Strong inhibition of Ewing tumor xenograft growth by combination of human interferon-alpha or interferon-beta with ifosfamide View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2002-10

AUTHORS

Josiane Sancéau, Marie-France Poupon, Olivier Delattre, Xavier Sastre-Garau, Juana Wietzerbin

ABSTRACT

Ewing sarcoma is the second most common bone tumor in childhood. Despite aggressive chemotherapy and radiotherapy strategies, the prognosis of patients with metastatic disease remains poor. We have recently reported that Ewing tumor cell proliferation was strongly inhibited by IFN-beta and to a lesser degree by IFN-alpha. Moreover, under IFN-beta treatment, some cell lines undergo apoptosis. Since the possibility of using IFNs for Ewing tumor treatments may be of interest, we have evaluated the efficacy of Hu-IFNs in a nude mice model of Ewing tumor xenografts. The results reported here show that human type I IFNs, Hu-IFN-alpha and Hu-IFN-beta impaired tumor xenograft take and displayed an anti-growth effect toward established xenografts. Furthermore, we have also shown that combined therapy with Hu-IFNs and ifosfamide (IFO), an alkylating agent widely used in high-dose chemotherapy of Ewing tumors, results in a strong antitumor effect. Pathological analysis showed that Hu-IFN-alpha/IFO and Hu-IFN-beta/IFO were characterized by a dramatic decrease in the mitotic index and marked necrosis, as well as extensive fibrosis associated with numerous calcifications. To our knowledge, this is the first demonstration of a potential antitumor effect of human type I IFNs and IFO on Ewing tumors, providing a rational foundation for a promising therapeutic approach to Ewing sarcoma. More... »

PAGES

1205881

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/sj.onc.1205881

DOI

http://dx.doi.org/10.1038/sj.onc.1205881

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1021758180

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/12400012


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antineoplastic Agents, Alkylating", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antineoplastic Combined Chemotherapy Protocols", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Bone Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA-Binding Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Ifosfamide", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Interferon-alpha", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Interferon-beta", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Nude", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "STAT1 Transcription Factor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Sarcoma, Ewing", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Trans-Activators", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Xenograft Model Antitumor Assays", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Institute Curie", 
          "id": "https://www.grid.ac/institutes/grid.418596.7", 
          "name": [
            "INSERM U365, Institut Curie, Section Recherche 26, rue d'Ulm, 75\u200a248 - Paris Cedex 05, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sanc\u00e9au", 
        "givenName": "Josiane", 
        "id": "sg:person.047512263.70", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.047512263.70"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute Curie", 
          "id": "https://www.grid.ac/institutes/grid.418596.7", 
          "name": [
            "CNRS-UMR 147, Institut Curie, Section Recherche 26, rue d'Ulm, 75\u200a248 - Paris Cedex 05, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Poupon", 
        "givenName": "Marie-France", 
        "id": "sg:person.0652076534.67", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0652076534.67"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute Curie", 
          "id": "https://www.grid.ac/institutes/grid.418596.7", 
          "name": [
            "INSERM U509, Institut Curie, Section Recherche 26, rue d'Ulm, 75\u200a248 - Paris Cedex 05, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Delattre", 
        "givenName": "Olivier", 
        "id": "sg:person.01346440237.46", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01346440237.46"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute Curie", 
          "id": "https://www.grid.ac/institutes/grid.418596.7", 
          "name": [
            "MD, Department of Pathology, Institut Curie, Section M\u00e9dicale, 26 rue d'Ulm, 75\u200a248 - Paris Cedex 05 - France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sastre-Garau", 
        "givenName": "Xavier", 
        "id": "sg:person.01354335252.66", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01354335252.66"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute Curie", 
          "id": "https://www.grid.ac/institutes/grid.418596.7", 
          "name": [
            "INSERM U365, Institut Curie, Section Recherche 26, rue d'Ulm, 75\u200a248 - Paris Cedex 05, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wietzerbin", 
        "givenName": "Juana", 
        "id": "sg:person.0770621016.51", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0770621016.51"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1111/j.1600-0609.1997.tb00965.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002390097"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0955-0674(97)80067-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002648644"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1097-0142(19960815)78:4<901::aid-cncr30>3.0.co;2-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005144409"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1074-7613(01)00154-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007783883"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/359162a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008302153", 
          "https://doi.org/10.1038/359162a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1097-0142(19990801)86:3<421::aid-cncr10>3.0.co;2-o", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009059907"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01877207", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010100005", 
          "https://doi.org/10.1007/bf01877207"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01877207", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010100005", 
          "https://doi.org/10.1007/bf01877207"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/sj.neo.7900128", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014790810"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.14.5.3230", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014950933"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1054/bjoc.2000.1438", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017924959", 
          "https://doi.org/10.1054/bjoc.2000.1438"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.13.12.7393", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019123032"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.91.4.1198", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020445985"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/taap.1996.0077", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028447256"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/1097-0142(20001215)89:12<2630::aid-cncr16>3.0.co;2-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029154741"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/1097-0142(20001215)89:12<2630::aid-cncr16>3.0.co;2-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029154741"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev.biochem.67.1.227", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033786268"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s004310051089", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034208654", 
          "https://doi.org/10.1007/s004310051089"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0959-8049(01)00131-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040645519"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2141.1991.tb08112.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044337232"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0166-2236(96)10071-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044886393"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s002620050525", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047533191", 
          "https://doi.org/10.1007/s002620050525"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0955-0674(00)00199-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048152369"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.273.14.8003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051049277"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ijc.2910570308", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053261318"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0037-1963(01)90114-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053298259"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0037-1963(01)90114-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053298259"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/107999001459132", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059206834"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/jir.1996.16.339", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059280251"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci200109841", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063416032"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074253940", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074265161", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074484288", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1634/theoncologist.3-3-198", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074484288"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074512844", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074539501", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074641695", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2001.19.3.870", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074750698"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077288142", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082416185", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082781841", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083054067", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083280350", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.1998.16.12.3736", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083360497"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2002-10", 
    "datePublishedReg": "2002-10-01", 
    "description": "Ewing sarcoma is the second most common bone tumor in childhood. Despite aggressive chemotherapy and radiotherapy strategies, the prognosis of patients with metastatic disease remains poor. We have recently reported that Ewing tumor cell proliferation was strongly inhibited by IFN-beta and to a lesser degree by IFN-alpha. Moreover, under IFN-beta treatment, some cell lines undergo apoptosis. Since the possibility of using IFNs for Ewing tumor treatments may be of interest, we have evaluated the efficacy of Hu-IFNs in a nude mice model of Ewing tumor xenografts. The results reported here show that human type I IFNs, Hu-IFN-alpha and Hu-IFN-beta impaired tumor xenograft take and displayed an anti-growth effect toward established xenografts. Furthermore, we have also shown that combined therapy with Hu-IFNs and ifosfamide (IFO), an alkylating agent widely used in high-dose chemotherapy of Ewing tumors, results in a strong antitumor effect. Pathological analysis showed that Hu-IFN-alpha/IFO and Hu-IFN-beta/IFO were characterized by a dramatic decrease in the mitotic index and marked necrosis, as well as extensive fibrosis associated with numerous calcifications. To our knowledge, this is the first demonstration of a potential antitumor effect of human type I IFNs and IFO on Ewing tumors, providing a rational foundation for a promising therapeutic approach to Ewing sarcoma.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/sj.onc.1205881", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1097543", 
        "issn": [
          "0950-9232", 
          "1476-5594"
        ], 
        "name": "Oncogene", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "50", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "21"
      }
    ], 
    "name": "Strong inhibition of Ewing tumor xenograft growth by combination of human interferon-alpha or interferon-beta with ifosfamide", 
    "pagination": "1205881", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "67aa45aca67bc09bcb9b63229ca802a2ff6603d8a38ab1c89b4fb8dca6a0b04a"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "12400012"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "8711562"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/sj.onc.1205881"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1021758180"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/sj.onc.1205881", 
      "https://app.dimensions.ai/details/publication/pub.1021758180"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T11:55", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000359_0000000359/records_29207_00000001.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://www.nature.com/articles/1205881"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/sj.onc.1205881'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/sj.onc.1205881'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/sj.onc.1205881'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/sj.onc.1205881'


 

This table displays all metadata directly associated to this object as RDF triples.

281 TRIPLES      21 PREDICATES      86 URIs      37 LITERALS      25 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/sj.onc.1205881 schema:about N028974fccc7246cbb5725c1ab2f770d4
2 N0462a4c8e2284a008192f1a119efda4b
3 N1b3db003995d4f5395aa56f885161f90
4 N2451808823724b368d5a655c3d6e7ba8
5 N340451e0d3ba44d09776292ad593e4ea
6 N4029ed2b75e0452c81acdc93e5522e5e
7 N40761d60db97407290686f1763687f57
8 N6800995f2d5a4d22b2122ead814c4216
9 N715fcefee9fc48d9beffb1c9b029ccf0
10 N98451401599f4edeaf1a5d041370004b
11 N99a18eeb347f4a2fb82b9b7768cb5c07
12 Nbfb06bbe85cc42d6b26e240937d692ff
13 Nc3352d5e31374fce8d98a48bb3c12a18
14 Nd09e1b191db540fabead629268463648
15 Nefd7367ee11b44ff8fdd0d5f98a037ae
16 Nf4e072c7107a40b28a7dafd4c1c9932a
17 anzsrc-for:11
18 anzsrc-for:1112
19 schema:author Nf216f4ea0d6a4fe8901952bd7e0b3329
20 schema:citation sg:pub.10.1007/bf01877207
21 sg:pub.10.1007/s002620050525
22 sg:pub.10.1007/s004310051089
23 sg:pub.10.1038/359162a0
24 sg:pub.10.1054/bjoc.2000.1438
25 https://app.dimensions.ai/details/publication/pub.1074253940
26 https://app.dimensions.ai/details/publication/pub.1074265161
27 https://app.dimensions.ai/details/publication/pub.1074484288
28 https://app.dimensions.ai/details/publication/pub.1074512844
29 https://app.dimensions.ai/details/publication/pub.1074539501
30 https://app.dimensions.ai/details/publication/pub.1074641695
31 https://app.dimensions.ai/details/publication/pub.1077288142
32 https://app.dimensions.ai/details/publication/pub.1082416185
33 https://app.dimensions.ai/details/publication/pub.1082781841
34 https://app.dimensions.ai/details/publication/pub.1083054067
35 https://app.dimensions.ai/details/publication/pub.1083280350
36 https://doi.org/10.1002/(sici)1097-0142(19960815)78:4<901::aid-cncr30>3.0.co;2-x
37 https://doi.org/10.1002/(sici)1097-0142(19990801)86:3<421::aid-cncr10>3.0.co;2-o
38 https://doi.org/10.1002/1097-0142(20001215)89:12<2630::aid-cncr16>3.0.co;2-z
39 https://doi.org/10.1002/ijc.2910570308
40 https://doi.org/10.1006/taap.1996.0077
41 https://doi.org/10.1016/s0037-1963(01)90114-3
42 https://doi.org/10.1016/s0166-2236(96)10071-0
43 https://doi.org/10.1016/s0955-0674(00)00199-x
44 https://doi.org/10.1016/s0955-0674(97)80067-1
45 https://doi.org/10.1016/s0959-8049(01)00131-9
46 https://doi.org/10.1016/s1074-7613(01)00154-6
47 https://doi.org/10.1038/sj.neo.7900128
48 https://doi.org/10.1073/pnas.91.4.1198
49 https://doi.org/10.1074/jbc.273.14.8003
50 https://doi.org/10.1089/107999001459132
51 https://doi.org/10.1089/jir.1996.16.339
52 https://doi.org/10.1111/j.1365-2141.1991.tb08112.x
53 https://doi.org/10.1111/j.1600-0609.1997.tb00965.x
54 https://doi.org/10.1128/mcb.13.12.7393
55 https://doi.org/10.1128/mcb.14.5.3230
56 https://doi.org/10.1146/annurev.biochem.67.1.227
57 https://doi.org/10.1172/jci200109841
58 https://doi.org/10.1200/jco.1998.16.12.3736
59 https://doi.org/10.1200/jco.2001.19.3.870
60 https://doi.org/10.1634/theoncologist.3-3-198
61 schema:datePublished 2002-10
62 schema:datePublishedReg 2002-10-01
63 schema:description Ewing sarcoma is the second most common bone tumor in childhood. Despite aggressive chemotherapy and radiotherapy strategies, the prognosis of patients with metastatic disease remains poor. We have recently reported that Ewing tumor cell proliferation was strongly inhibited by IFN-beta and to a lesser degree by IFN-alpha. Moreover, under IFN-beta treatment, some cell lines undergo apoptosis. Since the possibility of using IFNs for Ewing tumor treatments may be of interest, we have evaluated the efficacy of Hu-IFNs in a nude mice model of Ewing tumor xenografts. The results reported here show that human type I IFNs, Hu-IFN-alpha and Hu-IFN-beta impaired tumor xenograft take and displayed an anti-growth effect toward established xenografts. Furthermore, we have also shown that combined therapy with Hu-IFNs and ifosfamide (IFO), an alkylating agent widely used in high-dose chemotherapy of Ewing tumors, results in a strong antitumor effect. Pathological analysis showed that Hu-IFN-alpha/IFO and Hu-IFN-beta/IFO were characterized by a dramatic decrease in the mitotic index and marked necrosis, as well as extensive fibrosis associated with numerous calcifications. To our knowledge, this is the first demonstration of a potential antitumor effect of human type I IFNs and IFO on Ewing tumors, providing a rational foundation for a promising therapeutic approach to Ewing sarcoma.
64 schema:genre research_article
65 schema:inLanguage en
66 schema:isAccessibleForFree true
67 schema:isPartOf Na5681a140971491d88b21a7ac78c7ade
68 Nde72d891f078458ca856cbd72512f9d4
69 sg:journal.1097543
70 schema:name Strong inhibition of Ewing tumor xenograft growth by combination of human interferon-alpha or interferon-beta with ifosfamide
71 schema:pagination 1205881
72 schema:productId N0492af9506fd476c8c8d55a067a7223e
73 N4bc6b9d348bf480bbf78400967c44bb5
74 N6bceffac15734cc9b0741368210f5df3
75 N9f5c06a6e51a4295a98967e3d4ba4fbc
76 Nb45a7139175a4d13923b33f6bb17178f
77 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021758180
78 https://doi.org/10.1038/sj.onc.1205881
79 schema:sdDatePublished 2019-04-11T11:55
80 schema:sdLicense https://scigraph.springernature.com/explorer/license/
81 schema:sdPublisher N6d09909fa4b5415ba6326e76ec033332
82 schema:url http://www.nature.com/articles/1205881
83 sgo:license sg:explorer/license/
84 sgo:sdDataset articles
85 rdf:type schema:ScholarlyArticle
86 N028974fccc7246cbb5725c1ab2f770d4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
87 schema:name Sarcoma, Ewing
88 rdf:type schema:DefinedTerm
89 N0462a4c8e2284a008192f1a119efda4b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
90 schema:name STAT1 Transcription Factor
91 rdf:type schema:DefinedTerm
92 N0492af9506fd476c8c8d55a067a7223e schema:name nlm_unique_id
93 schema:value 8711562
94 rdf:type schema:PropertyValue
95 N11091655b67340c89a5a5ca7781a7581 rdf:first sg:person.01346440237.46
96 rdf:rest Ne7c1fb642f73468b9882d775148ffbd4
97 N1b3db003995d4f5395aa56f885161f90 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
98 schema:name DNA-Binding Proteins
99 rdf:type schema:DefinedTerm
100 N2451808823724b368d5a655c3d6e7ba8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
101 schema:name Trans-Activators
102 rdf:type schema:DefinedTerm
103 N340451e0d3ba44d09776292ad593e4ea schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
104 schema:name Humans
105 rdf:type schema:DefinedTerm
106 N4029ed2b75e0452c81acdc93e5522e5e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
107 schema:name Animals
108 rdf:type schema:DefinedTerm
109 N40761d60db97407290686f1763687f57 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
110 schema:name Ifosfamide
111 rdf:type schema:DefinedTerm
112 N4bc6b9d348bf480bbf78400967c44bb5 schema:name doi
113 schema:value 10.1038/sj.onc.1205881
114 rdf:type schema:PropertyValue
115 N6800995f2d5a4d22b2122ead814c4216 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
116 schema:name Interferon-beta
117 rdf:type schema:DefinedTerm
118 N6bceffac15734cc9b0741368210f5df3 schema:name dimensions_id
119 schema:value pub.1021758180
120 rdf:type schema:PropertyValue
121 N6d09909fa4b5415ba6326e76ec033332 schema:name Springer Nature - SN SciGraph project
122 rdf:type schema:Organization
123 N715fcefee9fc48d9beffb1c9b029ccf0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name Xenograft Model Antitumor Assays
125 rdf:type schema:DefinedTerm
126 N98451401599f4edeaf1a5d041370004b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
127 schema:name Interferon-alpha
128 rdf:type schema:DefinedTerm
129 N99a18eeb347f4a2fb82b9b7768cb5c07 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name Bone Neoplasms
131 rdf:type schema:DefinedTerm
132 N9f5c06a6e51a4295a98967e3d4ba4fbc schema:name readcube_id
133 schema:value 67aa45aca67bc09bcb9b63229ca802a2ff6603d8a38ab1c89b4fb8dca6a0b04a
134 rdf:type schema:PropertyValue
135 Na5681a140971491d88b21a7ac78c7ade schema:volumeNumber 21
136 rdf:type schema:PublicationVolume
137 Nb45a7139175a4d13923b33f6bb17178f schema:name pubmed_id
138 schema:value 12400012
139 rdf:type schema:PropertyValue
140 Nb48a3e745f3a476bad80733f9ff49da1 rdf:first sg:person.0770621016.51
141 rdf:rest rdf:nil
142 Nb911c89438ff40609884b4bb51c1a1b9 rdf:first sg:person.0652076534.67
143 rdf:rest N11091655b67340c89a5a5ca7781a7581
144 Nbfb06bbe85cc42d6b26e240937d692ff schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name Antineoplastic Agents, Alkylating
146 rdf:type schema:DefinedTerm
147 Nc3352d5e31374fce8d98a48bb3c12a18 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
148 schema:name Antineoplastic Combined Chemotherapy Protocols
149 rdf:type schema:DefinedTerm
150 Nd09e1b191db540fabead629268463648 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
151 schema:name Female
152 rdf:type schema:DefinedTerm
153 Nde72d891f078458ca856cbd72512f9d4 schema:issueNumber 50
154 rdf:type schema:PublicationIssue
155 Ne7c1fb642f73468b9882d775148ffbd4 rdf:first sg:person.01354335252.66
156 rdf:rest Nb48a3e745f3a476bad80733f9ff49da1
157 Nefd7367ee11b44ff8fdd0d5f98a037ae schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
158 schema:name Mice
159 rdf:type schema:DefinedTerm
160 Nf216f4ea0d6a4fe8901952bd7e0b3329 rdf:first sg:person.047512263.70
161 rdf:rest Nb911c89438ff40609884b4bb51c1a1b9
162 Nf4e072c7107a40b28a7dafd4c1c9932a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
163 schema:name Mice, Nude
164 rdf:type schema:DefinedTerm
165 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
166 schema:name Medical and Health Sciences
167 rdf:type schema:DefinedTerm
168 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
169 schema:name Oncology and Carcinogenesis
170 rdf:type schema:DefinedTerm
171 sg:journal.1097543 schema:issn 0950-9232
172 1476-5594
173 schema:name Oncogene
174 rdf:type schema:Periodical
175 sg:person.01346440237.46 schema:affiliation https://www.grid.ac/institutes/grid.418596.7
176 schema:familyName Delattre
177 schema:givenName Olivier
178 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01346440237.46
179 rdf:type schema:Person
180 sg:person.01354335252.66 schema:affiliation https://www.grid.ac/institutes/grid.418596.7
181 schema:familyName Sastre-Garau
182 schema:givenName Xavier
183 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01354335252.66
184 rdf:type schema:Person
185 sg:person.047512263.70 schema:affiliation https://www.grid.ac/institutes/grid.418596.7
186 schema:familyName Sancéau
187 schema:givenName Josiane
188 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.047512263.70
189 rdf:type schema:Person
190 sg:person.0652076534.67 schema:affiliation https://www.grid.ac/institutes/grid.418596.7
191 schema:familyName Poupon
192 schema:givenName Marie-France
193 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0652076534.67
194 rdf:type schema:Person
195 sg:person.0770621016.51 schema:affiliation https://www.grid.ac/institutes/grid.418596.7
196 schema:familyName Wietzerbin
197 schema:givenName Juana
198 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0770621016.51
199 rdf:type schema:Person
200 sg:pub.10.1007/bf01877207 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010100005
201 https://doi.org/10.1007/bf01877207
202 rdf:type schema:CreativeWork
203 sg:pub.10.1007/s002620050525 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047533191
204 https://doi.org/10.1007/s002620050525
205 rdf:type schema:CreativeWork
206 sg:pub.10.1007/s004310051089 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034208654
207 https://doi.org/10.1007/s004310051089
208 rdf:type schema:CreativeWork
209 sg:pub.10.1038/359162a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008302153
210 https://doi.org/10.1038/359162a0
211 rdf:type schema:CreativeWork
212 sg:pub.10.1054/bjoc.2000.1438 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017924959
213 https://doi.org/10.1054/bjoc.2000.1438
214 rdf:type schema:CreativeWork
215 https://app.dimensions.ai/details/publication/pub.1074253940 schema:CreativeWork
216 https://app.dimensions.ai/details/publication/pub.1074265161 schema:CreativeWork
217 https://app.dimensions.ai/details/publication/pub.1074484288 schema:CreativeWork
218 https://app.dimensions.ai/details/publication/pub.1074512844 schema:CreativeWork
219 https://app.dimensions.ai/details/publication/pub.1074539501 schema:CreativeWork
220 https://app.dimensions.ai/details/publication/pub.1074641695 schema:CreativeWork
221 https://app.dimensions.ai/details/publication/pub.1077288142 schema:CreativeWork
222 https://app.dimensions.ai/details/publication/pub.1082416185 schema:CreativeWork
223 https://app.dimensions.ai/details/publication/pub.1082781841 schema:CreativeWork
224 https://app.dimensions.ai/details/publication/pub.1083054067 schema:CreativeWork
225 https://app.dimensions.ai/details/publication/pub.1083280350 schema:CreativeWork
226 https://doi.org/10.1002/(sici)1097-0142(19960815)78:4<901::aid-cncr30>3.0.co;2-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1005144409
227 rdf:type schema:CreativeWork
228 https://doi.org/10.1002/(sici)1097-0142(19990801)86:3<421::aid-cncr10>3.0.co;2-o schema:sameAs https://app.dimensions.ai/details/publication/pub.1009059907
229 rdf:type schema:CreativeWork
230 https://doi.org/10.1002/1097-0142(20001215)89:12<2630::aid-cncr16>3.0.co;2-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1029154741
231 rdf:type schema:CreativeWork
232 https://doi.org/10.1002/ijc.2910570308 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053261318
233 rdf:type schema:CreativeWork
234 https://doi.org/10.1006/taap.1996.0077 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028447256
235 rdf:type schema:CreativeWork
236 https://doi.org/10.1016/s0037-1963(01)90114-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053298259
237 rdf:type schema:CreativeWork
238 https://doi.org/10.1016/s0166-2236(96)10071-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044886393
239 rdf:type schema:CreativeWork
240 https://doi.org/10.1016/s0955-0674(00)00199-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1048152369
241 rdf:type schema:CreativeWork
242 https://doi.org/10.1016/s0955-0674(97)80067-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002648644
243 rdf:type schema:CreativeWork
244 https://doi.org/10.1016/s0959-8049(01)00131-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040645519
245 rdf:type schema:CreativeWork
246 https://doi.org/10.1016/s1074-7613(01)00154-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007783883
247 rdf:type schema:CreativeWork
248 https://doi.org/10.1038/sj.neo.7900128 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014790810
249 rdf:type schema:CreativeWork
250 https://doi.org/10.1073/pnas.91.4.1198 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020445985
251 rdf:type schema:CreativeWork
252 https://doi.org/10.1074/jbc.273.14.8003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051049277
253 rdf:type schema:CreativeWork
254 https://doi.org/10.1089/107999001459132 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059206834
255 rdf:type schema:CreativeWork
256 https://doi.org/10.1089/jir.1996.16.339 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059280251
257 rdf:type schema:CreativeWork
258 https://doi.org/10.1111/j.1365-2141.1991.tb08112.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1044337232
259 rdf:type schema:CreativeWork
260 https://doi.org/10.1111/j.1600-0609.1997.tb00965.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1002390097
261 rdf:type schema:CreativeWork
262 https://doi.org/10.1128/mcb.13.12.7393 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019123032
263 rdf:type schema:CreativeWork
264 https://doi.org/10.1128/mcb.14.5.3230 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014950933
265 rdf:type schema:CreativeWork
266 https://doi.org/10.1146/annurev.biochem.67.1.227 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033786268
267 rdf:type schema:CreativeWork
268 https://doi.org/10.1172/jci200109841 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063416032
269 rdf:type schema:CreativeWork
270 https://doi.org/10.1200/jco.1998.16.12.3736 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083360497
271 rdf:type schema:CreativeWork
272 https://doi.org/10.1200/jco.2001.19.3.870 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074750698
273 rdf:type schema:CreativeWork
274 https://doi.org/10.1634/theoncologist.3-3-198 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074484288
275 rdf:type schema:CreativeWork
276 https://www.grid.ac/institutes/grid.418596.7 schema:alternateName Institute Curie
277 schema:name CNRS-UMR 147, Institut Curie, Section Recherche 26, rue d'Ulm, 75 248 - Paris Cedex 05, France
278 INSERM U365, Institut Curie, Section Recherche 26, rue d'Ulm, 75 248 - Paris Cedex 05, France
279 INSERM U509, Institut Curie, Section Recherche 26, rue d'Ulm, 75 248 - Paris Cedex 05, France
280 MD, Department of Pathology, Institut Curie, Section Médicale, 26 rue d'Ulm, 75 248 - Paris Cedex 05 - France
281 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...