Ultraviolet radiation and cutaneous malignant melanoma View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2003-05-19

AUTHORS

Chamelli Jhappan, Frances P Noonan, Glenn Merlino

ABSTRACT

Recent years have seen a steady rise in the incidence of cutaneous malignant melanoma worldwide. Although it is now appreciated that the key to understanding the process by which melanocytes are transformed into malignant melanoma lies in the interplay between genetic factors and the ultraviolet (UV) spectrum of sunlight, the nature of this relation has remained obscure. Recently, prospects for elucidating the molecular mechanisms underlying such gene–environment interactions have brightened considerably through the development of UV-responsive experimental animal models of melanoma. Genetically engineered mice and human skin xenografts constitute novel platforms upon which to build studies designed to elucidate the pathogenesis of UV-induced melanomagenesis. The future refinement of these in vivo models should provide a wealth of information on the cellular and genetic targets of UV, the pathways responsible for the repair of UV-induced DNA damage, and the molecular interactions between melanocytes and other skin cells in response to UV. It is anticipated that exploitation of these model systems will contribute significantly toward the development of effective approaches to the prevention and treatment of melanoma. More... »

PAGES

3099-3112

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/sj.onc.1206450

    DOI

    http://dx.doi.org/10.1038/sj.onc.1206450

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1013490838

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/12789287


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