Adult human mesenchymal stem cell as a target for neoplastic transformation View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2004-04-26

AUTHORS

Nedime Serakinci, Per Guldberg, Jorge S Burns, Basem Abdallah, Henrik Schrødder, Thomas Jensen, Moustapha Kassem

ABSTRACT

The neoplastic process may involve a cancer stem cell. This concept has emerged largely from the careful analysis of tumour biopsy systems from haematological, breast and brain tumours. However, the experimental systems necessary to provide the cellular and molecular evidence to support this important concept have been lacking. We have used adult mesenchymal stem cells (hMSC) transduced with the telomerase hTERT gene to investigate the neoplastic potential of adult stem cells. The hTERT-transduced line, hMSC-TERT20 at population doubling level (PDL) 256 showed loss of contact inhibition, anchorage independence and formed tumours in 10/10 mice. hMSC-TERT4 showed loss of contact inhibition at PDL 95, but did not exhibit anchorage independence and did not form tumours in mice. Both lines had a normal karyotype but showed deletion of the Ink4a/ARF locus. At later passage, hMSC-TERT4 also acquired an activating mutation in KRAS. In hMSC-TERT20, expression of the cell cycle-associated gene, DBCCR1 was lost due to promoter hypermethylation. This epigenetic event correlated with acquisition of tumorigenicity. These data suggest that the adult hMSCs can be targets for neoplastic transformation and have implications for the development of novel anticancer therapeutics and for the use of hMSC in tissue engineering and transplantation protocols. More... »

PAGES

5095-5098

References to SciGraph publications

  • 2000-06. Risky immortalization by telomerase in NATURE
  • 2002-06-27. Immortalization and transformation of primary human airway epithelial cells by gene transfer in ONCOGENE
  • 2002-10-09. Mutational analysis defines a minimum level of telomerase activity required for tumourigenic growth of human cells in ONCOGENE
  • 2002-06-20. Pluripotency of mesenchymal stem cells derived from adult marrow in NATURE
  • 2000-10-10. Concurrent disruption of p16INK4a and the ARF-p53 pathway predicts poor prognosis in aggressive non-Hodgkin's lymphoma in LEUKEMIA
  • 2002-06. Telomerase expression extends the proliferative life-span and maintains the osteogenic potential of human bone marrow stromal cells in NATURE BIOTECHNOLOGY
  • 2001-11. Stem cells, cancer, and cancer stem cells in NATURE
  • 2001-05. Negative regulation of G1/S transition by the candidate bladder tumour suppressor gene DBCCR1 in ONCOGENE
  • 1998-11. Both Rb/p16INK4a inactivation and telomerase activity are required to immortalize human epithelial cells in NATURE
  • 2002-06. Bone formation by human postnatal bone marrow stromal stem cells is enhanced by telomerase expression in NATURE BIOTECHNOLOGY
  • 2003-09. Mechanisms of sarcoma development in NATURE REVIEWS CANCER
  • 2003-06. Stem-cell hierarchy in skin cancer in NATURE REVIEWS CANCER
  • 2003-06. Contribution of stem cells and differentiated cells to epidermal tumours in NATURE REVIEWS CANCER
  • 2003-04-20. Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells in NATURE
  • 2003-04-20. Bmi-1 determines the proliferative capacity of normal and leukaemic stem cells in NATURE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/sj.onc.1207651

    DOI

    http://dx.doi.org/10.1038/sj.onc.1207651

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1001422247

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/15107831


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