Ontology type: schema:ScholarlyArticle Open Access: True
2001-09
AUTHORSMelissa J Knight, Christopher D Riffkin, Andrea M Muscat, David M Ashley, Christine J Hawkins
ABSTRACTFasL and TNF-related apoptosis-inducing ligand (TRAIL) belong to a subgroup of the TNF superfamily which induce apoptosis by binding to their death domain containing receptors. In the present study we have utilized a panel of seven cell lines derived from human malignant gliomas to characterize molecular pathways through which FasL and TRAIL induce apoptosis in sensitive glioma cells and the mechanisms of resistance in cell lines which survive the death stimuli. Our findings indicate that FADD and Caspase-8 are essential for FasL and TRAIL mediated apoptosis in glioma cells. One sensitive cell line (D270) can be protected from FasL and TRAIL induced death by anti-apoptotic Bcl-2 family members while another (D645) cannot, implying that these lines may represent glioma examples of type II and type I cells respectively. For the first time we demonstrate resistance to FasL but not to TRAIL within the one glioma cell line. Furthermore, we report distinct mechanisms of resistance within different glioma lines, including downregulation of Caspase-8 in U373MG. Cycloheximide sensitized four of the resistant cell lines suggesting the presence of labile inhibitors. None of the known apoptosis inhibitors examined accounted for the observed resistance, suggesting novel inhibitors may exist in glioma cells. More... »
PAGES1204810
http://scigraph.springernature.com/pub.10.1038/sj.onc.1204810
DOIhttp://dx.doi.org/10.1038/sj.onc.1204810
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1038375214
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/11593384
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Biochemistry and Cell Biology",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Biological Sciences",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Adaptor Proteins, Signal Transducing",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Antineoplastic Agents",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Apoptosis",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Apoptosis Regulatory Proteins",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Carrier Proteins",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Caspase 3",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Caspase 8",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Caspase 9",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Caspases",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Cisplatin",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Cycloheximide",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Drug Resistance, Neoplasm",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Enzyme Activation",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Fas Ligand Protein",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Fas-Associated Death Domain Protein",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Glioma",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Humans",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Ligands",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Membrane Glycoproteins",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Proto-Oncogene Proteins c-bcl-2",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "TNF-Related Apoptosis-Inducing Ligand",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Tumor Cells, Cultured",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Tumor Necrosis Factor-alpha",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "bcl-X Protein",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "University of Melbourne",
"id": "https://www.grid.ac/institutes/grid.1008.9",
"name": [
"Department of Haematology and Oncology, Royal Children's Hospital, Parkville, Australia",
"Murdoch Children's Research Institute, Royal Children's Hospital, Parkville, Australia",
"Department of Paediatrics, University of Melbourne, Parkville, Australia",
"Department of Surgery, Royal Melbourne Hospital, University of Melbourne, Parkville, Australia"
],
"type": "Organization"
},
"familyName": "Knight",
"givenName": "Melissa J",
"id": "sg:person.01111565061.66",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01111565061.66"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of Melbourne",
"id": "https://www.grid.ac/institutes/grid.1008.9",
"name": [
"Department of Haematology and Oncology, Royal Children's Hospital, Parkville, Australia",
"Murdoch Children's Research Institute, Royal Children's Hospital, Parkville, Australia",
"Department of Paediatrics, University of Melbourne, Parkville, Australia"
],
"type": "Organization"
},
"familyName": "Riffkin",
"givenName": "Christopher D",
"id": "sg:person.01031043423.47",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01031043423.47"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of Melbourne",
"id": "https://www.grid.ac/institutes/grid.1008.9",
"name": [
"Department of Haematology and Oncology, Royal Children's Hospital, Parkville, Australia",
"Murdoch Children's Research Institute, Royal Children's Hospital, Parkville, Australia",
"Department of Paediatrics, University of Melbourne, Parkville, Australia"
],
"type": "Organization"
},
"familyName": "Muscat",
"givenName": "Andrea M",
"id": "sg:person.01245660012.49",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01245660012.49"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of Melbourne",
"id": "https://www.grid.ac/institutes/grid.1008.9",
"name": [
"Department of Haematology and Oncology, Royal Children's Hospital, Parkville, Australia",
"Murdoch Children's Research Institute, Royal Children's Hospital, Parkville, Australia",
"Department of Paediatrics, University of Melbourne, Parkville, Australia"
],
"type": "Organization"
},
"familyName": "Ashley",
"givenName": "David M",
"id": "sg:person.01222136634.47",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01222136634.47"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of Melbourne",
"id": "https://www.grid.ac/institutes/grid.1008.9",
"name": [
"Department of Haematology and Oncology, Royal Children's Hospital, Parkville, Australia",
"Murdoch Children's Research Institute, Royal Children's Hospital, Parkville, Australia",
"Department of Paediatrics, University of Melbourne, Parkville, Australia"
],
"type": "Organization"
},
"familyName": "Hawkins",
"givenName": "Christine J",
"id": "sg:person.0625245221.23",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0625245221.23"
],
"type": "Person"
}
],
"citation": [
{
"id": "https://doi.org/10.1016/s0002-9440(10)64779-7",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1000825717"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1084/jem.187.8.1205",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1004357626"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s1074-7613(00)80211-3",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1005404638"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1093/emboj/17.6.1675",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1007962433"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/sj.onc.1202831",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1008255208",
"https://doi.org/10.1038/sj.onc.1202831"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/sj.onc.1202831",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1008255208",
"https://doi.org/10.1038/sj.onc.1202831"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0014-5793(98)00409-8",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1009490908"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s1074-7613(00)80551-8",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1011462224"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1074/jbc.272.13.8539",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1012796057"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/0003-2697(87)90021-2",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1013321498"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0301-472x(01)00627-0",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1013548809"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/40901",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1015400453",
"https://doi.org/10.1038/40901"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/40901",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1015400453",
"https://doi.org/10.1038/40901"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1084/jem.190.11.1679",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1018446192"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1083/jcb.139.1.205",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1019985676"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/25387",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1021123076",
"https://doi.org/10.1038/25387"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/25387",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1021123076",
"https://doi.org/10.1038/25387"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1074/jbc.274.17.11549",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1021218696"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1074/jbc.m910438199",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1021891321"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/75007",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1024503242",
"https://doi.org/10.1038/75007"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/75007",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1024503242",
"https://doi.org/10.1038/75007"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1093/nar/17.23.10137",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1025260825"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0002-9440(10)65434-x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1025467977"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0092-8674(00)81589-5",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1026636071"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/00005072-198105000-00001",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1026930222"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/40657",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1027258655",
"https://doi.org/10.1038/40657"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/40657",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1027258655",
"https://doi.org/10.1038/40657"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1073/pnas.96.26.14871",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1027697469"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1074/jbc.275.11.7988",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1028095285"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s000180050447",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1030591896",
"https://doi.org/10.1007/s000180050447"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1073/pnas.97.3.1230",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1030625626"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1074/jbc.274.20.13733",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1030902553"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/1097-4547(20000815)61:4<464::aid-jnr14>3.0.co;2-g",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1031087050"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1074/jbc.274.32.22532",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1033142503"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1073/pnas.96.22.12667",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1034213855"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1101/gad.13.15.1899",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1036777120"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1073/pnas.96.6.2885",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1038975726"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0960-9822(07)00420-4",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1039081920"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/0022-1759(91)90198-o",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1041435308"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/0022-1759(91)90198-o",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1041435308"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0092-8674(00)81590-1",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1042580199"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1074/jbc.274.3.1541",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1044581094"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1023/a:1009617727938",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1045070256",
"https://doi.org/10.1023/a:1009617727938"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1093/emboj/17.3.706",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1048228288"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1074/jbc.274.29.20049",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1048506556"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/sj.onc.1203936",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1048585697",
"https://doi.org/10.1038/sj.onc.1203936"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/sj.onc.1203936",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1048585697",
"https://doi.org/10.1038/sj.onc.1203936"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/0092-8674(93)90486-a",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1048726593"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0952-7915(98)80223-9",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1049365667"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1073/pnas.93.24.13786",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1051425991"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1023/a:1008267312782",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1056302853"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1126/science.7536343",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1062647462"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.3892/ijo.18.1.187",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1071511544"
],
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1074474480",
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1523/jneurosci.19-19-08244.1999",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1074523787"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1200/jco.1999.17.9.2941",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1074549931"
],
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1074569448",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1074590910",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1074595974",
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.4049/jimmunol.164.8.3961",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1074619205"
],
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1074693296",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1074731722",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1074775063",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1074795200",
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/j.1460-2075.1995.tb00245.x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1082842817"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/j.1460-2075.1995.tb00304.x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1082858095"
],
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1083318545",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1083390007",
"type": "CreativeWork"
}
],
"datePublished": "2001-09",
"datePublishedReg": "2001-09-01",
"description": "FasL and TNF-related apoptosis-inducing ligand (TRAIL) belong to a subgroup of the TNF superfamily which induce apoptosis by binding to their death domain containing receptors. In the present study we have utilized a panel of seven cell lines derived from human malignant gliomas to characterize molecular pathways through which FasL and TRAIL induce apoptosis in sensitive glioma cells and the mechanisms of resistance in cell lines which survive the death stimuli. Our findings indicate that FADD and Caspase-8 are essential for FasL and TRAIL mediated apoptosis in glioma cells. One sensitive cell line (D270) can be protected from FasL and TRAIL induced death by anti-apoptotic Bcl-2 family members while another (D645) cannot, implying that these lines may represent glioma examples of type II and type I cells respectively. For the first time we demonstrate resistance to FasL but not to TRAIL within the one glioma cell line. Furthermore, we report distinct mechanisms of resistance within different glioma lines, including downregulation of Caspase-8 in U373MG. Cycloheximide sensitized four of the resistant cell lines suggesting the presence of labile inhibitors. None of the known apoptosis inhibitors examined accounted for the observed resistance, suggesting novel inhibitors may exist in glioma cells.",
"genre": "research_article",
"id": "sg:pub.10.1038/sj.onc.1204810",
"inLanguage": [
"en"
],
"isAccessibleForFree": true,
"isPartOf": [
{
"id": "sg:journal.1097543",
"issn": [
"0950-9232",
"1476-5594"
],
"name": "Oncogene",
"type": "Periodical"
},
{
"issueNumber": "41",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "20"
}
],
"name": "Analysis of FasL and TRAIL induced apoptosis pathways in glioma cells",
"pagination": "1204810",
"productId": [
{
"name": "readcube_id",
"type": "PropertyValue",
"value": [
"b6cde18c95f58158d033b5015f9402d640658bfd37183a3d6cfb8f9842697fbb"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"11593384"
]
},
{
"name": "nlm_unique_id",
"type": "PropertyValue",
"value": [
"8711562"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1038/sj.onc.1204810"
]
},
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1038375214"
]
}
],
"sameAs": [
"https://doi.org/10.1038/sj.onc.1204810",
"https://app.dimensions.ai/details/publication/pub.1038375214"
],
"sdDataset": "articles",
"sdDatePublished": "2019-04-11T12:16",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000361_0000000361/records_54017_00000001.jsonl",
"type": "ScholarlyArticle",
"url": "http://www.nature.com/articles/1204810"
}
]
Download the RDF metadata as:Â json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/sj.onc.1204810'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/sj.onc.1204810'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/sj.onc.1204810'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/sj.onc.1204810'
This table displays all metadata directly associated to this object as RDF triples.
377 TRIPLES
21 PREDICATES
114 URIs
45 LITERALS
33 BLANK NODES