Development of T-cell lymphomas in Eμ-IEX-1 mice View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2003-10-09

AUTHORS

Yujin Zhang, Milton J Finegold, Françoise Porteu, Prasad Kanteti, Mei X Wu

ABSTRACT

Inhibition of apoptosis or abnormal cell survival can result in tumorigenesis by facilitating the insurgence of various mutations. Immediate-early response gene X-1 (IEX-1), protects T cells from apoptosis induced by the ligation of Fas or the T-cell receptor (TCR)/CD3 complex in Eμ-IEX-1 mice that direct the gene expression in both T and B cell lineages under the control of the Eμ enhancer. Consistent with a biased effect of IEX-1 towards T cells, Eμ-IEX-1 mice selectively developed T-cell lymphomas in the spleen, when they aged, which may be associated with increased levels of IEX-1 phosphorylation in T cells compared to B cells. The lymphomas were single positive (CD4+CD8−, CD4−CD8+), double positive (CD4+CD8+), or double negative (CD4−CD8−) T cells. They resulted from aberrantly clonal expansions of T cells expressing a specific TCR, as suggested by the TCR repertoire analysis using a panel of monoclonal antibodies recognizing TCR Vβ chain, as well as by TCR β gene rearrangements. The study provides, for the first time, unambiguous evidence of the oncogenic potential of IEX-1 in a cell-specific manner. The animal model may help our understanding of peripheral T-cell lymphoma development. More... »

PAGES

6845-6851

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/sj.onc.1206707

DOI

http://dx.doi.org/10.1038/sj.onc.1206707

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1018812683

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/14534530


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