Expression of the zinc transporter ZnT4 is decreased in the progression from early prostate disease to invasive prostate cancer View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2003-09-04

AUTHORS

Susan M Henshall, Daniel E H Afar, Krishan K Rasiah, Lisa G Horvath, Kurt Gish, Ingrid Caras, Vanitha Ramakrishnan, Melanie Wong, Ursula Jeffry, James G Kench, David I Quinn, Jennifer J Turner, Warick Delprado, C-Soon Lee, David Golovsky, Phillip C Brenner, Gordon F O'Neill, Raji Kooner, Phillip D Stricker, John J Grygiel, David H Mack, Robert L Sutherland

ABSTRACT

We have utilized oligonucleotide microarrays to identify novel genes of potential clinical and biological importance in prostate cancer. RNA from 74 prostate cancers and 164 normal body samples representing 40 different tissues were analysed using a customized Affymetrix GeneChip® oligonucleotide microarray representative of over 90% of the expressed human genome. The gene for the zinc transporter ZnT4 was one of several genes that displayed significantly higher expression in prostate cancer compared to normal tissues from other organs. A polyclonal antipeptide antibody was used to demonstrate ZnT4 expression in the epithelium of all 165 elements of benign and 326 elements of localized prostate cancers examined and in nine of 10 advanced prostate cancer specimens by immunohistochemistry. Interestingly, decreased intensity of ZnT4 immunoreactivity occurred in the progression from benign to invasive localized prostate cancer and to metastatic disease. Immunofluorescence analysis and surface biotinylation studies of cells expressing ZnT4 localised the protein to intracellular vesicles and to the plasma membrane. These findings are consistent with a role for ZnT4 in vesicular transport of zinc to the cell membrane and potentially in efflux of zinc in the prostate. More... »

PAGES

6005-6012

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/sj.onc.1206797

DOI

http://dx.doi.org/10.1038/sj.onc.1206797

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1026089133

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/12955079


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370 rdf:type schema:Organization
371 grid-institutes:grid.437825.f schema:alternateName Department of Anatomical Pathology, St Vincent's Hospital, NSW 2010, Darlinghurst, Australia
372 Department of Medical Oncology, St Vincent's Hospital, NSW 2010, Darlinghurst, Australia
373 Department of Urology, St Vincent's Hospital, NSW 2010, Darlinghurst, Australia
374 schema:name Department of Anatomical Pathology, St Vincent's Hospital, NSW 2010, Darlinghurst, Australia
375 Department of Medical Oncology, St Vincent's Hospital, NSW 2010, Darlinghurst, Australia
376 Department of Urology, St Vincent's Hospital, NSW 2010, Darlinghurst, Australia
377 rdf:type schema:Organization
 




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