Distinct functional domains of Nbs1 modulate the timing and magnitude of ATM activation after low doses of ionizing radiation View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2004-04

AUTHORS

Zuzana Hořejší, Jacob Falck, Christopher J Bakkenist, Michael B Kastan, Jiri Lukas, Jiri Bartek

ABSTRACT

The ATM kinase is a tumour suppressor and a key activator of genome integrity checkpoints in mammalian cells exposed to ionizing radiation (IR) and other insults that elicit DNA double-strand breaks (DSBs). In response to IR, autophosphorylation on serine 1981 causes dissociation of ATM dimers and initiates cellular ATM kinase activity. Here, we show that the kinetics and magnitude of ATM Ser1981 phosphorylation after exposure of human fibroblasts to low doses (2 Gy) of IR are altered in cells deficient in Nbs1, a substrate of ATM and a component of the MRN (Mre11-Rad50-Nbs1) complex involved in processing/repair of DSBs and ATM-dependent cell cycle checkpoints. Timely phosphorylation of both ATM Ser1981 and the ATM substrate Smc1 after IR were rescued via retrovirally mediated reconstitution of Nbs1-deficient cells by wild-type Nbs1 or mutants of Nbs1 defective in the FHA domain or nonphosphorylatable by ATM, but not by Nbs1 lacking the Mre11-interaction domain. Our data indicate that apart from its role downstream of ATM in the DNA damage checkpoint network, the MRN complex serves also as a modulator/amplifier of ATM activity. Although not absolutely required for ATM activation, the MRN nuclease complex may help reach the threshold activity of ATM necessary for optimal genome maintenance and prevention of cancer. More... »

PAGES

3122

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/sj.onc.1207447

DOI

http://dx.doi.org/10.1038/sj.onc.1207447

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1024136462

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/15048089


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