A new locus for resistance to γ-radiation-induced thymic lymphoma identified using inter-specific consomic and inter-specific recombinant congenic strains of mice View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2002-09

AUTHORS

Javier Santos, Xavier Montagutelli, Abraham Acevedo, Pilar López, Concepción Vaquero, Mónica Fernández, Maria-Rosa Arnau, Marek Szatanik, Eduardo Salido, Jean-Louis Guénet, José Fernández-Piqueras

ABSTRACT

Mice of the C57BL/6J inbred strain develop thymic lymphomas at very high frequency after acute gamma-irradiation, while mice of several inbred strains derived from the wild progenitor of the Mus spretus species and their F1 hybrids with C57BL/6J appear extremely resistant. Analysis of the genetic determinism of the gamma-radiation-induced thymic lymphoma (RITL) resistance with the help of inter-specific consomic strains (ICS), which carry a single introgressed Mus spretus chromosome on a C57BL/6J genetic background, provide significant evidence for the existence of a thymic lymphoma resistance (Tlyr1) locus on chromosome 19. The subsequent analysis of the backcross progeny resulting from a cross between consomic mice heterozygous for the Mus spretus chromosome 19 and C57BL/6J mice, together with the study of inter-specific recombinant congenic strains (IRCS), suggest that this Tlyr1 locus maps within the D19Mit60-D19Mit40 chromosome interval. In addition to the discovery of a new locus controlling RITL development, our study emphasizes the value of ICS and IRCS for the genetic analysis of cancer predisposition. More... »

PAGES

6680

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/sj.onc.1205846

DOI

http://dx.doi.org/10.1038/sj.onc.1205846

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1034784640

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/12242666


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