C3G-mediated suppression of oncogene-induced focus formation in fibroblasts involves inhibition of ERK activation, cyclin A expression and alterations of anchorage-independent ... View Full Text


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Article Info

DATE

2004-04-12

AUTHORS

Carmen Guerrero, Susana Martín-Encabo, Alberto Fernández-Medarde, Eugenio Santos

ABSTRACT

We showed previously that exogenous overexpression of C3G, a guanine nucleotide releasing factor (GEF) for Rap1 and R-Ras proteins, blocks the focus-forming activity of cotransfected, activated, sis, ras and v-raf oncogenes in NIH 3T3 cells. In this report, we show that C3G also interferes with dbl and R-Ras focus-forming activity and demonstrate that the transformation suppressor ability of C3G maps to its Crk-binding region (SH3-b domain). Using full-length C3G and C3GΔCat mutant, lacking catalytic domain, we showed here that overexpression of cotransfected C3G or C3GΔCat inhibited oncogenic Hraslys12-mediated phosphorylation of ERK, without altering Ras and Raf-1 kinase activation. We also showed that, overexpressed C3G and C3GΔCat inhibited the viability of oncogenic Ras-induced colonies in soft agar, indicating that C3G interferes with the anchorage-independent growth of Ras-transformed cells in a Rap1-independent manner. Consistent with both observations, overexpression of exogenous C3G and C3GΔCat also caused downregulation of Ras-induced cyclin A expression. Altogether, our results indicate that C3G interferes with at least two separate aspects of oncogenic transformation – cell cycle progression and loss of contact inhibition – and that these inhibitory effects probably account for its transformation suppressor activity. More... »

PAGES

4885-4893

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/sj.onc.1207622

DOI

http://dx.doi.org/10.1038/sj.onc.1207622

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1017888690

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/15077165


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