 cells
53 changes
54 clones
55 colony formation
56 constitutive activation
57 cultured melanoma cells
58 cutaneous malignant melanoma
59 cutaneous melanoma cells
60 ectopic expression
61 effect
62 efficient knockdown
63 endothelin-1
64 expression
65 extent
66 factors
67 fibroblast growth factor
68 formation
69 genes
70 growth
71 growth arrest
72 growth factor
73 hairpin RNA
74 hallmark
75 hepatocyte growth factor
76 implications
77 interference
78 kinase B
79 knockdown
80 lesser extent
81 lines
82 low proliferation rate
83 majority
84 majority of melanomas
85 malignant melanoma
86 melanoma
87 melanoma cell lines
88 melanoma cells
89 mutations
90 phenotypic changes
91 presence
92 previous work
93 proliferation rate
94 rate
95 rescue
96 response
97 senescence-like growth arrest
98 serine/threonine kinase B
99 short hairpin RNA
100 single-cell clones
101 stimulation
102 therapeutic implications
103 threonine kinase B
104 tumors
105 underwent apoptosis
106 variety
107 withdrawal
108 work
109 schema:name Growth factors rescue cutaneous melanoma cells from apoptosis induced by knockdown of mutated (V600E) B-RAF
110 schema:pagination 6292-6302
111 schema:productId N23fac7b39c8b4adbb57b8d8781186f10
112 Nafa1da6d149641d09a305c7bac4bab47
113 Nf409f8d730a849bc81e48f60d6335407
114 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050930151
115 https://doi.org/10.1038/sj.onc.1208758
116 schema:sdDatePublished 2021-12-01T19:17
117 schema:sdLicense https://scigraph.springernature.com/explorer/license/
118 schema:sdPublisher N96b786576c044b65958a9dc1003c2707
119 schema:url https://doi.org/10.1038/sj.onc.1208758
120 sgo:license sg:explorer/license/
121 sgo:sdDataset articles
122 rdf:type schema:ScholarlyArticle
123 N0955f70a3edf428b8f066967819cb9cf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name Humans
125 rdf:type schema:DefinedTerm
126 N23fac7b39c8b4adbb57b8d8781186f10 schema:name dimensions_id
127 schema:value pub.1050930151
128 rdf:type schema:PropertyValue
129 N28c4ca856cff45f3925e574b9ad51ab2 schema:issueNumber 41
130 rdf:type schema:PublicationIssue
131 N28d41819ca474a25abe880688c51f0da schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
132 schema:name Cell Line, Tumor
133 rdf:type schema:DefinedTerm
134 N2bf8409e220842968b9e6deb8bb48efe schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name Base Sequence
136 rdf:type schema:DefinedTerm
137 N428c629574e8409c8c5c02a26e2e0ea9 rdf:first sg:person.01130132302.52
138 rdf:rest N59b3bb832f0a4275921cda8c6d6b5ed7
139 N44d7e4168440458c889f238b25c07712 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
140 schema:name Alleles
141 rdf:type schema:DefinedTerm
142 N59b3bb832f0a4275921cda8c6d6b5ed7 rdf:first sg:person.0760021664.46
143 rdf:rest rdf:nil
144 N6d90f40f728b4d6993c2ade65c52ae8c schema:volumeNumber 24
145 rdf:type schema:PublicationVolume
146 N762feb5a33ed47c59526c8d445d73a34 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
147 schema:name Skin Neoplasms
148 rdf:type schema:DefinedTerm
149 N96b786576c044b65958a9dc1003c2707 schema:name Springer Nature - SN SciGraph project
150 rdf:type schema:Organization
151 Na9b02f6d51ef436fa74fe7d2cd962db3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
152 schema:name Apoptosis
153 rdf:type schema:DefinedTerm
154 Nafa1da6d149641d09a305c7bac4bab47 schema:name doi
155 schema:value 10.1038/sj.onc.1208758
156 rdf:type schema:PropertyValue
157 Nbef32ee5178b4037ba20206d16b1b727 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
158 schema:name Growth Substances
159 rdf:type schema:DefinedTerm
160 Nd0b966d4b2dc43ac9df9df630b184837 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
161 schema:name DNA Primers
162 rdf:type schema:DefinedTerm
163 Ne40a4cba0e7140e1930df1305b614939 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
164 schema:name Proto-Oncogene Proteins B-raf
165 rdf:type schema:DefinedTerm
166 Neae99f8abbc94a14b479f86e6683657f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
167 schema:name Melanoma
168 rdf:type schema:DefinedTerm
169 Nec4e334327484196820506d1d1bcb17f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
170 schema:name Mutation
171 rdf:type schema:DefinedTerm
172 Nf409f8d730a849bc81e48f60d6335407 schema:name pubmed_id
173 schema:value 16007203
174 rdf:type schema:PropertyValue
175 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
176 schema:name Medical and Health Sciences
177 rdf:type schema:DefinedTerm
178 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
179 schema:name Oncology and Carcinogenesis
180 rdf:type schema:DefinedTerm
181 sg:journal.1097543 schema:issn 0950-9232
182 1476-5594
183 schema:name Oncogene
184 schema:publisher Springer Nature
185 rdf:type schema:Periodical
186 sg:person.01130132302.52 schema:affiliation grid-institutes:grid.5254.6
187 schema:familyName Christensen
188 schema:givenName Claus
189 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01130132302.52
190 rdf:type schema:Person
191 sg:person.0760021664.46 schema:affiliation grid-institutes:grid.5254.6
192 schema:familyName Guldberg
193 schema:givenName Per
194 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0760021664.46
195 rdf:type schema:Person
196 sg:pub.10.1038/nature00766 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023536940
197 https://doi.org/10.1038/nature00766
198 rdf:type schema:CreativeWork
199 sg:pub.10.1038/nrm1498 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050758604
200 https://doi.org/10.1038/nrm1498
201 rdf:type schema:CreativeWork
202 sg:pub.10.1038/sj.onc.1203066 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016220528
203 https://doi.org/10.1038/sj.onc.1203066
204 rdf:type schema:CreativeWork
205 sg:pub.10.1038/sj.onc.1205034 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028697716
206 https://doi.org/10.1038/sj.onc.1205034
207 rdf:type schema:CreativeWork
208 sg:pub.10.1038/sj.onc.1205101 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051023398
209 https://doi.org/10.1038/sj.onc.1205101
210 rdf:type schema:CreativeWork
211 sg:pub.10.1038/sj.onc.1206427 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050315555
212 https://doi.org/10.1038/sj.onc.1206427
213 rdf:type schema:CreativeWork
214 sg:pub.10.1038/sj.onc.1206455 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022694494
215 https://doi.org/10.1038/sj.onc.1206455
216 rdf:type schema:CreativeWork
217 sg:pub.10.1038/sj.onc.1207785 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041507679
218 https://doi.org/10.1038/sj.onc.1207785
219 rdf:type schema:CreativeWork
220 sg:pub.10.1038/sj.onc.1207812 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007188913
221 https://doi.org/10.1038/sj.onc.1207812
222 rdf:type schema:CreativeWork
223 grid-institutes:grid.5254.6 schema:alternateName Institute of Cancer Biology, Danish Cancer Society, Strandboulevarden 49, DK-2100, Copenhagen, Denmark
224 schema:name Institute of Cancer Biology, Danish Cancer Society, Strandboulevarden 49, DK-2100, Copenhagen, Denmark
225 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...