RUNX1 transformation of primary embryonic fibroblasts is revealed in the absence of p53 View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2004-07

AUTHORS

Sandy F Wotton, Karen Blyth, Anna Kilbey, Alma Jenkins, Anne Terry, Florence Bernardin-Fried, Alan D Friedman, Euan W Baxter, James C Neil, Ewan R Cameron

ABSTRACT

The mammalian Runx gene family (Runx1-3) are transcription factors that play essential, lineage-specific roles in development. A growing body of evidence implicates these genes as mutational targets in cancer where, in different contexts, individual family members have been reported to act as tumour suppressors, dominant oncogenes or mediators of metastasis. We are exploring these paradoxical observations by ectopic expression of RUNX genes in primary murine embryonic fibroblasts where, in common with a number of other dominant oncogenes, RUNX1 induces senescence-like growth arrest in the presence of an intact p19(ARF)-p53 pathway. We now report that, in MEFs lacking functional p53, RUNX1 has apparently pro-oncogenic effects on cell growth that include cytoskeletal reorganization, reduced contact inhibition at confluence and accelerated tumour expansion in vivo. On the other hand, RUNX1 conferred no obvious growth advantage at low cell density and actually delayed entry of primary MEFs into S phase. We also found that ectopic RUNX1 interferes with the morphological and growth responses of p53-null MEFs to TGFbeta indicating that these effects are mediated by overlapping pathways. These observations help to elucidate the context-dependent consequences of loss and gain of Runx activity. More... »

PAGES

1207729

References to SciGraph publications

  • 2000-05. Exogenous cdk4 overcomes reducedcdk4 RNA and inhibition of G1 progression in hematopoietic cells expressing a dominant-negative CBF – a model for overcoming inhibition of proliferation by CBF oncoproteins in ONCOGENE
  • 1999-10. Haploinsufficiency of CBFA2 causes familial thrombocytopenia with propensity to develop acute myelogenous leukaemia in NATURE GENETICS
  • 2002-07. The t(8;21) fusion protein, AML1–ETO, specifically represses the transcription of the p14ARF tumor suppressor in acute myeloid leukemia in NATURE MEDICINE
  • 2002-01. Emerging targets: Molecular mechanisms of cell contact-mediated growth control in KIDNEY INTERNATIONAL
  • 2002-07. Core-binding factors in haematopoiesis and leukaemia in NATURE REVIEWS CANCER
  • 2002-05. AML1 stimulates G1 to S progression via its transactivation domain in ONCOGENE
  • 2003-03. Amplification of AML1 on a duplicated chromosome 21 in acute lymphoblastic leukemia: a study of 20 cases in LEUKEMIA
  • 1997-03. Embryonic lethality and impairment of haematopoiesis in mice heterozygous for an AML1-ETO fusion gene in NATURE GENETICS
  • 1992-03. Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours in NATURE
  • 1999-11. Leukaemia disease genes: large-scale cloning and pathway predictions in NATURE GENETICS
  • 1999-11. A full-length Cbfa1 gene product perturbs T-cell development and promotes lymphomagenesis in synergy with MYC in ONCOGENE
  • 1999-03. The t(8;21) fusion protein, AML1/ETO, transforms NIH3T3 cells and activates AP-1 in ONCOGENE
  • 2001-10. TGF-β signaling in tumor suppression and cancer progression in NATURE GENETICS
  • 2003-11. Cytostatic and apoptotic actions of TGF-β in homeostasis and cancer in NATURE REVIEWS CANCER
  • 2002-04. AML1 gene over-expression in childhood acute lymphoblastic leukemia in LEUKEMIA
  • 2000-02. Sensitivity to myc-induced apoptosis is retained in spontaneous and transplanted lymphomas of CD2-mycERTM mice in ONCOGENE
  • 2001-01. Runx2: A novel oncogenic effector revealed by in vivo complementation and retroviral tagging in ONCOGENE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/sj.onc.1207729

    DOI

    http://dx.doi.org/10.1038/sj.onc.1207729

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1037822233

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/15133495


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Genetics", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biological Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "3T3 Cells", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Animals", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cell Transformation, Neoplastic", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cellular Senescence", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Core Binding Factor Alpha 2 Subunit", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "DNA-Binding Proteins", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Fibroblasts", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mice", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Proto-Oncogene Proteins", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "S Phase", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Transcription Factors", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Tumor Suppressor Protein p53", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "University of Glasgow", 
              "id": "https://www.grid.ac/institutes/grid.8756.c", 
              "name": [
                "Molecular Oncology Laboratory, Institute of Comparative Medicine, Faculty of Veterinary Medicine, University of Glasgow, Bearsden Road, Glasgow G61 1QH, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Wotton", 
            "givenName": "Sandy F", 
            "id": "sg:person.0745113734.32", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0745113734.32"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Glasgow", 
              "id": "https://www.grid.ac/institutes/grid.8756.c", 
              "name": [
                "Molecular Oncology Laboratory, Institute of Comparative Medicine, Faculty of Veterinary Medicine, University of Glasgow, Bearsden Road, Glasgow G61 1QH, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Blyth", 
            "givenName": "Karen", 
            "id": "sg:person.01337331716.27", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01337331716.27"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Glasgow", 
              "id": "https://www.grid.ac/institutes/grid.8756.c", 
              "name": [
                "Molecular Oncology Laboratory, Institute of Comparative Medicine, Faculty of Veterinary Medicine, University of Glasgow, Bearsden Road, Glasgow G61 1QH, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kilbey", 
            "givenName": "Anna", 
            "id": "sg:person.01273106223.14", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01273106223.14"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Glasgow", 
              "id": "https://www.grid.ac/institutes/grid.8756.c", 
              "name": [
                "Molecular Oncology Laboratory, Institute of Comparative Medicine, Faculty of Veterinary Medicine, University of Glasgow, Bearsden Road, Glasgow G61 1QH, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Jenkins", 
            "givenName": "Alma", 
            "id": "sg:person.0576126354.81", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0576126354.81"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Glasgow", 
              "id": "https://www.grid.ac/institutes/grid.8756.c", 
              "name": [
                "Molecular Oncology Laboratory, Institute of Comparative Medicine, Faculty of Veterinary Medicine, University of Glasgow, Bearsden Road, Glasgow G61 1QH, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Terry", 
            "givenName": "Anne", 
            "id": "sg:person.0644241554.12", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0644241554.12"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Johns Hopkins University", 
              "id": "https://www.grid.ac/institutes/grid.21107.35", 
              "name": [
                "Division of Pediatric Oncology, John Hopkins University, Cancer Research Building, Room 253, 1650 Orleans Street, Baltimore, MD 21231, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Bernardin-Fried", 
            "givenName": "Florence", 
            "id": "sg:person.01250623466.05", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01250623466.05"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Johns Hopkins University", 
              "id": "https://www.grid.ac/institutes/grid.21107.35", 
              "name": [
                "Division of Pediatric Oncology, John Hopkins University, Cancer Research Building, Room 253, 1650 Orleans Street, Baltimore, MD 21231, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Friedman", 
            "givenName": "Alan D", 
            "id": "sg:person.016707721442.58", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016707721442.58"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Fred Hutchinson Cancer Research Center", 
              "id": "https://www.grid.ac/institutes/grid.270240.3", 
              "name": [
                "Fred Hutchinson Cancer Research Center, 1100 Fairview Ave., Seattle, WA 98109, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Baxter", 
            "givenName": "Euan W", 
            "id": "sg:person.01276602527.52", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01276602527.52"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Glasgow", 
              "id": "https://www.grid.ac/institutes/grid.8756.c", 
              "name": [
                "Molecular Oncology Laboratory, Institute of Comparative Medicine, Faculty of Veterinary Medicine, University of Glasgow, Bearsden Road, Glasgow G61 1QH, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Neil", 
            "givenName": "James C", 
            "id": "sg:person.01327210172.15", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01327210172.15"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Glasgow", 
              "id": "https://www.grid.ac/institutes/grid.8756.c", 
              "name": [
                "Molecular Oncology Laboratory, Institute of Comparative Medicine, Faculty of Veterinary Medicine, University of Glasgow, Bearsden Road, Glasgow G61 1QH, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Cameron", 
            "givenName": "Ewan R", 
            "id": "sg:person.01312017334.05", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01312017334.05"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1038/sj.onc.1203588", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000714314", 
              "https://doi.org/10.1038/sj.onc.1203588"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1203588", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000714314", 
              "https://doi.org/10.1038/sj.onc.1203588"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm726", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000759129", 
              "https://doi.org/10.1038/nm726"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm726", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000759129", 
              "https://doi.org/10.1038/nm726"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/18.12.3587", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002928860"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/pros.10233", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004039800"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/jvi.75.20.9790-9798.2001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004275066"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1203202", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004293631", 
              "https://doi.org/10.1038/sj.onc.1203202"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1203202", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004293631", 
              "https://doi.org/10.1038/sj.onc.1203202"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrc1208", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004573220", 
              "https://doi.org/10.1038/nrc1208"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrc1208", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004573220", 
              "https://doi.org/10.1038/nrc1208"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0034-6667(99)00046-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004701926"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0092-8674(03)00308-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007016505"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1633291100", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007202802"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1079-9796(03)00031-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007923678"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1079-9796(03)00031-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007923678"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.275.5.3438", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008327136"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/23.10.1686", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009166721"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng1001-117", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010058562", 
              "https://doi.org/10.1038/ng1001-117"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng1001-117", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010058562", 
              "https://doi.org/10.1038/ng1001-117"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng1001-117", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010058562", 
              "https://doi.org/10.1038/ng1001-117"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng1001-117", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010058562", 
              "https://doi.org/10.1038/ng1001-117"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1205447", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010570511", 
              "https://doi.org/10.1038/sj.onc.1205447"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1205447", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010570511", 
              "https://doi.org/10.1038/sj.onc.1205447"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1046/j.1523-1755.2002.0610s1099.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011554459", 
              "https://doi.org/10.1046/j.1523-1755.2002.0610s1099.x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/13793", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011872100", 
              "https://doi.org/10.1038/13793"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/13793", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011872100", 
              "https://doi.org/10.1038/13793"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/jvi.76.9.4364-4369.2002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017190337"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/(sici)1097-4644(19980601)69:3<353::aid-jcb12>3.0.co;2-d", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022682163"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.274.44.31577", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024479264"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0092-8674(00)81902-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026392285"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/356215a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027559823", 
              "https://doi.org/10.1038/356215a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/15531", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028078535", 
              "https://doi.org/10.1038/15531"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/15531", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028078535", 
              "https://doi.org/10.1038/15531"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.leu.2402849", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028416371", 
              "https://doi.org/10.1038/sj.leu.2402849"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.leu.2402849", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028416371", 
              "https://doi.org/10.1038/sj.leu.2402849"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/mcb.15.4.1974", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028775369"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1204090", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032144939", 
              "https://doi.org/10.1038/sj.onc.1204090"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1204090", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032144939", 
              "https://doi.org/10.1038/sj.onc.1204090"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/mcb.20.23.8783-8792.2000", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036395073"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0304-3835(98)00318-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038410537"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0092-8674(02)00690-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038516403"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0959-437x(03)00007-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039051125"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0959-437x(03)00007-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039051125"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1203321", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040048209", 
              "https://doi.org/10.1038/sj.onc.1203321"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1203321", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040048209", 
              "https://doi.org/10.1038/sj.onc.1203321"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng0397-303", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041991970", 
              "https://doi.org/10.1038/ng0397-303"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.97.1.174", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042427433"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.leu.2402399", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044356206", 
              "https://doi.org/10.1038/sj.leu.2402399"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.leu.2402399", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044356206", 
              "https://doi.org/10.1038/sj.leu.2402399"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.180309597", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044724051"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.94.16.8646", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044799114"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.c000485200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045371511"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1202459", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045912171", 
              "https://doi.org/10.1038/sj.onc.1202459"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1202459", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045912171", 
              "https://doi.org/10.1038/sj.onc.1202459"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m105947200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049028819"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.91.10.4509", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049142960"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/1098-2264(2001)9999:9999<::aid-gcc1107>3.0.co;2-c", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050547699"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrc840", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053102883", 
              "https://doi.org/10.1038/nrc840"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrc840", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053102883", 
              "https://doi.org/10.1038/nrc840"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2106/00004623-200100001-00007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1068894173"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074267280", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074619832", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074710157", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074735220", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074841701", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4049/jimmunol.169.6.2866", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1075119300"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1075208240", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082853107", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082886878", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1083249354", 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2004-07", 
        "datePublishedReg": "2004-07-01", 
        "description": "The mammalian Runx gene family (Runx1-3) are transcription factors that play essential, lineage-specific roles in development. A growing body of evidence implicates these genes as mutational targets in cancer where, in different contexts, individual family members have been reported to act as tumour suppressors, dominant oncogenes or mediators of metastasis. We are exploring these paradoxical observations by ectopic expression of RUNX genes in primary murine embryonic fibroblasts where, in common with a number of other dominant oncogenes, RUNX1 induces senescence-like growth arrest in the presence of an intact p19(ARF)-p53 pathway. We now report that, in MEFs lacking functional p53, RUNX1 has apparently pro-oncogenic effects on cell growth that include cytoskeletal reorganization, reduced contact inhibition at confluence and accelerated tumour expansion in vivo. On the other hand, RUNX1 conferred no obvious growth advantage at low cell density and actually delayed entry of primary MEFs into S phase. We also found that ectopic RUNX1 interferes with the morphological and growth responses of p53-null MEFs to TGFbeta indicating that these effects are mediated by overlapping pathways. These observations help to elucidate the context-dependent consequences of loss and gain of Runx activity.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1038/sj.onc.1207729", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": true, 
        "isPartOf": [
          {
            "id": "sg:journal.1097543", 
            "issn": [
              "0950-9232", 
              "1476-5594"
            ], 
            "name": "Oncogene", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "32", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "23"
          }
        ], 
        "name": "RUNX1 transformation of primary embryonic fibroblasts is revealed in the absence of p53", 
        "pagination": "1207729", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "b42cf0a90fcc3c36a15934442af1815777516935a7111ed52195ab3801eb9928"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "15133495"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "8711562"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/sj.onc.1207729"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1037822233"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/sj.onc.1207729", 
          "https://app.dimensions.ai/details/publication/pub.1037822233"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-11T12:15", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000361_0000000361/records_54014_00000001.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "http://www.nature.com/articles/1207729"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/sj.onc.1207729'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/sj.onc.1207729'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/sj.onc.1207729'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/sj.onc.1207729'


     

    This table displays all metadata directly associated to this object as RDF triples.

    353 TRIPLES      21 PREDICATES      94 URIs      33 LITERALS      21 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/sj.onc.1207729 schema:about N14814e41e7754a74b03a3edf71bead24
    2 N1beb7d17d67c4adeb051de9c0bc440bd
    3 N2780f159d85148b6b7165aee41ad139c
    4 N562c3f1724834f87b7a3e6cea5144002
    5 N575efb47e4c54b2ca444b20ccdde4537
    6 N7cb19ece2d114a2fa1aeae45da8eea7e
    7 N91fe69bf2ed44015a0e40a32d35e30ff
    8 Naaa1866723eb4bc99969dec0f8cd7c90
    9 Ncb9b0377215846db8e24a6465693fad2
    10 Ne017d9f087ef4ec4b2a22fae737e7f4c
    11 Nee634ec8863b4b0fbf30f7958bc2355a
    12 Nfa4f94eb4c5c4d578ac8b315e84564fd
    13 anzsrc-for:06
    14 anzsrc-for:0604
    15 schema:author N728a90d40597464887ab68bf0b928b08
    16 schema:citation sg:pub.10.1038/13793
    17 sg:pub.10.1038/15531
    18 sg:pub.10.1038/356215a0
    19 sg:pub.10.1038/ng0397-303
    20 sg:pub.10.1038/ng1001-117
    21 sg:pub.10.1038/nm726
    22 sg:pub.10.1038/nrc1208
    23 sg:pub.10.1038/nrc840
    24 sg:pub.10.1038/sj.leu.2402399
    25 sg:pub.10.1038/sj.leu.2402849
    26 sg:pub.10.1038/sj.onc.1202459
    27 sg:pub.10.1038/sj.onc.1203202
    28 sg:pub.10.1038/sj.onc.1203321
    29 sg:pub.10.1038/sj.onc.1203588
    30 sg:pub.10.1038/sj.onc.1204090
    31 sg:pub.10.1038/sj.onc.1205447
    32 sg:pub.10.1046/j.1523-1755.2002.0610s1099.x
    33 https://app.dimensions.ai/details/publication/pub.1074267280
    34 https://app.dimensions.ai/details/publication/pub.1074619832
    35 https://app.dimensions.ai/details/publication/pub.1074710157
    36 https://app.dimensions.ai/details/publication/pub.1074735220
    37 https://app.dimensions.ai/details/publication/pub.1074841701
    38 https://app.dimensions.ai/details/publication/pub.1075208240
    39 https://app.dimensions.ai/details/publication/pub.1082853107
    40 https://app.dimensions.ai/details/publication/pub.1082886878
    41 https://app.dimensions.ai/details/publication/pub.1083249354
    42 https://doi.org/10.1002/(sici)1097-4644(19980601)69:3<353::aid-jcb12>3.0.co;2-d
    43 https://doi.org/10.1002/1098-2264(2001)9999:9999<::aid-gcc1107>3.0.co;2-c
    44 https://doi.org/10.1002/pros.10233
    45 https://doi.org/10.1016/s0034-6667(99)00046-9
    46 https://doi.org/10.1016/s0092-8674(00)81902-9
    47 https://doi.org/10.1016/s0092-8674(02)00690-6
    48 https://doi.org/10.1016/s0092-8674(03)00308-8
    49 https://doi.org/10.1016/s0304-3835(98)00318-8
    50 https://doi.org/10.1016/s0959-437x(03)00007-8
    51 https://doi.org/10.1016/s1079-9796(03)00031-7
    52 https://doi.org/10.1073/pnas.1633291100
    53 https://doi.org/10.1073/pnas.180309597
    54 https://doi.org/10.1073/pnas.91.10.4509
    55 https://doi.org/10.1073/pnas.94.16.8646
    56 https://doi.org/10.1073/pnas.97.1.174
    57 https://doi.org/10.1074/jbc.274.44.31577
    58 https://doi.org/10.1074/jbc.275.5.3438
    59 https://doi.org/10.1074/jbc.c000485200
    60 https://doi.org/10.1074/jbc.m105947200
    61 https://doi.org/10.1093/nar/18.12.3587
    62 https://doi.org/10.1093/nar/23.10.1686
    63 https://doi.org/10.1128/jvi.75.20.9790-9798.2001
    64 https://doi.org/10.1128/jvi.76.9.4364-4369.2002
    65 https://doi.org/10.1128/mcb.15.4.1974
    66 https://doi.org/10.1128/mcb.20.23.8783-8792.2000
    67 https://doi.org/10.2106/00004623-200100001-00007
    68 https://doi.org/10.4049/jimmunol.169.6.2866
    69 schema:datePublished 2004-07
    70 schema:datePublishedReg 2004-07-01
    71 schema:description The mammalian Runx gene family (Runx1-3) are transcription factors that play essential, lineage-specific roles in development. A growing body of evidence implicates these genes as mutational targets in cancer where, in different contexts, individual family members have been reported to act as tumour suppressors, dominant oncogenes or mediators of metastasis. We are exploring these paradoxical observations by ectopic expression of RUNX genes in primary murine embryonic fibroblasts where, in common with a number of other dominant oncogenes, RUNX1 induces senescence-like growth arrest in the presence of an intact p19(ARF)-p53 pathway. We now report that, in MEFs lacking functional p53, RUNX1 has apparently pro-oncogenic effects on cell growth that include cytoskeletal reorganization, reduced contact inhibition at confluence and accelerated tumour expansion in vivo. On the other hand, RUNX1 conferred no obvious growth advantage at low cell density and actually delayed entry of primary MEFs into S phase. We also found that ectopic RUNX1 interferes with the morphological and growth responses of p53-null MEFs to TGFbeta indicating that these effects are mediated by overlapping pathways. These observations help to elucidate the context-dependent consequences of loss and gain of Runx activity.
    72 schema:genre research_article
    73 schema:inLanguage en
    74 schema:isAccessibleForFree true
    75 schema:isPartOf N0c63856208d84393b43bdfbe4b3eb86c
    76 N6bc96a63f37e420181e078eac8b2228d
    77 sg:journal.1097543
    78 schema:name RUNX1 transformation of primary embryonic fibroblasts is revealed in the absence of p53
    79 schema:pagination 1207729
    80 schema:productId N4d05b5169f6b49c591810c1d99f13092
    81 N58f18bb09d1741349398dc1796ba26a7
    82 N717b6dc4725644b4a942879aae2c2c5f
    83 Na46440b85210402b9be94e37d4f7a0c5
    84 Nf2795ed01f0147c9a575ee45fe8dc626
    85 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037822233
    86 https://doi.org/10.1038/sj.onc.1207729
    87 schema:sdDatePublished 2019-04-11T12:15
    88 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    89 schema:sdPublisher N199a625c35ea4a79b00119ef2c41536c
    90 schema:url http://www.nature.com/articles/1207729
    91 sgo:license sg:explorer/license/
    92 sgo:sdDataset articles
    93 rdf:type schema:ScholarlyArticle
    94 N0c63856208d84393b43bdfbe4b3eb86c schema:issueNumber 32
    95 rdf:type schema:PublicationIssue
    96 N0f96353b02384d88bcf98c01383f2007 rdf:first sg:person.01250623466.05
    97 rdf:rest N8eae207042e5477987f26032d54bd0ad
    98 N14814e41e7754a74b03a3edf71bead24 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    99 schema:name S Phase
    100 rdf:type schema:DefinedTerm
    101 N1936927139ce493994110278dd60b064 rdf:first sg:person.01337331716.27
    102 rdf:rest N231c84a0c4ed43e0af74445c41d79f40
    103 N199a625c35ea4a79b00119ef2c41536c schema:name Springer Nature - SN SciGraph project
    104 rdf:type schema:Organization
    105 N1beb7d17d67c4adeb051de9c0bc440bd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    106 schema:name 3T3 Cells
    107 rdf:type schema:DefinedTerm
    108 N231c84a0c4ed43e0af74445c41d79f40 rdf:first sg:person.01273106223.14
    109 rdf:rest Nf1a63b1298be4a6fa15505dac9474109
    110 N2780f159d85148b6b7165aee41ad139c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    111 schema:name Animals
    112 rdf:type schema:DefinedTerm
    113 N4d05b5169f6b49c591810c1d99f13092 schema:name nlm_unique_id
    114 schema:value 8711562
    115 rdf:type schema:PropertyValue
    116 N51b6029b96c84395bfeb72f61ad9995c rdf:first sg:person.01276602527.52
    117 rdf:rest Ne7e8b9a8c2b848bcb88a400221ccb640
    118 N562c3f1724834f87b7a3e6cea5144002 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    119 schema:name Tumor Suppressor Protein p53
    120 rdf:type schema:DefinedTerm
    121 N575efb47e4c54b2ca444b20ccdde4537 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    122 schema:name Mice
    123 rdf:type schema:DefinedTerm
    124 N58f18bb09d1741349398dc1796ba26a7 schema:name pubmed_id
    125 schema:value 15133495
    126 rdf:type schema:PropertyValue
    127 N5c61e8de68a84dcd9edd3622eb0e0164 rdf:first sg:person.0644241554.12
    128 rdf:rest N0f96353b02384d88bcf98c01383f2007
    129 N69a846fe96b04076a54f3883654ec55b rdf:first sg:person.01312017334.05
    130 rdf:rest rdf:nil
    131 N6bc96a63f37e420181e078eac8b2228d schema:volumeNumber 23
    132 rdf:type schema:PublicationVolume
    133 N717b6dc4725644b4a942879aae2c2c5f schema:name dimensions_id
    134 schema:value pub.1037822233
    135 rdf:type schema:PropertyValue
    136 N728a90d40597464887ab68bf0b928b08 rdf:first sg:person.0745113734.32
    137 rdf:rest N1936927139ce493994110278dd60b064
    138 N7cb19ece2d114a2fa1aeae45da8eea7e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    139 schema:name Proto-Oncogene Proteins
    140 rdf:type schema:DefinedTerm
    141 N8eae207042e5477987f26032d54bd0ad rdf:first sg:person.016707721442.58
    142 rdf:rest N51b6029b96c84395bfeb72f61ad9995c
    143 N91fe69bf2ed44015a0e40a32d35e30ff schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    144 schema:name Transcription Factors
    145 rdf:type schema:DefinedTerm
    146 Na46440b85210402b9be94e37d4f7a0c5 schema:name doi
    147 schema:value 10.1038/sj.onc.1207729
    148 rdf:type schema:PropertyValue
    149 Naaa1866723eb4bc99969dec0f8cd7c90 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    150 schema:name Cellular Senescence
    151 rdf:type schema:DefinedTerm
    152 Ncb9b0377215846db8e24a6465693fad2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    153 schema:name Fibroblasts
    154 rdf:type schema:DefinedTerm
    155 Ne017d9f087ef4ec4b2a22fae737e7f4c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    156 schema:name Cell Transformation, Neoplastic
    157 rdf:type schema:DefinedTerm
    158 Ne7e8b9a8c2b848bcb88a400221ccb640 rdf:first sg:person.01327210172.15
    159 rdf:rest N69a846fe96b04076a54f3883654ec55b
    160 Nee634ec8863b4b0fbf30f7958bc2355a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    161 schema:name Core Binding Factor Alpha 2 Subunit
    162 rdf:type schema:DefinedTerm
    163 Nf1a63b1298be4a6fa15505dac9474109 rdf:first sg:person.0576126354.81
    164 rdf:rest N5c61e8de68a84dcd9edd3622eb0e0164
    165 Nf2795ed01f0147c9a575ee45fe8dc626 schema:name readcube_id
    166 schema:value b42cf0a90fcc3c36a15934442af1815777516935a7111ed52195ab3801eb9928
    167 rdf:type schema:PropertyValue
    168 Nfa4f94eb4c5c4d578ac8b315e84564fd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    169 schema:name DNA-Binding Proteins
    170 rdf:type schema:DefinedTerm
    171 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
    172 schema:name Biological Sciences
    173 rdf:type schema:DefinedTerm
    174 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
    175 schema:name Genetics
    176 rdf:type schema:DefinedTerm
    177 sg:journal.1097543 schema:issn 0950-9232
    178 1476-5594
    179 schema:name Oncogene
    180 rdf:type schema:Periodical
    181 sg:person.01250623466.05 schema:affiliation https://www.grid.ac/institutes/grid.21107.35
    182 schema:familyName Bernardin-Fried
    183 schema:givenName Florence
    184 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01250623466.05
    185 rdf:type schema:Person
    186 sg:person.01273106223.14 schema:affiliation https://www.grid.ac/institutes/grid.8756.c
    187 schema:familyName Kilbey
    188 schema:givenName Anna
    189 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01273106223.14
    190 rdf:type schema:Person
    191 sg:person.01276602527.52 schema:affiliation https://www.grid.ac/institutes/grid.270240.3
    192 schema:familyName Baxter
    193 schema:givenName Euan W
    194 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01276602527.52
    195 rdf:type schema:Person
    196 sg:person.01312017334.05 schema:affiliation https://www.grid.ac/institutes/grid.8756.c
    197 schema:familyName Cameron
    198 schema:givenName Ewan R
    199 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01312017334.05
    200 rdf:type schema:Person
    201 sg:person.01327210172.15 schema:affiliation https://www.grid.ac/institutes/grid.8756.c
    202 schema:familyName Neil
    203 schema:givenName James C
    204 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01327210172.15
    205 rdf:type schema:Person
    206 sg:person.01337331716.27 schema:affiliation https://www.grid.ac/institutes/grid.8756.c
    207 schema:familyName Blyth
    208 schema:givenName Karen
    209 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01337331716.27
    210 rdf:type schema:Person
    211 sg:person.016707721442.58 schema:affiliation https://www.grid.ac/institutes/grid.21107.35
    212 schema:familyName Friedman
    213 schema:givenName Alan D
    214 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016707721442.58
    215 rdf:type schema:Person
    216 sg:person.0576126354.81 schema:affiliation https://www.grid.ac/institutes/grid.8756.c
    217 schema:familyName Jenkins
    218 schema:givenName Alma
    219 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0576126354.81
    220 rdf:type schema:Person
    221 sg:person.0644241554.12 schema:affiliation https://www.grid.ac/institutes/grid.8756.c
    222 schema:familyName Terry
    223 schema:givenName Anne
    224 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0644241554.12
    225 rdf:type schema:Person
    226 sg:person.0745113734.32 schema:affiliation https://www.grid.ac/institutes/grid.8756.c
    227 schema:familyName Wotton
    228 schema:givenName Sandy F
    229 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0745113734.32
    230 rdf:type schema:Person
    231 sg:pub.10.1038/13793 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011872100
    232 https://doi.org/10.1038/13793
    233 rdf:type schema:CreativeWork
    234 sg:pub.10.1038/15531 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028078535
    235 https://doi.org/10.1038/15531
    236 rdf:type schema:CreativeWork
    237 sg:pub.10.1038/356215a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027559823
    238 https://doi.org/10.1038/356215a0
    239 rdf:type schema:CreativeWork
    240 sg:pub.10.1038/ng0397-303 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041991970
    241 https://doi.org/10.1038/ng0397-303
    242 rdf:type schema:CreativeWork
    243 sg:pub.10.1038/ng1001-117 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010058562
    244 https://doi.org/10.1038/ng1001-117
    245 rdf:type schema:CreativeWork
    246 sg:pub.10.1038/nm726 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000759129
    247 https://doi.org/10.1038/nm726
    248 rdf:type schema:CreativeWork
    249 sg:pub.10.1038/nrc1208 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004573220
    250 https://doi.org/10.1038/nrc1208
    251 rdf:type schema:CreativeWork
    252 sg:pub.10.1038/nrc840 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053102883
    253 https://doi.org/10.1038/nrc840
    254 rdf:type schema:CreativeWork
    255 sg:pub.10.1038/sj.leu.2402399 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044356206
    256 https://doi.org/10.1038/sj.leu.2402399
    257 rdf:type schema:CreativeWork
    258 sg:pub.10.1038/sj.leu.2402849 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028416371
    259 https://doi.org/10.1038/sj.leu.2402849
    260 rdf:type schema:CreativeWork
    261 sg:pub.10.1038/sj.onc.1202459 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045912171
    262 https://doi.org/10.1038/sj.onc.1202459
    263 rdf:type schema:CreativeWork
    264 sg:pub.10.1038/sj.onc.1203202 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004293631
    265 https://doi.org/10.1038/sj.onc.1203202
    266 rdf:type schema:CreativeWork
    267 sg:pub.10.1038/sj.onc.1203321 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040048209
    268 https://doi.org/10.1038/sj.onc.1203321
    269 rdf:type schema:CreativeWork
    270 sg:pub.10.1038/sj.onc.1203588 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000714314
    271 https://doi.org/10.1038/sj.onc.1203588
    272 rdf:type schema:CreativeWork
    273 sg:pub.10.1038/sj.onc.1204090 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032144939
    274 https://doi.org/10.1038/sj.onc.1204090
    275 rdf:type schema:CreativeWork
    276 sg:pub.10.1038/sj.onc.1205447 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010570511
    277 https://doi.org/10.1038/sj.onc.1205447
    278 rdf:type schema:CreativeWork
    279 sg:pub.10.1046/j.1523-1755.2002.0610s1099.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1011554459
    280 https://doi.org/10.1046/j.1523-1755.2002.0610s1099.x
    281 rdf:type schema:CreativeWork
    282 https://app.dimensions.ai/details/publication/pub.1074267280 schema:CreativeWork
    283 https://app.dimensions.ai/details/publication/pub.1074619832 schema:CreativeWork
    284 https://app.dimensions.ai/details/publication/pub.1074710157 schema:CreativeWork
    285 https://app.dimensions.ai/details/publication/pub.1074735220 schema:CreativeWork
    286 https://app.dimensions.ai/details/publication/pub.1074841701 schema:CreativeWork
    287 https://app.dimensions.ai/details/publication/pub.1075208240 schema:CreativeWork
    288 https://app.dimensions.ai/details/publication/pub.1082853107 schema:CreativeWork
    289 https://app.dimensions.ai/details/publication/pub.1082886878 schema:CreativeWork
    290 https://app.dimensions.ai/details/publication/pub.1083249354 schema:CreativeWork
    291 https://doi.org/10.1002/(sici)1097-4644(19980601)69:3<353::aid-jcb12>3.0.co;2-d schema:sameAs https://app.dimensions.ai/details/publication/pub.1022682163
    292 rdf:type schema:CreativeWork
    293 https://doi.org/10.1002/1098-2264(2001)9999:9999<::aid-gcc1107>3.0.co;2-c schema:sameAs https://app.dimensions.ai/details/publication/pub.1050547699
    294 rdf:type schema:CreativeWork
    295 https://doi.org/10.1002/pros.10233 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004039800
    296 rdf:type schema:CreativeWork
    297 https://doi.org/10.1016/s0034-6667(99)00046-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004701926
    298 rdf:type schema:CreativeWork
    299 https://doi.org/10.1016/s0092-8674(00)81902-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026392285
    300 rdf:type schema:CreativeWork
    301 https://doi.org/10.1016/s0092-8674(02)00690-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038516403
    302 rdf:type schema:CreativeWork
    303 https://doi.org/10.1016/s0092-8674(03)00308-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007016505
    304 rdf:type schema:CreativeWork
    305 https://doi.org/10.1016/s0304-3835(98)00318-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038410537
    306 rdf:type schema:CreativeWork
    307 https://doi.org/10.1016/s0959-437x(03)00007-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039051125
    308 rdf:type schema:CreativeWork
    309 https://doi.org/10.1016/s1079-9796(03)00031-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007923678
    310 rdf:type schema:CreativeWork
    311 https://doi.org/10.1073/pnas.1633291100 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007202802
    312 rdf:type schema:CreativeWork
    313 https://doi.org/10.1073/pnas.180309597 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044724051
    314 rdf:type schema:CreativeWork
    315 https://doi.org/10.1073/pnas.91.10.4509 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049142960
    316 rdf:type schema:CreativeWork
    317 https://doi.org/10.1073/pnas.94.16.8646 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044799114
    318 rdf:type schema:CreativeWork
    319 https://doi.org/10.1073/pnas.97.1.174 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042427433
    320 rdf:type schema:CreativeWork
    321 https://doi.org/10.1074/jbc.274.44.31577 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024479264
    322 rdf:type schema:CreativeWork
    323 https://doi.org/10.1074/jbc.275.5.3438 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008327136
    324 rdf:type schema:CreativeWork
    325 https://doi.org/10.1074/jbc.c000485200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045371511
    326 rdf:type schema:CreativeWork
    327 https://doi.org/10.1074/jbc.m105947200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049028819
    328 rdf:type schema:CreativeWork
    329 https://doi.org/10.1093/nar/18.12.3587 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002928860
    330 rdf:type schema:CreativeWork
    331 https://doi.org/10.1093/nar/23.10.1686 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009166721
    332 rdf:type schema:CreativeWork
    333 https://doi.org/10.1128/jvi.75.20.9790-9798.2001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004275066
    334 rdf:type schema:CreativeWork
    335 https://doi.org/10.1128/jvi.76.9.4364-4369.2002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017190337
    336 rdf:type schema:CreativeWork
    337 https://doi.org/10.1128/mcb.15.4.1974 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028775369
    338 rdf:type schema:CreativeWork
    339 https://doi.org/10.1128/mcb.20.23.8783-8792.2000 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036395073
    340 rdf:type schema:CreativeWork
    341 https://doi.org/10.2106/00004623-200100001-00007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1068894173
    342 rdf:type schema:CreativeWork
    343 https://doi.org/10.4049/jimmunol.169.6.2866 schema:sameAs https://app.dimensions.ai/details/publication/pub.1075119300
    344 rdf:type schema:CreativeWork
    345 https://www.grid.ac/institutes/grid.21107.35 schema:alternateName Johns Hopkins University
    346 schema:name Division of Pediatric Oncology, John Hopkins University, Cancer Research Building, Room 253, 1650 Orleans Street, Baltimore, MD 21231, USA
    347 rdf:type schema:Organization
    348 https://www.grid.ac/institutes/grid.270240.3 schema:alternateName Fred Hutchinson Cancer Research Center
    349 schema:name Fred Hutchinson Cancer Research Center, 1100 Fairview Ave., Seattle, WA 98109, USA
    350 rdf:type schema:Organization
    351 https://www.grid.ac/institutes/grid.8756.c schema:alternateName University of Glasgow
    352 schema:name Molecular Oncology Laboratory, Institute of Comparative Medicine, Faculty of Veterinary Medicine, University of Glasgow, Bearsden Road, Glasgow G61 1QH, UK
    353 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...