A novel p53 mutational hotspot in skin tumors from UV-irradiated Xpc mutant mice alters transactivation functions View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2002-08

AUTHORS

Alberto Inga, Dorit Nahari, Susana Velasco-Miguel, Errol C Friedberg, Michael A Resnick

ABSTRACT

A mutation in codon 122 of the mouse p53 gene resulting in a T to L amino acid substitution (T122-->L) is frequently associated with skin cancer in UV-irradiated mice that are both homozygous mutant for the nucleotide excision repair (NER) gene Xpc (Xpc(-/-)) and hemizygous mutant for the p53 gene. We investigated the functional consequences of the mouse T122-->L mutation when expressed either in mammalian cells or in the yeast Saccharomyces cerevisiae. Similar to a non-functional allele, high expression of the T122-->L allele in p53(-/-) mouse embryo fibroblasts and human Saos-2 cells failed to suppress growth. However, the T122-->L mutant p53 showed wild-type transactivation levels with Bax and MDM2 promoters when expressed in either cell type and retained transactivation of the p21 and the c-Fos promoters in one cell line. Using a recently developed rheostatable p53 induction system in yeast we assessed the T122-->L transactivation capacity at low levels of protein expression using 12 different p53 response elements (REs). Compared to wild-type p53 the T122-->L protein manifested an unusual transactivation pattern comprising reduced and enhanced activity with specific REs. The high incidence of the T122-->L mutant allele in the Xpc(-/-) background suggests that both genetic and epigenetic conditions may facilitate the emergence of particular functional p53 mutations. Furthermore, the approach that we have taken also provides for the dissection of functions that may be retained in many p53 tumor alleles. More... »

PAGES

1205779

References to SciGraph publications

  • 1992-04. Definition of a consensus binding site for p53 in NATURE GENETICS
  • 2000-08. Procaspase 3/p21 complex formation to resist Fas-mediated cell death is initiated as a result of the phosphorylation of p21 by protein kinase A in CELL DEATH & DIFFERENTIATION
  • 1996-10. Structure–based rescue of common tumor–derived p53 mutants in NATURE MEDICINE
  • 1999-09. Murine fibroblasts lacking p21 undergo senescence and are resistant to transformation by oncogenic Ras in ONCOGENE
  • 2001-01. p53 mutants exhibiting enhanced transcriptional activation and altered promoter selectivity are revealed using a sensitive, yeast-based functional assay in ONCOGENE
  • 2000-08. Activation of the insulin-like growth factor II transcription by aflatoxin B1 induced p53 mutant 249 is caused by activation of transcription complexes; implications for a gain-of-function during the formation of hepatocellular carcinoma in ONCOGENE
  • 1998-10. p53 mutation with frequent novel codons but not a mutator phenotype in BRCA1- and BRCA2-associated breast tumours in ONCOGENE
  • 2001-06. p53 mutants can often transactivate promoters containing a p21 but not Bax or PIG3 responsive elements in ONCOGENE
  • 2001-02. Structural and functional involvement of p53 in BER in vitro and in vivo in ONCOGENE
  • 2000-11. Surfing the p53 network in NATURE
  • 2000-10. Age-dependent spontaneous mutagenesis in Xpc mice defective in nucleotide excision repair in ONCOGENE
  • 2001-08. In vivo site-directed mutagenesis using oligonucleotides in NATURE BIOTECHNOLOGY
  • 1999-12. Mechanisms of switching on p53: a role for covalent modification? in ONCOGENE
  • 1998-03. Identification of human p53 mutations with differential effects on the bax and p21 promoters using functional assays in yeast in ONCOGENE
  • 2000-03. A ribonucleotide reductase gene involved in a p53-dependent cell-cycle checkpoint for DNA damage in NATURE
  • 2001-06. Novel human p53 mutations that are toxic to yeast can enhance transactivation of specific promoters and reactivate tumor p53 mutants in ONCOGENE
  • 1999-04. Novel p53 mutants selected in BRCA-associated tumours which dissociate transformation suppression from other wild-type p53 functions in ONCOGENE
  • 2001-11. Cancer: How cells choose to die in NATURE
  • 1999-12. Regulation of p53 stability in ONCOGENE
  • 1997-02. p21Waf1/Cip1 protects against p53-mediated apoptosis of human melanoma cells in ONCOGENE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/sj.onc.1205779

    DOI

    http://dx.doi.org/10.1038/sj.onc.1205779

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1000521821

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/12173040


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