Loss of TGF-β type II receptor in fibroblasts promotes mammary carcinoma growth and invasion through upregulation of TGF-α-, MSP- and ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2005-07

AUTHORS

Nikki Cheng, Neil A Bhowmick, Anna Chytil, Agnieszka E Gorksa, Kimberly A Brown, Rebecca Muraoka, Carlos L Arteaga, Eric G Neilson, Simon W Hayward, Harold L Moses

ABSTRACT

Stromal fibroblasts regulate epithelial cell behavior through direct and indirect cell-cell interactions. To clarify the role of TGF-beta signaling in stromal fibroblasts during mammary development and tumorigenesis, we conditionally knocked out the TGF-beta type II receptor gene in mouse mammary fibroblasts (Tgfbr2(fspKO)). Tgfbr2(fspKO) mice exhibit defective mammary ductal development, characterized in part by increased ductal epithelial cell turnover associated with an increase in stromal fibroblast abundance. Tgfbr2(fspKO) mammary fibroblasts transplanted with mammary carcinoma cells promote growth and invasion, which is associated with increased activating phosphorylation of the receptors: erbB1, erbB2, RON, and c-Met. Furthermore, the increased receptor phosphorylation correlates with increased secretion of the cognate ligands by Tgfbr2(fspKO) fibroblasts. Treatment of tumor cells with fibroblast-conditioned medium leads to increased tumor cell proliferation and motility, which are blocked by addition of pharmacologic inhibitors of TGF-alpha signaling or neutralizing antibodies to macrophage-stimulating protein (MSP), HGF, or c-Met. These studies characterize a significant role for stromal TGF-beta signaling in mammary tissue homeostasis and mammary tumor progression via regulation of TGF-alpha, MSP, and HGF signaling pathways. More... »

PAGES

1208685

References to SciGraph publications

  • 2001. The Transforming Growth Factors Beta in Development and Functional Differentiation of the Mouse Mammary Gland in BIOACTIVE COMPONENTS OF HUMAN MILK
  • 2001-08. Hepatocellular expression of a dominant-negative mutant TGF-β type II receptor accelerates chemically induced hepatocarcinogenesis in ONCOGENE
  • 2004-02. Breast fibroblasts modulate epithelial cell proliferation in three-dimensional in vitro co-culture in BREAST CANCER RESEARCH
  • 2004-03. Collaborative activities of macrophage-stimulating protein and transforming growth factor-β1 in induction of epithelial to mesenchymal transition: roles of the RON receptor tyrosine kinase in ONCOGENE
  • 2000. Establishment of Mouse Mammary Cell Lines in METHODS IN MAMMARY GLAND BIOLOGY AND BREAST CANCER RESEARCH
  • 1980. Enhancement of spreading, phagocytosis and chemotaxis by macrophage stimulating protein (MSP). in MACROPHAGES AND LYMPHOCYTES
  • 2003-08. Host microenvironment in breast cancer development: Epithelial-cell–stromal-cell interactions and steroid hormone action in normal and cancerous mammary gland in BREAST CANCER RESEARCH
  • 1999-01. Generalized lacZ expression with the ROSA26 Cre reporter strain in NATURE GENETICS
  • 2001-08. Tumour-stromal interactions: Transforming growth factor-β isoforms and hepatocyte growth factor/scatter factor in mammary gland ductal morphogenesis in BREAST CANCER RESEARCH
  • 2000. Methods in Mammary Gland Biology and Breast Cancer Research in NONE
  • 2003-11. Cytostatic and apoptotic actions of TGF-β in homeostasis and cancer in NATURE REVIEWS CANCER
  • 2001-10. TGF-β signaling in tumor suppression and cancer progression in NATURE GENETICS
  • 2002-10. Autocrine TGFβ supports growth and survival of human breast cancer MDA-MB-231 cells in ONCOGENE
  • 2001-08. Tumour-stromal interactions: Role of the stroma in mammary development in BREAST CANCER RESEARCH
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/sj.onc.1208685

    DOI

    http://dx.doi.org/10.1038/sj.onc.1208685

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1024019697

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/15856015


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biochemistry and Cell Biology", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biological Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Animals", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cell Division", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Female", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Gene Deletion", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Gene Silencing", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Genes, Reporter", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Hepatocyte Growth Factor", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Homozygote", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mammary Neoplasms, Animal", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mice", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mice, Inbred C57BL", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mice, Knockout", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mice, Nude", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mucins", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Muscle Proteins", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Neoplasm Invasiveness", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Peptides", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Protein-Serine-Threonine Kinases", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Receptor, Transforming Growth Factor-beta Type II", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Receptors, Transforming Growth Factor beta", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Transforming Growth Factor alpha", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Trefoil Factor-2", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Vanderbilt University", 
              "id": "https://www.grid.ac/institutes/grid.152326.1", 
              "name": [
                "Department of Cancer Biology, Vanderbilt University School of Medicine, Nashville, TN 37232-6838, USA", 
                "Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37232-6838, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Cheng", 
            "givenName": "Nikki", 
            "id": "sg:person.01134615337.75", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01134615337.75"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Vanderbilt University", 
              "id": "https://www.grid.ac/institutes/grid.152326.1", 
              "name": [
                "Department of Cancer Biology, Vanderbilt University School of Medicine, Nashville, TN 37232-6838, USA", 
                "Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37232-6838, USA", 
                "Department of Urologic Surgery, Vanderbilt University School of Medicine, Nashville, TN 37232-6838, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Bhowmick", 
            "givenName": "Neil A", 
            "id": "sg:person.01102570737.23", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01102570737.23"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Vanderbilt University", 
              "id": "https://www.grid.ac/institutes/grid.152326.1", 
              "name": [
                "Department of Cancer Biology, Vanderbilt University School of Medicine, Nashville, TN 37232-6838, USA", 
                "Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37232-6838, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Chytil", 
            "givenName": "Anna", 
            "id": "sg:person.01063245124.71", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01063245124.71"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Vanderbilt University", 
              "id": "https://www.grid.ac/institutes/grid.152326.1", 
              "name": [
                "Department of Cancer Biology, Vanderbilt University School of Medicine, Nashville, TN 37232-6838, USA", 
                "Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37232-6838, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Gorksa", 
            "givenName": "Agnieszka E", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Vanderbilt University", 
              "id": "https://www.grid.ac/institutes/grid.152326.1", 
              "name": [
                "Department of Cancer Biology, Vanderbilt University School of Medicine, Nashville, TN 37232-6838, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Brown", 
            "givenName": "Kimberly A", 
            "id": "sg:person.012156036347.78", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012156036347.78"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Vanderbilt University", 
              "id": "https://www.grid.ac/institutes/grid.152326.1", 
              "name": [
                "Department of Cancer Biology, Vanderbilt University School of Medicine, Nashville, TN 37232-6838, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Muraoka", 
            "givenName": "Rebecca", 
            "id": "sg:person.0644226005.11", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0644226005.11"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Vanderbilt University", 
              "id": "https://www.grid.ac/institutes/grid.152326.1", 
              "name": [
                "Department of Cancer Biology, Vanderbilt University School of Medicine, Nashville, TN 37232-6838, USA", 
                "Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37232-6838, USA", 
                "Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232-6838, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Arteaga", 
            "givenName": "Carlos L", 
            "id": "sg:person.013436233237.01", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013436233237.01"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Vanderbilt University", 
              "id": "https://www.grid.ac/institutes/grid.152326.1", 
              "name": [
                "Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37232-6838, USA", 
                "Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232-6838, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Neilson", 
            "givenName": "Eric G", 
            "id": "sg:person.01261253004.94", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01261253004.94"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Vanderbilt University", 
              "id": "https://www.grid.ac/institutes/grid.152326.1", 
              "name": [
                "Department of Cancer Biology, Vanderbilt University School of Medicine, Nashville, TN 37232-6838, USA", 
                "Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37232-6838, USA", 
                "Department of Urologic Surgery, Vanderbilt University School of Medicine, Nashville, TN 37232-6838, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hayward", 
            "givenName": "Simon W", 
            "id": "sg:person.0701452031.39", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0701452031.39"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Vanderbilt University", 
              "id": "https://www.grid.ac/institutes/grid.152326.1", 
              "name": [
                "Department of Cancer Biology, Vanderbilt University School of Medicine, Nashville, TN 37232-6838, USA", 
                "Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37232-6838, USA", 
                "Department of Pathology, Vanderbilt University School of Medicine, Nashville, TN 37232-6838, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Moses", 
            "givenName": "Harold L", 
            "id": "sg:person.01065513554.26", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01065513554.26"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1038/sj.onc.1207282", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001625975", 
              "https://doi.org/10.1038/sj.onc.1207282"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1207282", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001625975", 
              "https://doi.org/10.1038/sj.onc.1207282"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1083/jcb.130.2.393", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002124384"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1006/excr.1998.4373", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002798698"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrc1208", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004573220", 
              "https://doi.org/10.1038/nrc1208"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrc1208", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004573220", 
              "https://doi.org/10.1038/nrc1208"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1090922", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004845332"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1046/j.1365-3083.2002.01177.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006914942"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/bcr949", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007818794", 
              "https://doi.org/10.1186/bcr949"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/dvdy.10065", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007918085"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/978-1-4615-4295-7_13", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008294807", 
              "https://doi.org/10.1007/978-1-4615-4295-7_13"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1091/mbc.10.4.1221", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008505050"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng1001-117", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010058562", 
              "https://doi.org/10.1038/ng1001-117"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng1001-117", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010058562", 
              "https://doi.org/10.1038/ng1001-117"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng1001-117", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010058562", 
              "https://doi.org/10.1038/ng1001-117"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng1001-117", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010058562", 
              "https://doi.org/10.1038/ng1001-117"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.87.1.75", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011157313"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0002-9440(10)63510-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011505622"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/978-1-4615-1371-1_7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011824299", 
              "https://doi.org/10.1007/978-1-4615-1371-1_7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1204544", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013087526", 
              "https://doi.org/10.1038/sj.onc.1204544"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1204544", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013087526", 
              "https://doi.org/10.1038/sj.onc.1204544"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0092-8674(83)90130-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015578795"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1205966", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015860507", 
              "https://doi.org/10.1038/sj.onc.1205966"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1205966", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015860507", 
              "https://doi.org/10.1038/sj.onc.1205966"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1046/j.1432-0436.2002.700903.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019053821"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/gene.10046", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021922995"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/bcr299", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025413233", 
              "https://doi.org/10.1186/bcr299"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/bcr301", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027892635", 
              "https://doi.org/10.1186/bcr301"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/5007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030839891", 
              "https://doi.org/10.1038/5007"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/5007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030839891", 
              "https://doi.org/10.1038/5007"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1046/j.1432-0436.1998.6330131.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031595983"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/1097-0029(20010115)52:2<224::aid-jemt1007>3.0.co;2-a", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034436633"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.2135113100", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034602125"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/mcb.12.3.954", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034836584"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/jcp.1041390323", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035182590"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/mcb.18.4.2344", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036467368"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/978-1-4615-4295-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038245607", 
              "https://doi.org/10.1007/978-1-4615-4295-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/978-1-4615-4295-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038245607", 
              "https://doi.org/10.1007/978-1-4615-4295-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0002-9440(10)63568-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039352615"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ijc.2910590107", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041678168"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0401064101", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041790673"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/path.1398", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042848739"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00002281-200211000-00009", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045105158"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00002281-200211000-00009", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045105158"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1172/jci117736", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048449749"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.bbrc.2004.04.150", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049191412"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1354/vp.38-4-357", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049500663"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1354/vp.38-4-357", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049500663"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1152/ajprenal.00451.2003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050500132"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1006/excr.1995.1220", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051509752"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/bcr615", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053101780", 
              "https://doi.org/10.1186/bcr615"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0962-8924(01)02130-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053339604"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1089/104454901317094945", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1059203632"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1067431", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062445708"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1172/jci15518", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1063415394"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1172/jci15970", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1063415464"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1172/jci18899", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1063416373"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2741/1382", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1070913671"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3892/ijo.18.4.669", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1071511616"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074582949", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074640262", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074782080", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074948724", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074957467", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1177/153537020122601106", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1074963108"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1177/153537020122601106", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1074963108"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074963914", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1075123981", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1075175856", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1075185012", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1076911265", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1079040335", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1079557995", 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/978-1-4684-8914-9_16", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1079595349", 
              "https://doi.org/10.1007/978-1-4684-8914-9_16"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1081650736", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082678134", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1083187498", 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2005-07", 
        "datePublishedReg": "2005-07-01", 
        "description": "Stromal fibroblasts regulate epithelial cell behavior through direct and indirect cell-cell interactions. To clarify the role of TGF-beta signaling in stromal fibroblasts during mammary development and tumorigenesis, we conditionally knocked out the TGF-beta type II receptor gene in mouse mammary fibroblasts (Tgfbr2(fspKO)). Tgfbr2(fspKO) mice exhibit defective mammary ductal development, characterized in part by increased ductal epithelial cell turnover associated with an increase in stromal fibroblast abundance. Tgfbr2(fspKO) mammary fibroblasts transplanted with mammary carcinoma cells promote growth and invasion, which is associated with increased activating phosphorylation of the receptors: erbB1, erbB2, RON, and c-Met. Furthermore, the increased receptor phosphorylation correlates with increased secretion of the cognate ligands by Tgfbr2(fspKO) fibroblasts. Treatment of tumor cells with fibroblast-conditioned medium leads to increased tumor cell proliferation and motility, which are blocked by addition of pharmacologic inhibitors of TGF-alpha signaling or neutralizing antibodies to macrophage-stimulating protein (MSP), HGF, or c-Met. These studies characterize a significant role for stromal TGF-beta signaling in mammary tissue homeostasis and mammary tumor progression via regulation of TGF-alpha, MSP, and HGF signaling pathways.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1038/sj.onc.1208685", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": true, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.2438863", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2474785", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2477509", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2682624", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2476873", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2438747", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1097543", 
            "issn": [
              "0950-9232", 
              "1476-5594"
            ], 
            "name": "Oncogene", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "32", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "24"
          }
        ], 
        "name": "Loss of TGF-\u03b2 type II receptor in fibroblasts promotes mammary carcinoma growth and invasion through upregulation of TGF-\u03b1-, MSP- and HGF-mediated signaling networks", 
        "pagination": "1208685", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "726f0721348471b6ba3a4bc345b0cf63c7c494ade1b5ececde12e1b4e6f93af0"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "15856015"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "8711562"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/sj.onc.1208685"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1024019697"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/sj.onc.1208685", 
          "https://app.dimensions.ai/details/publication/pub.1024019697"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-11T12:06", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000360_0000000360/records_118336_00000000.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "http://www.nature.com/articles/1208685"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/sj.onc.1208685'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/sj.onc.1208685'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/sj.onc.1208685'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/sj.onc.1208685'


     

    This table displays all metadata directly associated to this object as RDF triples.

    429 TRIPLES      21 PREDICATES      116 URIs      43 LITERALS      31 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/sj.onc.1208685 schema:about N10c948248aee4f0db240a997f51b389d
    2 N27ac6aea8164483ab0e883f7eb267907
    3 N431a7f92e86e423d8924f9e0eae60f64
    4 N467fc5d7e7be471db695d11a61d20a35
    5 N4acc1909603a4013a7494bde0836cbfc
    6 N51fb32be66ca4bc1815dcbbfb5f8ff3c
    7 N5a0e8ae542fb480c89eac3ee5c3ed51f
    8 N64bc8940d19b45d89f3f58faf21e68a3
    9 N652aff76fb064498bb78001a0d8fff0a
    10 N742c8e0a76824ead8b077e22fefe9edb
    11 N7d6f616c9884499abb5e5a5ae1e79717
    12 Nb3da6879c09144b1a7ec64c54439c328
    13 Nbe76d2de2a944d4f9bd47dfe76267650
    14 Nd295e9e89a3c47879942f4ec8d0d15f6
    15 Nd9e5de7fdbfa49158d9b600edf455f9d
    16 Nde4720a7a1304a50beae4a2a795c9e58
    17 Ndf3a19d0b4124c15a8c8359f0d2695b6
    18 Ndf7ddac3cb8140a690ef5ce0d33d5f15
    19 Ne45c520fe276412b8ae031926f0ff86c
    20 Nf27c09d4ae5e45f180cb128625dbc1a8
    21 Nf3c33227e02543e5a107d8736ec6dcd7
    22 Nf6924547959b4d49a614b7a5d804ceda
    23 anzsrc-for:06
    24 anzsrc-for:0601
    25 schema:author Nc21a718e13ca456a96f3489f2cbfd3e4
    26 schema:citation sg:pub.10.1007/978-1-4615-1371-1_7
    27 sg:pub.10.1007/978-1-4615-4295-7
    28 sg:pub.10.1007/978-1-4615-4295-7_13
    29 sg:pub.10.1007/978-1-4684-8914-9_16
    30 sg:pub.10.1038/5007
    31 sg:pub.10.1038/ng1001-117
    32 sg:pub.10.1038/nrc1208
    33 sg:pub.10.1038/sj.onc.1204544
    34 sg:pub.10.1038/sj.onc.1205966
    35 sg:pub.10.1038/sj.onc.1207282
    36 sg:pub.10.1186/bcr299
    37 sg:pub.10.1186/bcr301
    38 sg:pub.10.1186/bcr615
    39 sg:pub.10.1186/bcr949
    40 https://app.dimensions.ai/details/publication/pub.1074582949
    41 https://app.dimensions.ai/details/publication/pub.1074640262
    42 https://app.dimensions.ai/details/publication/pub.1074782080
    43 https://app.dimensions.ai/details/publication/pub.1074948724
    44 https://app.dimensions.ai/details/publication/pub.1074957467
    45 https://app.dimensions.ai/details/publication/pub.1074963914
    46 https://app.dimensions.ai/details/publication/pub.1075123981
    47 https://app.dimensions.ai/details/publication/pub.1075175856
    48 https://app.dimensions.ai/details/publication/pub.1075185012
    49 https://app.dimensions.ai/details/publication/pub.1076911265
    50 https://app.dimensions.ai/details/publication/pub.1079040335
    51 https://app.dimensions.ai/details/publication/pub.1079557995
    52 https://app.dimensions.ai/details/publication/pub.1081650736
    53 https://app.dimensions.ai/details/publication/pub.1082678134
    54 https://app.dimensions.ai/details/publication/pub.1083187498
    55 https://doi.org/10.1002/1097-0029(20010115)52:2<224::aid-jemt1007>3.0.co;2-a
    56 https://doi.org/10.1002/dvdy.10065
    57 https://doi.org/10.1002/gene.10046
    58 https://doi.org/10.1002/ijc.2910590107
    59 https://doi.org/10.1002/jcp.1041390323
    60 https://doi.org/10.1002/path.1398
    61 https://doi.org/10.1006/excr.1995.1220
    62 https://doi.org/10.1006/excr.1998.4373
    63 https://doi.org/10.1016/0092-8674(83)90130-7
    64 https://doi.org/10.1016/j.bbrc.2004.04.150
    65 https://doi.org/10.1016/s0002-9440(10)63510-9
    66 https://doi.org/10.1016/s0002-9440(10)63568-7
    67 https://doi.org/10.1016/s0962-8924(01)02130-4
    68 https://doi.org/10.1046/j.1365-3083.2002.01177.x
    69 https://doi.org/10.1046/j.1432-0436.1998.6330131.x
    70 https://doi.org/10.1046/j.1432-0436.2002.700903.x
    71 https://doi.org/10.1073/pnas.0401064101
    72 https://doi.org/10.1073/pnas.2135113100
    73 https://doi.org/10.1073/pnas.87.1.75
    74 https://doi.org/10.1083/jcb.130.2.393
    75 https://doi.org/10.1089/104454901317094945
    76 https://doi.org/10.1091/mbc.10.4.1221
    77 https://doi.org/10.1097/00002281-200211000-00009
    78 https://doi.org/10.1126/science.1067431
    79 https://doi.org/10.1126/science.1090922
    80 https://doi.org/10.1128/mcb.12.3.954
    81 https://doi.org/10.1128/mcb.18.4.2344
    82 https://doi.org/10.1152/ajprenal.00451.2003
    83 https://doi.org/10.1172/jci117736
    84 https://doi.org/10.1172/jci15518
    85 https://doi.org/10.1172/jci15970
    86 https://doi.org/10.1172/jci18899
    87 https://doi.org/10.1177/153537020122601106
    88 https://doi.org/10.1354/vp.38-4-357
    89 https://doi.org/10.2741/1382
    90 https://doi.org/10.3892/ijo.18.4.669
    91 schema:datePublished 2005-07
    92 schema:datePublishedReg 2005-07-01
    93 schema:description Stromal fibroblasts regulate epithelial cell behavior through direct and indirect cell-cell interactions. To clarify the role of TGF-beta signaling in stromal fibroblasts during mammary development and tumorigenesis, we conditionally knocked out the TGF-beta type II receptor gene in mouse mammary fibroblasts (Tgfbr2(fspKO)). Tgfbr2(fspKO) mice exhibit defective mammary ductal development, characterized in part by increased ductal epithelial cell turnover associated with an increase in stromal fibroblast abundance. Tgfbr2(fspKO) mammary fibroblasts transplanted with mammary carcinoma cells promote growth and invasion, which is associated with increased activating phosphorylation of the receptors: erbB1, erbB2, RON, and c-Met. Furthermore, the increased receptor phosphorylation correlates with increased secretion of the cognate ligands by Tgfbr2(fspKO) fibroblasts. Treatment of tumor cells with fibroblast-conditioned medium leads to increased tumor cell proliferation and motility, which are blocked by addition of pharmacologic inhibitors of TGF-alpha signaling or neutralizing antibodies to macrophage-stimulating protein (MSP), HGF, or c-Met. These studies characterize a significant role for stromal TGF-beta signaling in mammary tissue homeostasis and mammary tumor progression via regulation of TGF-alpha, MSP, and HGF signaling pathways.
    94 schema:genre research_article
    95 schema:inLanguage en
    96 schema:isAccessibleForFree true
    97 schema:isPartOf N58853521c3e8419aab2ff3d8ed773a1c
    98 N827c1b3cb9e54d69b075287fa0dfefeb
    99 sg:journal.1097543
    100 schema:name Loss of TGF-β type II receptor in fibroblasts promotes mammary carcinoma growth and invasion through upregulation of TGF-α-, MSP- and HGF-mediated signaling networks
    101 schema:pagination 1208685
    102 schema:productId N16e22b226f164e36968263d1a0cd2d6f
    103 N2a3975cec8c44416924b14cd26cc8d02
    104 N2abd1d74f03e4d9f903d58e1cbe85a41
    105 N59c55a0388b244fb93f7f3833f392f8f
    106 Ndebaf663ef1b412486b06cacf8090fce
    107 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024019697
    108 https://doi.org/10.1038/sj.onc.1208685
    109 schema:sdDatePublished 2019-04-11T12:06
    110 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    111 schema:sdPublisher N544983e5e2e9499982742033bd3d8aa5
    112 schema:url http://www.nature.com/articles/1208685
    113 sgo:license sg:explorer/license/
    114 sgo:sdDataset articles
    115 rdf:type schema:ScholarlyArticle
    116 N08ec3267eee245cd988675119e338c4e rdf:first sg:person.01261253004.94
    117 rdf:rest N297311c680d24f478cbec897d07d0338
    118 N10c948248aee4f0db240a997f51b389d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    119 schema:name Animals
    120 rdf:type schema:DefinedTerm
    121 N16e22b226f164e36968263d1a0cd2d6f schema:name dimensions_id
    122 schema:value pub.1024019697
    123 rdf:type schema:PropertyValue
    124 N1bb5dd6edc224af596a71591e3552564 rdf:first sg:person.01063245124.71
    125 rdf:rest N72fdd3358d384cbdad13a2b336cf4123
    126 N27ac6aea8164483ab0e883f7eb267907 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    127 schema:name Gene Deletion
    128 rdf:type schema:DefinedTerm
    129 N297311c680d24f478cbec897d07d0338 rdf:first sg:person.0701452031.39
    130 rdf:rest Nfae9aaf31bd54619893933d2b7a75440
    131 N2a3975cec8c44416924b14cd26cc8d02 schema:name nlm_unique_id
    132 schema:value 8711562
    133 rdf:type schema:PropertyValue
    134 N2abd1d74f03e4d9f903d58e1cbe85a41 schema:name readcube_id
    135 schema:value 726f0721348471b6ba3a4bc345b0cf63c7c494ade1b5ececde12e1b4e6f93af0
    136 rdf:type schema:PropertyValue
    137 N431a7f92e86e423d8924f9e0eae60f64 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    138 schema:name Neoplasm Invasiveness
    139 rdf:type schema:DefinedTerm
    140 N44d7ebe0ab1b465384a5463f2ae3ed3f schema:affiliation https://www.grid.ac/institutes/grid.152326.1
    141 schema:familyName Gorksa
    142 schema:givenName Agnieszka E
    143 rdf:type schema:Person
    144 N467fc5d7e7be471db695d11a61d20a35 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    145 schema:name Mice, Nude
    146 rdf:type schema:DefinedTerm
    147 N4acc1909603a4013a7494bde0836cbfc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    148 schema:name Homozygote
    149 rdf:type schema:DefinedTerm
    150 N51fb32be66ca4bc1815dcbbfb5f8ff3c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    151 schema:name Mucins
    152 rdf:type schema:DefinedTerm
    153 N544983e5e2e9499982742033bd3d8aa5 schema:name Springer Nature - SN SciGraph project
    154 rdf:type schema:Organization
    155 N55c2e9ce52474ac3b4e52b19708d3ae4 rdf:first sg:person.01102570737.23
    156 rdf:rest N1bb5dd6edc224af596a71591e3552564
    157 N571b51abd88c4bab9d5576693fe9fc30 rdf:first sg:person.012156036347.78
    158 rdf:rest N587e6c2ae5184ff29cf9dbd8898b7754
    159 N587e6c2ae5184ff29cf9dbd8898b7754 rdf:first sg:person.0644226005.11
    160 rdf:rest Nf625d9b611b648dfb92bb5a8103d7bd9
    161 N58853521c3e8419aab2ff3d8ed773a1c schema:issueNumber 32
    162 rdf:type schema:PublicationIssue
    163 N59c55a0388b244fb93f7f3833f392f8f schema:name pubmed_id
    164 schema:value 15856015
    165 rdf:type schema:PropertyValue
    166 N5a0e8ae542fb480c89eac3ee5c3ed51f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    167 schema:name Mammary Neoplasms, Animal
    168 rdf:type schema:DefinedTerm
    169 N64bc8940d19b45d89f3f58faf21e68a3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    170 schema:name Trefoil Factor-2
    171 rdf:type schema:DefinedTerm
    172 N652aff76fb064498bb78001a0d8fff0a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    173 schema:name Female
    174 rdf:type schema:DefinedTerm
    175 N72fdd3358d384cbdad13a2b336cf4123 rdf:first N44d7ebe0ab1b465384a5463f2ae3ed3f
    176 rdf:rest N571b51abd88c4bab9d5576693fe9fc30
    177 N742c8e0a76824ead8b077e22fefe9edb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    178 schema:name Genes, Reporter
    179 rdf:type schema:DefinedTerm
    180 N7d6f616c9884499abb5e5a5ae1e79717 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    181 schema:name Transforming Growth Factor alpha
    182 rdf:type schema:DefinedTerm
    183 N827c1b3cb9e54d69b075287fa0dfefeb schema:volumeNumber 24
    184 rdf:type schema:PublicationVolume
    185 Nb3da6879c09144b1a7ec64c54439c328 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    186 schema:name Protein-Serine-Threonine Kinases
    187 rdf:type schema:DefinedTerm
    188 Nbe76d2de2a944d4f9bd47dfe76267650 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    189 schema:name Receptor, Transforming Growth Factor-beta Type II
    190 rdf:type schema:DefinedTerm
    191 Nc21a718e13ca456a96f3489f2cbfd3e4 rdf:first sg:person.01134615337.75
    192 rdf:rest N55c2e9ce52474ac3b4e52b19708d3ae4
    193 Nd295e9e89a3c47879942f4ec8d0d15f6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    194 schema:name Muscle Proteins
    195 rdf:type schema:DefinedTerm
    196 Nd9e5de7fdbfa49158d9b600edf455f9d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    197 schema:name Gene Silencing
    198 rdf:type schema:DefinedTerm
    199 Nde4720a7a1304a50beae4a2a795c9e58 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    200 schema:name Hepatocyte Growth Factor
    201 rdf:type schema:DefinedTerm
    202 Ndebaf663ef1b412486b06cacf8090fce schema:name doi
    203 schema:value 10.1038/sj.onc.1208685
    204 rdf:type schema:PropertyValue
    205 Ndf3a19d0b4124c15a8c8359f0d2695b6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    206 schema:name Mice, Inbred C57BL
    207 rdf:type schema:DefinedTerm
    208 Ndf7ddac3cb8140a690ef5ce0d33d5f15 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    209 schema:name Mice
    210 rdf:type schema:DefinedTerm
    211 Ne45c520fe276412b8ae031926f0ff86c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    212 schema:name Mice, Knockout
    213 rdf:type schema:DefinedTerm
    214 Nf27c09d4ae5e45f180cb128625dbc1a8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    215 schema:name Receptors, Transforming Growth Factor beta
    216 rdf:type schema:DefinedTerm
    217 Nf3c33227e02543e5a107d8736ec6dcd7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    218 schema:name Peptides
    219 rdf:type schema:DefinedTerm
    220 Nf625d9b611b648dfb92bb5a8103d7bd9 rdf:first sg:person.013436233237.01
    221 rdf:rest N08ec3267eee245cd988675119e338c4e
    222 Nf6924547959b4d49a614b7a5d804ceda schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    223 schema:name Cell Division
    224 rdf:type schema:DefinedTerm
    225 Nfae9aaf31bd54619893933d2b7a75440 rdf:first sg:person.01065513554.26
    226 rdf:rest rdf:nil
    227 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
    228 schema:name Biological Sciences
    229 rdf:type schema:DefinedTerm
    230 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
    231 schema:name Biochemistry and Cell Biology
    232 rdf:type schema:DefinedTerm
    233 sg:grant.2438747 http://pending.schema.org/fundedItem sg:pub.10.1038/sj.onc.1208685
    234 rdf:type schema:MonetaryGrant
    235 sg:grant.2438863 http://pending.schema.org/fundedItem sg:pub.10.1038/sj.onc.1208685
    236 rdf:type schema:MonetaryGrant
    237 sg:grant.2474785 http://pending.schema.org/fundedItem sg:pub.10.1038/sj.onc.1208685
    238 rdf:type schema:MonetaryGrant
    239 sg:grant.2476873 http://pending.schema.org/fundedItem sg:pub.10.1038/sj.onc.1208685
    240 rdf:type schema:MonetaryGrant
    241 sg:grant.2477509 http://pending.schema.org/fundedItem sg:pub.10.1038/sj.onc.1208685
    242 rdf:type schema:MonetaryGrant
    243 sg:grant.2682624 http://pending.schema.org/fundedItem sg:pub.10.1038/sj.onc.1208685
    244 rdf:type schema:MonetaryGrant
    245 sg:journal.1097543 schema:issn 0950-9232
    246 1476-5594
    247 schema:name Oncogene
    248 rdf:type schema:Periodical
    249 sg:person.01063245124.71 schema:affiliation https://www.grid.ac/institutes/grid.152326.1
    250 schema:familyName Chytil
    251 schema:givenName Anna
    252 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01063245124.71
    253 rdf:type schema:Person
    254 sg:person.01065513554.26 schema:affiliation https://www.grid.ac/institutes/grid.152326.1
    255 schema:familyName Moses
    256 schema:givenName Harold L
    257 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01065513554.26
    258 rdf:type schema:Person
    259 sg:person.01102570737.23 schema:affiliation https://www.grid.ac/institutes/grid.152326.1
    260 schema:familyName Bhowmick
    261 schema:givenName Neil A
    262 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01102570737.23
    263 rdf:type schema:Person
    264 sg:person.01134615337.75 schema:affiliation https://www.grid.ac/institutes/grid.152326.1
    265 schema:familyName Cheng
    266 schema:givenName Nikki
    267 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01134615337.75
    268 rdf:type schema:Person
    269 sg:person.012156036347.78 schema:affiliation https://www.grid.ac/institutes/grid.152326.1
    270 schema:familyName Brown
    271 schema:givenName Kimberly A
    272 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012156036347.78
    273 rdf:type schema:Person
    274 sg:person.01261253004.94 schema:affiliation https://www.grid.ac/institutes/grid.152326.1
    275 schema:familyName Neilson
    276 schema:givenName Eric G
    277 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01261253004.94
    278 rdf:type schema:Person
    279 sg:person.013436233237.01 schema:affiliation https://www.grid.ac/institutes/grid.152326.1
    280 schema:familyName Arteaga
    281 schema:givenName Carlos L
    282 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013436233237.01
    283 rdf:type schema:Person
    284 sg:person.0644226005.11 schema:affiliation https://www.grid.ac/institutes/grid.152326.1
    285 schema:familyName Muraoka
    286 schema:givenName Rebecca
    287 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0644226005.11
    288 rdf:type schema:Person
    289 sg:person.0701452031.39 schema:affiliation https://www.grid.ac/institutes/grid.152326.1
    290 schema:familyName Hayward
    291 schema:givenName Simon W
    292 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0701452031.39
    293 rdf:type schema:Person
    294 sg:pub.10.1007/978-1-4615-1371-1_7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011824299
    295 https://doi.org/10.1007/978-1-4615-1371-1_7
    296 rdf:type schema:CreativeWork
    297 sg:pub.10.1007/978-1-4615-4295-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038245607
    298 https://doi.org/10.1007/978-1-4615-4295-7
    299 rdf:type schema:CreativeWork
    300 sg:pub.10.1007/978-1-4615-4295-7_13 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008294807
    301 https://doi.org/10.1007/978-1-4615-4295-7_13
    302 rdf:type schema:CreativeWork
    303 sg:pub.10.1007/978-1-4684-8914-9_16 schema:sameAs https://app.dimensions.ai/details/publication/pub.1079595349
    304 https://doi.org/10.1007/978-1-4684-8914-9_16
    305 rdf:type schema:CreativeWork
    306 sg:pub.10.1038/5007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030839891
    307 https://doi.org/10.1038/5007
    308 rdf:type schema:CreativeWork
    309 sg:pub.10.1038/ng1001-117 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010058562
    310 https://doi.org/10.1038/ng1001-117
    311 rdf:type schema:CreativeWork
    312 sg:pub.10.1038/nrc1208 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004573220
    313 https://doi.org/10.1038/nrc1208
    314 rdf:type schema:CreativeWork
    315 sg:pub.10.1038/sj.onc.1204544 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013087526
    316 https://doi.org/10.1038/sj.onc.1204544
    317 rdf:type schema:CreativeWork
    318 sg:pub.10.1038/sj.onc.1205966 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015860507
    319 https://doi.org/10.1038/sj.onc.1205966
    320 rdf:type schema:CreativeWork
    321 sg:pub.10.1038/sj.onc.1207282 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001625975
    322 https://doi.org/10.1038/sj.onc.1207282
    323 rdf:type schema:CreativeWork
    324 sg:pub.10.1186/bcr299 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025413233
    325 https://doi.org/10.1186/bcr299
    326 rdf:type schema:CreativeWork
    327 sg:pub.10.1186/bcr301 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027892635
    328 https://doi.org/10.1186/bcr301
    329 rdf:type schema:CreativeWork
    330 sg:pub.10.1186/bcr615 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053101780
    331 https://doi.org/10.1186/bcr615
    332 rdf:type schema:CreativeWork
    333 sg:pub.10.1186/bcr949 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007818794
    334 https://doi.org/10.1186/bcr949
    335 rdf:type schema:CreativeWork
    336 https://app.dimensions.ai/details/publication/pub.1074582949 schema:CreativeWork
    337 https://app.dimensions.ai/details/publication/pub.1074640262 schema:CreativeWork
    338 https://app.dimensions.ai/details/publication/pub.1074782080 schema:CreativeWork
    339 https://app.dimensions.ai/details/publication/pub.1074948724 schema:CreativeWork
    340 https://app.dimensions.ai/details/publication/pub.1074957467 schema:CreativeWork
    341 https://app.dimensions.ai/details/publication/pub.1074963914 schema:CreativeWork
    342 https://app.dimensions.ai/details/publication/pub.1075123981 schema:CreativeWork
    343 https://app.dimensions.ai/details/publication/pub.1075175856 schema:CreativeWork
    344 https://app.dimensions.ai/details/publication/pub.1075185012 schema:CreativeWork
    345 https://app.dimensions.ai/details/publication/pub.1076911265 schema:CreativeWork
    346 https://app.dimensions.ai/details/publication/pub.1079040335 schema:CreativeWork
    347 https://app.dimensions.ai/details/publication/pub.1079557995 schema:CreativeWork
    348 https://app.dimensions.ai/details/publication/pub.1081650736 schema:CreativeWork
    349 https://app.dimensions.ai/details/publication/pub.1082678134 schema:CreativeWork
    350 https://app.dimensions.ai/details/publication/pub.1083187498 schema:CreativeWork
    351 https://doi.org/10.1002/1097-0029(20010115)52:2<224::aid-jemt1007>3.0.co;2-a schema:sameAs https://app.dimensions.ai/details/publication/pub.1034436633
    352 rdf:type schema:CreativeWork
    353 https://doi.org/10.1002/dvdy.10065 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007918085
    354 rdf:type schema:CreativeWork
    355 https://doi.org/10.1002/gene.10046 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021922995
    356 rdf:type schema:CreativeWork
    357 https://doi.org/10.1002/ijc.2910590107 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041678168
    358 rdf:type schema:CreativeWork
    359 https://doi.org/10.1002/jcp.1041390323 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035182590
    360 rdf:type schema:CreativeWork
    361 https://doi.org/10.1002/path.1398 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042848739
    362 rdf:type schema:CreativeWork
    363 https://doi.org/10.1006/excr.1995.1220 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051509752
    364 rdf:type schema:CreativeWork
    365 https://doi.org/10.1006/excr.1998.4373 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002798698
    366 rdf:type schema:CreativeWork
    367 https://doi.org/10.1016/0092-8674(83)90130-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015578795
    368 rdf:type schema:CreativeWork
    369 https://doi.org/10.1016/j.bbrc.2004.04.150 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049191412
    370 rdf:type schema:CreativeWork
    371 https://doi.org/10.1016/s0002-9440(10)63510-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011505622
    372 rdf:type schema:CreativeWork
    373 https://doi.org/10.1016/s0002-9440(10)63568-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039352615
    374 rdf:type schema:CreativeWork
    375 https://doi.org/10.1016/s0962-8924(01)02130-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053339604
    376 rdf:type schema:CreativeWork
    377 https://doi.org/10.1046/j.1365-3083.2002.01177.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1006914942
    378 rdf:type schema:CreativeWork
    379 https://doi.org/10.1046/j.1432-0436.1998.6330131.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1031595983
    380 rdf:type schema:CreativeWork
    381 https://doi.org/10.1046/j.1432-0436.2002.700903.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1019053821
    382 rdf:type schema:CreativeWork
    383 https://doi.org/10.1073/pnas.0401064101 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041790673
    384 rdf:type schema:CreativeWork
    385 https://doi.org/10.1073/pnas.2135113100 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034602125
    386 rdf:type schema:CreativeWork
    387 https://doi.org/10.1073/pnas.87.1.75 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011157313
    388 rdf:type schema:CreativeWork
    389 https://doi.org/10.1083/jcb.130.2.393 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002124384
    390 rdf:type schema:CreativeWork
    391 https://doi.org/10.1089/104454901317094945 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059203632
    392 rdf:type schema:CreativeWork
    393 https://doi.org/10.1091/mbc.10.4.1221 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008505050
    394 rdf:type schema:CreativeWork
    395 https://doi.org/10.1097/00002281-200211000-00009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045105158
    396 rdf:type schema:CreativeWork
    397 https://doi.org/10.1126/science.1067431 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062445708
    398 rdf:type schema:CreativeWork
    399 https://doi.org/10.1126/science.1090922 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004845332
    400 rdf:type schema:CreativeWork
    401 https://doi.org/10.1128/mcb.12.3.954 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034836584
    402 rdf:type schema:CreativeWork
    403 https://doi.org/10.1128/mcb.18.4.2344 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036467368
    404 rdf:type schema:CreativeWork
    405 https://doi.org/10.1152/ajprenal.00451.2003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050500132
    406 rdf:type schema:CreativeWork
    407 https://doi.org/10.1172/jci117736 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048449749
    408 rdf:type schema:CreativeWork
    409 https://doi.org/10.1172/jci15518 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063415394
    410 rdf:type schema:CreativeWork
    411 https://doi.org/10.1172/jci15970 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063415464
    412 rdf:type schema:CreativeWork
    413 https://doi.org/10.1172/jci18899 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063416373
    414 rdf:type schema:CreativeWork
    415 https://doi.org/10.1177/153537020122601106 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074963108
    416 rdf:type schema:CreativeWork
    417 https://doi.org/10.1354/vp.38-4-357 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049500663
    418 rdf:type schema:CreativeWork
    419 https://doi.org/10.2741/1382 schema:sameAs https://app.dimensions.ai/details/publication/pub.1070913671
    420 rdf:type schema:CreativeWork
    421 https://doi.org/10.3892/ijo.18.4.669 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071511616
    422 rdf:type schema:CreativeWork
    423 https://www.grid.ac/institutes/grid.152326.1 schema:alternateName Vanderbilt University
    424 schema:name Department of Cancer Biology, Vanderbilt University School of Medicine, Nashville, TN 37232-6838, USA
    425 Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232-6838, USA
    426 Department of Pathology, Vanderbilt University School of Medicine, Nashville, TN 37232-6838, USA
    427 Department of Urologic Surgery, Vanderbilt University School of Medicine, Nashville, TN 37232-6838, USA
    428 Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37232-6838, USA
    429 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...