The Id2 gene is a novel target of transcriptional activation by EWS-ETS fusion proteins in Ewing family tumors View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2002-11-25

AUTHORS

Hiroyuki Nishimori, Yasushi Sasaki, Koichi Yoshida, Hideto Irifune, Hitoshi Zembutsu, Toshihiro Tanaka, Tomoki Aoyama, Taisuke Hosaka, Satoshi Kawaguchi, Takuro Wada, Jun-ichi Hata, Junya Toguchida, Yusuke Nakamura, Takashi Tokino

ABSTRACT

We report here that the Id2 (inhibitor of DNA binding 2) gene is a novel target of transcriptional activation by EWS–FLI1 and EWS–ERG, two fusion proteins that characterize Ewing family tumors (EFTs). To identify downstream targets of these EWS–ETS fusion proteins, we introduced EWS–ETS fusion constructs into a human fibrosarcoma cell line by retroviral transduction. cDNA microarray analysis revealed that Id2 expression was up-regulated by introducing the EWS–ETS fusion gene but not by the normal full-length ETS gene. An Id2 promoter-luciferase reporter assay showed that transactivation by EWS–ETS involves the minimal Id2 promoter and may function in cooperation with c-Myc within the full-length regulatory region. A chromatin immunoprecipitation assay revealed direct interaction between the Id2 promoter and EWS-FLI1 fusion protein in vivo. Significantly higher expression of Id2 and c-Myc was observed in all of the six EFT cell lines examined compared to six other sarcoma cell lines. Moreover, high levels of Id2 expression were also observed in five of the six primary tumors examined. Id2 is generally thought to affect the balance between cell differentiation and proliferation in development and is highly expressed in several cancer types. Considering these previous studies, our data suggest that the oncogenic effect of EWS–ETS may be mediated in part by up-regulating Id2 expression. More... »

PAGES

8302-8309

References to SciGraph publications

  • 2001-12-20. Id and development in ONCOGENE
  • 2001-06-01. Molecular Analysis of the 9p21 Locus and p53 Genes in Ewing Family Tumors in LABORATORY INVESTIGATION
  • 2001-12-20. Id proteins at the cross-road of development and cancer in ONCOGENE
  • 2000-10. Id2 is a retinoblastoma protein target and mediates signalling by Myc oncoproteins in NATURE
  • 2001-05-31. Analysis of the expression of cell cycle regulators in Ewing cell lines: EWS-FLI-1 modulates p57KIP2 and c-Myc expression in ONCOGENE
  • 1997-12. EWS/FLI1-induced manic fringe renders NIH 3T3 cells tumorigenic in NATURE GENETICS
  • 2001-12-20. Id proteins in cell cycle control and cellular senescence in ONCOGENE
  • 1999-02. Development of peripheral lymphoid organs and natural killer cells depends on the helix–loop–helix inhibitor Id2 in NATURE
  • 2001-02-01. PDGF-C is an EWS/FLI induced transforming growth factor in Ewing family tumors in ONCOGENE
  • 1994-02. A second Ewing's sarcoma translocation, t(21;22), fuses the EWS gene to another ETS–family transcription factor, ERG in NATURE GENETICS
  • 1997-03-13. A new member of the ETS family fused to EWS in Ewing tumors in ONCOGENE
  • 1998-10-21. EWS/FLI1 up regulates mE2-C, a cyclin-selective ubiquitin conjugating enzyme involved in cyclin B destruction in ONCOGENE
  • 1992-09. Gene fusion with an ETS DNA-binding domain caused by chromosome translocation in human tumours in NATURE
  • 1999-10. Repression of the gene encoding the TGF-β type II receptor is a major target of the EWS-FLI1 oncoprotein in NATURE GENETICS
  • Journal

    TITLE

    Oncogene

    ISSUE

    54

    VOLUME

    21

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/sj.onc.1206025

    DOI

    http://dx.doi.org/10.1038/sj.onc.1206025

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1049196640

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/12447693


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