Reduced expression of Hugl-1, the human homologue of Drosophila tumour suppressor gene lgl, contributes to progression of colorectal cancer View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2005-04

AUTHORS

Carl C Schimanski, Gösta Schmitz, Anuba Kashyap, Anja K Bosserhoff, Frauke Bataille, Stephan C Schäfer, Hans A Lehr, Martin R Berger, Peter R Galle, Susanne Strand, Dennis Strand

ABSTRACT

The human gene, human giant larvae (Hugl-1/Llg1/Lgl1) has significant homology to the Drosophila tumour suppressor gene lethal(2)giant larvae (lgl). The lgl gene codes for a cortical cytoskeleton protein, Lgl, that binds Myosin II and is involved in maintaining cell polarity and epithelial integrity. The human protein, Hugl-1 contains several conserved functional domains found in Lgl, suggesting that these proteins may have closely related functions. Whether loss of Hugl expression plays a role in human tumorigenesis has so far not been extensively investigated. Thus, we evaluated tumour tissues from 94 patients undergoing surgery for colorectal cancer (CRC) for loss of Hugl-1 transcription and compared our findings with the clinical data from each of these patients. We found that Hugl-1 was lost in 75% of tumour samples and these losses were associated with advanced stage and particularly with lymph node metastases. Reduced Hugl-1 expression during the adenoma-carcinoma sequence occurring as early as in colorectal adenomas was detected by both immunohistochemical and reverse transcription-polymerase chain reaction analysis. Functional assays with ecdysone-inducible cell lines revealed that Hugl-1 expression increased cell adhesion and decreased cell migration. Our studies thus indicate that downregulation of Hugl-1 contributes to CRC progression. More... »

PAGES

1208520

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/sj.onc.1208520

DOI

http://dx.doi.org/10.1038/sj.onc.1208520

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1038877911

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/15735678


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adenoma", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Blotting, Western", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Caco-2 Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Carcinoma", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Adhesion", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Cycle", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Differentiation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Line", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Line, Tumor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Movement", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Colorectal Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cytoskeletal Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cytoskeleton", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Disease Progression", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Down-Regulation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Drosophila Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Drosophila melanogaster", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Expression Regulation, Neoplastic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Green Fluorescent Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Immunohistochemistry", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Intestinal Mucosa", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Microscopy, Fluorescence", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein Structure, Tertiary", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Reverse Transcriptase Polymerase Chain Reaction", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Transcription, Genetic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tumor Suppressor Proteins", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Johannes Gutenberg University of Mainz", 
          "id": "https://www.grid.ac/institutes/grid.5802.f", 
          "name": [
            "First Department of Internal Medicine, Johannes Gutenberg University, 55101 Mainz, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Schimanski", 
        "givenName": "Carl C", 
        "id": "sg:person.01032450575.16", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01032450575.16"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Johannes Gutenberg University of Mainz", 
          "id": "https://www.grid.ac/institutes/grid.5802.f", 
          "name": [
            "First Department of Internal Medicine, Johannes Gutenberg University, 55101 Mainz, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Schmitz", 
        "givenName": "G\u00f6sta", 
        "id": "sg:person.0610670546.86", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0610670546.86"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Johannes Gutenberg University of Mainz", 
          "id": "https://www.grid.ac/institutes/grid.5802.f", 
          "name": [
            "First Department of Internal Medicine, Johannes Gutenberg University, 55101 Mainz, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kashyap", 
        "givenName": "Anuba", 
        "id": "sg:person.01324320312.48", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01324320312.48"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Regensburg", 
          "id": "https://www.grid.ac/institutes/grid.7727.5", 
          "name": [
            "Institute of Pathology, University Regensburg, 93053 Regensburg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bosserhoff", 
        "givenName": "Anja K", 
        "id": "sg:person.01110673311.51", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01110673311.51"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Regensburg", 
          "id": "https://www.grid.ac/institutes/grid.7727.5", 
          "name": [
            "Institute of Pathology, University Regensburg, 93053 Regensburg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bataille", 
        "givenName": "Frauke", 
        "id": "sg:person.01155705067.32", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01155705067.32"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Johannes Gutenberg University of Mainz", 
          "id": "https://www.grid.ac/institutes/grid.5802.f", 
          "name": [
            "Institute of Pathology, Johannes Gutenberg University, 55131 Mainz, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sch\u00e4fer", 
        "givenName": "Stephan C", 
        "id": "sg:person.01016207776.05", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01016207776.05"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Johannes Gutenberg University of Mainz", 
          "id": "https://www.grid.ac/institutes/grid.5802.f", 
          "name": [
            "Institute of Pathology, Johannes Gutenberg University, 55131 Mainz, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lehr", 
        "givenName": "Hans A", 
        "id": "sg:person.0754541346.65", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0754541346.65"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "German Cancer Research Center", 
          "id": "https://www.grid.ac/institutes/grid.7497.d", 
          "name": [
            "Unit of Toxicology and Chemotherapy, German Cancer Research Center, 69120 Heidelberg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Berger", 
        "givenName": "Martin R", 
        "id": "sg:person.01256203524.22", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01256203524.22"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Johannes Gutenberg University of Mainz", 
          "id": "https://www.grid.ac/institutes/grid.5802.f", 
          "name": [
            "First Department of Internal Medicine, Johannes Gutenberg University, 55101 Mainz, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Galle", 
        "givenName": "Peter R", 
        "id": "sg:person.01301201567.26", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01301201567.26"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Johannes Gutenberg University of Mainz", 
          "id": "https://www.grid.ac/institutes/grid.5802.f", 
          "name": [
            "First Department of Internal Medicine, Johannes Gutenberg University, 55101 Mainz, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Strand", 
        "givenName": "Susanne", 
        "id": "sg:person.01307636443.24", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01307636443.24"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Johannes Gutenberg University of Mainz", 
          "id": "https://www.grid.ac/institutes/grid.5802.f", 
          "name": [
            "First Department of Internal Medicine, Johannes Gutenberg University, 55101 Mainz, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Strand", 
        "givenName": "Dennis", 
        "id": "sg:person.01311454410.09", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01311454410.09"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1002/bies.10286", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004928992"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/jmg.37.4.298", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005604240"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ygyno.2004.01.025", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006163672"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-03-2100", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007443002"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncb948", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007534413", 
          "https://doi.org/10.1038/ncb948"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncb948", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007534413", 
          "https://doi.org/10.1038/ncb948"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/annonc/mdf127", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012034927"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000134167", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012740477"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0168-9525(93)90209-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014683468"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bjc.1998.645", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018731498", 
          "https://doi.org/10.1038/bjc.1998.645"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bjc.1998.645", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018731498", 
          "https://doi.org/10.1038/bjc.1998.645"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/dbio.1993.1195", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019277856"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.127.5.1345", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020875862"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.127.5.1361", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025955929"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.1178004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026179013"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ijc.2910540413", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026679042"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35046087", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028466624", 
          "https://doi.org/10.1038/35046087"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncb896", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028473525", 
          "https://doi.org/10.1038/ncb896"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncb896", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028473525", 
          "https://doi.org/10.1038/ncb896"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s004270050145", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030378760", 
          "https://doi.org/10.1007/s004270050145"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0960-9822(03)00244-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031773981"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0960-9822(03)00244-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031773981"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1207154", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032828482", 
          "https://doi.org/10.1038/sj.onc.1207154"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1207154", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032828482", 
          "https://doi.org/10.1038/sj.onc.1207154"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0925-4773(97)00658-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033207672"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/dbio.1995.0017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034121117"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1203309", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034620804", 
          "https://doi.org/10.1038/sj.onc.1203309"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1203309", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034620804", 
          "https://doi.org/10.1038/sj.onc.1203309"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1208023", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036029035", 
          "https://doi.org/10.1038/sj.onc.1208023"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1208023", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036029035", 
          "https://doi.org/10.1038/sj.onc.1208023"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/1097-0142(19920915)70:4+<1727::aid-cncr2820701613>3.0.co;2-p", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037513657"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/gcc.1140", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041395480"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0022-1759(91)90198-o", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041435308"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0022-1759(91)90198-o", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041435308"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.273.50.33610", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041771343"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/carcin/23.11.1791", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043214175"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1098-2264(199701)18:1<50::aid-gcc6>3.0.co;2-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046926552"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1098-2264(199907)25:3<230::aid-gcc5>3.0.co;2-e", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047782488"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1469-1809.1992.tb01136.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048163209"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1203982", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049311071", 
          "https://doi.org/10.1038/sj.onc.1203982"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1203982", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049311071", 
          "https://doi.org/10.1038/sj.onc.1203982"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3322/canjclin.46.1.5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050719159"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.122612899", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052050263"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.66.1.188", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052653110"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.96525", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062663347"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074842308", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1075329287", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082405862", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082524966", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082689333", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083300825", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2005-04", 
    "datePublishedReg": "2005-04-01", 
    "description": "The human gene, human giant larvae (Hugl-1/Llg1/Lgl1) has significant homology to the Drosophila tumour suppressor gene lethal(2)giant larvae (lgl). The lgl gene codes for a cortical cytoskeleton protein, Lgl, that binds Myosin II and is involved in maintaining cell polarity and epithelial integrity. The human protein, Hugl-1 contains several conserved functional domains found in Lgl, suggesting that these proteins may have closely related functions. Whether loss of Hugl expression plays a role in human tumorigenesis has so far not been extensively investigated. Thus, we evaluated tumour tissues from 94 patients undergoing surgery for colorectal cancer (CRC) for loss of Hugl-1 transcription and compared our findings with the clinical data from each of these patients. We found that Hugl-1 was lost in 75% of tumour samples and these losses were associated with advanced stage and particularly with lymph node metastases. Reduced Hugl-1 expression during the adenoma-carcinoma sequence occurring as early as in colorectal adenomas was detected by both immunohistochemical and reverse transcription-polymerase chain reaction analysis. Functional assays with ecdysone-inducible cell lines revealed that Hugl-1 expression increased cell adhesion and decreased cell migration. Our studies thus indicate that downregulation of Hugl-1 contributes to CRC progression.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/sj.onc.1208520", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1097543", 
        "issn": [
          "0950-9232", 
          "1476-5594"
        ], 
        "name": "Oncogene", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "19", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "24"
      }
    ], 
    "name": "Reduced expression of Hugl-1, the human homologue of Drosophila tumour suppressor gene lgl, contributes to progression of colorectal cancer", 
    "pagination": "1208520", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "b931d981c32c551babd3434c0f453c4c310f6a941075ff7e0d3162510d1bfdd1"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "15735678"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "8711562"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/sj.onc.1208520"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1038877911"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/sj.onc.1208520", 
      "https://app.dimensions.ai/details/publication/pub.1038877911"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T12:39", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000363_0000000363/records_70043_00000001.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://www.nature.com/articles/1208520"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/sj.onc.1208520'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/sj.onc.1208520'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/sj.onc.1208520'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/sj.onc.1208520'


 

This table displays all metadata directly associated to this object as RDF triples.

411 TRIPLES      21 PREDICATES      105 URIs      55 LITERALS      43 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/sj.onc.1208520 schema:about N05b81510475040459c8f240336d587a9
2 N0ec7ffd87aa749babbe8eea8663ca429
3 N0fb475e4cd974a09928c27b23a7e9c19
4 N113de687756c4c53bf375e5b83498862
5 N2d6fc067ca4a4e8f917313544c39427f
6 N2de732b39dfc4cfa824b450297fcd06d
7 N30c72066bed64419b3e44c3157948f4e
8 N316edca669004c17b5f26e70839762c9
9 N34650a1bcbc34923b16ecb07a31fb335
10 N3ee32ea6b17b436fb1de88305733ef30
11 N3f69b7c970844c8b82ad2444f4bdc8b8
12 N40f035f355ef4b3eb4c5d5bbf051e2c4
13 N50756f6bee084d0892e80b74e597f2b6
14 N53d974d63e084bf88ebb099a9c1ca6aa
15 N5f9369f8444b4a0f8c7f291cd61a8927
16 N5f9dc6ceaeb74ca5974feb3d12c11ff0
17 N707fa3fb9a9b4abd97881dc3e1af1b08
18 N711a656f989f4b288504a3b479ce0c0a
19 N71347d8015a149eeb06a1307104a80c5
20 N7b75fa1cf15941ca80f06021d58d46cf
21 N7d2335a05919439faea9c0e9bc6d9eee
22 N8aa1cf743bb947d3bb0e0530e1d66a22
23 N973042d1f96942aa8305a80f92341b4e
24 Na5476090cb994b6fba15ddbe3aae83c6
25 Na5d062e478294e818d0eeae3d31bff87
26 Nba70b1ec719b441ba690a2b386fe4d57
27 Nbcbd64ff30824d3780e405928a6678cd
28 Ndb6db7ae1c5040c983729d6d46c57e7d
29 Ne01a13e7dd524e4ba296c5fcbc69b806
30 Ne1d67e0bafee4d4b976480cd1a936b5d
31 Ne1dc7e4956154d21a8595f7c56514efd
32 Neb051650f23c46dd8aa2e25703240e36
33 Nf72f6ea6801c4e7497ff773d05f443ad
34 Nf82ed93322464328a901b09dcba13a59
35 anzsrc-for:11
36 anzsrc-for:1112
37 schema:author N942d1b5fe3164fa094041a5401cf94a9
38 schema:citation sg:pub.10.1007/s004270050145
39 sg:pub.10.1038/35046087
40 sg:pub.10.1038/bjc.1998.645
41 sg:pub.10.1038/ncb896
42 sg:pub.10.1038/ncb948
43 sg:pub.10.1038/sj.onc.1203309
44 sg:pub.10.1038/sj.onc.1203982
45 sg:pub.10.1038/sj.onc.1207154
46 sg:pub.10.1038/sj.onc.1208023
47 https://app.dimensions.ai/details/publication/pub.1074842308
48 https://app.dimensions.ai/details/publication/pub.1075329287
49 https://app.dimensions.ai/details/publication/pub.1082405862
50 https://app.dimensions.ai/details/publication/pub.1082524966
51 https://app.dimensions.ai/details/publication/pub.1082689333
52 https://app.dimensions.ai/details/publication/pub.1083300825
53 https://doi.org/10.1002/(sici)1098-2264(199701)18:1<50::aid-gcc6>3.0.co;2-0
54 https://doi.org/10.1002/(sici)1098-2264(199907)25:3<230::aid-gcc5>3.0.co;2-e
55 https://doi.org/10.1002/1097-0142(19920915)70:4+<1727::aid-cncr2820701613>3.0.co;2-p
56 https://doi.org/10.1002/bies.10286
57 https://doi.org/10.1002/gcc.1140
58 https://doi.org/10.1002/ijc.2910540413
59 https://doi.org/10.1006/dbio.1993.1195
60 https://doi.org/10.1006/dbio.1995.0017
61 https://doi.org/10.1016/0022-1759(91)90198-o
62 https://doi.org/10.1016/0168-9525(93)90209-z
63 https://doi.org/10.1016/j.ygyno.2004.01.025
64 https://doi.org/10.1016/s0925-4773(97)00658-8
65 https://doi.org/10.1016/s0960-9822(03)00244-6
66 https://doi.org/10.1073/pnas.122612899
67 https://doi.org/10.1074/jbc.273.50.33610
68 https://doi.org/10.1083/jcb.127.5.1345
69 https://doi.org/10.1083/jcb.127.5.1361
70 https://doi.org/10.1083/jcb.66.1.188
71 https://doi.org/10.1093/annonc/mdf127
72 https://doi.org/10.1093/carcin/23.11.1791
73 https://doi.org/10.1101/gad.1178004
74 https://doi.org/10.1111/j.1469-1809.1992.tb01136.x
75 https://doi.org/10.1126/science.96525
76 https://doi.org/10.1136/jmg.37.4.298
77 https://doi.org/10.1158/0008-5472.can-03-2100
78 https://doi.org/10.1159/000134167
79 https://doi.org/10.3322/canjclin.46.1.5
80 schema:datePublished 2005-04
81 schema:datePublishedReg 2005-04-01
82 schema:description The human gene, human giant larvae (Hugl-1/Llg1/Lgl1) has significant homology to the Drosophila tumour suppressor gene lethal(2)giant larvae (lgl). The lgl gene codes for a cortical cytoskeleton protein, Lgl, that binds Myosin II and is involved in maintaining cell polarity and epithelial integrity. The human protein, Hugl-1 contains several conserved functional domains found in Lgl, suggesting that these proteins may have closely related functions. Whether loss of Hugl expression plays a role in human tumorigenesis has so far not been extensively investigated. Thus, we evaluated tumour tissues from 94 patients undergoing surgery for colorectal cancer (CRC) for loss of Hugl-1 transcription and compared our findings with the clinical data from each of these patients. We found that Hugl-1 was lost in 75% of tumour samples and these losses were associated with advanced stage and particularly with lymph node metastases. Reduced Hugl-1 expression during the adenoma-carcinoma sequence occurring as early as in colorectal adenomas was detected by both immunohistochemical and reverse transcription-polymerase chain reaction analysis. Functional assays with ecdysone-inducible cell lines revealed that Hugl-1 expression increased cell adhesion and decreased cell migration. Our studies thus indicate that downregulation of Hugl-1 contributes to CRC progression.
83 schema:genre research_article
84 schema:inLanguage en
85 schema:isAccessibleForFree true
86 schema:isPartOf N6cb7b223d1094ea4956dcef6a0a9150a
87 Nf0d86e5e6a3d42a5b0ab2565ebd215ac
88 sg:journal.1097543
89 schema:name Reduced expression of Hugl-1, the human homologue of Drosophila tumour suppressor gene lgl, contributes to progression of colorectal cancer
90 schema:pagination 1208520
91 schema:productId N71566cae2b4840d7ad18c0783368db20
92 N790efdb1b76f443cbc1cab2930822b1b
93 Nb23c784421654d58a492f8b470c1ca49
94 Nca53fc5dfc784b1aa6e1351b5d186440
95 Nf88c554c79584fbf97ab640d0d48211e
96 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038877911
97 https://doi.org/10.1038/sj.onc.1208520
98 schema:sdDatePublished 2019-04-11T12:39
99 schema:sdLicense https://scigraph.springernature.com/explorer/license/
100 schema:sdPublisher N9e785ce9f204464d8d73b5974c6b5053
101 schema:url http://www.nature.com/articles/1208520
102 sgo:license sg:explorer/license/
103 sgo:sdDataset articles
104 rdf:type schema:ScholarlyArticle
105 N05b81510475040459c8f240336d587a9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
106 schema:name Colorectal Neoplasms
107 rdf:type schema:DefinedTerm
108 N0ec7ffd87aa749babbe8eea8663ca429 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
109 schema:name Drosophila melanogaster
110 rdf:type schema:DefinedTerm
111 N0fb475e4cd974a09928c27b23a7e9c19 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
112 schema:name Cytoskeletal Proteins
113 rdf:type schema:DefinedTerm
114 N113de687756c4c53bf375e5b83498862 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
115 schema:name Blotting, Western
116 rdf:type schema:DefinedTerm
117 N2b671f62d89f4b358190d257ca78fc17 rdf:first sg:person.01311454410.09
118 rdf:rest rdf:nil
119 N2d6fc067ca4a4e8f917313544c39427f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
120 schema:name Immunohistochemistry
121 rdf:type schema:DefinedTerm
122 N2de732b39dfc4cfa824b450297fcd06d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
123 schema:name Adenoma
124 rdf:type schema:DefinedTerm
125 N30c72066bed64419b3e44c3157948f4e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
126 schema:name Protein Structure, Tertiary
127 rdf:type schema:DefinedTerm
128 N316edca669004c17b5f26e70839762c9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
129 schema:name Reverse Transcriptase Polymerase Chain Reaction
130 rdf:type schema:DefinedTerm
131 N3384f1d4d7d14f0eb8da7fcfc76ac829 rdf:first sg:person.0754541346.65
132 rdf:rest N54c8c5f2534f449f9221be778450a848
133 N34650a1bcbc34923b16ecb07a31fb335 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
134 schema:name Cell Adhesion
135 rdf:type schema:DefinedTerm
136 N3ee32ea6b17b436fb1de88305733ef30 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
137 schema:name Tumor Suppressor Proteins
138 rdf:type schema:DefinedTerm
139 N3f69b7c970844c8b82ad2444f4bdc8b8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
140 schema:name Neoplasms
141 rdf:type schema:DefinedTerm
142 N40f035f355ef4b3eb4c5d5bbf051e2c4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
143 schema:name Microscopy, Fluorescence
144 rdf:type schema:DefinedTerm
145 N43d54ab896e4440780c42f7c159b58c2 rdf:first sg:person.01110673311.51
146 rdf:rest N61ebc716b7954589afe40b57d91ba3fd
147 N50756f6bee084d0892e80b74e597f2b6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
148 schema:name Cell Differentiation
149 rdf:type schema:DefinedTerm
150 N53d974d63e084bf88ebb099a9c1ca6aa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
151 schema:name Adult
152 rdf:type schema:DefinedTerm
153 N54c8c5f2534f449f9221be778450a848 rdf:first sg:person.01256203524.22
154 rdf:rest N8544a82b57714861adb0c677666493e2
155 N58509c7fa37f4075b5d85927d57e2e83 rdf:first sg:person.01307636443.24
156 rdf:rest N2b671f62d89f4b358190d257ca78fc17
157 N5f9369f8444b4a0f8c7f291cd61a8927 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
158 schema:name Animals
159 rdf:type schema:DefinedTerm
160 N5f9dc6ceaeb74ca5974feb3d12c11ff0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
161 schema:name Disease Progression
162 rdf:type schema:DefinedTerm
163 N61ebc716b7954589afe40b57d91ba3fd rdf:first sg:person.01155705067.32
164 rdf:rest Nc5685c4da9b64bd19f5f882af913d3aa
165 N6cb7b223d1094ea4956dcef6a0a9150a schema:issueNumber 19
166 rdf:type schema:PublicationIssue
167 N707fa3fb9a9b4abd97881dc3e1af1b08 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
168 schema:name Drosophila Proteins
169 rdf:type schema:DefinedTerm
170 N711a656f989f4b288504a3b479ce0c0a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
171 schema:name Carcinoma
172 rdf:type schema:DefinedTerm
173 N71347d8015a149eeb06a1307104a80c5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
174 schema:name Cell Line
175 rdf:type schema:DefinedTerm
176 N71566cae2b4840d7ad18c0783368db20 schema:name nlm_unique_id
177 schema:value 8711562
178 rdf:type schema:PropertyValue
179 N790efdb1b76f443cbc1cab2930822b1b schema:name doi
180 schema:value 10.1038/sj.onc.1208520
181 rdf:type schema:PropertyValue
182 N7b75fa1cf15941ca80f06021d58d46cf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
183 schema:name Cytoskeleton
184 rdf:type schema:DefinedTerm
185 N7d2335a05919439faea9c0e9bc6d9eee schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
186 schema:name Caco-2 Cells
187 rdf:type schema:DefinedTerm
188 N8544a82b57714861adb0c677666493e2 rdf:first sg:person.01301201567.26
189 rdf:rest N58509c7fa37f4075b5d85927d57e2e83
190 N8aa1cf743bb947d3bb0e0530e1d66a22 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
191 schema:name Cell Movement
192 rdf:type schema:DefinedTerm
193 N942d1b5fe3164fa094041a5401cf94a9 rdf:first sg:person.01032450575.16
194 rdf:rest N9a16bf341e844c1d819e2e9ea63c0eed
195 N973042d1f96942aa8305a80f92341b4e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
196 schema:name Gene Expression Regulation, Neoplastic
197 rdf:type schema:DefinedTerm
198 N9a16bf341e844c1d819e2e9ea63c0eed rdf:first sg:person.0610670546.86
199 rdf:rest Nca9a22465bcf45809500ed20139e49a7
200 N9e785ce9f204464d8d73b5974c6b5053 schema:name Springer Nature - SN SciGraph project
201 rdf:type schema:Organization
202 Na5476090cb994b6fba15ddbe3aae83c6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
203 schema:name Humans
204 rdf:type schema:DefinedTerm
205 Na5d062e478294e818d0eeae3d31bff87 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
206 schema:name Down-Regulation
207 rdf:type schema:DefinedTerm
208 Nb23c784421654d58a492f8b470c1ca49 schema:name pubmed_id
209 schema:value 15735678
210 rdf:type schema:PropertyValue
211 Nba70b1ec719b441ba690a2b386fe4d57 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
212 schema:name Cell Cycle
213 rdf:type schema:DefinedTerm
214 Nbcbd64ff30824d3780e405928a6678cd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
215 schema:name Female
216 rdf:type schema:DefinedTerm
217 Nc5685c4da9b64bd19f5f882af913d3aa rdf:first sg:person.01016207776.05
218 rdf:rest N3384f1d4d7d14f0eb8da7fcfc76ac829
219 Nca53fc5dfc784b1aa6e1351b5d186440 schema:name dimensions_id
220 schema:value pub.1038877911
221 rdf:type schema:PropertyValue
222 Nca9a22465bcf45809500ed20139e49a7 rdf:first sg:person.01324320312.48
223 rdf:rest N43d54ab896e4440780c42f7c159b58c2
224 Ndb6db7ae1c5040c983729d6d46c57e7d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
225 schema:name Green Fluorescent Proteins
226 rdf:type schema:DefinedTerm
227 Ne01a13e7dd524e4ba296c5fcbc69b806 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
228 schema:name Proteins
229 rdf:type schema:DefinedTerm
230 Ne1d67e0bafee4d4b976480cd1a936b5d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
231 schema:name Intestinal Mucosa
232 rdf:type schema:DefinedTerm
233 Ne1dc7e4956154d21a8595f7c56514efd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
234 schema:name Middle Aged
235 rdf:type schema:DefinedTerm
236 Neb051650f23c46dd8aa2e25703240e36 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
237 schema:name Male
238 rdf:type schema:DefinedTerm
239 Nf0d86e5e6a3d42a5b0ab2565ebd215ac schema:volumeNumber 24
240 rdf:type schema:PublicationVolume
241 Nf72f6ea6801c4e7497ff773d05f443ad schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
242 schema:name Cell Line, Tumor
243 rdf:type schema:DefinedTerm
244 Nf82ed93322464328a901b09dcba13a59 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
245 schema:name Transcription, Genetic
246 rdf:type schema:DefinedTerm
247 Nf88c554c79584fbf97ab640d0d48211e schema:name readcube_id
248 schema:value b931d981c32c551babd3434c0f453c4c310f6a941075ff7e0d3162510d1bfdd1
249 rdf:type schema:PropertyValue
250 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
251 schema:name Medical and Health Sciences
252 rdf:type schema:DefinedTerm
253 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
254 schema:name Oncology and Carcinogenesis
255 rdf:type schema:DefinedTerm
256 sg:journal.1097543 schema:issn 0950-9232
257 1476-5594
258 schema:name Oncogene
259 rdf:type schema:Periodical
260 sg:person.01016207776.05 schema:affiliation https://www.grid.ac/institutes/grid.5802.f
261 schema:familyName Schäfer
262 schema:givenName Stephan C
263 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01016207776.05
264 rdf:type schema:Person
265 sg:person.01032450575.16 schema:affiliation https://www.grid.ac/institutes/grid.5802.f
266 schema:familyName Schimanski
267 schema:givenName Carl C
268 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01032450575.16
269 rdf:type schema:Person
270 sg:person.01110673311.51 schema:affiliation https://www.grid.ac/institutes/grid.7727.5
271 schema:familyName Bosserhoff
272 schema:givenName Anja K
273 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01110673311.51
274 rdf:type schema:Person
275 sg:person.01155705067.32 schema:affiliation https://www.grid.ac/institutes/grid.7727.5
276 schema:familyName Bataille
277 schema:givenName Frauke
278 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01155705067.32
279 rdf:type schema:Person
280 sg:person.01256203524.22 schema:affiliation https://www.grid.ac/institutes/grid.7497.d
281 schema:familyName Berger
282 schema:givenName Martin R
283 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01256203524.22
284 rdf:type schema:Person
285 sg:person.01301201567.26 schema:affiliation https://www.grid.ac/institutes/grid.5802.f
286 schema:familyName Galle
287 schema:givenName Peter R
288 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01301201567.26
289 rdf:type schema:Person
290 sg:person.01307636443.24 schema:affiliation https://www.grid.ac/institutes/grid.5802.f
291 schema:familyName Strand
292 schema:givenName Susanne
293 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01307636443.24
294 rdf:type schema:Person
295 sg:person.01311454410.09 schema:affiliation https://www.grid.ac/institutes/grid.5802.f
296 schema:familyName Strand
297 schema:givenName Dennis
298 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01311454410.09
299 rdf:type schema:Person
300 sg:person.01324320312.48 schema:affiliation https://www.grid.ac/institutes/grid.5802.f
301 schema:familyName Kashyap
302 schema:givenName Anuba
303 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01324320312.48
304 rdf:type schema:Person
305 sg:person.0610670546.86 schema:affiliation https://www.grid.ac/institutes/grid.5802.f
306 schema:familyName Schmitz
307 schema:givenName Gösta
308 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0610670546.86
309 rdf:type schema:Person
310 sg:person.0754541346.65 schema:affiliation https://www.grid.ac/institutes/grid.5802.f
311 schema:familyName Lehr
312 schema:givenName Hans A
313 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0754541346.65
314 rdf:type schema:Person
315 sg:pub.10.1007/s004270050145 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030378760
316 https://doi.org/10.1007/s004270050145
317 rdf:type schema:CreativeWork
318 sg:pub.10.1038/35046087 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028466624
319 https://doi.org/10.1038/35046087
320 rdf:type schema:CreativeWork
321 sg:pub.10.1038/bjc.1998.645 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018731498
322 https://doi.org/10.1038/bjc.1998.645
323 rdf:type schema:CreativeWork
324 sg:pub.10.1038/ncb896 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028473525
325 https://doi.org/10.1038/ncb896
326 rdf:type schema:CreativeWork
327 sg:pub.10.1038/ncb948 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007534413
328 https://doi.org/10.1038/ncb948
329 rdf:type schema:CreativeWork
330 sg:pub.10.1038/sj.onc.1203309 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034620804
331 https://doi.org/10.1038/sj.onc.1203309
332 rdf:type schema:CreativeWork
333 sg:pub.10.1038/sj.onc.1203982 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049311071
334 https://doi.org/10.1038/sj.onc.1203982
335 rdf:type schema:CreativeWork
336 sg:pub.10.1038/sj.onc.1207154 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032828482
337 https://doi.org/10.1038/sj.onc.1207154
338 rdf:type schema:CreativeWork
339 sg:pub.10.1038/sj.onc.1208023 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036029035
340 https://doi.org/10.1038/sj.onc.1208023
341 rdf:type schema:CreativeWork
342 https://app.dimensions.ai/details/publication/pub.1074842308 schema:CreativeWork
343 https://app.dimensions.ai/details/publication/pub.1075329287 schema:CreativeWork
344 https://app.dimensions.ai/details/publication/pub.1082405862 schema:CreativeWork
345 https://app.dimensions.ai/details/publication/pub.1082524966 schema:CreativeWork
346 https://app.dimensions.ai/details/publication/pub.1082689333 schema:CreativeWork
347 https://app.dimensions.ai/details/publication/pub.1083300825 schema:CreativeWork
348 https://doi.org/10.1002/(sici)1098-2264(199701)18:1<50::aid-gcc6>3.0.co;2-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046926552
349 rdf:type schema:CreativeWork
350 https://doi.org/10.1002/(sici)1098-2264(199907)25:3<230::aid-gcc5>3.0.co;2-e schema:sameAs https://app.dimensions.ai/details/publication/pub.1047782488
351 rdf:type schema:CreativeWork
352 https://doi.org/10.1002/1097-0142(19920915)70:4+<1727::aid-cncr2820701613>3.0.co;2-p schema:sameAs https://app.dimensions.ai/details/publication/pub.1037513657
353 rdf:type schema:CreativeWork
354 https://doi.org/10.1002/bies.10286 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004928992
355 rdf:type schema:CreativeWork
356 https://doi.org/10.1002/gcc.1140 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041395480
357 rdf:type schema:CreativeWork
358 https://doi.org/10.1002/ijc.2910540413 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026679042
359 rdf:type schema:CreativeWork
360 https://doi.org/10.1006/dbio.1993.1195 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019277856
361 rdf:type schema:CreativeWork
362 https://doi.org/10.1006/dbio.1995.0017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034121117
363 rdf:type schema:CreativeWork
364 https://doi.org/10.1016/0022-1759(91)90198-o schema:sameAs https://app.dimensions.ai/details/publication/pub.1041435308
365 rdf:type schema:CreativeWork
366 https://doi.org/10.1016/0168-9525(93)90209-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1014683468
367 rdf:type schema:CreativeWork
368 https://doi.org/10.1016/j.ygyno.2004.01.025 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006163672
369 rdf:type schema:CreativeWork
370 https://doi.org/10.1016/s0925-4773(97)00658-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033207672
371 rdf:type schema:CreativeWork
372 https://doi.org/10.1016/s0960-9822(03)00244-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031773981
373 rdf:type schema:CreativeWork
374 https://doi.org/10.1073/pnas.122612899 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052050263
375 rdf:type schema:CreativeWork
376 https://doi.org/10.1074/jbc.273.50.33610 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041771343
377 rdf:type schema:CreativeWork
378 https://doi.org/10.1083/jcb.127.5.1345 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020875862
379 rdf:type schema:CreativeWork
380 https://doi.org/10.1083/jcb.127.5.1361 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025955929
381 rdf:type schema:CreativeWork
382 https://doi.org/10.1083/jcb.66.1.188 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052653110
383 rdf:type schema:CreativeWork
384 https://doi.org/10.1093/annonc/mdf127 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012034927
385 rdf:type schema:CreativeWork
386 https://doi.org/10.1093/carcin/23.11.1791 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043214175
387 rdf:type schema:CreativeWork
388 https://doi.org/10.1101/gad.1178004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026179013
389 rdf:type schema:CreativeWork
390 https://doi.org/10.1111/j.1469-1809.1992.tb01136.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1048163209
391 rdf:type schema:CreativeWork
392 https://doi.org/10.1126/science.96525 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062663347
393 rdf:type schema:CreativeWork
394 https://doi.org/10.1136/jmg.37.4.298 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005604240
395 rdf:type schema:CreativeWork
396 https://doi.org/10.1158/0008-5472.can-03-2100 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007443002
397 rdf:type schema:CreativeWork
398 https://doi.org/10.1159/000134167 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012740477
399 rdf:type schema:CreativeWork
400 https://doi.org/10.3322/canjclin.46.1.5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050719159
401 rdf:type schema:CreativeWork
402 https://www.grid.ac/institutes/grid.5802.f schema:alternateName Johannes Gutenberg University of Mainz
403 schema:name First Department of Internal Medicine, Johannes Gutenberg University, 55101 Mainz, Germany
404 Institute of Pathology, Johannes Gutenberg University, 55131 Mainz, Germany
405 rdf:type schema:Organization
406 https://www.grid.ac/institutes/grid.7497.d schema:alternateName German Cancer Research Center
407 schema:name Unit of Toxicology and Chemotherapy, German Cancer Research Center, 69120 Heidelberg, Germany
408 rdf:type schema:Organization
409 https://www.grid.ac/institutes/grid.7727.5 schema:alternateName University of Regensburg
410 schema:name Institute of Pathology, University Regensburg, 93053 Regensburg, Germany
411 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...