<i>In vitro</i> evidence for complex modes of nuclear β-catenin signaling during prostate growth and tumorigenesis View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2002-04

AUTHORS

Dennis R Chesire, Charles M Ewing, Wesley R Gage, William B Isaacs

ABSTRACT

Understanding the molecular etiology of prostate cancer (CaP) progression is paramount for broadening current diagnostic and therapeutic modalities. Current interest in the role of wnt pathway signaling in prostate tumorigenesis was generated with the finding of beta-catenin mutation and corresponding nuclear localization in primary lesions. The recent finding of beta-catenin-induced enhancement of androgen receptor (AR) function potentially ties beta-catenin to key regulatory steps of prostate cell growth, differentiation, and transformation. By immunohistological analysis of metastatic tumors, we detected nuclear beta-catenin in 20% of lethal CaP cases, suggesting a more common role for beta-catenin in advanced disease than would be predicted by its mutation rate. Interestingly, beta-catenin nuclear localization was found to occur concomitantly with androgen-induced regrowth of normal rat prostate. These in vivo observations likely implicate beta-catenin involvement in both normal and neoplastic prostate physiology, thus prompting our interest in further characterizing modes of beta-catenin signaling in prostate cells. Extending our previous findings, we demonstrate that transient beta-catenin over-expression stimulates T cell factor (TCF) signaling in most CaP cell lines. Further, this activity is not subject to cross-regulation by phosphoinositide-3-kinase (PI3-K)/Akt signaling, a stimulatory pathway often upregulated in CaP upon PTEN inactivation. Consistent with a previous report, we observed that transient beta-catenin over-expression enhances AR-mediated transcription off two natural target gene promoters. However, we were unable to recapitulate beta-catenin-induced stimulation of ectopically expressed AR in AR-negative cells, suggesting that other AR-associated factors are required for this activity. Although LNCaP cells are capable of this mode of AR co-stimulation, stable expression of mutant beta-catenin did not alter their proliferative response to androgen. In total, our characterization of beta-catenin signaling in CaP reveals the complex nature of its activity in prostate tissue, indicating that beta-catenin potentially contributes to multiple stimulatory inputs required for disease progression. More... »

PAGES

2679-2694

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/sj.onc.1205352

DOI

http://dx.doi.org/10.1038/sj.onc.1205352

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1020203525

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/11965541


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Blotting, Western", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Nucleus", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Transformation, Neoplastic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cytoskeletal Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Immunoenzyme Techniques", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "In Vitro Techniques", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Luciferases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Membrane Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "PTEN Phosphohydrolase", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Phosphatidylinositol 3-Kinases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Phosphoric Monoester Hydrolases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Phosphorylation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prostate", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prostatic Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein Tyrosine Phosphatases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein-Serine-Threonine Kinases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Proto-Oncogene Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Proto-Oncogene Proteins c-akt", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rats", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Receptors, Androgen", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Signal Transduction", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "TCF Transcription Factors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Trans-Activators", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Transcription Factor 7-Like 2 Protein", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Transcription Factors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Transfection", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tumor Cells, Cultured", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "beta Catenin", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Johns Hopkins University", 
          "id": "https://www.grid.ac/institutes/grid.21107.35", 
          "name": [
            "Brady Urological Institute Research Laboratories, The Johns Hopkins Medical Institutions, Baltimore, Maryland, MD 21287, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chesire", 
        "givenName": "Dennis R", 
        "id": "sg:person.01230522161.16", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01230522161.16"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Johns Hopkins University", 
          "id": "https://www.grid.ac/institutes/grid.21107.35", 
          "name": [
            "Brady Urological Institute Research Laboratories, The Johns Hopkins Medical Institutions, Baltimore, Maryland, MD 21287, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ewing", 
        "givenName": "Charles M", 
        "id": "sg:person.016426335517.40", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016426335517.40"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Johns Hopkins University", 
          "id": "https://www.grid.ac/institutes/grid.21107.35", 
          "name": [
            "Johns Hopkins Oncology Center, The Johns Hopkins Medical Institutions, Baltimore, Maryland, MD 21287, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gage", 
        "givenName": "Wesley R", 
        "id": "sg:person.013327610047.81", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013327610047.81"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Johns Hopkins University", 
          "id": "https://www.grid.ac/institutes/grid.21107.35", 
          "name": [
            "Brady Urological Institute Research Laboratories, The Johns Hopkins Medical Institutions, Baltimore, Maryland, MD 21287, USA", 
            "Johns Hopkins Oncology Center, The Johns Hopkins Medical Institutions, Baltimore, Maryland, MD 21287, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Isaacs", 
        "givenName": "William B", 
        "id": "sg:person.01145536753.98", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01145536753.98"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1073/pnas.95.26.15339", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001077238"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/37284", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001112208", 
          "https://doi.org/10.1038/37284"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/37284", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001112208", 
          "https://doi.org/10.1038/37284"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.275.5307.1787", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002102308"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1097-0045(19990201)38:2<166::aid-pros11>3.0.co;2-a", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002178065"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/1270", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002695839", 
          "https://doi.org/10.1038/1270"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/1270", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002695839", 
          "https://doi.org/10.1038/1270"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.274.12.7777", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003207993"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0304-419x(99)00026-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005426586"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.2006419", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006821475"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.146.4.855", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007951870"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.274.15.10173", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008424707"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0022-5347(01)62431-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009867639"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s004280000283", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009999563", 
          "https://doi.org/10.1007/s004280000283"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/emboj/16.13.3797", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012071604"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/j.1939-4640.1994.tb01682.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012620540"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.272.40.24735", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013670323"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.200107066", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017310113"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1097-0045(19980401)35:1<63::aid-pros9>3.0.co;2-i", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017648681"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm0497-402", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019051370", 
          "https://doi.org/10.1038/nm0497-402"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1097-2765(00)80200-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021271730"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3109/00313028409084731", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021961698"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3109/00313028409084731", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021961698"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jnci/91.22.1922", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023170749"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/abio.2000.4605", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023880463"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1521-1878(199912)22:1<1021::aid-bies6>3.0.co;2-p", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024295171"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.210394297", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025909528"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0960-9822(00)80088-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027505793"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.200102028", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028802139"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/21674", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030432913", 
          "https://doi.org/10.1038/21674"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.274.43.30419", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030631934"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.149.2.249", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031180024"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(00)81208-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032117929"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0960-9822(99)80091-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032917501"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0002-9440(10)65247-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033819435"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.95.26.15587", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034579275"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/18884", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037595361", 
          "https://doi.org/10.1038/18884"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/18884", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037595361", 
          "https://doi.org/10.1038/18884"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/73448", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038152509", 
          "https://doi.org/10.1038/73448"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/73448", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038152509", 
          "https://doi.org/10.1038/73448"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.944801", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039074450"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3109/07853890109002068", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039599115"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.274.25.18017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040155302"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.150152697", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040437548"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/378785a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042289302", 
          "https://doi.org/10.1038/378785a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0002-9440(10)65278-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042491211"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.281.5382.1509", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042662127"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/pros.2990110106", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043553042"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/1097-0045(20001201)45:4<323::aid-pros7>3.0.co;2-w", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044542741"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1202627", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047778748", 
          "https://doi.org/10.1038/sj.onc.1202627"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1202627", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047778748", 
          "https://doi.org/10.1038/sj.onc.1202627"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m005342200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047806495"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35001602", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048586851", 
          "https://doi.org/10.1038/35001602"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35001602", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048586851", 
          "https://doi.org/10.1038/35001602"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.10.20.2527", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049612654"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s001090050372", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051645147", 
          "https://doi.org/10.1007/s001090050372"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.275.5307.1784", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062556119"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.283.5406.1317", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062564324"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.289.5481.950", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062570598"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/mend.13.11.0369", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064331736"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074253928", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074359878", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074521009", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074525948", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074617105", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074640218", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074673385", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074677046", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074698410", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074750432", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074792783", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074805936", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074834920", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074836341", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074870419", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1076844154", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1080187199", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082397609", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083280356", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2002-04", 
    "datePublishedReg": "2002-04-01", 
    "description": "Understanding the molecular etiology of prostate cancer (CaP) progression is paramount for broadening current diagnostic and therapeutic modalities. Current interest in the role of wnt pathway signaling in prostate tumorigenesis was generated with the finding of beta-catenin mutation and corresponding nuclear localization in primary lesions. The recent finding of beta-catenin-induced enhancement of androgen receptor (AR) function potentially ties beta-catenin to key regulatory steps of prostate cell growth, differentiation, and transformation. By immunohistological analysis of metastatic tumors, we detected nuclear beta-catenin in 20% of lethal CaP cases, suggesting a more common role for beta-catenin in advanced disease than would be predicted by its mutation rate. Interestingly, beta-catenin nuclear localization was found to occur concomitantly with androgen-induced regrowth of normal rat prostate. These in vivo observations likely implicate beta-catenin involvement in both normal and neoplastic prostate physiology, thus prompting our interest in further characterizing modes of beta-catenin signaling in prostate cells. Extending our previous findings, we demonstrate that transient beta-catenin over-expression stimulates T cell factor (TCF) signaling in most CaP cell lines. Further, this activity is not subject to cross-regulation by phosphoinositide-3-kinase (PI3-K)/Akt signaling, a stimulatory pathway often upregulated in CaP upon PTEN inactivation. Consistent with a previous report, we observed that transient beta-catenin over-expression enhances AR-mediated transcription off two natural target gene promoters. However, we were unable to recapitulate beta-catenin-induced stimulation of ectopically expressed AR in AR-negative cells, suggesting that other AR-associated factors are required for this activity. Although LNCaP cells are capable of this mode of AR co-stimulation, stable expression of mutant beta-catenin did not alter their proliferative response to androgen. In total, our characterization of beta-catenin signaling in CaP reveals the complex nature of its activity in prostate tissue, indicating that beta-catenin potentially contributes to multiple stimulatory inputs required for disease progression.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/sj.onc.1205352", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2440140", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1097543", 
        "issn": [
          "0950-9232", 
          "1476-5594"
        ], 
        "name": "Oncogene", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "17", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "21"
      }
    ], 
    "name": "In vitro evidence for complex modes of nuclear \u03b2-catenin signaling during prostate growth and tumorigenesis", 
    "pagination": "2679-2694", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "604349d36bd69ecbe945e2dbd1aa3383c86422390de15d7230ace4b9b832b9f9"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "11965541"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "8711562"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/sj.onc.1205352"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1020203525"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/sj.onc.1205352", 
      "https://app.dimensions.ai/details/publication/pub.1020203525"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T11:50", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000359_0000000359/records_29182_00000001.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/1205352"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/sj.onc.1205352'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/sj.onc.1205352'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/sj.onc.1205352'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/sj.onc.1205352'


 

This table displays all metadata directly associated to this object as RDF triples.

425 TRIPLES      21 PREDICATES      132 URIs      52 LITERALS      40 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/sj.onc.1205352 schema:about N189985fc89fe4779804eed92d69b18d5
2 N18ec77dc058646b19f36b4dc6c275cff
3 N2305af0bcfc7436a9267c8ccc789e8cf
4 N25a3190f0389417ca827c4a004ebb055
5 N39d8d6a341fa4405bf3e064f5ac66cd6
6 N3cbd450f648048c780994dfc0e57bf2d
7 N3da5c28d1ceb495fbbdb2bebe889ddf2
8 N4351f4b00bd048448af1c65faa03aabe
9 N461dd41367e24d7f95755d4d4fd036ee
10 N484d127bdcf74bb7bae5b7aac6719f5b
11 N4d8f911e65ac4287a21d282168115913
12 N565153e412c145b4a737cad7477ef6ef
13 N68924fa3a1bc4d7aab67610076949be7
14 N76d201c04a614ece83a59a62e9a71335
15 N7cf9e8a4a99d4c63a5119d6573417feb
16 N8b91198724924976bd6a0d44929f5848
17 N90ad70912bb84aaea34b08a3d5dc46e1
18 N9cbc7cdf8e384fbbab2de2f1ed225d83
19 Na1ff181da3c047f99def9bc0fc54608d
20 Na95dad57126e417994cbb2a122344930
21 Nb5dc66eedb8d41868aa752f63b6bd9c1
22 Nbd7131ad38d7468da2a01ed04e8c51c5
23 Nd217741838b441f181270790ed76b9e9
24 Nd4e452e48653445fbc54f329e6e7ee44
25 Nd6e7c7dedc9a4039aac1b43651e20b7a
26 Ne3055cb074d541ca940e453fecb5d372
27 Ne8645c5493924c87b94c645567034c29
28 Ne9013595d65d42f98298f58e3aaefeba
29 Neb0ca2c5ef5b422b89d0eb64a921f4a8
30 Nf2b63e17ce2141e9b3c96f9bf22d17ed
31 Nf68356eefd7740819a6ba5abf6c948a9
32 anzsrc-for:06
33 anzsrc-for:0601
34 schema:author N55257e262eb24149a589181c38f09a38
35 schema:citation sg:pub.10.1007/s001090050372
36 sg:pub.10.1007/s004280000283
37 sg:pub.10.1038/1270
38 sg:pub.10.1038/18884
39 sg:pub.10.1038/21674
40 sg:pub.10.1038/35001602
41 sg:pub.10.1038/37284
42 sg:pub.10.1038/378785a0
43 sg:pub.10.1038/73448
44 sg:pub.10.1038/nm0497-402
45 sg:pub.10.1038/sj.onc.1202627
46 https://app.dimensions.ai/details/publication/pub.1074253928
47 https://app.dimensions.ai/details/publication/pub.1074359878
48 https://app.dimensions.ai/details/publication/pub.1074521009
49 https://app.dimensions.ai/details/publication/pub.1074525948
50 https://app.dimensions.ai/details/publication/pub.1074617105
51 https://app.dimensions.ai/details/publication/pub.1074640218
52 https://app.dimensions.ai/details/publication/pub.1074673385
53 https://app.dimensions.ai/details/publication/pub.1074677046
54 https://app.dimensions.ai/details/publication/pub.1074698410
55 https://app.dimensions.ai/details/publication/pub.1074750432
56 https://app.dimensions.ai/details/publication/pub.1074792783
57 https://app.dimensions.ai/details/publication/pub.1074805936
58 https://app.dimensions.ai/details/publication/pub.1074834920
59 https://app.dimensions.ai/details/publication/pub.1074836341
60 https://app.dimensions.ai/details/publication/pub.1074870419
61 https://app.dimensions.ai/details/publication/pub.1076844154
62 https://app.dimensions.ai/details/publication/pub.1080187199
63 https://app.dimensions.ai/details/publication/pub.1082397609
64 https://app.dimensions.ai/details/publication/pub.1083280356
65 https://doi.org/10.1002/(sici)1097-0045(19980401)35:1<63::aid-pros9>3.0.co;2-i
66 https://doi.org/10.1002/(sici)1097-0045(19990201)38:2<166::aid-pros11>3.0.co;2-a
67 https://doi.org/10.1002/(sici)1521-1878(199912)22:1<1021::aid-bies6>3.0.co;2-p
68 https://doi.org/10.1002/1097-0045(20001201)45:4<323::aid-pros7>3.0.co;2-w
69 https://doi.org/10.1002/j.1939-4640.1994.tb01682.x
70 https://doi.org/10.1002/pros.2990110106
71 https://doi.org/10.1006/abio.2000.4605
72 https://doi.org/10.1016/s0002-9440(10)65247-9
73 https://doi.org/10.1016/s0002-9440(10)65278-9
74 https://doi.org/10.1016/s0022-5347(01)62431-5
75 https://doi.org/10.1016/s0092-8674(00)81208-8
76 https://doi.org/10.1016/s0304-419x(99)00026-8
77 https://doi.org/10.1016/s0960-9822(00)80088-3
78 https://doi.org/10.1016/s0960-9822(99)80091-8
79 https://doi.org/10.1016/s1097-2765(00)80200-2
80 https://doi.org/10.1073/pnas.150152697
81 https://doi.org/10.1073/pnas.210394297
82 https://doi.org/10.1073/pnas.95.26.15339
83 https://doi.org/10.1073/pnas.95.26.15587
84 https://doi.org/10.1074/jbc.272.40.24735
85 https://doi.org/10.1074/jbc.274.12.7777
86 https://doi.org/10.1074/jbc.274.15.10173
87 https://doi.org/10.1074/jbc.274.25.18017
88 https://doi.org/10.1074/jbc.274.43.30419
89 https://doi.org/10.1074/jbc.m005342200
90 https://doi.org/10.1083/jcb.146.4.855
91 https://doi.org/10.1083/jcb.149.2.249
92 https://doi.org/10.1083/jcb.200102028
93 https://doi.org/10.1083/jcb.200107066
94 https://doi.org/10.1093/emboj/16.13.3797
95 https://doi.org/10.1093/jnci/91.22.1922
96 https://doi.org/10.1101/gad.10.20.2527
97 https://doi.org/10.1101/gad.944801
98 https://doi.org/10.1126/science.2006419
99 https://doi.org/10.1126/science.275.5307.1784
100 https://doi.org/10.1126/science.275.5307.1787
101 https://doi.org/10.1126/science.281.5382.1509
102 https://doi.org/10.1126/science.283.5406.1317
103 https://doi.org/10.1126/science.289.5481.950
104 https://doi.org/10.1210/mend.13.11.0369
105 https://doi.org/10.3109/00313028409084731
106 https://doi.org/10.3109/07853890109002068
107 schema:datePublished 2002-04
108 schema:datePublishedReg 2002-04-01
109 schema:description Understanding the molecular etiology of prostate cancer (CaP) progression is paramount for broadening current diagnostic and therapeutic modalities. Current interest in the role of wnt pathway signaling in prostate tumorigenesis was generated with the finding of beta-catenin mutation and corresponding nuclear localization in primary lesions. The recent finding of beta-catenin-induced enhancement of androgen receptor (AR) function potentially ties beta-catenin to key regulatory steps of prostate cell growth, differentiation, and transformation. By immunohistological analysis of metastatic tumors, we detected nuclear beta-catenin in 20% of lethal CaP cases, suggesting a more common role for beta-catenin in advanced disease than would be predicted by its mutation rate. Interestingly, beta-catenin nuclear localization was found to occur concomitantly with androgen-induced regrowth of normal rat prostate. These in vivo observations likely implicate beta-catenin involvement in both normal and neoplastic prostate physiology, thus prompting our interest in further characterizing modes of beta-catenin signaling in prostate cells. Extending our previous findings, we demonstrate that transient beta-catenin over-expression stimulates T cell factor (TCF) signaling in most CaP cell lines. Further, this activity is not subject to cross-regulation by phosphoinositide-3-kinase (PI3-K)/Akt signaling, a stimulatory pathway often upregulated in CaP upon PTEN inactivation. Consistent with a previous report, we observed that transient beta-catenin over-expression enhances AR-mediated transcription off two natural target gene promoters. However, we were unable to recapitulate beta-catenin-induced stimulation of ectopically expressed AR in AR-negative cells, suggesting that other AR-associated factors are required for this activity. Although LNCaP cells are capable of this mode of AR co-stimulation, stable expression of mutant beta-catenin did not alter their proliferative response to androgen. In total, our characterization of beta-catenin signaling in CaP reveals the complex nature of its activity in prostate tissue, indicating that beta-catenin potentially contributes to multiple stimulatory inputs required for disease progression.
110 schema:genre research_article
111 schema:inLanguage en
112 schema:isAccessibleForFree true
113 schema:isPartOf N275058224d4b4a86ba0023f82616adc5
114 Na825a4a9541e400599208797d4d1dc62
115 sg:journal.1097543
116 schema:name <i>In vitro</i> evidence for complex modes of nuclear β-catenin signaling during prostate growth and tumorigenesis
117 schema:pagination 2679-2694
118 schema:productId N2a9839d68dbc4af28c996ecc9a3cbc67
119 N86a1da6c706a47999c7640945bf336d7
120 Na9b904a105004ba8bdd5aaaa67a9f0f3
121 Nbb0a58cbc51c4d70bac280cd89725282
122 Nfd830c7527f44c2ea064a1e6ec7efbff
123 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020203525
124 https://doi.org/10.1038/sj.onc.1205352
125 schema:sdDatePublished 2019-04-11T11:50
126 schema:sdLicense https://scigraph.springernature.com/explorer/license/
127 schema:sdPublisher N447e1ba7fd32495d9917e03cfdfaea36
128 schema:url https://www.nature.com/articles/1205352
129 sgo:license sg:explorer/license/
130 sgo:sdDataset articles
131 rdf:type schema:ScholarlyArticle
132 N0319af28fb76449e91cc2ac0c805ccaa rdf:first sg:person.016426335517.40
133 rdf:rest Nbf26a11fd81d407baf8b13739abf558e
134 N189985fc89fe4779804eed92d69b18d5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name Membrane Proteins
136 rdf:type schema:DefinedTerm
137 N18ec77dc058646b19f36b4dc6c275cff schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name Tumor Cells, Cultured
139 rdf:type schema:DefinedTerm
140 N2305af0bcfc7436a9267c8ccc789e8cf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
141 schema:name Cytoskeletal Proteins
142 rdf:type schema:DefinedTerm
143 N25a3190f0389417ca827c4a004ebb055 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
144 schema:name Prostatic Neoplasms
145 rdf:type schema:DefinedTerm
146 N275058224d4b4a86ba0023f82616adc5 schema:volumeNumber 21
147 rdf:type schema:PublicationVolume
148 N2a9839d68dbc4af28c996ecc9a3cbc67 schema:name readcube_id
149 schema:value 604349d36bd69ecbe945e2dbd1aa3383c86422390de15d7230ace4b9b832b9f9
150 rdf:type schema:PropertyValue
151 N39d8d6a341fa4405bf3e064f5ac66cd6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
152 schema:name Phosphoric Monoester Hydrolases
153 rdf:type schema:DefinedTerm
154 N3cbd450f648048c780994dfc0e57bf2d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
155 schema:name Humans
156 rdf:type schema:DefinedTerm
157 N3da5c28d1ceb495fbbdb2bebe889ddf2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
158 schema:name Phosphatidylinositol 3-Kinases
159 rdf:type schema:DefinedTerm
160 N4351f4b00bd048448af1c65faa03aabe schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
161 schema:name Prostate
162 rdf:type schema:DefinedTerm
163 N447e1ba7fd32495d9917e03cfdfaea36 schema:name Springer Nature - SN SciGraph project
164 rdf:type schema:Organization
165 N461dd41367e24d7f95755d4d4fd036ee schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
166 schema:name Cell Transformation, Neoplastic
167 rdf:type schema:DefinedTerm
168 N484d127bdcf74bb7bae5b7aac6719f5b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
169 schema:name Receptors, Androgen
170 rdf:type schema:DefinedTerm
171 N4d8f911e65ac4287a21d282168115913 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
172 schema:name Signal Transduction
173 rdf:type schema:DefinedTerm
174 N55257e262eb24149a589181c38f09a38 rdf:first sg:person.01230522161.16
175 rdf:rest N0319af28fb76449e91cc2ac0c805ccaa
176 N565153e412c145b4a737cad7477ef6ef schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
177 schema:name In Vitro Techniques
178 rdf:type schema:DefinedTerm
179 N68924fa3a1bc4d7aab67610076949be7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
180 schema:name Proto-Oncogene Proteins
181 rdf:type schema:DefinedTerm
182 N76d201c04a614ece83a59a62e9a71335 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
183 schema:name Cell Nucleus
184 rdf:type schema:DefinedTerm
185 N7cf9e8a4a99d4c63a5119d6573417feb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
186 schema:name Phosphorylation
187 rdf:type schema:DefinedTerm
188 N86a1da6c706a47999c7640945bf336d7 schema:name nlm_unique_id
189 schema:value 8711562
190 rdf:type schema:PropertyValue
191 N8b91198724924976bd6a0d44929f5848 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
192 schema:name Luciferases
193 rdf:type schema:DefinedTerm
194 N90ad70912bb84aaea34b08a3d5dc46e1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
195 schema:name Trans-Activators
196 rdf:type schema:DefinedTerm
197 N9cbc7cdf8e384fbbab2de2f1ed225d83 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
198 schema:name Proto-Oncogene Proteins c-akt
199 rdf:type schema:DefinedTerm
200 Na1ff181da3c047f99def9bc0fc54608d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
201 schema:name Protein Tyrosine Phosphatases
202 rdf:type schema:DefinedTerm
203 Na825a4a9541e400599208797d4d1dc62 schema:issueNumber 17
204 rdf:type schema:PublicationIssue
205 Na95dad57126e417994cbb2a122344930 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
206 schema:name Protein-Serine-Threonine Kinases
207 rdf:type schema:DefinedTerm
208 Na9b904a105004ba8bdd5aaaa67a9f0f3 schema:name doi
209 schema:value 10.1038/sj.onc.1205352
210 rdf:type schema:PropertyValue
211 Nb5dc66eedb8d41868aa752f63b6bd9c1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
212 schema:name Transfection
213 rdf:type schema:DefinedTerm
214 Nbb0a58cbc51c4d70bac280cd89725282 schema:name dimensions_id
215 schema:value pub.1020203525
216 rdf:type schema:PropertyValue
217 Nbd7131ad38d7468da2a01ed04e8c51c5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
218 schema:name Animals
219 rdf:type schema:DefinedTerm
220 Nbf26a11fd81d407baf8b13739abf558e rdf:first sg:person.013327610047.81
221 rdf:rest Ncb11eb1ac0df49568a0f09551bd2c54a
222 Ncb11eb1ac0df49568a0f09551bd2c54a rdf:first sg:person.01145536753.98
223 rdf:rest rdf:nil
224 Nd217741838b441f181270790ed76b9e9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
225 schema:name PTEN Phosphohydrolase
226 rdf:type schema:DefinedTerm
227 Nd4e452e48653445fbc54f329e6e7ee44 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
228 schema:name Transcription Factor 7-Like 2 Protein
229 rdf:type schema:DefinedTerm
230 Nd6e7c7dedc9a4039aac1b43651e20b7a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
231 schema:name Male
232 rdf:type schema:DefinedTerm
233 Ne3055cb074d541ca940e453fecb5d372 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
234 schema:name TCF Transcription Factors
235 rdf:type schema:DefinedTerm
236 Ne8645c5493924c87b94c645567034c29 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
237 schema:name Rats
238 rdf:type schema:DefinedTerm
239 Ne9013595d65d42f98298f58e3aaefeba schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
240 schema:name Transcription Factors
241 rdf:type schema:DefinedTerm
242 Neb0ca2c5ef5b422b89d0eb64a921f4a8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
243 schema:name Blotting, Western
244 rdf:type schema:DefinedTerm
245 Nf2b63e17ce2141e9b3c96f9bf22d17ed schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
246 schema:name beta Catenin
247 rdf:type schema:DefinedTerm
248 Nf68356eefd7740819a6ba5abf6c948a9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
249 schema:name Immunoenzyme Techniques
250 rdf:type schema:DefinedTerm
251 Nfd830c7527f44c2ea064a1e6ec7efbff schema:name pubmed_id
252 schema:value 11965541
253 rdf:type schema:PropertyValue
254 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
255 schema:name Biological Sciences
256 rdf:type schema:DefinedTerm
257 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
258 schema:name Biochemistry and Cell Biology
259 rdf:type schema:DefinedTerm
260 sg:grant.2440140 http://pending.schema.org/fundedItem sg:pub.10.1038/sj.onc.1205352
261 rdf:type schema:MonetaryGrant
262 sg:journal.1097543 schema:issn 0950-9232
263 1476-5594
264 schema:name Oncogene
265 rdf:type schema:Periodical
266 sg:person.01145536753.98 schema:affiliation https://www.grid.ac/institutes/grid.21107.35
267 schema:familyName Isaacs
268 schema:givenName William B
269 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01145536753.98
270 rdf:type schema:Person
271 sg:person.01230522161.16 schema:affiliation https://www.grid.ac/institutes/grid.21107.35
272 schema:familyName Chesire
273 schema:givenName Dennis R
274 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01230522161.16
275 rdf:type schema:Person
276 sg:person.013327610047.81 schema:affiliation https://www.grid.ac/institutes/grid.21107.35
277 schema:familyName Gage
278 schema:givenName Wesley R
279 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013327610047.81
280 rdf:type schema:Person
281 sg:person.016426335517.40 schema:affiliation https://www.grid.ac/institutes/grid.21107.35
282 schema:familyName Ewing
283 schema:givenName Charles M
284 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016426335517.40
285 rdf:type schema:Person
286 sg:pub.10.1007/s001090050372 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051645147
287 https://doi.org/10.1007/s001090050372
288 rdf:type schema:CreativeWork
289 sg:pub.10.1007/s004280000283 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009999563
290 https://doi.org/10.1007/s004280000283
291 rdf:type schema:CreativeWork
292 sg:pub.10.1038/1270 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002695839
293 https://doi.org/10.1038/1270
294 rdf:type schema:CreativeWork
295 sg:pub.10.1038/18884 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037595361
296 https://doi.org/10.1038/18884
297 rdf:type schema:CreativeWork
298 sg:pub.10.1038/21674 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030432913
299 https://doi.org/10.1038/21674
300 rdf:type schema:CreativeWork
301 sg:pub.10.1038/35001602 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048586851
302 https://doi.org/10.1038/35001602
303 rdf:type schema:CreativeWork
304 sg:pub.10.1038/37284 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001112208
305 https://doi.org/10.1038/37284
306 rdf:type schema:CreativeWork
307 sg:pub.10.1038/378785a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042289302
308 https://doi.org/10.1038/378785a0
309 rdf:type schema:CreativeWork
310 sg:pub.10.1038/73448 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038152509
311 https://doi.org/10.1038/73448
312 rdf:type schema:CreativeWork
313 sg:pub.10.1038/nm0497-402 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019051370
314 https://doi.org/10.1038/nm0497-402
315 rdf:type schema:CreativeWork
316 sg:pub.10.1038/sj.onc.1202627 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047778748
317 https://doi.org/10.1038/sj.onc.1202627
318 rdf:type schema:CreativeWork
319 https://app.dimensions.ai/details/publication/pub.1074253928 schema:CreativeWork
320 https://app.dimensions.ai/details/publication/pub.1074359878 schema:CreativeWork
321 https://app.dimensions.ai/details/publication/pub.1074521009 schema:CreativeWork
322 https://app.dimensions.ai/details/publication/pub.1074525948 schema:CreativeWork
323 https://app.dimensions.ai/details/publication/pub.1074617105 schema:CreativeWork
324 https://app.dimensions.ai/details/publication/pub.1074640218 schema:CreativeWork
325 https://app.dimensions.ai/details/publication/pub.1074673385 schema:CreativeWork
326 https://app.dimensions.ai/details/publication/pub.1074677046 schema:CreativeWork
327 https://app.dimensions.ai/details/publication/pub.1074698410 schema:CreativeWork
328 https://app.dimensions.ai/details/publication/pub.1074750432 schema:CreativeWork
329 https://app.dimensions.ai/details/publication/pub.1074792783 schema:CreativeWork
330 https://app.dimensions.ai/details/publication/pub.1074805936 schema:CreativeWork
331 https://app.dimensions.ai/details/publication/pub.1074834920 schema:CreativeWork
332 https://app.dimensions.ai/details/publication/pub.1074836341 schema:CreativeWork
333 https://app.dimensions.ai/details/publication/pub.1074870419 schema:CreativeWork
334 https://app.dimensions.ai/details/publication/pub.1076844154 schema:CreativeWork
335 https://app.dimensions.ai/details/publication/pub.1080187199 schema:CreativeWork
336 https://app.dimensions.ai/details/publication/pub.1082397609 schema:CreativeWork
337 https://app.dimensions.ai/details/publication/pub.1083280356 schema:CreativeWork
338 https://doi.org/10.1002/(sici)1097-0045(19980401)35:1<63::aid-pros9>3.0.co;2-i schema:sameAs https://app.dimensions.ai/details/publication/pub.1017648681
339 rdf:type schema:CreativeWork
340 https://doi.org/10.1002/(sici)1097-0045(19990201)38:2<166::aid-pros11>3.0.co;2-a schema:sameAs https://app.dimensions.ai/details/publication/pub.1002178065
341 rdf:type schema:CreativeWork
342 https://doi.org/10.1002/(sici)1521-1878(199912)22:1<1021::aid-bies6>3.0.co;2-p schema:sameAs https://app.dimensions.ai/details/publication/pub.1024295171
343 rdf:type schema:CreativeWork
344 https://doi.org/10.1002/1097-0045(20001201)45:4<323::aid-pros7>3.0.co;2-w schema:sameAs https://app.dimensions.ai/details/publication/pub.1044542741
345 rdf:type schema:CreativeWork
346 https://doi.org/10.1002/j.1939-4640.1994.tb01682.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1012620540
347 rdf:type schema:CreativeWork
348 https://doi.org/10.1002/pros.2990110106 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043553042
349 rdf:type schema:CreativeWork
350 https://doi.org/10.1006/abio.2000.4605 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023880463
351 rdf:type schema:CreativeWork
352 https://doi.org/10.1016/s0002-9440(10)65247-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033819435
353 rdf:type schema:CreativeWork
354 https://doi.org/10.1016/s0002-9440(10)65278-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042491211
355 rdf:type schema:CreativeWork
356 https://doi.org/10.1016/s0022-5347(01)62431-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009867639
357 rdf:type schema:CreativeWork
358 https://doi.org/10.1016/s0092-8674(00)81208-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032117929
359 rdf:type schema:CreativeWork
360 https://doi.org/10.1016/s0304-419x(99)00026-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005426586
361 rdf:type schema:CreativeWork
362 https://doi.org/10.1016/s0960-9822(00)80088-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027505793
363 rdf:type schema:CreativeWork
364 https://doi.org/10.1016/s0960-9822(99)80091-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032917501
365 rdf:type schema:CreativeWork
366 https://doi.org/10.1016/s1097-2765(00)80200-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021271730
367 rdf:type schema:CreativeWork
368 https://doi.org/10.1073/pnas.150152697 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040437548
369 rdf:type schema:CreativeWork
370 https://doi.org/10.1073/pnas.210394297 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025909528
371 rdf:type schema:CreativeWork
372 https://doi.org/10.1073/pnas.95.26.15339 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001077238
373 rdf:type schema:CreativeWork
374 https://doi.org/10.1073/pnas.95.26.15587 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034579275
375 rdf:type schema:CreativeWork
376 https://doi.org/10.1074/jbc.272.40.24735 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013670323
377 rdf:type schema:CreativeWork
378 https://doi.org/10.1074/jbc.274.12.7777 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003207993
379 rdf:type schema:CreativeWork
380 https://doi.org/10.1074/jbc.274.15.10173 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008424707
381 rdf:type schema:CreativeWork
382 https://doi.org/10.1074/jbc.274.25.18017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040155302
383 rdf:type schema:CreativeWork
384 https://doi.org/10.1074/jbc.274.43.30419 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030631934
385 rdf:type schema:CreativeWork
386 https://doi.org/10.1074/jbc.m005342200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047806495
387 rdf:type schema:CreativeWork
388 https://doi.org/10.1083/jcb.146.4.855 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007951870
389 rdf:type schema:CreativeWork
390 https://doi.org/10.1083/jcb.149.2.249 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031180024
391 rdf:type schema:CreativeWork
392 https://doi.org/10.1083/jcb.200102028 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028802139
393 rdf:type schema:CreativeWork
394 https://doi.org/10.1083/jcb.200107066 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017310113
395 rdf:type schema:CreativeWork
396 https://doi.org/10.1093/emboj/16.13.3797 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012071604
397 rdf:type schema:CreativeWork
398 https://doi.org/10.1093/jnci/91.22.1922 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023170749
399 rdf:type schema:CreativeWork
400 https://doi.org/10.1101/gad.10.20.2527 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049612654
401 rdf:type schema:CreativeWork
402 https://doi.org/10.1101/gad.944801 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039074450
403 rdf:type schema:CreativeWork
404 https://doi.org/10.1126/science.2006419 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006821475
405 rdf:type schema:CreativeWork
406 https://doi.org/10.1126/science.275.5307.1784 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062556119
407 rdf:type schema:CreativeWork
408 https://doi.org/10.1126/science.275.5307.1787 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002102308
409 rdf:type schema:CreativeWork
410 https://doi.org/10.1126/science.281.5382.1509 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042662127
411 rdf:type schema:CreativeWork
412 https://doi.org/10.1126/science.283.5406.1317 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062564324
413 rdf:type schema:CreativeWork
414 https://doi.org/10.1126/science.289.5481.950 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062570598
415 rdf:type schema:CreativeWork
416 https://doi.org/10.1210/mend.13.11.0369 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064331736
417 rdf:type schema:CreativeWork
418 https://doi.org/10.3109/00313028409084731 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021961698
419 rdf:type schema:CreativeWork
420 https://doi.org/10.3109/07853890109002068 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039599115
421 rdf:type schema:CreativeWork
422 https://www.grid.ac/institutes/grid.21107.35 schema:alternateName Johns Hopkins University
423 schema:name Brady Urological Institute Research Laboratories, The Johns Hopkins Medical Institutions, Baltimore, Maryland, MD 21287, USA
424 Johns Hopkins Oncology Center, The Johns Hopkins Medical Institutions, Baltimore, Maryland, MD 21287, USA
425 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...