Expression of thyroid hormone receptor/erbA genes is altered in human breast cancer View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2002-06

AUTHORS

José M Silva, Gemma Domínguez, José M González-Sancho, José M García, Javier Silva, Carmen García-Andrade, Antonia Navarro, Alberto Muñoz, Félix Bonilla

ABSTRACT

The relation between thyroid status and diseases and cancer is unclear. No detailed analysis of thyroid hormone receptor (TR) expression in human breast cancer has been reported. We have analysed the expression and mutational status of the TRalpha1, encoded by the c-erbA proto-oncogene, TRbeta1 and TRbeta2 isoforms in 70 sporadic breast cancers. Alterations in the RNA level of TRbeta1, TRalpha1, or both were found in a number of patients. No expression of TRbeta2 RNA was detected. Western blotting analysis confirmed the differences in expression at the protein level in those cases where sufficient tumor sample was available. Additionally, tumor-specific truncated TRbeta1 RNA was found in six patients. Strikingly, three transcripts shared the same breakpoint. Only one tumor carried the corresponding deletion at the genomic DNA level, suggesting that the remaining abnormal TRbeta1 transcripts are aberrant splicing products. Though no significant correlation was found between TRbeta1 alteration and any clinical parameter, it showed a tendency to associate with early age of onset (<50 years). Our results reveal specific alterations in the expression of TRbeta and TRalpha genes in a subset of breast cancer patients, suggesting that deregulation of thyroid hormone target genes may be involved in the generation of this neoplasia. More... »

PAGES

1205534

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/sj.onc.1205534

DOI

http://dx.doi.org/10.1038/sj.onc.1205534

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1050028974

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/12082618


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