Translocations involving c-myc and c-myc function View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2001-09

AUTHORS

Linda M Boxer, Chi V Dang

ABSTRACT

c-MYC is the prototype for oncogene activation by chromosomal translocation. In contrast to the tightly regulated expression of c-myc in normal cells, c-myc is frequently deregulated in human cancers. Herein, aspects of c-myc gene activation and the function of the c-Myc protein are reviewed. The c-myc gene produces an oncogenic transcription factor that affects diverse cellular processes involved in cell growth, cell proliferation, apoptosis and cellular metabolism. Complete removal of c-myc results in slowed cell growth and proliferation, suggesting that while c-myc is not required for cell proliferation, it acts as an integrator and accelerator of cellular metabolism and proliferation. More... »

PAGES

1204595

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/sj.onc.1204595

DOI

http://dx.doi.org/10.1038/sj.onc.1204595

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1009176520

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/11607812


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