Interactions of EGFR and caveolin-1 in human glioblastoma cells: evidence that tyrosine phosphorylation regulates EGFR association with caveolae View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2004-07-26

AUTHORS

Abedelnasser Abulrob, Sabina Giuseppin, Moises F Andrade, Angela McDermid, Maria Moreno, Danica Stanimirovic

ABSTRACT

Epidermal growth factor receptor (EGFR) amplification and type III mutation (EGFRvIII), associated with constitutive tyrosine kinase activation and high malignancy, are commonly observed in glioblastoma tumors. The association of EGFR and EGFRvIII with caveolins was investigated in human glioblastoma cell lines, U87MG and U87MG-EGFRvIII. Caveolin-1 expression, determined by RT–PCR, real-time quantitative PCR and Western blot, was upregulated in glioblastoma cell lines (two-fold) and tumors (20–300-fold) compared to primary human astrocytes and nonmalignant brain tissue, respectively. U87MG-EGFRvIII expressed higher levels of caveolin-1 than U87MG. In contrast, the expression of caveolin-2 and -3 were downregulated in glioblastoma cells compared to astrocytes. A colocalization of EGFR, but not of EGFRvIII, with lipid rafts and caveolin-1 was observed by immunocytochemistry. Association of EGFR and EGFRvIII with caveolae, assessed in vitro by binding to caveolin scaffolding domain peptides and in vivo by immunocolocalization studies in cells and caveolae-enriched cellular fraction, was phosphorylation-dependent: ligand-induced phosphorylation of EGFR resulted in dissociation of EGFR from caveolae. In contrast, inhibition of the EGFRvIII constitutive tyrosine phosphorylation by AG1478 increased association of EGFRvIII with caveolin-1. AG1478 also increased caveolin-1 expression and reduced glioblastoma cell growth in a semi-solid agar. The evidence suggests that the phosphorylation-regulated sequestration of EGFR in caveolae may be involved in arresting constitutive or ligand-induced signaling through EGFR responsible for glial cell transformation. More... »

PAGES

6967-6979

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/sj.onc.1207911

DOI

http://dx.doi.org/10.1038/sj.onc.1207911

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1001198838

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/15273741


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Caveolin 1", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Caveolins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Division", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Line, Tumor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "ErbB Receptors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Glioblastoma", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Phosphorylation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Quinazolines", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tyrosine", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tyrphostins", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Cerebrovascular Research Group, Institute for Biological Sciences, National Research Council Canada, K1A0R6, Ottawa, ON, Canada", 
          "id": "http://www.grid.ac/institutes/grid.418626.f", 
          "name": [
            "Cerebrovascular Research Group, Institute for Biological Sciences, National Research Council Canada, K1A0R6, Ottawa, ON, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Abulrob", 
        "givenName": "Abedelnasser", 
        "id": "sg:person.0643277257.10", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0643277257.10"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Cerebrovascular Research Group, Institute for Biological Sciences, National Research Council Canada, K1A0R6, Ottawa, ON, Canada", 
          "id": "http://www.grid.ac/institutes/grid.418626.f", 
          "name": [
            "Cerebrovascular Research Group, Institute for Biological Sciences, National Research Council Canada, K1A0R6, Ottawa, ON, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Giuseppin", 
        "givenName": "Sabina", 
        "id": "sg:person.01062263144.09", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01062263144.09"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Cerebrovascular Research Group, Institute for Biological Sciences, National Research Council Canada, K1A0R6, Ottawa, ON, Canada", 
          "id": "http://www.grid.ac/institutes/grid.418626.f", 
          "name": [
            "Cerebrovascular Research Group, Institute for Biological Sciences, National Research Council Canada, K1A0R6, Ottawa, ON, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Andrade", 
        "givenName": "Moises F", 
        "id": "sg:person.01272456500.65", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01272456500.65"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Cerebrovascular Research Group, Institute for Biological Sciences, National Research Council Canada, K1A0R6, Ottawa, ON, Canada", 
          "id": "http://www.grid.ac/institutes/grid.418626.f", 
          "name": [
            "Cerebrovascular Research Group, Institute for Biological Sciences, National Research Council Canada, K1A0R6, Ottawa, ON, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "McDermid", 
        "givenName": "Angela", 
        "id": "sg:person.01176511544.07", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01176511544.07"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Cerebrovascular Research Group, Institute for Biological Sciences, National Research Council Canada, K1A0R6, Ottawa, ON, Canada", 
          "id": "http://www.grid.ac/institutes/grid.418626.f", 
          "name": [
            "Cerebrovascular Research Group, Institute for Biological Sciences, National Research Council Canada, K1A0R6, Ottawa, ON, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Moreno", 
        "givenName": "Maria", 
        "id": "sg:person.0622621033.74", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0622621033.74"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Cerebrovascular Research Group, Institute for Biological Sciences, National Research Council Canada, K1A0R6, Ottawa, ON, Canada", 
          "id": "http://www.grid.ac/institutes/grid.418626.f", 
          "name": [
            "Cerebrovascular Research Group, Institute for Biological Sciences, National Research Council Canada, K1A0R6, Ottawa, ON, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Stanimirovic", 
        "givenName": "Danica", 
        "id": "sg:person.01337470643.07", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01337470643.07"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1023/a:1013884426692", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022330300", 
          "https://doi.org/10.1023/a:1013884426692"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2004-07-26", 
    "datePublishedReg": "2004-07-26", 
    "description": "Epidermal growth factor receptor (EGFR) amplification and type III mutation (EGFRvIII), associated with constitutive tyrosine kinase activation and high malignancy, are commonly observed in glioblastoma tumors. The association of EGFR and EGFRvIII with caveolins was investigated in human glioblastoma cell lines, U87MG and U87MG-EGFRvIII. Caveolin-1 expression, determined by RT\u2013PCR, real-time quantitative PCR and Western blot, was upregulated in glioblastoma cell lines (two-fold) and tumors (20\u2013300-fold) compared to primary human astrocytes and nonmalignant brain tissue, respectively. U87MG-EGFRvIII expressed higher levels of caveolin-1 than U87MG. In contrast, the expression of caveolin-2 and -3 were downregulated in glioblastoma cells compared to astrocytes. A colocalization of EGFR, but not of EGFRvIII, with lipid rafts and caveolin-1 was observed by immunocytochemistry. Association of EGFR and EGFRvIII with caveolae, assessed in vitro by binding to caveolin scaffolding domain peptides and in vivo by immunocolocalization studies in cells and caveolae-enriched cellular fraction, was phosphorylation-dependent: ligand-induced phosphorylation of EGFR resulted in dissociation of EGFR from caveolae. In contrast, inhibition of the EGFRvIII constitutive tyrosine phosphorylation by AG1478 increased association of EGFRvIII with caveolin-1. AG1478 also increased caveolin-1 expression and reduced glioblastoma cell growth in a semi-solid agar. The evidence suggests that the phosphorylation-regulated sequestration of EGFR in caveolae may be involved in arresting constitutive or ligand-induced signaling through EGFR responsible for glial cell transformation.", 
    "genre": "article", 
    "id": "sg:pub.10.1038/sj.onc.1207911", 
    "inLanguage": "en", 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1097543", 
        "issn": [
          "0950-9232", 
          "1476-5594"
        ], 
        "name": "Oncogene", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "41", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "23"
      }
    ], 
    "keywords": [
      "association of eGFR", 
      "glioblastoma cell lines", 
      "nonmalignant brain tissue", 
      "primary human astrocytes", 
      "epidermal growth factor receptor (EGFR) amplification", 
      "glioblastoma cells", 
      "caveolin-1 expression", 
      "cell lines", 
      "constitutive tyrosine kinase activation", 
      "glial cell transformation", 
      "human glioblastoma cell lines", 
      "glioblastoma cell growth", 
      "RT-PCR", 
      "real-time quantitative PCR", 
      "ligand-induced phosphorylation", 
      "interaction of EGFR", 
      "human astrocytes", 
      "high malignancy", 
      "expression of caveolin-2", 
      "human glioblastoma cells", 
      "brain tissue", 
      "EGFR", 
      "tyrosine phosphorylation", 
      "receptor amplification", 
      "tyrosine kinase activation", 
      "Western blot", 
      "constitutive tyrosine phosphorylation", 
      "EGFRvIII", 
      "glioblastoma tumors", 
      "Immunocolocalization studies", 
      "astrocytes", 
      "tumors", 
      "association", 
      "quantitative PCR", 
      "semi-solid agar", 
      "kinase activation", 
      "cell growth", 
      "U87MG", 
      "caveolin-1", 
      "AG1478", 
      "cell transformation", 
      "cells", 
      "cellular fractions", 
      "expression", 
      "domain peptide", 
      "phosphorylation", 
      "high levels", 
      "malignancy", 
      "EGFR association", 
      "lipid rafts", 
      "evidence", 
      "immunocytochemistry", 
      "type III mutation", 
      "caveolae", 
      "blot", 
      "inhibition", 
      "vivo", 
      "tissue", 
      "activation", 
      "contrast", 
      "colocalization", 
      "PCR", 
      "signaling", 
      "caveolin", 
      "peptides", 
      "mutations", 
      "levels", 
      "lines", 
      "study", 
      "caveolin-2", 
      "amplification", 
      "agar", 
      "rafts", 
      "fraction", 
      "growth", 
      "sequestration", 
      "dissociation", 
      "interaction", 
      "transformation", 
      "growth factor receptor (EGFR) amplification", 
      "factor receptor (EGFR) amplification", 
      "III mutation", 
      "U87MG-EGFRvIII", 
      "colocalization of EGFR", 
      "caveolae-enriched cellular fraction", 
      "dissociation of EGFR", 
      "EGFRvIII constitutive tyrosine phosphorylation", 
      "association of EGFRvIII", 
      "phosphorylation-regulated sequestration"
    ], 
    "name": "Interactions of EGFR and caveolin-1 in human glioblastoma cells: evidence that tyrosine phosphorylation regulates EGFR association with caveolae", 
    "pagination": "6967-6979", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1001198838"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/sj.onc.1207911"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "15273741"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/sj.onc.1207911", 
      "https://app.dimensions.ai/details/publication/pub.1001198838"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2021-12-01T19:16", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20211201/entities/gbq_results/article/article_392.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1038/sj.onc.1207911"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/sj.onc.1207911'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/sj.onc.1207911'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/sj.onc.1207911'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/sj.onc.1207911'


 

This table displays all metadata directly associated to this object as RDF triples.

238 TRIPLES      22 PREDICATES      128 URIs      118 LITERALS      18 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/sj.onc.1207911 schema:about N11d7e31b93274594b61d48fbfdd7fd18
2 N1876b3039a5a4367825b03bff4a259ab
3 N236a497581b54674b5538229c51ca75b
4 N3b2e6ea0d9754a1cab259f391490e930
5 N61532d11879a4ad1983f3ac5b08923b9
6 N6670e4eb97dd41c682c2dd12858a88d9
7 N69331637b8a84318a40f9e6f27ef5b8b
8 N6dfb45e2068a445db08547a6cf7a3467
9 Nd256f1f222c347618d75c88247d3eb88
10 Nd381e4ee38de440da264c998e5625118
11 Ne13876b2816e4754b3185a586818f609
12 anzsrc-for:11
13 anzsrc-for:1103
14 anzsrc-for:1112
15 schema:author Nf67e6f2762ea4b4a96bc25c9637295da
16 schema:citation sg:pub.10.1023/a:1013884426692
17 schema:datePublished 2004-07-26
18 schema:datePublishedReg 2004-07-26
19 schema:description Epidermal growth factor receptor (EGFR) amplification and type III mutation (EGFRvIII), associated with constitutive tyrosine kinase activation and high malignancy, are commonly observed in glioblastoma tumors. The association of EGFR and EGFRvIII with caveolins was investigated in human glioblastoma cell lines, U87MG and U87MG-EGFRvIII. Caveolin-1 expression, determined by RT–PCR, real-time quantitative PCR and Western blot, was upregulated in glioblastoma cell lines (two-fold) and tumors (20–300-fold) compared to primary human astrocytes and nonmalignant brain tissue, respectively. U87MG-EGFRvIII expressed higher levels of caveolin-1 than U87MG. In contrast, the expression of caveolin-2 and -3 were downregulated in glioblastoma cells compared to astrocytes. A colocalization of EGFR, but not of EGFRvIII, with lipid rafts and caveolin-1 was observed by immunocytochemistry. Association of EGFR and EGFRvIII with caveolae, assessed in vitro by binding to caveolin scaffolding domain peptides and in vivo by immunocolocalization studies in cells and caveolae-enriched cellular fraction, was phosphorylation-dependent: ligand-induced phosphorylation of EGFR resulted in dissociation of EGFR from caveolae. In contrast, inhibition of the EGFRvIII constitutive tyrosine phosphorylation by AG1478 increased association of EGFRvIII with caveolin-1. AG1478 also increased caveolin-1 expression and reduced glioblastoma cell growth in a semi-solid agar. The evidence suggests that the phosphorylation-regulated sequestration of EGFR in caveolae may be involved in arresting constitutive or ligand-induced signaling through EGFR responsible for glial cell transformation.
20 schema:genre article
21 schema:inLanguage en
22 schema:isAccessibleForFree true
23 schema:isPartOf N4838b9f660fa4f2e9a41206c0b012596
24 Nf179d7510f274fdd8b4ec39ce5063678
25 sg:journal.1097543
26 schema:keywords AG1478
27 EGFR
28 EGFR association
29 EGFRvIII
30 EGFRvIII constitutive tyrosine phosphorylation
31 III mutation
32 Immunocolocalization studies
33 PCR
34 RT-PCR
35 U87MG
36 U87MG-EGFRvIII
37 Western blot
38 activation
39 agar
40 amplification
41 association
42 association of EGFRvIII
43 association of eGFR
44 astrocytes
45 blot
46 brain tissue
47 caveolae
48 caveolae-enriched cellular fraction
49 caveolin
50 caveolin-1
51 caveolin-1 expression
52 caveolin-2
53 cell growth
54 cell lines
55 cell transformation
56 cells
57 cellular fractions
58 colocalization
59 colocalization of EGFR
60 constitutive tyrosine kinase activation
61 constitutive tyrosine phosphorylation
62 contrast
63 dissociation
64 dissociation of EGFR
65 domain peptide
66 epidermal growth factor receptor (EGFR) amplification
67 evidence
68 expression
69 expression of caveolin-2
70 factor receptor (EGFR) amplification
71 fraction
72 glial cell transformation
73 glioblastoma cell growth
74 glioblastoma cell lines
75 glioblastoma cells
76 glioblastoma tumors
77 growth
78 growth factor receptor (EGFR) amplification
79 high levels
80 high malignancy
81 human astrocytes
82 human glioblastoma cell lines
83 human glioblastoma cells
84 immunocytochemistry
85 inhibition
86 interaction
87 interaction of EGFR
88 kinase activation
89 levels
90 ligand-induced phosphorylation
91 lines
92 lipid rafts
93 malignancy
94 mutations
95 nonmalignant brain tissue
96 peptides
97 phosphorylation
98 phosphorylation-regulated sequestration
99 primary human astrocytes
100 quantitative PCR
101 rafts
102 real-time quantitative PCR
103 receptor amplification
104 semi-solid agar
105 sequestration
106 signaling
107 study
108 tissue
109 transformation
110 tumors
111 type III mutation
112 tyrosine kinase activation
113 tyrosine phosphorylation
114 vivo
115 schema:name Interactions of EGFR and caveolin-1 in human glioblastoma cells: evidence that tyrosine phosphorylation regulates EGFR association with caveolae
116 schema:pagination 6967-6979
117 schema:productId N77c89fb6a8a24744b9163946fa59a741
118 N8cec06f47f6f434d8afcc3021772eca3
119 Na9e05144406042c1bd71ac127d04ce89
120 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001198838
121 https://doi.org/10.1038/sj.onc.1207911
122 schema:sdDatePublished 2021-12-01T19:16
123 schema:sdLicense https://scigraph.springernature.com/explorer/license/
124 schema:sdPublisher N149d3ee3ffb04b53bc5a87155a82bda7
125 schema:url https://doi.org/10.1038/sj.onc.1207911
126 sgo:license sg:explorer/license/
127 sgo:sdDataset articles
128 rdf:type schema:ScholarlyArticle
129 N0ff0225027e34ed881780510b008587a rdf:first sg:person.01062263144.09
130 rdf:rest Nf17de7225e244f98a81df79d36ef466d
131 N11d7e31b93274594b61d48fbfdd7fd18 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
132 schema:name Caveolin 1
133 rdf:type schema:DefinedTerm
134 N149d3ee3ffb04b53bc5a87155a82bda7 schema:name Springer Nature - SN SciGraph project
135 rdf:type schema:Organization
136 N1876b3039a5a4367825b03bff4a259ab schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
137 schema:name Quinazolines
138 rdf:type schema:DefinedTerm
139 N236a497581b54674b5538229c51ca75b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
140 schema:name Humans
141 rdf:type schema:DefinedTerm
142 N285eb69c256947bda0f258505ffd2c99 rdf:first sg:person.0622621033.74
143 rdf:rest N28a9614e3f024b6aa78fa838507d3b8a
144 N28a9614e3f024b6aa78fa838507d3b8a rdf:first sg:person.01337470643.07
145 rdf:rest rdf:nil
146 N3b2e6ea0d9754a1cab259f391490e930 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
147 schema:name Glioblastoma
148 rdf:type schema:DefinedTerm
149 N4838b9f660fa4f2e9a41206c0b012596 schema:issueNumber 41
150 rdf:type schema:PublicationIssue
151 N61532d11879a4ad1983f3ac5b08923b9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
152 schema:name Tyrosine
153 rdf:type schema:DefinedTerm
154 N6670e4eb97dd41c682c2dd12858a88d9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
155 schema:name Cell Line, Tumor
156 rdf:type schema:DefinedTerm
157 N69331637b8a84318a40f9e6f27ef5b8b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
158 schema:name ErbB Receptors
159 rdf:type schema:DefinedTerm
160 N6dfb45e2068a445db08547a6cf7a3467 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
161 schema:name Caveolins
162 rdf:type schema:DefinedTerm
163 N77c89fb6a8a24744b9163946fa59a741 schema:name pubmed_id
164 schema:value 15273741
165 rdf:type schema:PropertyValue
166 N8cec06f47f6f434d8afcc3021772eca3 schema:name doi
167 schema:value 10.1038/sj.onc.1207911
168 rdf:type schema:PropertyValue
169 Na9e05144406042c1bd71ac127d04ce89 schema:name dimensions_id
170 schema:value pub.1001198838
171 rdf:type schema:PropertyValue
172 Nab1159a98b2143afb46215b3adb46dc1 rdf:first sg:person.01176511544.07
173 rdf:rest N285eb69c256947bda0f258505ffd2c99
174 Nd256f1f222c347618d75c88247d3eb88 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
175 schema:name Phosphorylation
176 rdf:type schema:DefinedTerm
177 Nd381e4ee38de440da264c998e5625118 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
178 schema:name Tyrphostins
179 rdf:type schema:DefinedTerm
180 Ne13876b2816e4754b3185a586818f609 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
181 schema:name Cell Division
182 rdf:type schema:DefinedTerm
183 Nf179d7510f274fdd8b4ec39ce5063678 schema:volumeNumber 23
184 rdf:type schema:PublicationVolume
185 Nf17de7225e244f98a81df79d36ef466d rdf:first sg:person.01272456500.65
186 rdf:rest Nab1159a98b2143afb46215b3adb46dc1
187 Nf67e6f2762ea4b4a96bc25c9637295da rdf:first sg:person.0643277257.10
188 rdf:rest N0ff0225027e34ed881780510b008587a
189 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
190 schema:name Medical and Health Sciences
191 rdf:type schema:DefinedTerm
192 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
193 schema:name Clinical Sciences
194 rdf:type schema:DefinedTerm
195 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
196 schema:name Oncology and Carcinogenesis
197 rdf:type schema:DefinedTerm
198 sg:journal.1097543 schema:issn 0950-9232
199 1476-5594
200 schema:name Oncogene
201 schema:publisher Springer Nature
202 rdf:type schema:Periodical
203 sg:person.01062263144.09 schema:affiliation grid-institutes:grid.418626.f
204 schema:familyName Giuseppin
205 schema:givenName Sabina
206 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01062263144.09
207 rdf:type schema:Person
208 sg:person.01176511544.07 schema:affiliation grid-institutes:grid.418626.f
209 schema:familyName McDermid
210 schema:givenName Angela
211 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01176511544.07
212 rdf:type schema:Person
213 sg:person.01272456500.65 schema:affiliation grid-institutes:grid.418626.f
214 schema:familyName Andrade
215 schema:givenName Moises F
216 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01272456500.65
217 rdf:type schema:Person
218 sg:person.01337470643.07 schema:affiliation grid-institutes:grid.418626.f
219 schema:familyName Stanimirovic
220 schema:givenName Danica
221 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01337470643.07
222 rdf:type schema:Person
223 sg:person.0622621033.74 schema:affiliation grid-institutes:grid.418626.f
224 schema:familyName Moreno
225 schema:givenName Maria
226 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0622621033.74
227 rdf:type schema:Person
228 sg:person.0643277257.10 schema:affiliation grid-institutes:grid.418626.f
229 schema:familyName Abulrob
230 schema:givenName Abedelnasser
231 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0643277257.10
232 rdf:type schema:Person
233 sg:pub.10.1023/a:1013884426692 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022330300
234 https://doi.org/10.1023/a:1013884426692
235 rdf:type schema:CreativeWork
236 grid-institutes:grid.418626.f schema:alternateName Cerebrovascular Research Group, Institute for Biological Sciences, National Research Council Canada, K1A0R6, Ottawa, ON, Canada
237 schema:name Cerebrovascular Research Group, Institute for Biological Sciences, National Research Council Canada, K1A0R6, Ottawa, ON, Canada
238 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...