Analysis of genetic and epigenetic processes that influence p14ARF expression in breast cancer View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2001-07

AUTHORS

J Silva, G Domínguez, J M Silva, J M García, I Gallego, C Corbacho, M Provencio, P España, F Bonilla

ABSTRACT

The INK4a/ARF locus encodes two unrelated cell cycle-regulatory proteins that both function in tumor suppression, p16INK4a and p14ARF. In human tumors including breast cancer, alterations affecting selectively p14ARF have been poorly analysed. We have performed a comprehensive analysis of the inactivation mechanisms (mutation, homozygous and hemizygous deletion, and promoter hypermethylation) in a large series of 100 primary breast carcinomas. RT-PCR showed expression variable of the p14ARF transcript, with 17% demonstrating overexpression and 26% demonstrating decreased expression. No detectable alterations were observed in the majority of cases with overexpressed p14ARF mRNA, but 77% of tumors with decreased expression presented at least one of these genetic/epigenetic alterations. Nevertheless, a statistically significant correlation was observed between decreased p14ARF expression and several poor prognostic parameters. More... »

PAGES

4586

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/sj.onc.1204617

DOI

http://dx.doi.org/10.1038/sj.onc.1204617

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1007401365

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/11494155


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