Nijmegen breakage syndrome gene, NBS1, and molecular links to factors for genome stability View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2002-12

AUTHORS

Hiroshi Tauchi, Shinya Matsuura, Junya Kobayashi, Shuichi Sakamoto, Kenshi Komatsu

ABSTRACT

DNA double-strand breaks represent the most potentially serious damage to a genome and hence, at least two pathways of DNA repair have evolved; namely, homologous recombination repair and non-homologous end joining. Defects in both rejoining processes result in genomic instability including chromosome rearrangements, LOH and gene mutations, which may lead to development of malignancies. Nijmegen breakage syndrome is a recessive genetic disorder, characterized by elevated sensitivity to ionizing radiation that induces double-strand breaks, and high frequency of malignancies. NBS1, the product of the gene underlying the disease, forms a multimeric complex with hMRE11/hRAD50 nuclease and recruits them to the vicinity of sites of DNA damage by direct binding to phosphorylated histone H2AX. The combination of the highly-conserved NBS1 forkhead associated domain and BRCA1 C-terminus domain has a crucial role for recognition of damaged sites. Thereafter, the NBS1-complex proceeds to rejoin double-strand breaks predominantly by homologous recombination repair in vertebrates. This process collaborates with cell-cycle checkpoints at S and G2 phase to facilitate DNA repair. NBS1 is also associated with telomere maintenance and DNA replication. Based on recent knowledge regarding NBS1, we propose here a two-step binding mechanism for damage recognition by repair proteins, and describe the molecular links to factors for genome stability. More... »

PAGES

1206136

References to SciGraph publications

  • 2001-12. AID is required to initiate Nbs1/γ-H2AX focus formation and mutations at sites of class switching in NATURE
  • 1998-06. Positional cloning of the gene for Nijmegen breakage syndrome in NATURE GENETICS
  • 2002-08. The Rad50 zinc-hook is a structure joining Mre11 complexes in DNA recombination and repair in NATURE
  • 2000-04. ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway in NATURE
  • 1999-12. DNA damage-induced cell cycle checkpoints and DNA strand break repair in development and tumorigenesis in ONCOGENE
  • 2000-12. A role for Saccharomyces cerevisiae histone H2A in DNA repair in NATURE
  • 2002-03. The DNA damage-dependent intra–S phase checkpoint is regulated by parallel pathways in NATURE GENETICS
  • 2002-01. Protection of mammalian telomeres in ONCOGENE
  • 1997-09. Clustering of missense mutations in the ataxia-telanglectasia gene in a sporadic T-cell leukaemia in NATURE GENETICS
  • 2001-04. The ATM–Chk2–Cdc25A checkpoint pathway guards against radioresistant DNA synthesis in NATURE
  • 1996-07. Accelerated telomere shortening in ataxia telangiectasia in NATURE GENETICS
  • 2002-06. Nbs1 promotes ATM dependent phosphorylation events including those required for G1/S arrest in ONCOGENE
  • 1999-09. Gross chromosomal rearrangements in Saccharomyces cerevisiae replication and recombination defective mutants in NATURE GENETICS
  • 2001-09. DNA double strand break repair and chromosomal translocation: Lessons from animal models in ONCOGENE
  • 1997-10. Biallelic mutations in the ATM gene in T-prolymphocytic leukemia in NATURE MEDICINE
  • 2000-05. ATM phosphorylation of Nijmegen breakage syndrome protein is required in a DNA damage response in NATURE
  • 2000-05. Functional link between ataxia-telangiectasia and Nijmegen breakage syndrome gene products in NATURE
  • 2000-07. Cell-cycle-regulated association of RAD50/MRE11/NBS1 with TRF2 and human telomeres in NATURE GENETICS
  • 2000-11. Clinical ascertainment of Nijmegen breakage syndrome (NBS) and prevalence of the major mutation, 657del5, in three Slav populations in EUROPEAN JOURNAL OF HUMAN GENETICS
  • 2001-04. An alternative mode of translation permits production of a variant NBS1 protein from the common Nijmegen breakage syndrome allele in NATURE GENETICS
  • 2001-09. Checkpoint activation in response to double-strand breaks requires the Mre11/Rad50/Xrs2 complex in NATURE CELL BIOLOGY
  • 2002-05. The MRE11 complex: at the crossroads of DNA repair and checkpoint signalling in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 2001-03. Recombinational DNA double-strand breaks in mice precede synapsis in NATURE GENETICS
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/sj.onc.1206136

    DOI

    http://dx.doi.org/10.1038/sj.onc.1206136

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1035503266

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/12483513


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