ILK mediates actin filament rearrangements and cell migration and invasion through PI3K/Akt/Rac1 signaling View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2005-04

AUTHORS

Yong Qian, Xiaosong Zhong, Daniel C Flynn, Jenny Z Zheng, Meng Qiao, Chuanyue Wu, Shoukat Dedhar, Xianglin Shi, Bing-Hua Jiang

ABSTRACT

One of the hallmarks of integrin signaling is an increase in cell migration and invasion, both of which are associated with actin filament rearrangements. Integrin-linked kinase (ILK) is a cytoplasmic effector of integrin receptors. ILK is known to be involved in multiple cellular functions. However, the signaling pathways involved in ILK-mediated cellular structure and motility remain to be elucidated. Here, we have demonstrated that overexpression of ILK was sufficient to induce actin filament rearrangements, to form cell motility structures, and to increase cell migration and invasion in a phosphatidylinositol 3-kinase (PI3K)-dependent manner. This corresponds with the activation of both Akt and p70 ribosomal protein S6 kinase (p70S6K1). Overexpression of dominant-negative mutants of Akt inhibited ILK-dependent activation of p70S6K1, indicating that Akt is upstream of p70S6K1 in response to ILK signaling. Overexpression of ILK was sufficient to induce Rac1 activation, which was abolish by a PI3K inhibitor, indicating that Rac1 activity is involved in ILK signaling in a PI3K dependent manner. Inhibition of Akt, Rac1, or p70S6K1 inhibited the effects of ILK on actin filaments and cell migration, suggesting a regulatory role of the PI3K/Akt/p70S6K1/Rac1 signaling pathway in response to ILK signaling. We have shown that overexpression of a dominant-negative ILK was sufficient to abolish fibronectin peptide (PHSRN)-induced rearrangements of actin filaments and cell migration and invasion. Taken together, our results identify a mechanism through which ILK can regulate both integrin-associated rearrangements of actin filaments and cell migration and invasion at the integrin receptor-proximal region. More... »

PAGES

3154-3165

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/sj.onc.1208525

DOI

http://dx.doi.org/10.1038/sj.onc.1208525

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1043551535

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/15735674


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Blotting, Western", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Movement", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chickens", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cytoplasm", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Enzyme Activation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Fibroblasts", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Fibronectins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genes, Dominant", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Integrins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Microscopy, Fluorescence", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mutation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Phosphatidylinositol 3-Kinases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Phosphorylation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Plasmids", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein-Serine-Threonine Kinases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Proto-Oncogene Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Proto-Oncogene Proteins c-akt", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Ribosomal Protein S6 Kinases, 70-kDa", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Signal Transduction", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Wound Healing", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "cdc42 GTP-Binding Protein", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "rac1 GTP-Binding Protein", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "National Institute for Occupational Safety and Health", 
          "id": "https://www.grid.ac/institutes/grid.416809.2", 
          "name": [
            "Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26506, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Qian", 
        "givenName": "Yong", 
        "id": "sg:person.01361150504.00", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01361150504.00"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "West Virginia University", 
          "id": "https://www.grid.ac/institutes/grid.268154.c", 
          "name": [
            "The Mary Babb Randolph Cancer Center and the Department of Microbiology, Immunology, and Cell Biology, West Virginia University, Morgantown, WV 26506-9300, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhong", 
        "givenName": "Xiaosong", 
        "id": "sg:person.011606612417.05", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011606612417.05"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "West Virginia University", 
          "id": "https://www.grid.ac/institutes/grid.268154.c", 
          "name": [
            "The Mary Babb Randolph Cancer Center and the Department of Microbiology, Immunology, and Cell Biology, West Virginia University, Morgantown, WV 26506-9300, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Flynn", 
        "givenName": "Daniel C", 
        "id": "sg:person.01300024427.45", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01300024427.45"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "West Virginia University", 
          "id": "https://www.grid.ac/institutes/grid.268154.c", 
          "name": [
            "The Mary Babb Randolph Cancer Center and the Department of Microbiology, Immunology, and Cell Biology, West Virginia University, Morgantown, WV 26506-9300, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zheng", 
        "givenName": "Jenny Z", 
        "id": "sg:person.0674171654.32", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0674171654.32"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "West Virginia University", 
          "id": "https://www.grid.ac/institutes/grid.268154.c", 
          "name": [
            "The Mary Babb Randolph Cancer Center and the Department of Microbiology, Immunology, and Cell Biology, West Virginia University, Morgantown, WV 26506-9300, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Qiao", 
        "givenName": "Meng", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Pittsburgh", 
          "id": "https://www.grid.ac/institutes/grid.21925.3d", 
          "name": [
            "Department of Pathology, University of Pittsburgh, Pittsburgh, PA 15261, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wu", 
        "givenName": "Chuanyue", 
        "id": "sg:person.012772056017.65", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012772056017.65"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of British Columbia", 
          "id": "https://www.grid.ac/institutes/grid.17091.3e", 
          "name": [
            "Department of Biochemistry, University of British Columbia, BC, Cancer Agency and Vancouver Hospital, Jack Bell Research Center, Vancouver, BC, Canada V6H 3Z6"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Dedhar", 
        "givenName": "Shoukat", 
        "id": "sg:person.0704747176.81", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0704747176.81"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Institute for Occupational Safety and Health", 
          "id": "https://www.grid.ac/institutes/grid.416809.2", 
          "name": [
            "Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26506, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Shi", 
        "givenName": "Xianglin", 
        "id": "sg:person.01236164564.95", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01236164564.95"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "West Virginia University", 
          "id": "https://www.grid.ac/institutes/grid.268154.c", 
          "name": [
            "The Mary Babb Randolph Cancer Center and the Department of Microbiology, Immunology, and Cell Biology, West Virginia University, Morgantown, WV 26506-9300, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jiang", 
        "givenName": "Bing-Hua", 
        "id": "sg:person.011352625147.80", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011352625147.80"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1002/(sici)1097-0029(19991001)47:1<67::aid-jemt7>3.0.co;2-p", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000006401"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0163-7258(02)00192-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000250039"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.res.86.8.892", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002026857"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajpcell.00142.2003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003601205"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.040560897", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009427155"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1091/mbc.01-08-0398", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012685828"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(00)81257-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014119038"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0962-8924(01)02152-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014140410"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0955-0674(99)00083-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014578287"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m102940200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017819162"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/376599a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019263292", 
          "https://doi.org/10.1038/376599a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.98.1.136", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019734493"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1023/a:1023777013659", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020945232", 
          "https://doi.org/10.1023/a:1023777013659"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/scbi.2000.0364", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021228041"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m108257200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022998023"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0898-6568(01)00246-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023418084"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0960-9822(02)00973-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024839636"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/379091a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026082455", 
          "https://doi.org/10.1038/379091a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1201753", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026764034", 
          "https://doi.org/10.1038/sj.onc.1201753"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1201753", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026764034", 
          "https://doi.org/10.1038/sj.onc.1201753"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1046/j.1440-1711.2000.00928.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028263458", 
          "https://doi.org/10.1046/j.1440-1711.2000.00928.x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(00)80486-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032018827"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1204910", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032591546", 
          "https://doi.org/10.1038/sj.onc.1204910"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1204910", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032591546", 
          "https://doi.org/10.1038/sj.onc.1204910"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1385/ir:21:2-3:83", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032815453", 
          "https://doi.org/10.1385/ir:21:2-3:83"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0960-9822(01)00599-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032945519"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1097-0185(19990301)254:3<348::aid-ar5>3.0.co;2-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033211989"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev.biochem.68.1.965", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034140297"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.200108077", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034315874"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1203928", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035885592", 
          "https://doi.org/10.1038/sj.onc.1203928"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1203928", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035885592", 
          "https://doi.org/10.1038/sj.onc.1203928"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0968-0004(01)01958-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036134633"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.r900037199", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037338424"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1203877", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041442636", 
          "https://doi.org/10.1038/sj.onc.1203877"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1203877", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041442636", 
          "https://doi.org/10.1038/sj.onc.1203877"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1203258", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043845856", 
          "https://doi.org/10.1038/sj.onc.1203258"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1203258", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043845856", 
          "https://doi.org/10.1038/sj.onc.1203258"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.152.5.1007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046226680"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.279.5350.509", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047090124"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m207517200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047991640"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0968-0004(00)01605-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048047171"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.11.18.2295", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051224316"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev.cellbio.14.1.305", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053104868"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.14670/hh-14.1001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074498339"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074554962", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074588331", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074737905", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/jappl.2001.91.2.963", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074850669"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2005-04", 
    "datePublishedReg": "2005-04-01", 
    "description": "One of the hallmarks of integrin signaling is an increase in cell migration and invasion, both of which are associated with actin filament rearrangements. Integrin-linked kinase (ILK) is a cytoplasmic effector of integrin receptors. ILK is known to be involved in multiple cellular functions. However, the signaling pathways involved in ILK-mediated cellular structure and motility remain to be elucidated. Here, we have demonstrated that overexpression of ILK was sufficient to induce actin filament rearrangements, to form cell motility structures, and to increase cell migration and invasion in a phosphatidylinositol 3-kinase (PI3K)-dependent manner. This corresponds with the activation of both Akt and p70 ribosomal protein S6 kinase (p70S6K1). Overexpression of dominant-negative mutants of Akt inhibited ILK-dependent activation of p70S6K1, indicating that Akt is upstream of p70S6K1 in response to ILK signaling. Overexpression of ILK was sufficient to induce Rac1 activation, which was abolish by a PI3K inhibitor, indicating that Rac1 activity is involved in ILK signaling in a PI3K dependent manner. Inhibition of Akt, Rac1, or p70S6K1 inhibited the effects of ILK on actin filaments and cell migration, suggesting a regulatory role of the PI3K/Akt/p70S6K1/Rac1 signaling pathway in response to ILK signaling. We have shown that overexpression of a dominant-negative ILK was sufficient to abolish fibronectin peptide (PHSRN)-induced rearrangements of actin filaments and cell migration and invasion. Taken together, our results identify a mechanism through which ILK can regulate both integrin-associated rearrangements of actin filaments and cell migration and invasion at the integrin receptor-proximal region.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/sj.onc.1208525", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2496364", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2438406", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2626318", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2471637", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2517372", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1097543", 
        "issn": [
          "0950-9232", 
          "1476-5594"
        ], 
        "name": "Oncogene", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "19", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "24"
      }
    ], 
    "name": "ILK mediates actin filament rearrangements and cell migration and invasion through PI3K/Akt/Rac1 signaling", 
    "pagination": "3154-3165", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "cf739c0e8a7a20ed395d59d15bde16009b9b3118b134ec70f85038919e6e0514"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "15735674"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "8711562"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/sj.onc.1208525"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1043551535"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/sj.onc.1208525", 
      "https://app.dimensions.ai/details/publication/pub.1043551535"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T12:43", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000363_0000000363/records_70064_00000001.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/1208525"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/sj.onc.1208525'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/sj.onc.1208525'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/sj.onc.1208525'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/sj.onc.1208525'


 

This table displays all metadata directly associated to this object as RDF triples.

375 TRIPLES      21 PREDICATES      96 URIs      45 LITERALS      33 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/sj.onc.1208525 schema:about N0aafb97172d54d7eb43d7632497920e9
2 N242c5a97473e441d804fab8bedf9d744
3 N2482b97a43c94591af5264d4cda1ea7b
4 N248aa14896764ea2b135081033359095
5 N27953f675119415f841335f42bb004e3
6 N3369d12af7314cf9b79ad37be676f205
7 N3755b432c5644ece97778f9aa44d6d9b
8 N3f00bf4f91064a2685c647adac4068b8
9 N440b5a7569b641c88b6eae2d9d335dda
10 N4863406ef3414434b91dc7dab4c8cbdd
11 N54a977ac1df945a5b32c82ca71ac8a05
12 N61a13bdfa6d54d1eb380fe21c0201e19
13 N8d184421455d40cc8a1e779c029e7b34
14 N9b3ea0688005494bae177f0a9805ce17
15 Nbdd7868a3a114544995eda76459263e0
16 Nbeb1858b7a9b4c628fcf1572b04339cb
17 Nc6bfb57faf164f6bb5e3634c5ed39d13
18 Nc9ca641417244c6d9b6cf353e97640aa
19 Nd2f2f394c8e44cc7a353a66e1900505a
20 Nda09f0bf753342fc83915a709ba346df
21 Nde4034f6e7ba4fbf99b23f7eaef41592
22 Ne287b7d21e554d0baa01c04750df5caa
23 Ne605b21157764e61b3aceb8ec4fad07f
24 Nf4863dffd64b456ba8aa9e62921b13b7
25 anzsrc-for:06
26 anzsrc-for:0601
27 schema:author N4ddcf6c5c9414dd8bf5b4592f7bccbe6
28 schema:citation sg:pub.10.1023/a:1023777013659
29 sg:pub.10.1038/376599a0
30 sg:pub.10.1038/379091a0
31 sg:pub.10.1038/sj.onc.1201753
32 sg:pub.10.1038/sj.onc.1203258
33 sg:pub.10.1038/sj.onc.1203877
34 sg:pub.10.1038/sj.onc.1203928
35 sg:pub.10.1038/sj.onc.1204910
36 sg:pub.10.1046/j.1440-1711.2000.00928.x
37 sg:pub.10.1385/ir:21:2-3:83
38 https://app.dimensions.ai/details/publication/pub.1074554962
39 https://app.dimensions.ai/details/publication/pub.1074588331
40 https://app.dimensions.ai/details/publication/pub.1074737905
41 https://doi.org/10.1002/(sici)1097-0029(19991001)47:1<67::aid-jemt7>3.0.co;2-p
42 https://doi.org/10.1002/(sici)1097-0185(19990301)254:3<348::aid-ar5>3.0.co;2-5
43 https://doi.org/10.1006/scbi.2000.0364
44 https://doi.org/10.1016/s0092-8674(00)80486-9
45 https://doi.org/10.1016/s0092-8674(00)81257-x
46 https://doi.org/10.1016/s0163-7258(02)00192-4
47 https://doi.org/10.1016/s0898-6568(01)00246-7
48 https://doi.org/10.1016/s0955-0674(99)00083-6
49 https://doi.org/10.1016/s0960-9822(01)00599-1
50 https://doi.org/10.1016/s0960-9822(02)00973-9
51 https://doi.org/10.1016/s0962-8924(01)02152-3
52 https://doi.org/10.1016/s0968-0004(00)01605-4
53 https://doi.org/10.1016/s0968-0004(01)01958-2
54 https://doi.org/10.1073/pnas.040560897
55 https://doi.org/10.1073/pnas.98.1.136
56 https://doi.org/10.1074/jbc.m102940200
57 https://doi.org/10.1074/jbc.m108257200
58 https://doi.org/10.1074/jbc.m207517200
59 https://doi.org/10.1074/jbc.r900037199
60 https://doi.org/10.1083/jcb.152.5.1007
61 https://doi.org/10.1083/jcb.200108077
62 https://doi.org/10.1091/mbc.01-08-0398
63 https://doi.org/10.1101/gad.11.18.2295
64 https://doi.org/10.1126/science.279.5350.509
65 https://doi.org/10.1146/annurev.biochem.68.1.965
66 https://doi.org/10.1146/annurev.cellbio.14.1.305
67 https://doi.org/10.1152/ajpcell.00142.2003
68 https://doi.org/10.1152/jappl.2001.91.2.963
69 https://doi.org/10.1161/01.res.86.8.892
70 https://doi.org/10.14670/hh-14.1001
71 schema:datePublished 2005-04
72 schema:datePublishedReg 2005-04-01
73 schema:description One of the hallmarks of integrin signaling is an increase in cell migration and invasion, both of which are associated with actin filament rearrangements. Integrin-linked kinase (ILK) is a cytoplasmic effector of integrin receptors. ILK is known to be involved in multiple cellular functions. However, the signaling pathways involved in ILK-mediated cellular structure and motility remain to be elucidated. Here, we have demonstrated that overexpression of ILK was sufficient to induce actin filament rearrangements, to form cell motility structures, and to increase cell migration and invasion in a phosphatidylinositol 3-kinase (PI3K)-dependent manner. This corresponds with the activation of both Akt and p70 ribosomal protein S6 kinase (p70S6K1). Overexpression of dominant-negative mutants of Akt inhibited ILK-dependent activation of p70S6K1, indicating that Akt is upstream of p70S6K1 in response to ILK signaling. Overexpression of ILK was sufficient to induce Rac1 activation, which was abolish by a PI3K inhibitor, indicating that Rac1 activity is involved in ILK signaling in a PI3K dependent manner. Inhibition of Akt, Rac1, or p70S6K1 inhibited the effects of ILK on actin filaments and cell migration, suggesting a regulatory role of the PI3K/Akt/p70S6K1/Rac1 signaling pathway in response to ILK signaling. We have shown that overexpression of a dominant-negative ILK was sufficient to abolish fibronectin peptide (PHSRN)-induced rearrangements of actin filaments and cell migration and invasion. Taken together, our results identify a mechanism through which ILK can regulate both integrin-associated rearrangements of actin filaments and cell migration and invasion at the integrin receptor-proximal region.
74 schema:genre research_article
75 schema:inLanguage en
76 schema:isAccessibleForFree true
77 schema:isPartOf N180470d5aa754ee08e0626e8e25cebfa
78 N3e1690ad35ba41798d32ceba5d4ad902
79 sg:journal.1097543
80 schema:name ILK mediates actin filament rearrangements and cell migration and invasion through PI3K/Akt/Rac1 signaling
81 schema:pagination 3154-3165
82 schema:productId N3121ddc292574569bab170e4e682293b
83 N36e178b742f144c9869b82cd7c8258e0
84 N777254f658964cc5b1076e2b87aef100
85 Na2d0457dce6645d6bd4d398aea1b7d07
86 Ndfd7e21d5e0e4223af67b843ff54c71b
87 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043551535
88 https://doi.org/10.1038/sj.onc.1208525
89 schema:sdDatePublished 2019-04-11T12:43
90 schema:sdLicense https://scigraph.springernature.com/explorer/license/
91 schema:sdPublisher N2660f66d160e4cb1a9bc8878832e9384
92 schema:url https://www.nature.com/articles/1208525
93 sgo:license sg:explorer/license/
94 sgo:sdDataset articles
95 rdf:type schema:ScholarlyArticle
96 N0aafb97172d54d7eb43d7632497920e9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
97 schema:name Humans
98 rdf:type schema:DefinedTerm
99 N0aba9885f4bc42c2ae99e9279f7b5171 rdf:first sg:person.012772056017.65
100 rdf:rest N7dc0f5e951ef4b2099537096ae874f53
101 N180470d5aa754ee08e0626e8e25cebfa schema:volumeNumber 24
102 rdf:type schema:PublicationVolume
103 N242c5a97473e441d804fab8bedf9d744 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
104 schema:name rac1 GTP-Binding Protein
105 rdf:type schema:DefinedTerm
106 N2482b97a43c94591af5264d4cda1ea7b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
107 schema:name Protein-Serine-Threonine Kinases
108 rdf:type schema:DefinedTerm
109 N248aa14896764ea2b135081033359095 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
110 schema:name Ribosomal Protein S6 Kinases, 70-kDa
111 rdf:type schema:DefinedTerm
112 N2660f66d160e4cb1a9bc8878832e9384 schema:name Springer Nature - SN SciGraph project
113 rdf:type schema:Organization
114 N27953f675119415f841335f42bb004e3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
115 schema:name Plasmids
116 rdf:type schema:DefinedTerm
117 N3121ddc292574569bab170e4e682293b schema:name pubmed_id
118 schema:value 15735674
119 rdf:type schema:PropertyValue
120 N3369d12af7314cf9b79ad37be676f205 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
121 schema:name Animals
122 rdf:type schema:DefinedTerm
123 N36e178b742f144c9869b82cd7c8258e0 schema:name dimensions_id
124 schema:value pub.1043551535
125 rdf:type schema:PropertyValue
126 N3755b432c5644ece97778f9aa44d6d9b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
127 schema:name Integrins
128 rdf:type schema:DefinedTerm
129 N3b1761a2f6264ab99e71baec442a5792 rdf:first sg:person.0674171654.32
130 rdf:rest N8736f766558c47279fc13feeb000b939
131 N3e1690ad35ba41798d32ceba5d4ad902 schema:issueNumber 19
132 rdf:type schema:PublicationIssue
133 N3f00bf4f91064a2685c647adac4068b8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
134 schema:name Genes, Dominant
135 rdf:type schema:DefinedTerm
136 N440b5a7569b641c88b6eae2d9d335dda schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
137 schema:name Wound Healing
138 rdf:type schema:DefinedTerm
139 N4863406ef3414434b91dc7dab4c8cbdd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
140 schema:name cdc42 GTP-Binding Protein
141 rdf:type schema:DefinedTerm
142 N4ddcf6c5c9414dd8bf5b4592f7bccbe6 rdf:first sg:person.01361150504.00
143 rdf:rest Nd47c13e836b84ac8a4e2f5f820d69ac4
144 N54a977ac1df945a5b32c82ca71ac8a05 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name Mutation
146 rdf:type schema:DefinedTerm
147 N591f62750a5d4c3ca74e1678ee963448 rdf:first sg:person.01236164564.95
148 rdf:rest Ncbdabe392dff412ca7280cdbc82ea5af
149 N61a13bdfa6d54d1eb380fe21c0201e19 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
150 schema:name Phosphatidylinositol 3-Kinases
151 rdf:type schema:DefinedTerm
152 N733f3d1b4a0940878552435767eee61d rdf:first sg:person.01300024427.45
153 rdf:rest N3b1761a2f6264ab99e71baec442a5792
154 N777254f658964cc5b1076e2b87aef100 schema:name readcube_id
155 schema:value cf739c0e8a7a20ed395d59d15bde16009b9b3118b134ec70f85038919e6e0514
156 rdf:type schema:PropertyValue
157 N7dc0f5e951ef4b2099537096ae874f53 rdf:first sg:person.0704747176.81
158 rdf:rest N591f62750a5d4c3ca74e1678ee963448
159 N8736f766558c47279fc13feeb000b939 rdf:first Ndddf5d6a79b54741a018e30d934b57e2
160 rdf:rest N0aba9885f4bc42c2ae99e9279f7b5171
161 N8d184421455d40cc8a1e779c029e7b34 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
162 schema:name Cytoplasm
163 rdf:type schema:DefinedTerm
164 N9b3ea0688005494bae177f0a9805ce17 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
165 schema:name Proto-Oncogene Proteins c-akt
166 rdf:type schema:DefinedTerm
167 Na2d0457dce6645d6bd4d398aea1b7d07 schema:name nlm_unique_id
168 schema:value 8711562
169 rdf:type schema:PropertyValue
170 Nbdd7868a3a114544995eda76459263e0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
171 schema:name Blotting, Western
172 rdf:type schema:DefinedTerm
173 Nbeb1858b7a9b4c628fcf1572b04339cb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
174 schema:name Fibroblasts
175 rdf:type schema:DefinedTerm
176 Nc6bfb57faf164f6bb5e3634c5ed39d13 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
177 schema:name Fibronectins
178 rdf:type schema:DefinedTerm
179 Nc9ca641417244c6d9b6cf353e97640aa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
180 schema:name Signal Transduction
181 rdf:type schema:DefinedTerm
182 Ncbdabe392dff412ca7280cdbc82ea5af rdf:first sg:person.011352625147.80
183 rdf:rest rdf:nil
184 Nd2f2f394c8e44cc7a353a66e1900505a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
185 schema:name Microscopy, Fluorescence
186 rdf:type schema:DefinedTerm
187 Nd47c13e836b84ac8a4e2f5f820d69ac4 rdf:first sg:person.011606612417.05
188 rdf:rest N733f3d1b4a0940878552435767eee61d
189 Nda09f0bf753342fc83915a709ba346df schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
190 schema:name Chickens
191 rdf:type schema:DefinedTerm
192 Ndddf5d6a79b54741a018e30d934b57e2 schema:affiliation https://www.grid.ac/institutes/grid.268154.c
193 schema:familyName Qiao
194 schema:givenName Meng
195 rdf:type schema:Person
196 Nde4034f6e7ba4fbf99b23f7eaef41592 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
197 schema:name Enzyme Activation
198 rdf:type schema:DefinedTerm
199 Ndfd7e21d5e0e4223af67b843ff54c71b schema:name doi
200 schema:value 10.1038/sj.onc.1208525
201 rdf:type schema:PropertyValue
202 Ne287b7d21e554d0baa01c04750df5caa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
203 schema:name Cell Movement
204 rdf:type schema:DefinedTerm
205 Ne605b21157764e61b3aceb8ec4fad07f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
206 schema:name Phosphorylation
207 rdf:type schema:DefinedTerm
208 Nf4863dffd64b456ba8aa9e62921b13b7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
209 schema:name Proto-Oncogene Proteins
210 rdf:type schema:DefinedTerm
211 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
212 schema:name Biological Sciences
213 rdf:type schema:DefinedTerm
214 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
215 schema:name Biochemistry and Cell Biology
216 rdf:type schema:DefinedTerm
217 sg:grant.2438406 http://pending.schema.org/fundedItem sg:pub.10.1038/sj.onc.1208525
218 rdf:type schema:MonetaryGrant
219 sg:grant.2471637 http://pending.schema.org/fundedItem sg:pub.10.1038/sj.onc.1208525
220 rdf:type schema:MonetaryGrant
221 sg:grant.2496364 http://pending.schema.org/fundedItem sg:pub.10.1038/sj.onc.1208525
222 rdf:type schema:MonetaryGrant
223 sg:grant.2517372 http://pending.schema.org/fundedItem sg:pub.10.1038/sj.onc.1208525
224 rdf:type schema:MonetaryGrant
225 sg:grant.2626318 http://pending.schema.org/fundedItem sg:pub.10.1038/sj.onc.1208525
226 rdf:type schema:MonetaryGrant
227 sg:journal.1097543 schema:issn 0950-9232
228 1476-5594
229 schema:name Oncogene
230 rdf:type schema:Periodical
231 sg:person.011352625147.80 schema:affiliation https://www.grid.ac/institutes/grid.268154.c
232 schema:familyName Jiang
233 schema:givenName Bing-Hua
234 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011352625147.80
235 rdf:type schema:Person
236 sg:person.011606612417.05 schema:affiliation https://www.grid.ac/institutes/grid.268154.c
237 schema:familyName Zhong
238 schema:givenName Xiaosong
239 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011606612417.05
240 rdf:type schema:Person
241 sg:person.01236164564.95 schema:affiliation https://www.grid.ac/institutes/grid.416809.2
242 schema:familyName Shi
243 schema:givenName Xianglin
244 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01236164564.95
245 rdf:type schema:Person
246 sg:person.012772056017.65 schema:affiliation https://www.grid.ac/institutes/grid.21925.3d
247 schema:familyName Wu
248 schema:givenName Chuanyue
249 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012772056017.65
250 rdf:type schema:Person
251 sg:person.01300024427.45 schema:affiliation https://www.grid.ac/institutes/grid.268154.c
252 schema:familyName Flynn
253 schema:givenName Daniel C
254 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01300024427.45
255 rdf:type schema:Person
256 sg:person.01361150504.00 schema:affiliation https://www.grid.ac/institutes/grid.416809.2
257 schema:familyName Qian
258 schema:givenName Yong
259 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01361150504.00
260 rdf:type schema:Person
261 sg:person.0674171654.32 schema:affiliation https://www.grid.ac/institutes/grid.268154.c
262 schema:familyName Zheng
263 schema:givenName Jenny Z
264 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0674171654.32
265 rdf:type schema:Person
266 sg:person.0704747176.81 schema:affiliation https://www.grid.ac/institutes/grid.17091.3e
267 schema:familyName Dedhar
268 schema:givenName Shoukat
269 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0704747176.81
270 rdf:type schema:Person
271 sg:pub.10.1023/a:1023777013659 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020945232
272 https://doi.org/10.1023/a:1023777013659
273 rdf:type schema:CreativeWork
274 sg:pub.10.1038/376599a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019263292
275 https://doi.org/10.1038/376599a0
276 rdf:type schema:CreativeWork
277 sg:pub.10.1038/379091a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026082455
278 https://doi.org/10.1038/379091a0
279 rdf:type schema:CreativeWork
280 sg:pub.10.1038/sj.onc.1201753 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026764034
281 https://doi.org/10.1038/sj.onc.1201753
282 rdf:type schema:CreativeWork
283 sg:pub.10.1038/sj.onc.1203258 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043845856
284 https://doi.org/10.1038/sj.onc.1203258
285 rdf:type schema:CreativeWork
286 sg:pub.10.1038/sj.onc.1203877 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041442636
287 https://doi.org/10.1038/sj.onc.1203877
288 rdf:type schema:CreativeWork
289 sg:pub.10.1038/sj.onc.1203928 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035885592
290 https://doi.org/10.1038/sj.onc.1203928
291 rdf:type schema:CreativeWork
292 sg:pub.10.1038/sj.onc.1204910 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032591546
293 https://doi.org/10.1038/sj.onc.1204910
294 rdf:type schema:CreativeWork
295 sg:pub.10.1046/j.1440-1711.2000.00928.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1028263458
296 https://doi.org/10.1046/j.1440-1711.2000.00928.x
297 rdf:type schema:CreativeWork
298 sg:pub.10.1385/ir:21:2-3:83 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032815453
299 https://doi.org/10.1385/ir:21:2-3:83
300 rdf:type schema:CreativeWork
301 https://app.dimensions.ai/details/publication/pub.1074554962 schema:CreativeWork
302 https://app.dimensions.ai/details/publication/pub.1074588331 schema:CreativeWork
303 https://app.dimensions.ai/details/publication/pub.1074737905 schema:CreativeWork
304 https://doi.org/10.1002/(sici)1097-0029(19991001)47:1<67::aid-jemt7>3.0.co;2-p schema:sameAs https://app.dimensions.ai/details/publication/pub.1000006401
305 rdf:type schema:CreativeWork
306 https://doi.org/10.1002/(sici)1097-0185(19990301)254:3<348::aid-ar5>3.0.co;2-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033211989
307 rdf:type schema:CreativeWork
308 https://doi.org/10.1006/scbi.2000.0364 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021228041
309 rdf:type schema:CreativeWork
310 https://doi.org/10.1016/s0092-8674(00)80486-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032018827
311 rdf:type schema:CreativeWork
312 https://doi.org/10.1016/s0092-8674(00)81257-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1014119038
313 rdf:type schema:CreativeWork
314 https://doi.org/10.1016/s0163-7258(02)00192-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000250039
315 rdf:type schema:CreativeWork
316 https://doi.org/10.1016/s0898-6568(01)00246-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023418084
317 rdf:type schema:CreativeWork
318 https://doi.org/10.1016/s0955-0674(99)00083-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014578287
319 rdf:type schema:CreativeWork
320 https://doi.org/10.1016/s0960-9822(01)00599-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032945519
321 rdf:type schema:CreativeWork
322 https://doi.org/10.1016/s0960-9822(02)00973-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024839636
323 rdf:type schema:CreativeWork
324 https://doi.org/10.1016/s0962-8924(01)02152-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014140410
325 rdf:type schema:CreativeWork
326 https://doi.org/10.1016/s0968-0004(00)01605-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048047171
327 rdf:type schema:CreativeWork
328 https://doi.org/10.1016/s0968-0004(01)01958-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036134633
329 rdf:type schema:CreativeWork
330 https://doi.org/10.1073/pnas.040560897 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009427155
331 rdf:type schema:CreativeWork
332 https://doi.org/10.1073/pnas.98.1.136 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019734493
333 rdf:type schema:CreativeWork
334 https://doi.org/10.1074/jbc.m102940200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017819162
335 rdf:type schema:CreativeWork
336 https://doi.org/10.1074/jbc.m108257200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022998023
337 rdf:type schema:CreativeWork
338 https://doi.org/10.1074/jbc.m207517200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047991640
339 rdf:type schema:CreativeWork
340 https://doi.org/10.1074/jbc.r900037199 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037338424
341 rdf:type schema:CreativeWork
342 https://doi.org/10.1083/jcb.152.5.1007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046226680
343 rdf:type schema:CreativeWork
344 https://doi.org/10.1083/jcb.200108077 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034315874
345 rdf:type schema:CreativeWork
346 https://doi.org/10.1091/mbc.01-08-0398 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012685828
347 rdf:type schema:CreativeWork
348 https://doi.org/10.1101/gad.11.18.2295 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051224316
349 rdf:type schema:CreativeWork
350 https://doi.org/10.1126/science.279.5350.509 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047090124
351 rdf:type schema:CreativeWork
352 https://doi.org/10.1146/annurev.biochem.68.1.965 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034140297
353 rdf:type schema:CreativeWork
354 https://doi.org/10.1146/annurev.cellbio.14.1.305 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053104868
355 rdf:type schema:CreativeWork
356 https://doi.org/10.1152/ajpcell.00142.2003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003601205
357 rdf:type schema:CreativeWork
358 https://doi.org/10.1152/jappl.2001.91.2.963 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074850669
359 rdf:type schema:CreativeWork
360 https://doi.org/10.1161/01.res.86.8.892 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002026857
361 rdf:type schema:CreativeWork
362 https://doi.org/10.14670/hh-14.1001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074498339
363 rdf:type schema:CreativeWork
364 https://www.grid.ac/institutes/grid.17091.3e schema:alternateName University of British Columbia
365 schema:name Department of Biochemistry, University of British Columbia, BC, Cancer Agency and Vancouver Hospital, Jack Bell Research Center, Vancouver, BC, Canada V6H 3Z6
366 rdf:type schema:Organization
367 https://www.grid.ac/institutes/grid.21925.3d schema:alternateName University of Pittsburgh
368 schema:name Department of Pathology, University of Pittsburgh, Pittsburgh, PA 15261, USA
369 rdf:type schema:Organization
370 https://www.grid.ac/institutes/grid.268154.c schema:alternateName West Virginia University
371 schema:name The Mary Babb Randolph Cancer Center and the Department of Microbiology, Immunology, and Cell Biology, West Virginia University, Morgantown, WV 26506-9300, USA
372 rdf:type schema:Organization
373 https://www.grid.ac/institutes/grid.416809.2 schema:alternateName National Institute for Occupational Safety and Health
374 schema:name Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26506, USA
375 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...