Identification of pigment epithelium-derived factor as a direct target of the p53 family member genes View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2005-04-18

AUTHORS

Yasushi Sasaki, Yasuyoshi Naishiro, Yuichiro Oshima, Kohzoh Imai, Yusuke Nakamura, Takashi Tokino

ABSTRACT

p63 and p73 show a high degree of structural homology to p53 and are members of a family of transcriptional factors that can activate transcription of p53-responsive genes. p53 is mutated in more than 50% of human cancers, whereas p63 and p73 are rarely mutated. Studies of knockout mice also revealed an unexpected functional diversity among the p53 family. To determine how p63 and p73 are involved in tumorigenesis and normal development, we used cDNA microarray to examine 9216 genes in human colorectal cancer cells. We discovered that the expression of pigment epithelium-derived factor (PEDF) was specifically induced by either p63 or p73, but not by p53. We also report here that the PEDF gene contains a response element specific for p63 and p73 in its promoter region and is a direct target of p63 and p73. Collectively, p63 and p73 may be involved in cell fate by inducing PEDF expression. More... »

PAGES

5131-5136

References to SciGraph publications

  • 2001-09-01. Adenovirus-mediated transfer of the p53 family genes, p73 and p51/p63 induces cell cycle arrest and apoptosis in colorectal cancer cell lines: potential application to gene therapy of colorectal cancer in GENE THERAPY
  • 1992-04. Definition of a consensus binding site for p53 in NATURE GENETICS
  • 2000-03. p73-deficient mice have neurological, pheromonal and inflammatory defects but lack spontaneous tumours in NATURE
  • 1997-09. p73 is a human p53-related protein that can induce apoptosis in NATURE
  • 2000-11. Surfing the p53 network in NATURE
  • 1992-03. Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours in NATURE
  • 2003-05-12. Pigment epithelium–derived factor regulates the vasculature and mass of the prostate and pancreas in NATURE MEDICINE
  • 1999-04. p63 is a p53 homologue required for limb and epidermal morphogenesis in NATURE
  • 1997. P53 Gene Alterations in Human Tumors: Perspectives for Cancer Control in RISK AND PROGRESSION FACTORS IN CARCINOGENESIS
  • 2002-08. p73: Friend or foe in tumorigenesis in NATURE REVIEWS CANCER
  • 1998-07. Cloning and functional analysis of human p51, which structurally and functionally resembles p53 in NATURE MEDICINE
  • 1999-04. p63 is essential for regenerative proliferation in limb, craniofacial and epithelial development in NATURE
  • 2000-09. Angiogenesis in cancer and other diseases in NATURE
  • 1995-02. Dormancy of micrometastases: Balanced proliferation and apoptosis in the presence of angiogenesis suppression in NATURE MEDICINE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/sj.onc.1208695

    DOI

    http://dx.doi.org/10.1038/sj.onc.1208695

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1034291709

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/15856012


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    59 direct target
    60 diversity
    61 elements
    62 epithelium-derived factor
    63 expression
    64 factors
    65 family
    66 fate
    67 functional diversity
    68 genes
    69 high degree
    70 homology
    71 human cancers
    72 human colorectal cancer cells
    73 identification
    74 knockout mice
    75 member genes
    76 members
    77 mice
    78 microarray
    79 normal development
    80 p53
    81 p53 family
    82 p53-responsive genes
    83 p63
    84 p73
    85 pigment epithelium-derived factor
    86 promoter region
    87 region
    88 response element
    89 structural homology
    90 study
    91 target
    92 transcription
    93 transcriptional factors
    94 tumorigenesis
    95 unexpected functional diversity
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