Matriptase/MT-SP1 is required for postnatal survival, epidermal barrier function, hair follicle development, and thymic homeostasis View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2002-05

AUTHORS

Karin List, Christian C Haudenschild, Roman Szabo, WanJun Chen, Sharon M Wahl, William Swaim, Lars H Engelholm, Niels Behrendt, Thomas H Bugge

ABSTRACT

Matriptase/MT-SP1 is a novel tumor-associated type II transmembrane serine protease that is highly expressed in the epidermis, thymic stroma, and other epithelia. A null mutation was introduced into the Matriptase/MT-SP1 gene of mice to determine the role of Matriptase/MT-SP1 in epidermal development and neoplasia. Matriptase/MT-SP1-deficient mice developed to term but uniformly died within 48 h of birth. All epidermal surfaces of newborn mice were grossly abnormal with a dry, red, shiny, and wrinkled appearance. Matriptase/MT-SP1-deficiency caused striking malformations of the stratum corneum, characterized by dysmorphic and pleomorphic corneocytes and the absence of vesicular bodies in transitional layer cells. This aberrant skin development seriously compromised both inward and outward epidermal barrier function, leading to the rapid and fatal dehydration of Matriptase/MT-SP1-deficient pups. Loss of Matriptase/MT-SP1 also seriously affected hair follicle development resulting in generalized follicular hypoplasia, absence of erupted vibrissae, lack of vibrissal hair canal formation, ingrown vibrissae, and wholesale abortion of vibrissal follicles. Furthermore, Matriptase/MT-SP1-deficiency resulted in dramatically increased thymocyte apoptosis, and depletion of thymocytes. This study demonstrates that Matriptase/MT-SP1 has pleiotropic functions in the development of the epidermis, hair follicles, and cellular immune system. More... »

PAGES

1205502

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/sj.onc.1205502

DOI

http://dx.doi.org/10.1038/sj.onc.1205502

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1037365961

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/12032844


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1114", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Paediatrics and Reproductive Medicine", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Amino Acid Sequence", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals, Newborn", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Apoptosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Base Sequence", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Epidermis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Deletion", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genes, Lethal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hair Follicle", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Homeostasis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Membrane Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Knockout", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Microscopy, Electron, Scanning", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Molecular Sequence Data", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Permeability", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "RNA, Messenger", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Reverse Transcriptase Polymerase Chain Reaction", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Serine Endopeptidases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Skin Abnormalities", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Survival Rate", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Thymus Gland", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Trypsin", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Copenhagen University Hospital", 
          "id": "https://www.grid.ac/institutes/grid.4973.9", 
          "name": [
            "Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, 30 Convent Drive, Bethesda, Maryland, MD 20892, USA", 
            "Finsen Laboratory, Strandboulevarden 49, DK-2100, Copenhagen, Denmark"
          ], 
          "type": "Organization"
        }, 
        "familyName": "List", 
        "givenName": "Karin", 
        "id": "sg:person.0732167013.17", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0732167013.17"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "American Red Cross", 
          "id": "https://www.grid.ac/institutes/grid.281926.6", 
          "name": [
            "Department of Experimental Pathology, American Red Cross, 15601 Crabbs Branch Way, Rockville, Maryland, MD 20855, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Haudenschild", 
        "givenName": "Christian C", 
        "id": "sg:person.0646007772.95", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0646007772.95"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Institute of Dental and Craniofacial Research", 
          "id": "https://www.grid.ac/institutes/grid.419633.a", 
          "name": [
            "Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, 30 Convent Drive, Bethesda, Maryland, MD 20892, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Szabo", 
        "givenName": "Roman", 
        "id": "sg:person.01214436364.64", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01214436364.64"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Institute of Dental and Craniofacial Research", 
          "id": "https://www.grid.ac/institutes/grid.419633.a", 
          "name": [
            "Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, 30 Convent Drive, Bethesda, Maryland, MD 20892, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chen", 
        "givenName": "WanJun", 
        "id": "sg:person.015033407720.62", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015033407720.62"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Institute of Dental and Craniofacial Research", 
          "id": "https://www.grid.ac/institutes/grid.419633.a", 
          "name": [
            "Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, 30 Convent Drive, Bethesda, Maryland, MD 20892, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wahl", 
        "givenName": "Sharon M", 
        "id": "sg:person.01076747244.03", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01076747244.03"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Institutes of Health", 
          "id": "https://www.grid.ac/institutes/grid.94365.3d", 
          "name": [
            "Cellular Imaging Core, National Institutes of Dental and Craniofacial Research, National Institutes of Health, 30 Convent Drive, Bethesda, Maryland, MD 20892, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Swaim", 
        "givenName": "William", 
        "id": "sg:person.011333065747.95", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011333065747.95"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Copenhagen University Hospital", 
          "id": "https://www.grid.ac/institutes/grid.4973.9", 
          "name": [
            "Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, 30 Convent Drive, Bethesda, Maryland, MD 20892, USA", 
            "Finsen Laboratory, Strandboulevarden 49, DK-2100, Copenhagen, Denmark"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Engelholm", 
        "givenName": "Lars H", 
        "id": "sg:person.01235007302.41", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01235007302.41"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Copenhagen University Hospital", 
          "id": "https://www.grid.ac/institutes/grid.4973.9", 
          "name": [
            "Finsen Laboratory, Strandboulevarden 49, DK-2100, Copenhagen, Denmark"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Behrendt", 
        "givenName": "Niels", 
        "id": "sg:person.0717132740.90", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0717132740.90"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Institute of Dental and Craniofacial Research", 
          "id": "https://www.grid.ac/institutes/grid.419633.a", 
          "name": [
            "Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, 30 Convent Drive, Bethesda, Maryland, MD 20892, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bugge", 
        "givenName": "Thomas H", 
        "id": "sg:person.014711620557.63", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014711620557.63"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/s000180050497", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001277092", 
          "https://doi.org/10.1007/s000180050497"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/10454411000110040101", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001886730"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/10454411000110040101", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001886730"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/87120", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002644604", 
          "https://doi.org/10.1038/87120"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/87120", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002644604", 
          "https://doi.org/10.1038/87120"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1046/j.1523-1747.1999.00494.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004186948", 
          "https://doi.org/10.1046/j.1523-1747.1999.00494.x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.90.11.4937", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004826685"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(78)92646-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006291485"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(78)92646-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006291485"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev.immunol.17.1.829", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007123819"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-3-642-50059-6_32", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009265786", 
          "https://doi.org/10.1007/978-3-642-50059-6_32"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng0395-279", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010363963", 
          "https://doi.org/10.1038/ng0395-279"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.815400", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011055195"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.95.3.1044", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011215933"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1471-4906(00)01797-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012650838"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0955-0674(00)00139-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013944187"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.jidsp.5640236", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013989693", 
          "https://doi.org/10.1038/sj.jidsp.5640236"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng0196-52", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014624587", 
          "https://doi.org/10.1038/ng0196-52"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.165.11.6504", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016876459"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/20.14.3795", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016988020"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1097-4652(199808)176:2<255::aid-jcp4>3.0.co;2-n", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017879158"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.151.2.389", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017995802"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1046/j.0022-202x.2001.01368.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018039611", 
          "https://doi.org/10.1046/j.0022-202x.2001.01368.x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1159/000050604", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018749967", 
          "https://doi.org/10.1159/000050604"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0002-9440(10)64081-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018860490"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1699-0463.1999.tb01521.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019084351"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1699-0463.1999.tb01521.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019084351"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1432-1327.2001.02016.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019704149"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(00)80429-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024942781"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/smim.2000.0263", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025146929"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0167-4838(99)00263-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028417342"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.194.4.439", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028809469"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11883-000-0079-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030920897", 
          "https://doi.org/10.1007/s11883-000-0079-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.150149097", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032915020"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1357-2725(99)00089-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034058623"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.96.20.11054", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035218308"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.r000020200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035731335"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000015125", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036229465"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0923-1811(00)00124-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036354323"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.153.2.243", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038285639"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1046/j.1523-1747.1998.00144.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038469641", 
          "https://doi.org/10.1046/j.1523-1747.1998.00144.x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1357-2725(00)00061-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041466965"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m007802200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042691561"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/368419a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046408145", 
          "https://doi.org/10.1038/368419a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.149.1.228", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048493899"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s002510050515", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048959733", 
          "https://doi.org/10.1007/s002510050515"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/emm.1999.2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049247351", 
          "https://doi.org/10.1038/emm.1999.2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/emm.1999.2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049247351", 
          "https://doi.org/10.1038/emm.1999.2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0378-1119(00)00225-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049260070"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0303-7207(86)90141-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050250780"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0303-7207(86)90141-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050250780"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.274.26.18237", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052484722"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m002941200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052743483"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0960-9822(00)80011-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053379477"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1017/s0016672300010168", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053876109"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1017/s0016672300010168", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053876109"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1064638", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062445432"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.280.5362.450", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062560790"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.7529942", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062647448"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.7824952", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062649846"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1096/fasebj.14.2.319", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074584722"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1075369670", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1076965484", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/oxfordjournals.jhered.a111411", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1082690076"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083379737", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2002-05", 
    "datePublishedReg": "2002-05-01", 
    "description": "Matriptase/MT-SP1 is a novel tumor-associated type II transmembrane serine protease that is highly expressed in the epidermis, thymic stroma, and other epithelia. A null mutation was introduced into the Matriptase/MT-SP1 gene of mice to determine the role of Matriptase/MT-SP1 in epidermal development and neoplasia. Matriptase/MT-SP1-deficient mice developed to term but uniformly died within 48 h of birth. All epidermal surfaces of newborn mice were grossly abnormal with a dry, red, shiny, and wrinkled appearance. Matriptase/MT-SP1-deficiency caused striking malformations of the stratum corneum, characterized by dysmorphic and pleomorphic corneocytes and the absence of vesicular bodies in transitional layer cells. This aberrant skin development seriously compromised both inward and outward epidermal barrier function, leading to the rapid and fatal dehydration of Matriptase/MT-SP1-deficient pups. Loss of Matriptase/MT-SP1 also seriously affected hair follicle development resulting in generalized follicular hypoplasia, absence of erupted vibrissae, lack of vibrissal hair canal formation, ingrown vibrissae, and wholesale abortion of vibrissal follicles. Furthermore, Matriptase/MT-SP1-deficiency resulted in dramatically increased thymocyte apoptosis, and depletion of thymocytes. This study demonstrates that Matriptase/MT-SP1 has pleiotropic functions in the development of the epidermis, hair follicles, and cellular immune system.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/sj.onc.1205502", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2715908", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2724655", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2715533", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2724626", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1097543", 
        "issn": [
          "0950-9232", 
          "1476-5594"
        ], 
        "name": "Oncogene", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "23", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "21"
      }
    ], 
    "name": "Matriptase/MT-SP1 is required for postnatal survival, epidermal barrier function, hair follicle development, and thymic homeostasis", 
    "pagination": "1205502", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "b1ff251837c0f259cff44f104d19b651ca6a8ba7ffc782d73e2bf32a034b1fb8"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "12032844"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "8711562"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/sj.onc.1205502"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1037365961"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/sj.onc.1205502", 
      "https://app.dimensions.ai/details/publication/pub.1037365961"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T11:58", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000359_0000000359/records_29222_00000002.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://www.nature.com/articles/1205502"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/sj.onc.1205502'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/sj.onc.1205502'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/sj.onc.1205502'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/sj.onc.1205502'


 

This table displays all metadata directly associated to this object as RDF triples.

429 TRIPLES      21 PREDICATES      112 URIs      46 LITERALS      34 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/sj.onc.1205502 schema:about N00541cd6cd6545df9c8fe75db07971dd
2 N019ac03a1a00443e8b2088c42edf6337
3 N0443cfef2c844b98b74e889ba313ed15
4 N06009c87a10b4b28b44f7a2946961b10
5 N0645e90f998c4879ae2bef48df3e421c
6 N0e696d2e9f2d4daba107067bc5e11ca6
7 N1ca9282eec93404c87a78788eb750373
8 N26d5c19387c7407ebb62c71277638c81
9 N2e4856ded294490daee7c30c8c23120b
10 N480886bdda1a4ddcb2969bb52b69fea6
11 N65798e45b764425ba839006863347586
12 N84c23c5e27234a728f2e45c927cfa616
13 N8d18e830b8e0411d81a521b1169f62cc
14 N99e4ae1821244950915bf903049adb49
15 N9ab7109b8dd24c0fa69692277ca4c9f9
16 Na97a890973c1477db3547ec3462a1a14
17 Nbae2c836cce041cea535aed79a038464
18 Nd9726dc186574070bc41223a6fcf8a6c
19 Ne1505bfc66494e29b3dd9aae68946aa3
20 Ne588866131984f40b8d88128015bfb98
21 Nef7055b5512e48fd971947f71371620f
22 Nf1e55df8f77d4f2fbdd39bb9fead5837
23 Nf2e97603be434f1697c5f0b04399d2b3
24 Nfbea7bf04384437da06bc30495409db7
25 Nfd2789c9fb104fa9948ff2b33aea964b
26 anzsrc-for:11
27 anzsrc-for:1114
28 schema:author N8d7731109bf14ef2bbce00db79c0e19d
29 schema:citation sg:pub.10.1007/978-3-642-50059-6_32
30 sg:pub.10.1007/s000180050497
31 sg:pub.10.1007/s002510050515
32 sg:pub.10.1007/s11883-000-0079-z
33 sg:pub.10.1038/368419a0
34 sg:pub.10.1038/87120
35 sg:pub.10.1038/emm.1999.2
36 sg:pub.10.1038/ng0196-52
37 sg:pub.10.1038/ng0395-279
38 sg:pub.10.1038/sj.jidsp.5640236
39 sg:pub.10.1046/j.0022-202x.2001.01368.x
40 sg:pub.10.1046/j.1523-1747.1998.00144.x
41 sg:pub.10.1046/j.1523-1747.1999.00494.x
42 sg:pub.10.1159/000050604
43 https://app.dimensions.ai/details/publication/pub.1075369670
44 https://app.dimensions.ai/details/publication/pub.1076965484
45 https://app.dimensions.ai/details/publication/pub.1083379737
46 https://doi.org/10.1002/(sici)1097-4652(199808)176:2<255::aid-jcp4>3.0.co;2-n
47 https://doi.org/10.1006/smim.2000.0263
48 https://doi.org/10.1016/0303-7207(86)90141-3
49 https://doi.org/10.1016/s0002-9440(10)64081-3
50 https://doi.org/10.1016/s0092-8674(00)80429-8
51 https://doi.org/10.1016/s0140-6736(78)92646-6
52 https://doi.org/10.1016/s0167-4838(99)00263-0
53 https://doi.org/10.1016/s0378-1119(00)00225-0
54 https://doi.org/10.1016/s0923-1811(00)00124-9
55 https://doi.org/10.1016/s0955-0674(00)00139-3
56 https://doi.org/10.1016/s0960-9822(00)80011-1
57 https://doi.org/10.1016/s1357-2725(00)00061-3
58 https://doi.org/10.1016/s1357-2725(99)00089-8
59 https://doi.org/10.1016/s1471-4906(00)01797-x
60 https://doi.org/10.1017/s0016672300010168
61 https://doi.org/10.1046/j.1432-1327.2001.02016.x
62 https://doi.org/10.1073/pnas.150149097
63 https://doi.org/10.1073/pnas.90.11.4937
64 https://doi.org/10.1073/pnas.95.3.1044
65 https://doi.org/10.1073/pnas.96.20.11054
66 https://doi.org/10.1074/jbc.274.26.18237
67 https://doi.org/10.1074/jbc.m002941200
68 https://doi.org/10.1074/jbc.m007802200
69 https://doi.org/10.1074/jbc.r000020200
70 https://doi.org/10.1083/jcb.151.2.389
71 https://doi.org/10.1083/jcb.153.2.243
72 https://doi.org/10.1084/jem.149.1.228
73 https://doi.org/10.1084/jem.194.4.439
74 https://doi.org/10.1093/nar/20.14.3795
75 https://doi.org/10.1093/oxfordjournals.jhered.a111411
76 https://doi.org/10.1096/fasebj.14.2.319
77 https://doi.org/10.1101/gad.815400
78 https://doi.org/10.1111/j.1699-0463.1999.tb01521.x
79 https://doi.org/10.1126/science.1064638
80 https://doi.org/10.1126/science.280.5362.450
81 https://doi.org/10.1126/science.7529942
82 https://doi.org/10.1126/science.7824952
83 https://doi.org/10.1146/annurev.immunol.17.1.829
84 https://doi.org/10.1159/000015125
85 https://doi.org/10.1177/10454411000110040101
86 https://doi.org/10.4049/jimmunol.165.11.6504
87 schema:datePublished 2002-05
88 schema:datePublishedReg 2002-05-01
89 schema:description Matriptase/MT-SP1 is a novel tumor-associated type II transmembrane serine protease that is highly expressed in the epidermis, thymic stroma, and other epithelia. A null mutation was introduced into the Matriptase/MT-SP1 gene of mice to determine the role of Matriptase/MT-SP1 in epidermal development and neoplasia. Matriptase/MT-SP1-deficient mice developed to term but uniformly died within 48 h of birth. All epidermal surfaces of newborn mice were grossly abnormal with a dry, red, shiny, and wrinkled appearance. Matriptase/MT-SP1-deficiency caused striking malformations of the stratum corneum, characterized by dysmorphic and pleomorphic corneocytes and the absence of vesicular bodies in transitional layer cells. This aberrant skin development seriously compromised both inward and outward epidermal barrier function, leading to the rapid and fatal dehydration of Matriptase/MT-SP1-deficient pups. Loss of Matriptase/MT-SP1 also seriously affected hair follicle development resulting in generalized follicular hypoplasia, absence of erupted vibrissae, lack of vibrissal hair canal formation, ingrown vibrissae, and wholesale abortion of vibrissal follicles. Furthermore, Matriptase/MT-SP1-deficiency resulted in dramatically increased thymocyte apoptosis, and depletion of thymocytes. This study demonstrates that Matriptase/MT-SP1 has pleiotropic functions in the development of the epidermis, hair follicles, and cellular immune system.
90 schema:genre research_article
91 schema:inLanguage en
92 schema:isAccessibleForFree true
93 schema:isPartOf N812c45149a01463cbbd23c65d16194fe
94 N81ff74941b4643239da91e1ea07fab74
95 sg:journal.1097543
96 schema:name Matriptase/MT-SP1 is required for postnatal survival, epidermal barrier function, hair follicle development, and thymic homeostasis
97 schema:pagination 1205502
98 schema:productId N1060d9cf37af4d73ac2cc5770a73c0f9
99 N134d0c2e144345be86ef3a70291af38b
100 N287042fac9594658ba3a65234a38e5e3
101 N38c3ca31b9cd4b8d8926e89ac6ff2eb2
102 N92ab4ca4724741a482a47e0b6286c80a
103 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037365961
104 https://doi.org/10.1038/sj.onc.1205502
105 schema:sdDatePublished 2019-04-11T11:58
106 schema:sdLicense https://scigraph.springernature.com/explorer/license/
107 schema:sdPublisher Nbc9f5890504143fa89935c2bfa5ab904
108 schema:url http://www.nature.com/articles/1205502
109 sgo:license sg:explorer/license/
110 sgo:sdDataset articles
111 rdf:type schema:ScholarlyArticle
112 N00541cd6cd6545df9c8fe75db07971dd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
113 schema:name Mice
114 rdf:type schema:DefinedTerm
115 N019ac03a1a00443e8b2088c42edf6337 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
116 schema:name Epidermis
117 rdf:type schema:DefinedTerm
118 N0443cfef2c844b98b74e889ba313ed15 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
119 schema:name Female
120 rdf:type schema:DefinedTerm
121 N06009c87a10b4b28b44f7a2946961b10 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
122 schema:name Mice, Knockout
123 rdf:type schema:DefinedTerm
124 N0645e90f998c4879ae2bef48df3e421c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
125 schema:name RNA, Messenger
126 rdf:type schema:DefinedTerm
127 N0e696d2e9f2d4daba107067bc5e11ca6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
128 schema:name Serine Endopeptidases
129 rdf:type schema:DefinedTerm
130 N1060d9cf37af4d73ac2cc5770a73c0f9 schema:name nlm_unique_id
131 schema:value 8711562
132 rdf:type schema:PropertyValue
133 N134d0c2e144345be86ef3a70291af38b schema:name pubmed_id
134 schema:value 12032844
135 rdf:type schema:PropertyValue
136 N1507baffcc2d4432b7a53bf0482d2b24 rdf:first sg:person.014711620557.63
137 rdf:rest rdf:nil
138 N1ca9282eec93404c87a78788eb750373 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
139 schema:name Homeostasis
140 rdf:type schema:DefinedTerm
141 N26d5c19387c7407ebb62c71277638c81 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
142 schema:name Molecular Sequence Data
143 rdf:type schema:DefinedTerm
144 N287042fac9594658ba3a65234a38e5e3 schema:name dimensions_id
145 schema:value pub.1037365961
146 rdf:type schema:PropertyValue
147 N2e4856ded294490daee7c30c8c23120b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
148 schema:name Animals
149 rdf:type schema:DefinedTerm
150 N31f74fc0c2574eb1ba0aa2f954709447 rdf:first sg:person.01076747244.03
151 rdf:rest Nd2b29e23d478464c95458761ccda9ce0
152 N38c3ca31b9cd4b8d8926e89ac6ff2eb2 schema:name doi
153 schema:value 10.1038/sj.onc.1205502
154 rdf:type schema:PropertyValue
155 N3bda49a0cb744b1cad740c4317d057ed rdf:first sg:person.01235007302.41
156 rdf:rest Nf83cadf7d1694baeb964609aebac6530
157 N480886bdda1a4ddcb2969bb52b69fea6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
158 schema:name Male
159 rdf:type schema:DefinedTerm
160 N5b96f1b25886416eace7ccdb857d88d9 rdf:first sg:person.015033407720.62
161 rdf:rest N31f74fc0c2574eb1ba0aa2f954709447
162 N5ffa319c503d4aaaae72dd25c7e8300b rdf:first sg:person.0646007772.95
163 rdf:rest Na2ab96e907644c2d84461e1665cf2c2e
164 N65798e45b764425ba839006863347586 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
165 schema:name Apoptosis
166 rdf:type schema:DefinedTerm
167 N812c45149a01463cbbd23c65d16194fe schema:issueNumber 23
168 rdf:type schema:PublicationIssue
169 N81ff74941b4643239da91e1ea07fab74 schema:volumeNumber 21
170 rdf:type schema:PublicationVolume
171 N84c23c5e27234a728f2e45c927cfa616 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
172 schema:name Reverse Transcriptase Polymerase Chain Reaction
173 rdf:type schema:DefinedTerm
174 N8d18e830b8e0411d81a521b1169f62cc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
175 schema:name Permeability
176 rdf:type schema:DefinedTerm
177 N8d7731109bf14ef2bbce00db79c0e19d rdf:first sg:person.0732167013.17
178 rdf:rest N5ffa319c503d4aaaae72dd25c7e8300b
179 N92ab4ca4724741a482a47e0b6286c80a schema:name readcube_id
180 schema:value b1ff251837c0f259cff44f104d19b651ca6a8ba7ffc782d73e2bf32a034b1fb8
181 rdf:type schema:PropertyValue
182 N99e4ae1821244950915bf903049adb49 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
183 schema:name Genes, Lethal
184 rdf:type schema:DefinedTerm
185 N9ab7109b8dd24c0fa69692277ca4c9f9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
186 schema:name Base Sequence
187 rdf:type schema:DefinedTerm
188 Na2ab96e907644c2d84461e1665cf2c2e rdf:first sg:person.01214436364.64
189 rdf:rest N5b96f1b25886416eace7ccdb857d88d9
190 Na97a890973c1477db3547ec3462a1a14 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
191 schema:name Thymus Gland
192 rdf:type schema:DefinedTerm
193 Nbae2c836cce041cea535aed79a038464 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
194 schema:name Hair Follicle
195 rdf:type schema:DefinedTerm
196 Nbc9f5890504143fa89935c2bfa5ab904 schema:name Springer Nature - SN SciGraph project
197 rdf:type schema:Organization
198 Nd2b29e23d478464c95458761ccda9ce0 rdf:first sg:person.011333065747.95
199 rdf:rest N3bda49a0cb744b1cad740c4317d057ed
200 Nd9726dc186574070bc41223a6fcf8a6c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
201 schema:name Amino Acid Sequence
202 rdf:type schema:DefinedTerm
203 Ne1505bfc66494e29b3dd9aae68946aa3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
204 schema:name Membrane Proteins
205 rdf:type schema:DefinedTerm
206 Ne588866131984f40b8d88128015bfb98 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
207 schema:name Microscopy, Electron, Scanning
208 rdf:type schema:DefinedTerm
209 Nef7055b5512e48fd971947f71371620f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
210 schema:name Trypsin
211 rdf:type schema:DefinedTerm
212 Nf1e55df8f77d4f2fbdd39bb9fead5837 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
213 schema:name Gene Deletion
214 rdf:type schema:DefinedTerm
215 Nf2e97603be434f1697c5f0b04399d2b3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
216 schema:name Animals, Newborn
217 rdf:type schema:DefinedTerm
218 Nf83cadf7d1694baeb964609aebac6530 rdf:first sg:person.0717132740.90
219 rdf:rest N1507baffcc2d4432b7a53bf0482d2b24
220 Nfbea7bf04384437da06bc30495409db7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
221 schema:name Skin Abnormalities
222 rdf:type schema:DefinedTerm
223 Nfd2789c9fb104fa9948ff2b33aea964b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
224 schema:name Survival Rate
225 rdf:type schema:DefinedTerm
226 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
227 schema:name Medical and Health Sciences
228 rdf:type schema:DefinedTerm
229 anzsrc-for:1114 schema:inDefinedTermSet anzsrc-for:
230 schema:name Paediatrics and Reproductive Medicine
231 rdf:type schema:DefinedTerm
232 sg:grant.2715533 http://pending.schema.org/fundedItem sg:pub.10.1038/sj.onc.1205502
233 rdf:type schema:MonetaryGrant
234 sg:grant.2715908 http://pending.schema.org/fundedItem sg:pub.10.1038/sj.onc.1205502
235 rdf:type schema:MonetaryGrant
236 sg:grant.2724626 http://pending.schema.org/fundedItem sg:pub.10.1038/sj.onc.1205502
237 rdf:type schema:MonetaryGrant
238 sg:grant.2724655 http://pending.schema.org/fundedItem sg:pub.10.1038/sj.onc.1205502
239 rdf:type schema:MonetaryGrant
240 sg:journal.1097543 schema:issn 0950-9232
241 1476-5594
242 schema:name Oncogene
243 rdf:type schema:Periodical
244 sg:person.01076747244.03 schema:affiliation https://www.grid.ac/institutes/grid.419633.a
245 schema:familyName Wahl
246 schema:givenName Sharon M
247 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01076747244.03
248 rdf:type schema:Person
249 sg:person.011333065747.95 schema:affiliation https://www.grid.ac/institutes/grid.94365.3d
250 schema:familyName Swaim
251 schema:givenName William
252 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011333065747.95
253 rdf:type schema:Person
254 sg:person.01214436364.64 schema:affiliation https://www.grid.ac/institutes/grid.419633.a
255 schema:familyName Szabo
256 schema:givenName Roman
257 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01214436364.64
258 rdf:type schema:Person
259 sg:person.01235007302.41 schema:affiliation https://www.grid.ac/institutes/grid.4973.9
260 schema:familyName Engelholm
261 schema:givenName Lars H
262 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01235007302.41
263 rdf:type schema:Person
264 sg:person.014711620557.63 schema:affiliation https://www.grid.ac/institutes/grid.419633.a
265 schema:familyName Bugge
266 schema:givenName Thomas H
267 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014711620557.63
268 rdf:type schema:Person
269 sg:person.015033407720.62 schema:affiliation https://www.grid.ac/institutes/grid.419633.a
270 schema:familyName Chen
271 schema:givenName WanJun
272 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015033407720.62
273 rdf:type schema:Person
274 sg:person.0646007772.95 schema:affiliation https://www.grid.ac/institutes/grid.281926.6
275 schema:familyName Haudenschild
276 schema:givenName Christian C
277 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0646007772.95
278 rdf:type schema:Person
279 sg:person.0717132740.90 schema:affiliation https://www.grid.ac/institutes/grid.4973.9
280 schema:familyName Behrendt
281 schema:givenName Niels
282 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0717132740.90
283 rdf:type schema:Person
284 sg:person.0732167013.17 schema:affiliation https://www.grid.ac/institutes/grid.4973.9
285 schema:familyName List
286 schema:givenName Karin
287 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0732167013.17
288 rdf:type schema:Person
289 sg:pub.10.1007/978-3-642-50059-6_32 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009265786
290 https://doi.org/10.1007/978-3-642-50059-6_32
291 rdf:type schema:CreativeWork
292 sg:pub.10.1007/s000180050497 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001277092
293 https://doi.org/10.1007/s000180050497
294 rdf:type schema:CreativeWork
295 sg:pub.10.1007/s002510050515 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048959733
296 https://doi.org/10.1007/s002510050515
297 rdf:type schema:CreativeWork
298 sg:pub.10.1007/s11883-000-0079-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1030920897
299 https://doi.org/10.1007/s11883-000-0079-z
300 rdf:type schema:CreativeWork
301 sg:pub.10.1038/368419a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046408145
302 https://doi.org/10.1038/368419a0
303 rdf:type schema:CreativeWork
304 sg:pub.10.1038/87120 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002644604
305 https://doi.org/10.1038/87120
306 rdf:type schema:CreativeWork
307 sg:pub.10.1038/emm.1999.2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049247351
308 https://doi.org/10.1038/emm.1999.2
309 rdf:type schema:CreativeWork
310 sg:pub.10.1038/ng0196-52 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014624587
311 https://doi.org/10.1038/ng0196-52
312 rdf:type schema:CreativeWork
313 sg:pub.10.1038/ng0395-279 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010363963
314 https://doi.org/10.1038/ng0395-279
315 rdf:type schema:CreativeWork
316 sg:pub.10.1038/sj.jidsp.5640236 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013989693
317 https://doi.org/10.1038/sj.jidsp.5640236
318 rdf:type schema:CreativeWork
319 sg:pub.10.1046/j.0022-202x.2001.01368.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1018039611
320 https://doi.org/10.1046/j.0022-202x.2001.01368.x
321 rdf:type schema:CreativeWork
322 sg:pub.10.1046/j.1523-1747.1998.00144.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1038469641
323 https://doi.org/10.1046/j.1523-1747.1998.00144.x
324 rdf:type schema:CreativeWork
325 sg:pub.10.1046/j.1523-1747.1999.00494.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1004186948
326 https://doi.org/10.1046/j.1523-1747.1999.00494.x
327 rdf:type schema:CreativeWork
328 sg:pub.10.1159/000050604 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018749967
329 https://doi.org/10.1159/000050604
330 rdf:type schema:CreativeWork
331 https://app.dimensions.ai/details/publication/pub.1075369670 schema:CreativeWork
332 https://app.dimensions.ai/details/publication/pub.1076965484 schema:CreativeWork
333 https://app.dimensions.ai/details/publication/pub.1083379737 schema:CreativeWork
334 https://doi.org/10.1002/(sici)1097-4652(199808)176:2<255::aid-jcp4>3.0.co;2-n schema:sameAs https://app.dimensions.ai/details/publication/pub.1017879158
335 rdf:type schema:CreativeWork
336 https://doi.org/10.1006/smim.2000.0263 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025146929
337 rdf:type schema:CreativeWork
338 https://doi.org/10.1016/0303-7207(86)90141-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050250780
339 rdf:type schema:CreativeWork
340 https://doi.org/10.1016/s0002-9440(10)64081-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018860490
341 rdf:type schema:CreativeWork
342 https://doi.org/10.1016/s0092-8674(00)80429-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024942781
343 rdf:type schema:CreativeWork
344 https://doi.org/10.1016/s0140-6736(78)92646-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006291485
345 rdf:type schema:CreativeWork
346 https://doi.org/10.1016/s0167-4838(99)00263-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028417342
347 rdf:type schema:CreativeWork
348 https://doi.org/10.1016/s0378-1119(00)00225-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049260070
349 rdf:type schema:CreativeWork
350 https://doi.org/10.1016/s0923-1811(00)00124-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036354323
351 rdf:type schema:CreativeWork
352 https://doi.org/10.1016/s0955-0674(00)00139-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013944187
353 rdf:type schema:CreativeWork
354 https://doi.org/10.1016/s0960-9822(00)80011-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053379477
355 rdf:type schema:CreativeWork
356 https://doi.org/10.1016/s1357-2725(00)00061-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041466965
357 rdf:type schema:CreativeWork
358 https://doi.org/10.1016/s1357-2725(99)00089-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034058623
359 rdf:type schema:CreativeWork
360 https://doi.org/10.1016/s1471-4906(00)01797-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1012650838
361 rdf:type schema:CreativeWork
362 https://doi.org/10.1017/s0016672300010168 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053876109
363 rdf:type schema:CreativeWork
364 https://doi.org/10.1046/j.1432-1327.2001.02016.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1019704149
365 rdf:type schema:CreativeWork
366 https://doi.org/10.1073/pnas.150149097 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032915020
367 rdf:type schema:CreativeWork
368 https://doi.org/10.1073/pnas.90.11.4937 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004826685
369 rdf:type schema:CreativeWork
370 https://doi.org/10.1073/pnas.95.3.1044 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011215933
371 rdf:type schema:CreativeWork
372 https://doi.org/10.1073/pnas.96.20.11054 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035218308
373 rdf:type schema:CreativeWork
374 https://doi.org/10.1074/jbc.274.26.18237 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052484722
375 rdf:type schema:CreativeWork
376 https://doi.org/10.1074/jbc.m002941200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052743483
377 rdf:type schema:CreativeWork
378 https://doi.org/10.1074/jbc.m007802200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042691561
379 rdf:type schema:CreativeWork
380 https://doi.org/10.1074/jbc.r000020200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035731335
381 rdf:type schema:CreativeWork
382 https://doi.org/10.1083/jcb.151.2.389 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017995802
383 rdf:type schema:CreativeWork
384 https://doi.org/10.1083/jcb.153.2.243 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038285639
385 rdf:type schema:CreativeWork
386 https://doi.org/10.1084/jem.149.1.228 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048493899
387 rdf:type schema:CreativeWork
388 https://doi.org/10.1084/jem.194.4.439 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028809469
389 rdf:type schema:CreativeWork
390 https://doi.org/10.1093/nar/20.14.3795 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016988020
391 rdf:type schema:CreativeWork
392 https://doi.org/10.1093/oxfordjournals.jhered.a111411 schema:sameAs https://app.dimensions.ai/details/publication/pub.1082690076
393 rdf:type schema:CreativeWork
394 https://doi.org/10.1096/fasebj.14.2.319 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074584722
395 rdf:type schema:CreativeWork
396 https://doi.org/10.1101/gad.815400 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011055195
397 rdf:type schema:CreativeWork
398 https://doi.org/10.1111/j.1699-0463.1999.tb01521.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1019084351
399 rdf:type schema:CreativeWork
400 https://doi.org/10.1126/science.1064638 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062445432
401 rdf:type schema:CreativeWork
402 https://doi.org/10.1126/science.280.5362.450 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062560790
403 rdf:type schema:CreativeWork
404 https://doi.org/10.1126/science.7529942 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062647448
405 rdf:type schema:CreativeWork
406 https://doi.org/10.1126/science.7824952 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062649846
407 rdf:type schema:CreativeWork
408 https://doi.org/10.1146/annurev.immunol.17.1.829 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007123819
409 rdf:type schema:CreativeWork
410 https://doi.org/10.1159/000015125 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036229465
411 rdf:type schema:CreativeWork
412 https://doi.org/10.1177/10454411000110040101 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001886730
413 rdf:type schema:CreativeWork
414 https://doi.org/10.4049/jimmunol.165.11.6504 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016876459
415 rdf:type schema:CreativeWork
416 https://www.grid.ac/institutes/grid.281926.6 schema:alternateName American Red Cross
417 schema:name Department of Experimental Pathology, American Red Cross, 15601 Crabbs Branch Way, Rockville, Maryland, MD 20855, USA
418 rdf:type schema:Organization
419 https://www.grid.ac/institutes/grid.419633.a schema:alternateName National Institute of Dental and Craniofacial Research
420 schema:name Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, 30 Convent Drive, Bethesda, Maryland, MD 20892, USA
421 Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, 30 Convent Drive, Bethesda, Maryland, MD 20892, USA
422 rdf:type schema:Organization
423 https://www.grid.ac/institutes/grid.4973.9 schema:alternateName Copenhagen University Hospital
424 schema:name Finsen Laboratory, Strandboulevarden 49, DK-2100, Copenhagen, Denmark
425 Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, 30 Convent Drive, Bethesda, Maryland, MD 20892, USA
426 rdf:type schema:Organization
427 https://www.grid.ac/institutes/grid.94365.3d schema:alternateName National Institutes of Health
428 schema:name Cellular Imaging Core, National Institutes of Dental and Craniofacial Research, National Institutes of Health, 30 Convent Drive, Bethesda, Maryland, MD 20892, USA
429 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...