Analysis of FasL and TRAIL induced apoptosis pathways in glioma cells View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2001-09

AUTHORS

Melissa J Knight, Christopher D Riffkin, Andrea M Muscat, David M Ashley, Christine J Hawkins

ABSTRACT

FasL and TNF-related apoptosis-inducing ligand (TRAIL) belong to a subgroup of the TNF superfamily which induce apoptosis by binding to their death domain containing receptors. In the present study we have utilized a panel of seven cell lines derived from human malignant gliomas to characterize molecular pathways through which FasL and TRAIL induce apoptosis in sensitive glioma cells and the mechanisms of resistance in cell lines which survive the death stimuli. Our findings indicate that FADD and Caspase-8 are essential for FasL and TRAIL mediated apoptosis in glioma cells. One sensitive cell line (D270) can be protected from FasL and TRAIL induced death by anti-apoptotic Bcl-2 family members while another (D645) cannot, implying that these lines may represent glioma examples of type II and type I cells respectively. For the first time we demonstrate resistance to FasL but not to TRAIL within the one glioma cell line. Furthermore, we report distinct mechanisms of resistance within different glioma lines, including downregulation of Caspase-8 in U373MG. Cycloheximide sensitized four of the resistant cell lines suggesting the presence of labile inhibitors. None of the known apoptosis inhibitors examined accounted for the observed resistance, suggesting novel inhibitors may exist in glioma cells. More... »

PAGES

1204810

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/sj.onc.1204810

DOI

http://dx.doi.org/10.1038/sj.onc.1204810

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1038375214

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/11593384


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adaptor Proteins, Signal Transducing", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antineoplastic Agents", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Apoptosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Apoptosis Regulatory Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Carrier Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Caspase 3", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Caspase 8", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Caspase 9", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Caspases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cisplatin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cycloheximide", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Drug Resistance, Neoplasm", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Enzyme Activation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Fas Ligand Protein", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Fas-Associated Death Domain Protein", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Glioma", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Ligands", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Membrane Glycoproteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Proto-Oncogene Proteins c-bcl-2", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "TNF-Related Apoptosis-Inducing Ligand", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tumor Cells, Cultured", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tumor Necrosis Factor-alpha", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "bcl-X Protein", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University of Melbourne", 
          "id": "https://www.grid.ac/institutes/grid.1008.9", 
          "name": [
            "Department of Haematology and Oncology, Royal Children's Hospital, Parkville, Australia", 
            "Murdoch Children's Research Institute, Royal Children's Hospital, Parkville, Australia", 
            "Department of Paediatrics, University of Melbourne, Parkville, Australia", 
            "Department of Surgery, Royal Melbourne Hospital, University of Melbourne, Parkville, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Knight", 
        "givenName": "Melissa J", 
        "id": "sg:person.01111565061.66", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01111565061.66"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Melbourne", 
          "id": "https://www.grid.ac/institutes/grid.1008.9", 
          "name": [
            "Department of Haematology and Oncology, Royal Children's Hospital, Parkville, Australia", 
            "Murdoch Children's Research Institute, Royal Children's Hospital, Parkville, Australia", 
            "Department of Paediatrics, University of Melbourne, Parkville, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Riffkin", 
        "givenName": "Christopher D", 
        "id": "sg:person.01031043423.47", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01031043423.47"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Melbourne", 
          "id": "https://www.grid.ac/institutes/grid.1008.9", 
          "name": [
            "Department of Haematology and Oncology, Royal Children's Hospital, Parkville, Australia", 
            "Murdoch Children's Research Institute, Royal Children's Hospital, Parkville, Australia", 
            "Department of Paediatrics, University of Melbourne, Parkville, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Muscat", 
        "givenName": "Andrea M", 
        "id": "sg:person.01245660012.49", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01245660012.49"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Melbourne", 
          "id": "https://www.grid.ac/institutes/grid.1008.9", 
          "name": [
            "Department of Haematology and Oncology, Royal Children's Hospital, Parkville, Australia", 
            "Murdoch Children's Research Institute, Royal Children's Hospital, Parkville, Australia", 
            "Department of Paediatrics, University of Melbourne, Parkville, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ashley", 
        "givenName": "David M", 
        "id": "sg:person.01222136634.47", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01222136634.47"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Melbourne", 
          "id": "https://www.grid.ac/institutes/grid.1008.9", 
          "name": [
            "Department of Haematology and Oncology, Royal Children's Hospital, Parkville, Australia", 
            "Murdoch Children's Research Institute, Royal Children's Hospital, Parkville, Australia", 
            "Department of Paediatrics, University of Melbourne, Parkville, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hawkins", 
        "givenName": "Christine J", 
        "id": "sg:person.0625245221.23", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0625245221.23"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/s0002-9440(10)64779-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000825717"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.187.8.1205", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004357626"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1074-7613(00)80211-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005404638"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/emboj/17.6.1675", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007962433"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1202831", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008255208", 
          "https://doi.org/10.1038/sj.onc.1202831"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1202831", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008255208", 
          "https://doi.org/10.1038/sj.onc.1202831"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0014-5793(98)00409-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009490908"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1074-7613(00)80551-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011462224"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.272.13.8539", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012796057"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0003-2697(87)90021-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013321498"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0301-472x(01)00627-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013548809"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/40901", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015400453", 
          "https://doi.org/10.1038/40901"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/40901", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015400453", 
          "https://doi.org/10.1038/40901"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.190.11.1679", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018446192"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.139.1.205", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019985676"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/25387", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021123076", 
          "https://doi.org/10.1038/25387"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/25387", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021123076", 
          "https://doi.org/10.1038/25387"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.274.17.11549", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021218696"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m910438199", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021891321"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/75007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024503242", 
          "https://doi.org/10.1038/75007"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/75007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024503242", 
          "https://doi.org/10.1038/75007"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/17.23.10137", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025260825"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0002-9440(10)65434-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025467977"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(00)81589-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026636071"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00005072-198105000-00001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026930222"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/40657", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027258655", 
          "https://doi.org/10.1038/40657"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/40657", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027258655", 
          "https://doi.org/10.1038/40657"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.96.26.14871", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027697469"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.275.11.7988", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028095285"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s000180050447", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030591896", 
          "https://doi.org/10.1007/s000180050447"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.97.3.1230", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030625626"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.274.20.13733", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030902553"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/1097-4547(20000815)61:4<464::aid-jnr14>3.0.co;2-g", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031087050"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.274.32.22532", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033142503"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.96.22.12667", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034213855"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.13.15.1899", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036777120"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.96.6.2885", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038975726"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0960-9822(07)00420-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039081920"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0022-1759(91)90198-o", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041435308"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0022-1759(91)90198-o", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041435308"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(00)81590-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042580199"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.274.3.1541", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044581094"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1023/a:1009617727938", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045070256", 
          "https://doi.org/10.1023/a:1009617727938"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/emboj/17.3.706", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048228288"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.274.29.20049", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048506556"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1203936", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048585697", 
          "https://doi.org/10.1038/sj.onc.1203936"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1203936", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048585697", 
          "https://doi.org/10.1038/sj.onc.1203936"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(93)90486-a", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048726593"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0952-7915(98)80223-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049365667"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.93.24.13786", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051425991"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1023/a:1008267312782", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056302853"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.7536343", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062647462"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3892/ijo.18.1.187", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071511544"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074474480", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1523/jneurosci.19-19-08244.1999", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074523787"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.1999.17.9.2941", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074549931"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074569448", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074590910", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074595974", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.164.8.3961", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074619205"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074693296", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074731722", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074775063", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074795200", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/j.1460-2075.1995.tb00245.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1082842817"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/j.1460-2075.1995.tb00304.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1082858095"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083318545", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083390007", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2001-09", 
    "datePublishedReg": "2001-09-01", 
    "description": "FasL and TNF-related apoptosis-inducing ligand (TRAIL) belong to a subgroup of the TNF superfamily which induce apoptosis by binding to their death domain containing receptors. In the present study we have utilized a panel of seven cell lines derived from human malignant gliomas to characterize molecular pathways through which FasL and TRAIL induce apoptosis in sensitive glioma cells and the mechanisms of resistance in cell lines which survive the death stimuli. Our findings indicate that FADD and Caspase-8 are essential for FasL and TRAIL mediated apoptosis in glioma cells. One sensitive cell line (D270) can be protected from FasL and TRAIL induced death by anti-apoptotic Bcl-2 family members while another (D645) cannot, implying that these lines may represent glioma examples of type II and type I cells respectively. For the first time we demonstrate resistance to FasL but not to TRAIL within the one glioma cell line. Furthermore, we report distinct mechanisms of resistance within different glioma lines, including downregulation of Caspase-8 in U373MG. Cycloheximide sensitized four of the resistant cell lines suggesting the presence of labile inhibitors. None of the known apoptosis inhibitors examined accounted for the observed resistance, suggesting novel inhibitors may exist in glioma cells.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/sj.onc.1204810", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1097543", 
        "issn": [
          "0950-9232", 
          "1476-5594"
        ], 
        "name": "Oncogene", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "41", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "20"
      }
    ], 
    "name": "Analysis of FasL and TRAIL induced apoptosis pathways in glioma cells", 
    "pagination": "1204810", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "b6cde18c95f58158d033b5015f9402d640658bfd37183a3d6cfb8f9842697fbb"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "11593384"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "8711562"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/sj.onc.1204810"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1038375214"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/sj.onc.1204810", 
      "https://app.dimensions.ai/details/publication/pub.1038375214"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T12:16", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000361_0000000361/records_54017_00000001.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://www.nature.com/articles/1204810"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/sj.onc.1204810'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/sj.onc.1204810'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/sj.onc.1204810'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/sj.onc.1204810'


 

This table displays all metadata directly associated to this object as RDF triples.

377 TRIPLES      21 PREDICATES      114 URIs      45 LITERALS      33 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/sj.onc.1204810 schema:about N167a4d2a865344e28b36e8b8d92af737
2 N2555ce3e169148a6ba57f98a7177468a
3 N2beaeaa6246b4907bc77352dceb55c80
4 N40f9d5f73645443a918d79d75d59fe52
5 N43f04fde8fd44bfca7f0e32032334998
6 N497e10689be1446da6e92fa419b5238a
7 N669ec8d2b0ff4bbcae05788e9b52bcf0
8 N69d931a7c5f54883870e3f137117b95c
9 N6f17f609c4d5454090e6f937a7ca469c
10 N7c9509ca7c174c5cb98f988824421580
11 N7ccf0404218545d1a7f4032eadb3b9c5
12 N7dc345e65cee499f9419a93a43031a5f
13 N99271a9714ed46f0a46f2dc0cff6cdf1
14 N9cd3925f3c32417b90de52d6677cbb8d
15 Na2a62bbd846e434eb669314bc63dd4eb
16 Nb69e9424446649848a49212a591e6a3d
17 Nbfef0fa0b0ca4ed89155c0d44f064af8
18 Ndd6742e226c94071ae07c95fe58d0844
19 Ndd940179f2ee4d7ca6e5883eac492d41
20 Ne22b72c94c8e43b58011c19134e01350
21 Ne817b98414b14901a854592104b87032
22 Nf59edd5dce7a4b5ba4461b865f1b8300
23 Nfbfd1715270f4325a761fb166d9098d2
24 Nfe9eac82a74a4156976c550b62a106c3
25 anzsrc-for:06
26 anzsrc-for:0601
27 schema:author N3995346be0a24702a16883cb5dce38d4
28 schema:citation sg:pub.10.1007/s000180050447
29 sg:pub.10.1023/a:1009617727938
30 sg:pub.10.1038/25387
31 sg:pub.10.1038/40657
32 sg:pub.10.1038/40901
33 sg:pub.10.1038/75007
34 sg:pub.10.1038/sj.onc.1202831
35 sg:pub.10.1038/sj.onc.1203936
36 https://app.dimensions.ai/details/publication/pub.1074474480
37 https://app.dimensions.ai/details/publication/pub.1074569448
38 https://app.dimensions.ai/details/publication/pub.1074590910
39 https://app.dimensions.ai/details/publication/pub.1074595974
40 https://app.dimensions.ai/details/publication/pub.1074693296
41 https://app.dimensions.ai/details/publication/pub.1074731722
42 https://app.dimensions.ai/details/publication/pub.1074775063
43 https://app.dimensions.ai/details/publication/pub.1074795200
44 https://app.dimensions.ai/details/publication/pub.1083318545
45 https://app.dimensions.ai/details/publication/pub.1083390007
46 https://doi.org/10.1002/1097-4547(20000815)61:4<464::aid-jnr14>3.0.co;2-g
47 https://doi.org/10.1002/j.1460-2075.1995.tb00245.x
48 https://doi.org/10.1002/j.1460-2075.1995.tb00304.x
49 https://doi.org/10.1016/0003-2697(87)90021-2
50 https://doi.org/10.1016/0022-1759(91)90198-o
51 https://doi.org/10.1016/0092-8674(93)90486-a
52 https://doi.org/10.1016/s0002-9440(10)64779-7
53 https://doi.org/10.1016/s0002-9440(10)65434-x
54 https://doi.org/10.1016/s0014-5793(98)00409-8
55 https://doi.org/10.1016/s0092-8674(00)81589-5
56 https://doi.org/10.1016/s0092-8674(00)81590-1
57 https://doi.org/10.1016/s0301-472x(01)00627-0
58 https://doi.org/10.1016/s0952-7915(98)80223-9
59 https://doi.org/10.1016/s0960-9822(07)00420-4
60 https://doi.org/10.1016/s1074-7613(00)80211-3
61 https://doi.org/10.1016/s1074-7613(00)80551-8
62 https://doi.org/10.1023/a:1008267312782
63 https://doi.org/10.1073/pnas.93.24.13786
64 https://doi.org/10.1073/pnas.96.22.12667
65 https://doi.org/10.1073/pnas.96.26.14871
66 https://doi.org/10.1073/pnas.96.6.2885
67 https://doi.org/10.1073/pnas.97.3.1230
68 https://doi.org/10.1074/jbc.272.13.8539
69 https://doi.org/10.1074/jbc.274.17.11549
70 https://doi.org/10.1074/jbc.274.20.13733
71 https://doi.org/10.1074/jbc.274.29.20049
72 https://doi.org/10.1074/jbc.274.3.1541
73 https://doi.org/10.1074/jbc.274.32.22532
74 https://doi.org/10.1074/jbc.275.11.7988
75 https://doi.org/10.1074/jbc.m910438199
76 https://doi.org/10.1083/jcb.139.1.205
77 https://doi.org/10.1084/jem.187.8.1205
78 https://doi.org/10.1084/jem.190.11.1679
79 https://doi.org/10.1093/emboj/17.3.706
80 https://doi.org/10.1093/emboj/17.6.1675
81 https://doi.org/10.1093/nar/17.23.10137
82 https://doi.org/10.1097/00005072-198105000-00001
83 https://doi.org/10.1101/gad.13.15.1899
84 https://doi.org/10.1126/science.7536343
85 https://doi.org/10.1200/jco.1999.17.9.2941
86 https://doi.org/10.1523/jneurosci.19-19-08244.1999
87 https://doi.org/10.3892/ijo.18.1.187
88 https://doi.org/10.4049/jimmunol.164.8.3961
89 schema:datePublished 2001-09
90 schema:datePublishedReg 2001-09-01
91 schema:description FasL and TNF-related apoptosis-inducing ligand (TRAIL) belong to a subgroup of the TNF superfamily which induce apoptosis by binding to their death domain containing receptors. In the present study we have utilized a panel of seven cell lines derived from human malignant gliomas to characterize molecular pathways through which FasL and TRAIL induce apoptosis in sensitive glioma cells and the mechanisms of resistance in cell lines which survive the death stimuli. Our findings indicate that FADD and Caspase-8 are essential for FasL and TRAIL mediated apoptosis in glioma cells. One sensitive cell line (D270) can be protected from FasL and TRAIL induced death by anti-apoptotic Bcl-2 family members while another (D645) cannot, implying that these lines may represent glioma examples of type II and type I cells respectively. For the first time we demonstrate resistance to FasL but not to TRAIL within the one glioma cell line. Furthermore, we report distinct mechanisms of resistance within different glioma lines, including downregulation of Caspase-8 in U373MG. Cycloheximide sensitized four of the resistant cell lines suggesting the presence of labile inhibitors. None of the known apoptosis inhibitors examined accounted for the observed resistance, suggesting novel inhibitors may exist in glioma cells.
92 schema:genre research_article
93 schema:inLanguage en
94 schema:isAccessibleForFree true
95 schema:isPartOf N59898dbf221f458e865c27add3ab5bbc
96 Nb825b8b6201d4636ba2fe068c2bd3b01
97 sg:journal.1097543
98 schema:name Analysis of FasL and TRAIL induced apoptosis pathways in glioma cells
99 schema:pagination 1204810
100 schema:productId N16ea49f11496461eb653fbbc9016caf3
101 N444b4ccfee2a4b9684a7a98e1d0bd939
102 Nad359d81ecf04e97b4a6c0ff7afe7d69
103 Ne606b572c56f4b4e95cb31944875b395
104 Nf010325722934a30a340c537d7aab4c9
105 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038375214
106 https://doi.org/10.1038/sj.onc.1204810
107 schema:sdDatePublished 2019-04-11T12:16
108 schema:sdLicense https://scigraph.springernature.com/explorer/license/
109 schema:sdPublisher Na4e4491844db4dda952ca5bfa0427ebd
110 schema:url http://www.nature.com/articles/1204810
111 sgo:license sg:explorer/license/
112 sgo:sdDataset articles
113 rdf:type schema:ScholarlyArticle
114 N167a4d2a865344e28b36e8b8d92af737 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
115 schema:name Cycloheximide
116 rdf:type schema:DefinedTerm
117 N16ea49f11496461eb653fbbc9016caf3 schema:name readcube_id
118 schema:value b6cde18c95f58158d033b5015f9402d640658bfd37183a3d6cfb8f9842697fbb
119 rdf:type schema:PropertyValue
120 N2555ce3e169148a6ba57f98a7177468a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
121 schema:name bcl-X Protein
122 rdf:type schema:DefinedTerm
123 N2beaeaa6246b4907bc77352dceb55c80 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name Caspase 8
125 rdf:type schema:DefinedTerm
126 N3995346be0a24702a16883cb5dce38d4 rdf:first sg:person.01111565061.66
127 rdf:rest N83e71504a9cb4bf4b7ceebf184901cef
128 N40f9d5f73645443a918d79d75d59fe52 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
129 schema:name Carrier Proteins
130 rdf:type schema:DefinedTerm
131 N43f04fde8fd44bfca7f0e32032334998 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
132 schema:name Antineoplastic Agents
133 rdf:type schema:DefinedTerm
134 N444b4ccfee2a4b9684a7a98e1d0bd939 schema:name dimensions_id
135 schema:value pub.1038375214
136 rdf:type schema:PropertyValue
137 N497e10689be1446da6e92fa419b5238a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name Tumor Necrosis Factor-alpha
139 rdf:type schema:DefinedTerm
140 N59898dbf221f458e865c27add3ab5bbc schema:issueNumber 41
141 rdf:type schema:PublicationIssue
142 N669ec8d2b0ff4bbcae05788e9b52bcf0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
143 schema:name Ligands
144 rdf:type schema:DefinedTerm
145 N69d931a7c5f54883870e3f137117b95c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
146 schema:name Caspase 9
147 rdf:type schema:DefinedTerm
148 N6f17f609c4d5454090e6f937a7ca469c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
149 schema:name Adaptor Proteins, Signal Transducing
150 rdf:type schema:DefinedTerm
151 N77d7d089cb52471d8581f9c3cc8feab6 rdf:first sg:person.01222136634.47
152 rdf:rest Nc7da9c4c0d184d86a389b394fd756755
153 N7c9509ca7c174c5cb98f988824421580 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
154 schema:name Tumor Cells, Cultured
155 rdf:type schema:DefinedTerm
156 N7ccf0404218545d1a7f4032eadb3b9c5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
157 schema:name Caspases
158 rdf:type schema:DefinedTerm
159 N7dc345e65cee499f9419a93a43031a5f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
160 schema:name Drug Resistance, Neoplasm
161 rdf:type schema:DefinedTerm
162 N83e71504a9cb4bf4b7ceebf184901cef rdf:first sg:person.01031043423.47
163 rdf:rest N93c45955b3fb47a2a948bd6d1cd1add6
164 N93c45955b3fb47a2a948bd6d1cd1add6 rdf:first sg:person.01245660012.49
165 rdf:rest N77d7d089cb52471d8581f9c3cc8feab6
166 N99271a9714ed46f0a46f2dc0cff6cdf1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
167 schema:name Apoptosis
168 rdf:type schema:DefinedTerm
169 N9cd3925f3c32417b90de52d6677cbb8d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
170 schema:name Apoptosis Regulatory Proteins
171 rdf:type schema:DefinedTerm
172 Na2a62bbd846e434eb669314bc63dd4eb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
173 schema:name Glioma
174 rdf:type schema:DefinedTerm
175 Na4e4491844db4dda952ca5bfa0427ebd schema:name Springer Nature - SN SciGraph project
176 rdf:type schema:Organization
177 Nad359d81ecf04e97b4a6c0ff7afe7d69 schema:name doi
178 schema:value 10.1038/sj.onc.1204810
179 rdf:type schema:PropertyValue
180 Nb69e9424446649848a49212a591e6a3d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
181 schema:name Fas Ligand Protein
182 rdf:type schema:DefinedTerm
183 Nb825b8b6201d4636ba2fe068c2bd3b01 schema:volumeNumber 20
184 rdf:type schema:PublicationVolume
185 Nbfef0fa0b0ca4ed89155c0d44f064af8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
186 schema:name Humans
187 rdf:type schema:DefinedTerm
188 Nc7da9c4c0d184d86a389b394fd756755 rdf:first sg:person.0625245221.23
189 rdf:rest rdf:nil
190 Ndd6742e226c94071ae07c95fe58d0844 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
191 schema:name Proto-Oncogene Proteins c-bcl-2
192 rdf:type schema:DefinedTerm
193 Ndd940179f2ee4d7ca6e5883eac492d41 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
194 schema:name Cisplatin
195 rdf:type schema:DefinedTerm
196 Ne22b72c94c8e43b58011c19134e01350 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
197 schema:name Fas-Associated Death Domain Protein
198 rdf:type schema:DefinedTerm
199 Ne606b572c56f4b4e95cb31944875b395 schema:name pubmed_id
200 schema:value 11593384
201 rdf:type schema:PropertyValue
202 Ne817b98414b14901a854592104b87032 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
203 schema:name Enzyme Activation
204 rdf:type schema:DefinedTerm
205 Nf010325722934a30a340c537d7aab4c9 schema:name nlm_unique_id
206 schema:value 8711562
207 rdf:type schema:PropertyValue
208 Nf59edd5dce7a4b5ba4461b865f1b8300 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
209 schema:name Membrane Glycoproteins
210 rdf:type schema:DefinedTerm
211 Nfbfd1715270f4325a761fb166d9098d2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
212 schema:name Caspase 3
213 rdf:type schema:DefinedTerm
214 Nfe9eac82a74a4156976c550b62a106c3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
215 schema:name TNF-Related Apoptosis-Inducing Ligand
216 rdf:type schema:DefinedTerm
217 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
218 schema:name Biological Sciences
219 rdf:type schema:DefinedTerm
220 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
221 schema:name Biochemistry and Cell Biology
222 rdf:type schema:DefinedTerm
223 sg:journal.1097543 schema:issn 0950-9232
224 1476-5594
225 schema:name Oncogene
226 rdf:type schema:Periodical
227 sg:person.01031043423.47 schema:affiliation https://www.grid.ac/institutes/grid.1008.9
228 schema:familyName Riffkin
229 schema:givenName Christopher D
230 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01031043423.47
231 rdf:type schema:Person
232 sg:person.01111565061.66 schema:affiliation https://www.grid.ac/institutes/grid.1008.9
233 schema:familyName Knight
234 schema:givenName Melissa J
235 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01111565061.66
236 rdf:type schema:Person
237 sg:person.01222136634.47 schema:affiliation https://www.grid.ac/institutes/grid.1008.9
238 schema:familyName Ashley
239 schema:givenName David M
240 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01222136634.47
241 rdf:type schema:Person
242 sg:person.01245660012.49 schema:affiliation https://www.grid.ac/institutes/grid.1008.9
243 schema:familyName Muscat
244 schema:givenName Andrea M
245 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01245660012.49
246 rdf:type schema:Person
247 sg:person.0625245221.23 schema:affiliation https://www.grid.ac/institutes/grid.1008.9
248 schema:familyName Hawkins
249 schema:givenName Christine J
250 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0625245221.23
251 rdf:type schema:Person
252 sg:pub.10.1007/s000180050447 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030591896
253 https://doi.org/10.1007/s000180050447
254 rdf:type schema:CreativeWork
255 sg:pub.10.1023/a:1009617727938 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045070256
256 https://doi.org/10.1023/a:1009617727938
257 rdf:type schema:CreativeWork
258 sg:pub.10.1038/25387 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021123076
259 https://doi.org/10.1038/25387
260 rdf:type schema:CreativeWork
261 sg:pub.10.1038/40657 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027258655
262 https://doi.org/10.1038/40657
263 rdf:type schema:CreativeWork
264 sg:pub.10.1038/40901 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015400453
265 https://doi.org/10.1038/40901
266 rdf:type schema:CreativeWork
267 sg:pub.10.1038/75007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024503242
268 https://doi.org/10.1038/75007
269 rdf:type schema:CreativeWork
270 sg:pub.10.1038/sj.onc.1202831 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008255208
271 https://doi.org/10.1038/sj.onc.1202831
272 rdf:type schema:CreativeWork
273 sg:pub.10.1038/sj.onc.1203936 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048585697
274 https://doi.org/10.1038/sj.onc.1203936
275 rdf:type schema:CreativeWork
276 https://app.dimensions.ai/details/publication/pub.1074474480 schema:CreativeWork
277 https://app.dimensions.ai/details/publication/pub.1074569448 schema:CreativeWork
278 https://app.dimensions.ai/details/publication/pub.1074590910 schema:CreativeWork
279 https://app.dimensions.ai/details/publication/pub.1074595974 schema:CreativeWork
280 https://app.dimensions.ai/details/publication/pub.1074693296 schema:CreativeWork
281 https://app.dimensions.ai/details/publication/pub.1074731722 schema:CreativeWork
282 https://app.dimensions.ai/details/publication/pub.1074775063 schema:CreativeWork
283 https://app.dimensions.ai/details/publication/pub.1074795200 schema:CreativeWork
284 https://app.dimensions.ai/details/publication/pub.1083318545 schema:CreativeWork
285 https://app.dimensions.ai/details/publication/pub.1083390007 schema:CreativeWork
286 https://doi.org/10.1002/1097-4547(20000815)61:4<464::aid-jnr14>3.0.co;2-g schema:sameAs https://app.dimensions.ai/details/publication/pub.1031087050
287 rdf:type schema:CreativeWork
288 https://doi.org/10.1002/j.1460-2075.1995.tb00245.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1082842817
289 rdf:type schema:CreativeWork
290 https://doi.org/10.1002/j.1460-2075.1995.tb00304.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1082858095
291 rdf:type schema:CreativeWork
292 https://doi.org/10.1016/0003-2697(87)90021-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013321498
293 rdf:type schema:CreativeWork
294 https://doi.org/10.1016/0022-1759(91)90198-o schema:sameAs https://app.dimensions.ai/details/publication/pub.1041435308
295 rdf:type schema:CreativeWork
296 https://doi.org/10.1016/0092-8674(93)90486-a schema:sameAs https://app.dimensions.ai/details/publication/pub.1048726593
297 rdf:type schema:CreativeWork
298 https://doi.org/10.1016/s0002-9440(10)64779-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000825717
299 rdf:type schema:CreativeWork
300 https://doi.org/10.1016/s0002-9440(10)65434-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1025467977
301 rdf:type schema:CreativeWork
302 https://doi.org/10.1016/s0014-5793(98)00409-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009490908
303 rdf:type schema:CreativeWork
304 https://doi.org/10.1016/s0092-8674(00)81589-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026636071
305 rdf:type schema:CreativeWork
306 https://doi.org/10.1016/s0092-8674(00)81590-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042580199
307 rdf:type schema:CreativeWork
308 https://doi.org/10.1016/s0301-472x(01)00627-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013548809
309 rdf:type schema:CreativeWork
310 https://doi.org/10.1016/s0952-7915(98)80223-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049365667
311 rdf:type schema:CreativeWork
312 https://doi.org/10.1016/s0960-9822(07)00420-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039081920
313 rdf:type schema:CreativeWork
314 https://doi.org/10.1016/s1074-7613(00)80211-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005404638
315 rdf:type schema:CreativeWork
316 https://doi.org/10.1016/s1074-7613(00)80551-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011462224
317 rdf:type schema:CreativeWork
318 https://doi.org/10.1023/a:1008267312782 schema:sameAs https://app.dimensions.ai/details/publication/pub.1056302853
319 rdf:type schema:CreativeWork
320 https://doi.org/10.1073/pnas.93.24.13786 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051425991
321 rdf:type schema:CreativeWork
322 https://doi.org/10.1073/pnas.96.22.12667 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034213855
323 rdf:type schema:CreativeWork
324 https://doi.org/10.1073/pnas.96.26.14871 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027697469
325 rdf:type schema:CreativeWork
326 https://doi.org/10.1073/pnas.96.6.2885 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038975726
327 rdf:type schema:CreativeWork
328 https://doi.org/10.1073/pnas.97.3.1230 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030625626
329 rdf:type schema:CreativeWork
330 https://doi.org/10.1074/jbc.272.13.8539 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012796057
331 rdf:type schema:CreativeWork
332 https://doi.org/10.1074/jbc.274.17.11549 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021218696
333 rdf:type schema:CreativeWork
334 https://doi.org/10.1074/jbc.274.20.13733 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030902553
335 rdf:type schema:CreativeWork
336 https://doi.org/10.1074/jbc.274.29.20049 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048506556
337 rdf:type schema:CreativeWork
338 https://doi.org/10.1074/jbc.274.3.1541 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044581094
339 rdf:type schema:CreativeWork
340 https://doi.org/10.1074/jbc.274.32.22532 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033142503
341 rdf:type schema:CreativeWork
342 https://doi.org/10.1074/jbc.275.11.7988 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028095285
343 rdf:type schema:CreativeWork
344 https://doi.org/10.1074/jbc.m910438199 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021891321
345 rdf:type schema:CreativeWork
346 https://doi.org/10.1083/jcb.139.1.205 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019985676
347 rdf:type schema:CreativeWork
348 https://doi.org/10.1084/jem.187.8.1205 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004357626
349 rdf:type schema:CreativeWork
350 https://doi.org/10.1084/jem.190.11.1679 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018446192
351 rdf:type schema:CreativeWork
352 https://doi.org/10.1093/emboj/17.3.706 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048228288
353 rdf:type schema:CreativeWork
354 https://doi.org/10.1093/emboj/17.6.1675 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007962433
355 rdf:type schema:CreativeWork
356 https://doi.org/10.1093/nar/17.23.10137 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025260825
357 rdf:type schema:CreativeWork
358 https://doi.org/10.1097/00005072-198105000-00001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026930222
359 rdf:type schema:CreativeWork
360 https://doi.org/10.1101/gad.13.15.1899 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036777120
361 rdf:type schema:CreativeWork
362 https://doi.org/10.1126/science.7536343 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062647462
363 rdf:type schema:CreativeWork
364 https://doi.org/10.1200/jco.1999.17.9.2941 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074549931
365 rdf:type schema:CreativeWork
366 https://doi.org/10.1523/jneurosci.19-19-08244.1999 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074523787
367 rdf:type schema:CreativeWork
368 https://doi.org/10.3892/ijo.18.1.187 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071511544
369 rdf:type schema:CreativeWork
370 https://doi.org/10.4049/jimmunol.164.8.3961 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074619205
371 rdf:type schema:CreativeWork
372 https://www.grid.ac/institutes/grid.1008.9 schema:alternateName University of Melbourne
373 schema:name Department of Haematology and Oncology, Royal Children's Hospital, Parkville, Australia
374 Department of Paediatrics, University of Melbourne, Parkville, Australia
375 Department of Surgery, Royal Melbourne Hospital, University of Melbourne, Parkville, Australia
376 Murdoch Children's Research Institute, Royal Children's Hospital, Parkville, Australia
377 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...