Galectin-3 enhances cyclin D1 promoter activity through SP1 and a cAMP-responsive element in human breast epithelial cells View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2002-11

AUTHORS

Huei-Min Lin, Richard G Pestell, Avraham Raz, Hyeong-Reh Choi Kim

ABSTRACT

Galectin-3 is a multifunctional carbohydrate-binding protein found in the nucleus, cytoplasm and the extracellular milieu. Nuclear galectin-3 expression is associated with cell proliferation, and its role in pre-mRNA splicing has been suggested. In this report, we investigated the role of galectin-3 on cyclin D(1) gene expression, a critical inducer of the cell cycle and a potential oncogene in human cancer. We found that galectin-3 induces cyclin D(1) promoter activity in human breast epithelial cells independent of cell adhesion through multiple cis-elements, including the SP1 and CRE sites. We present evidence that galectin-3 induction of the cyclin D(1) promoter may result from enhancement/stabilization of nuclear protein-DNA complex formation at the CRE site of the cyclin D(1) promoter. We also show that galectin-3 co-operates with, but does not depend on, pRb for cyclin D(1) promoter activation. The present study reveals a growth promoting activity of galectin-3 through cyclin D(1) induction, and suggests a novel function of nuclear galectin-3 in the regulation of gene transcription. More... »

PAGES

1205820

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/sj.onc.1205820

DOI

http://dx.doi.org/10.1038/sj.onc.1205820

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1013824345

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/12439750


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Genetics", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Base Sequence", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Breast", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cyclic AMP", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cyclin D1", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA Primers", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Electrophoretic Mobility Shift Assay", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Epithelial Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Galectin 3", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Promoter Regions, Genetic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Sp1 Transcription Factor", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "National Institutes of Health", 
          "id": "https://www.grid.ac/institutes/grid.94365.3d", 
          "name": [
            "Department of Pathology, Wayne State University, School of Medicine, Detroit, Michigan, MI 48201, USA", 
            "Current address: Laboratory of Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, MD 20892-4255, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lin", 
        "givenName": "Huei-Min", 
        "id": "sg:person.01050716754.14", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01050716754.14"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Albert Einstein College of Medicine", 
          "id": "https://www.grid.ac/institutes/grid.251993.5", 
          "name": [
            "The Albert Einstein Cancer Center, Department of Medicine and Developmental and Molecular Biology, Albert Einstein College of Medicine, 1300 Morris Park Ave., Bronx, New York, NY 10461, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pestell", 
        "givenName": "Richard G", 
        "id": "sg:person.01230657614.02", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01230657614.02"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Wayne State University", 
          "id": "https://www.grid.ac/institutes/grid.254444.7", 
          "name": [
            "Breast Cancer Program, Barbara Ann Karmanos Cancer Institute, Wayne State University, School of Medicine, Detroit, Michigan, MI 48201, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Raz", 
        "givenName": "Avraham", 
        "id": "sg:person.01031334163.92", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01031334163.92"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Wayne State University", 
          "id": "https://www.grid.ac/institutes/grid.254444.7", 
          "name": [
            "Department of Pathology, Wayne State University, School of Medicine, Detroit, Michigan, MI 48201, USA", 
            "Breast Cancer Program, Barbara Ann Karmanos Cancer Institute, Wayne State University, School of Medicine, Detroit, Michigan, MI 48201, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kim", 
        "givenName": "Hyeong-Reh Choi", 
        "id": "sg:person.013330316604.88", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013330316604.88"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1006/bbrc.1995.2777", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000870104"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1202057", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001411249", 
          "https://doi.org/10.1038/sj.onc.1202057"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1202057", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001411249", 
          "https://doi.org/10.1038/sj.onc.1202057"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(94)90540-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001605098"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m100795200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002592071"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.271.34.20608", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003667263"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1023/a:1005913810250", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004908096", 
          "https://doi.org/10.1023/a:1005913810250"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.14.6.4032", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005593472"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.270.40.23589", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006951784"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/abbi.1997.0447", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007151758"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.19.4.2690", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009920172"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(91)90181-w", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010061423"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.15.7.3463", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010196427"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.92.4.1213", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011202755"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.18.6.3212", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012730091"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m000643200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018510117"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.143.7.1997", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021177961"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/carcin/21.11.1941", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024057183"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.274.11.7341", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025951197"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/emboj/18.5.1367", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026750816"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.271.37.22570", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027229407"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.274.36.25245", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027236521"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.93.23.12861", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027259595"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.133.2.391", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031511757"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0014-5793(00)01547-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031819526"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.93.13.6737", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035066592"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.21.16.5631-5643.2001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035212034"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.15.5.2600", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035576061"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m200154200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038304411"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1097-4652(199607)168:1<51::aid-jcp7>3.0.co;2-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038876490"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m005522200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039119103"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bj3080697", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039628005"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bj3080697", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039628005"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m107668200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040619628"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(95)90385-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044189874"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ijc.2910560404", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046250244"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.19.8.5785", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050921566"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0959-437x(05)80334-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051678666"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.12.6.2455", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053452659"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/er.20.4.501", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064285750"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074512857", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1075481573", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078977262", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082853618", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083182822", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2002-11", 
    "datePublishedReg": "2002-11-01", 
    "description": "Galectin-3 is a multifunctional carbohydrate-binding protein found in the nucleus, cytoplasm and the extracellular milieu. Nuclear galectin-3 expression is associated with cell proliferation, and its role in pre-mRNA splicing has been suggested. In this report, we investigated the role of galectin-3 on cyclin D(1) gene expression, a critical inducer of the cell cycle and a potential oncogene in human cancer. We found that galectin-3 induces cyclin D(1) promoter activity in human breast epithelial cells independent of cell adhesion through multiple cis-elements, including the SP1 and CRE sites. We present evidence that galectin-3 induction of the cyclin D(1) promoter may result from enhancement/stabilization of nuclear protein-DNA complex formation at the CRE site of the cyclin D(1) promoter. We also show that galectin-3 co-operates with, but does not depend on, pRb for cyclin D(1) promoter activation. The present study reveals a growth promoting activity of galectin-3 through cyclin D(1) induction, and suggests a novel function of nuclear galectin-3 in the regulation of gene transcription.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/sj.onc.1205820", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2626390", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2469631", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2472028", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1097543", 
        "issn": [
          "0950-9232", 
          "1476-5594"
        ], 
        "name": "Oncogene", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "52", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "21"
      }
    ], 
    "name": "Galectin-3 enhances cyclin D1 promoter activity through SP1 and a cAMP-responsive element in human breast epithelial cells", 
    "pagination": "1205820", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "41db10c99ba6916ab4f5b64fe09e967e7654360ba2e79cb35ad32773b9517d60"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "12439750"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "8711562"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/sj.onc.1205820"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1013824345"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/sj.onc.1205820", 
      "https://app.dimensions.ai/details/publication/pub.1013824345"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T11:52", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000359_0000000359/records_29194_00000000.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://www.nature.com/articles/1205820"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/sj.onc.1205820'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/sj.onc.1205820'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/sj.onc.1205820'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/sj.onc.1205820'


 

This table displays all metadata directly associated to this object as RDF triples.

274 TRIPLES      21 PREDICATES      83 URIs      32 LITERALS      20 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/sj.onc.1205820 schema:about N51412375559f4dc08ebedefc1bc3e9f6
2 N5c0934cfaa7d4d1b86d1502c7c507e7f
3 N63b6656e30624315b969286e48128c04
4 N6ce73cbd345140c58e7f96ad29bb7673
5 N70fabad76e7c4785b5e0e895a86522d5
6 Na5afe18b467941dcb574be7aa1120e3a
7 Na8543b17871f470b91b20d9703c8346a
8 Nb63b9c9d820d449da2d953fc1736a445
9 Nb89837cd2e9c4b10b3099257f2c103de
10 Nc3f57abe8c564b40b5e038c10800b014
11 Ne7a2195fcf47440baa96de1e7621e660
12 anzsrc-for:06
13 anzsrc-for:0604
14 schema:author N6924daea569347d6ad07cc72a0dfdd4b
15 schema:citation sg:pub.10.1023/a:1005913810250
16 sg:pub.10.1038/sj.onc.1202057
17 https://app.dimensions.ai/details/publication/pub.1074512857
18 https://app.dimensions.ai/details/publication/pub.1075481573
19 https://app.dimensions.ai/details/publication/pub.1078977262
20 https://app.dimensions.ai/details/publication/pub.1082853618
21 https://app.dimensions.ai/details/publication/pub.1083182822
22 https://doi.org/10.1002/(sici)1097-4652(199607)168:1<51::aid-jcp7>3.0.co;2-7
23 https://doi.org/10.1002/ijc.2910560404
24 https://doi.org/10.1006/abbi.1997.0447
25 https://doi.org/10.1006/bbrc.1995.2777
26 https://doi.org/10.1016/0092-8674(91)90181-w
27 https://doi.org/10.1016/0092-8674(94)90540-1
28 https://doi.org/10.1016/0092-8674(95)90385-2
29 https://doi.org/10.1016/s0014-5793(00)01547-7
30 https://doi.org/10.1016/s0959-437x(05)80334-x
31 https://doi.org/10.1042/bj3080697
32 https://doi.org/10.1073/pnas.92.4.1213
33 https://doi.org/10.1073/pnas.93.13.6737
34 https://doi.org/10.1073/pnas.93.23.12861
35 https://doi.org/10.1074/jbc.270.40.23589
36 https://doi.org/10.1074/jbc.271.34.20608
37 https://doi.org/10.1074/jbc.271.37.22570
38 https://doi.org/10.1074/jbc.274.11.7341
39 https://doi.org/10.1074/jbc.274.36.25245
40 https://doi.org/10.1074/jbc.m000643200
41 https://doi.org/10.1074/jbc.m005522200
42 https://doi.org/10.1074/jbc.m100795200
43 https://doi.org/10.1074/jbc.m107668200
44 https://doi.org/10.1074/jbc.m200154200
45 https://doi.org/10.1083/jcb.133.2.391
46 https://doi.org/10.1083/jcb.143.7.1997
47 https://doi.org/10.1093/carcin/21.11.1941
48 https://doi.org/10.1093/emboj/18.5.1367
49 https://doi.org/10.1128/mcb.12.6.2455
50 https://doi.org/10.1128/mcb.14.6.4032
51 https://doi.org/10.1128/mcb.15.5.2600
52 https://doi.org/10.1128/mcb.15.7.3463
53 https://doi.org/10.1128/mcb.18.6.3212
54 https://doi.org/10.1128/mcb.19.4.2690
55 https://doi.org/10.1128/mcb.19.8.5785
56 https://doi.org/10.1128/mcb.21.16.5631-5643.2001
57 https://doi.org/10.1210/er.20.4.501
58 schema:datePublished 2002-11
59 schema:datePublishedReg 2002-11-01
60 schema:description Galectin-3 is a multifunctional carbohydrate-binding protein found in the nucleus, cytoplasm and the extracellular milieu. Nuclear galectin-3 expression is associated with cell proliferation, and its role in pre-mRNA splicing has been suggested. In this report, we investigated the role of galectin-3 on cyclin D(1) gene expression, a critical inducer of the cell cycle and a potential oncogene in human cancer. We found that galectin-3 induces cyclin D(1) promoter activity in human breast epithelial cells independent of cell adhesion through multiple cis-elements, including the SP1 and CRE sites. We present evidence that galectin-3 induction of the cyclin D(1) promoter may result from enhancement/stabilization of nuclear protein-DNA complex formation at the CRE site of the cyclin D(1) promoter. We also show that galectin-3 co-operates with, but does not depend on, pRb for cyclin D(1) promoter activation. The present study reveals a growth promoting activity of galectin-3 through cyclin D(1) induction, and suggests a novel function of nuclear galectin-3 in the regulation of gene transcription.
61 schema:genre research_article
62 schema:inLanguage en
63 schema:isAccessibleForFree true
64 schema:isPartOf Nbff92f168a93492d9935de6d1a6dacc1
65 Nd02c8681b5cd4fbea4ea42fdc06bec97
66 sg:journal.1097543
67 schema:name Galectin-3 enhances cyclin D1 promoter activity through SP1 and a cAMP-responsive element in human breast epithelial cells
68 schema:pagination 1205820
69 schema:productId N15e4363162af49cd958ffcce9e1185c4
70 N9a3100eba0504c56b5270d453ee9d1fc
71 Na27ef3e926724e8eac8ee3c5e7ac680e
72 Nb273e3f23308497984d92a49ac5ec412
73 Nf1a8f64c40d142fe8d84bce2558dd415
74 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013824345
75 https://doi.org/10.1038/sj.onc.1205820
76 schema:sdDatePublished 2019-04-11T11:52
77 schema:sdLicense https://scigraph.springernature.com/explorer/license/
78 schema:sdPublisher Nbcf1fcfd0caa4032aa535edf8e12296a
79 schema:url http://www.nature.com/articles/1205820
80 sgo:license sg:explorer/license/
81 sgo:sdDataset articles
82 rdf:type schema:ScholarlyArticle
83 N15e4363162af49cd958ffcce9e1185c4 schema:name nlm_unique_id
84 schema:value 8711562
85 rdf:type schema:PropertyValue
86 N51412375559f4dc08ebedefc1bc3e9f6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
87 schema:name Sp1 Transcription Factor
88 rdf:type schema:DefinedTerm
89 N5c0934cfaa7d4d1b86d1502c7c507e7f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
90 schema:name Epithelial Cells
91 rdf:type schema:DefinedTerm
92 N5df24e7e20374db88a71e7ffe25f2557 rdf:first sg:person.01230657614.02
93 rdf:rest N607e7b44c4be427f98c2cb3e9d86ed31
94 N607e7b44c4be427f98c2cb3e9d86ed31 rdf:first sg:person.01031334163.92
95 rdf:rest Ndf018841b48f4dd482d67ee9fdb41a7c
96 N63b6656e30624315b969286e48128c04 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
97 schema:name Breast
98 rdf:type schema:DefinedTerm
99 N6924daea569347d6ad07cc72a0dfdd4b rdf:first sg:person.01050716754.14
100 rdf:rest N5df24e7e20374db88a71e7ffe25f2557
101 N6ce73cbd345140c58e7f96ad29bb7673 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
102 schema:name Electrophoretic Mobility Shift Assay
103 rdf:type schema:DefinedTerm
104 N70fabad76e7c4785b5e0e895a86522d5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
105 schema:name Promoter Regions, Genetic
106 rdf:type schema:DefinedTerm
107 N9a3100eba0504c56b5270d453ee9d1fc schema:name dimensions_id
108 schema:value pub.1013824345
109 rdf:type schema:PropertyValue
110 Na27ef3e926724e8eac8ee3c5e7ac680e schema:name pubmed_id
111 schema:value 12439750
112 rdf:type schema:PropertyValue
113 Na5afe18b467941dcb574be7aa1120e3a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
114 schema:name Cyclic AMP
115 rdf:type schema:DefinedTerm
116 Na8543b17871f470b91b20d9703c8346a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
117 schema:name DNA Primers
118 rdf:type schema:DefinedTerm
119 Nb273e3f23308497984d92a49ac5ec412 schema:name doi
120 schema:value 10.1038/sj.onc.1205820
121 rdf:type schema:PropertyValue
122 Nb63b9c9d820d449da2d953fc1736a445 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
123 schema:name Humans
124 rdf:type schema:DefinedTerm
125 Nb89837cd2e9c4b10b3099257f2c103de schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
126 schema:name Base Sequence
127 rdf:type schema:DefinedTerm
128 Nbcf1fcfd0caa4032aa535edf8e12296a schema:name Springer Nature - SN SciGraph project
129 rdf:type schema:Organization
130 Nbff92f168a93492d9935de6d1a6dacc1 schema:issueNumber 52
131 rdf:type schema:PublicationIssue
132 Nc3f57abe8c564b40b5e038c10800b014 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
133 schema:name Cyclin D1
134 rdf:type schema:DefinedTerm
135 Nd02c8681b5cd4fbea4ea42fdc06bec97 schema:volumeNumber 21
136 rdf:type schema:PublicationVolume
137 Ndf018841b48f4dd482d67ee9fdb41a7c rdf:first sg:person.013330316604.88
138 rdf:rest rdf:nil
139 Ne7a2195fcf47440baa96de1e7621e660 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
140 schema:name Galectin 3
141 rdf:type schema:DefinedTerm
142 Nf1a8f64c40d142fe8d84bce2558dd415 schema:name readcube_id
143 schema:value 41db10c99ba6916ab4f5b64fe09e967e7654360ba2e79cb35ad32773b9517d60
144 rdf:type schema:PropertyValue
145 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
146 schema:name Biological Sciences
147 rdf:type schema:DefinedTerm
148 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
149 schema:name Genetics
150 rdf:type schema:DefinedTerm
151 sg:grant.2469631 http://pending.schema.org/fundedItem sg:pub.10.1038/sj.onc.1205820
152 rdf:type schema:MonetaryGrant
153 sg:grant.2472028 http://pending.schema.org/fundedItem sg:pub.10.1038/sj.onc.1205820
154 rdf:type schema:MonetaryGrant
155 sg:grant.2626390 http://pending.schema.org/fundedItem sg:pub.10.1038/sj.onc.1205820
156 rdf:type schema:MonetaryGrant
157 sg:journal.1097543 schema:issn 0950-9232
158 1476-5594
159 schema:name Oncogene
160 rdf:type schema:Periodical
161 sg:person.01031334163.92 schema:affiliation https://www.grid.ac/institutes/grid.254444.7
162 schema:familyName Raz
163 schema:givenName Avraham
164 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01031334163.92
165 rdf:type schema:Person
166 sg:person.01050716754.14 schema:affiliation https://www.grid.ac/institutes/grid.94365.3d
167 schema:familyName Lin
168 schema:givenName Huei-Min
169 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01050716754.14
170 rdf:type schema:Person
171 sg:person.01230657614.02 schema:affiliation https://www.grid.ac/institutes/grid.251993.5
172 schema:familyName Pestell
173 schema:givenName Richard G
174 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01230657614.02
175 rdf:type schema:Person
176 sg:person.013330316604.88 schema:affiliation https://www.grid.ac/institutes/grid.254444.7
177 schema:familyName Kim
178 schema:givenName Hyeong-Reh Choi
179 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013330316604.88
180 rdf:type schema:Person
181 sg:pub.10.1023/a:1005913810250 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004908096
182 https://doi.org/10.1023/a:1005913810250
183 rdf:type schema:CreativeWork
184 sg:pub.10.1038/sj.onc.1202057 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001411249
185 https://doi.org/10.1038/sj.onc.1202057
186 rdf:type schema:CreativeWork
187 https://app.dimensions.ai/details/publication/pub.1074512857 schema:CreativeWork
188 https://app.dimensions.ai/details/publication/pub.1075481573 schema:CreativeWork
189 https://app.dimensions.ai/details/publication/pub.1078977262 schema:CreativeWork
190 https://app.dimensions.ai/details/publication/pub.1082853618 schema:CreativeWork
191 https://app.dimensions.ai/details/publication/pub.1083182822 schema:CreativeWork
192 https://doi.org/10.1002/(sici)1097-4652(199607)168:1<51::aid-jcp7>3.0.co;2-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038876490
193 rdf:type schema:CreativeWork
194 https://doi.org/10.1002/ijc.2910560404 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046250244
195 rdf:type schema:CreativeWork
196 https://doi.org/10.1006/abbi.1997.0447 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007151758
197 rdf:type schema:CreativeWork
198 https://doi.org/10.1006/bbrc.1995.2777 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000870104
199 rdf:type schema:CreativeWork
200 https://doi.org/10.1016/0092-8674(91)90181-w schema:sameAs https://app.dimensions.ai/details/publication/pub.1010061423
201 rdf:type schema:CreativeWork
202 https://doi.org/10.1016/0092-8674(94)90540-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001605098
203 rdf:type schema:CreativeWork
204 https://doi.org/10.1016/0092-8674(95)90385-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044189874
205 rdf:type schema:CreativeWork
206 https://doi.org/10.1016/s0014-5793(00)01547-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031819526
207 rdf:type schema:CreativeWork
208 https://doi.org/10.1016/s0959-437x(05)80334-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1051678666
209 rdf:type schema:CreativeWork
210 https://doi.org/10.1042/bj3080697 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039628005
211 rdf:type schema:CreativeWork
212 https://doi.org/10.1073/pnas.92.4.1213 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011202755
213 rdf:type schema:CreativeWork
214 https://doi.org/10.1073/pnas.93.13.6737 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035066592
215 rdf:type schema:CreativeWork
216 https://doi.org/10.1073/pnas.93.23.12861 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027259595
217 rdf:type schema:CreativeWork
218 https://doi.org/10.1074/jbc.270.40.23589 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006951784
219 rdf:type schema:CreativeWork
220 https://doi.org/10.1074/jbc.271.34.20608 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003667263
221 rdf:type schema:CreativeWork
222 https://doi.org/10.1074/jbc.271.37.22570 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027229407
223 rdf:type schema:CreativeWork
224 https://doi.org/10.1074/jbc.274.11.7341 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025951197
225 rdf:type schema:CreativeWork
226 https://doi.org/10.1074/jbc.274.36.25245 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027236521
227 rdf:type schema:CreativeWork
228 https://doi.org/10.1074/jbc.m000643200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018510117
229 rdf:type schema:CreativeWork
230 https://doi.org/10.1074/jbc.m005522200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039119103
231 rdf:type schema:CreativeWork
232 https://doi.org/10.1074/jbc.m100795200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002592071
233 rdf:type schema:CreativeWork
234 https://doi.org/10.1074/jbc.m107668200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040619628
235 rdf:type schema:CreativeWork
236 https://doi.org/10.1074/jbc.m200154200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038304411
237 rdf:type schema:CreativeWork
238 https://doi.org/10.1083/jcb.133.2.391 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031511757
239 rdf:type schema:CreativeWork
240 https://doi.org/10.1083/jcb.143.7.1997 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021177961
241 rdf:type schema:CreativeWork
242 https://doi.org/10.1093/carcin/21.11.1941 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024057183
243 rdf:type schema:CreativeWork
244 https://doi.org/10.1093/emboj/18.5.1367 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026750816
245 rdf:type schema:CreativeWork
246 https://doi.org/10.1128/mcb.12.6.2455 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053452659
247 rdf:type schema:CreativeWork
248 https://doi.org/10.1128/mcb.14.6.4032 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005593472
249 rdf:type schema:CreativeWork
250 https://doi.org/10.1128/mcb.15.5.2600 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035576061
251 rdf:type schema:CreativeWork
252 https://doi.org/10.1128/mcb.15.7.3463 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010196427
253 rdf:type schema:CreativeWork
254 https://doi.org/10.1128/mcb.18.6.3212 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012730091
255 rdf:type schema:CreativeWork
256 https://doi.org/10.1128/mcb.19.4.2690 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009920172
257 rdf:type schema:CreativeWork
258 https://doi.org/10.1128/mcb.19.8.5785 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050921566
259 rdf:type schema:CreativeWork
260 https://doi.org/10.1128/mcb.21.16.5631-5643.2001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035212034
261 rdf:type schema:CreativeWork
262 https://doi.org/10.1210/er.20.4.501 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064285750
263 rdf:type schema:CreativeWork
264 https://www.grid.ac/institutes/grid.251993.5 schema:alternateName Albert Einstein College of Medicine
265 schema:name The Albert Einstein Cancer Center, Department of Medicine and Developmental and Molecular Biology, Albert Einstein College of Medicine, 1300 Morris Park Ave., Bronx, New York, NY 10461, USA
266 rdf:type schema:Organization
267 https://www.grid.ac/institutes/grid.254444.7 schema:alternateName Wayne State University
268 schema:name Breast Cancer Program, Barbara Ann Karmanos Cancer Institute, Wayne State University, School of Medicine, Detroit, Michigan, MI 48201, USA
269 Department of Pathology, Wayne State University, School of Medicine, Detroit, Michigan, MI 48201, USA
270 rdf:type schema:Organization
271 https://www.grid.ac/institutes/grid.94365.3d schema:alternateName National Institutes of Health
272 schema:name Current address: Laboratory of Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, MD 20892-4255, USA
273 Department of Pathology, Wayne State University, School of Medicine, Detroit, Michigan, MI 48201, USA
274 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...