Inhibition of Ku heterodimer DNA end binding activity during granulocytic differentiation of human promyelocytic cell lines View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2001-07

AUTHORS

Catherine Muller, Sylvie Monferran, Alexander-Christopher Gamp, Patrick Calsou, Bernard Salles

ABSTRACT

The heterodimeric Ku protein (composed of the Ku 86 and Ku 70 sub-units) is a nuclear protein which binds to DNA termini without sequence specificity. Ku is the DNA-targeting component of the large catalytic sub-unit of the DNA-dependent protein kinase complex that is required for the repair of DNA double-strand breaks in mammalian cells. We studied the expression and function of Ku/DNA-PK during granulocytic differentiation of two human promyelocytic cell lines, HL60 and NB4, a process associated to decreased radiation resistance. After 3 days exposure to differentiating agents (either all-trans-retinoic acid or DMSO), Ku binding to double stranded (ds)-DNA ends declined dramatically whereas Ku protein levels remain unchanged. The nuclear, but not cytoplasmic, fraction of differentiated HL60 cells extracts exhibited a heat-sensitive inhibitory activity towards DNA binding of recombinant Ku heterodimer. We further demonstrate that immunoprecipitation of Ku is impaired in extracts from differentiated cells by using two antibodies that recognize epitopes within the C-terminus DNA binding domains of Ku 70 and Ku 86 proteins. These results favor the hypothesis of a protein interacting with Ku that would prevent DNA binding of heterodimerized Ku protein by steric hindrance. More... »

PAGES

1204571

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/sj.onc.1204571

DOI

http://dx.doi.org/10.1038/sj.onc.1204571

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1015180388

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/11466618


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antibodies, Monoclonal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antigens, Nuclear", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Differentiation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Extracts", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Line", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Nucleus", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA Helicases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA Repair", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA-Binding Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Dimerization", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Down-Regulation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Epitopes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Granulocytes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "HL-60 Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Ku Autoantigen", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Myeloid Progenitor Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Nuclear Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Precipitin Tests", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein Structure, Tertiary", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Institute of Pharmacology and Structural Biology", 
          "id": "https://www.grid.ac/institutes/grid.461904.e", 
          "name": [
            "Institut de Pharmacologie et de Biologie Structurale (CNRS, UPR 9062) 205 route de Narbonne, 31077 Toulouse cedex, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Muller", 
        "givenName": "Catherine", 
        "id": "sg:person.01330570655.94", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01330570655.94"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute of Pharmacology and Structural Biology", 
          "id": "https://www.grid.ac/institutes/grid.461904.e", 
          "name": [
            "Institut de Pharmacologie et de Biologie Structurale (CNRS, UPR 9062) 205 route de Narbonne, 31077 Toulouse cedex, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Monferran", 
        "givenName": "Sylvie", 
        "id": "sg:person.01052647563.22", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01052647563.22"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute of Pharmacology and Structural Biology", 
          "id": "https://www.grid.ac/institutes/grid.461904.e", 
          "name": [
            "Institut de Pharmacologie et de Biologie Structurale (CNRS, UPR 9062) 205 route de Narbonne, 31077 Toulouse cedex, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gamp", 
        "givenName": "Alexander-Christopher", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute of Pharmacology and Structural Biology", 
          "id": "https://www.grid.ac/institutes/grid.461904.e", 
          "name": [
            "Institut de Pharmacologie et de Biologie Structurale (CNRS, UPR 9062) 205 route de Narbonne, 31077 Toulouse cedex, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Calsou", 
        "givenName": "Patrick", 
        "id": "sg:person.01150573763.54", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01150573763.54"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute of Pharmacology and Structural Biology", 
          "id": "https://www.grid.ac/institutes/grid.461904.e", 
          "name": [
            "Institut de Pharmacologie et de Biologie Structurale (CNRS, UPR 9062) 205 route de Narbonne, 31077 Toulouse cedex, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Salles", 
        "givenName": "Bernard", 
        "id": "sg:person.01117626560.25", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01117626560.25"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/978-1-59259-455-9_17", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002979114", 
          "https://doi.org/10.1007/978-1-59259-455-9_17"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0300-9084(99)80044-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004343398"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.273.2.842", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004618265"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/bi982584b", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004751005"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/bi982584b", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004751005"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1074-7613(00)80386-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006443258"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1201676", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007726776", 
          "https://doi.org/10.1038/sj.onc.1201676"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1201676", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007726776", 
          "https://doi.org/10.1038/sj.onc.1201676"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.10.12.6460", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008802581"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.20.9.2996-3003.2000", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008873869"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/emboj/16.22.6874", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012206512"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.94.25.13588", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014375194"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0006-291x(05)80847-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015574104"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.19.5.3877", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017597749"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood.v97.7.2084", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018510508"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1074-7613(00)80109-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019893544"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.13.8.916", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020704432"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.175.6.1677", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021056467"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/emboj/16.16.5098", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022356293"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01323757", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022504412", 
          "https://doi.org/10.1007/bf01323757"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01323757", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022504412", 
          "https://doi.org/10.1007/bf01323757"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/0955300001004237", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024378537"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.95.2.525", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026593896"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0006-291x(82)91448-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027248182"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.186.6.921", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028423828"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(95)90447-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030354983"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/emboj/17.2.609", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031304476"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0014-4827(88)90319-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032116130"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.182.6.1625", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032535091"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.272.47.29919", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032612007"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.97.11.5907", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033914834"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1074-7613(00)80619-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036547123"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/stem.5530130731", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037803982"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/stem.5530130731", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037803982"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0014-5793(94)00863-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038020499"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bj3080131", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038512519"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bj3080131", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038512519"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.16.9.5186", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045665860"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2249.1990.tb08110.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045745062"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.16.1.37", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046375593"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(93)90057-w", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047151578"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/15.8.3493", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047465581"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.92.1.320", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049454574"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1201402", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050217602", 
          "https://doi.org/10.1038/sj.onc.1201402"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1201402", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050217602", 
          "https://doi.org/10.1038/sj.onc.1201402"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(95)90482-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050858444"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/bi00366a013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055172196"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.3175673", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062596396"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.165.11.6347", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074730895"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077373932", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077990249", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078808704", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079439212", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079508296", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079676708", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1081654129", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082400232", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082773357", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082816710", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082827747", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/j.1460-2075.1996.tb00688.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1082902137"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082955588", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083047820", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083119791", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083319614", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2001-07", 
    "datePublishedReg": "2001-07-01", 
    "description": "The heterodimeric Ku protein (composed of the Ku 86 and Ku 70 sub-units) is a nuclear protein which binds to DNA termini without sequence specificity. Ku is the DNA-targeting component of the large catalytic sub-unit of the DNA-dependent protein kinase complex that is required for the repair of DNA double-strand breaks in mammalian cells. We studied the expression and function of Ku/DNA-PK during granulocytic differentiation of two human promyelocytic cell lines, HL60 and NB4, a process associated to decreased radiation resistance. After 3 days exposure to differentiating agents (either all-trans-retinoic acid or DMSO), Ku binding to double stranded (ds)-DNA ends declined dramatically whereas Ku protein levels remain unchanged. The nuclear, but not cytoplasmic, fraction of differentiated HL60 cells extracts exhibited a heat-sensitive inhibitory activity towards DNA binding of recombinant Ku heterodimer. We further demonstrate that immunoprecipitation of Ku is impaired in extracts from differentiated cells by using two antibodies that recognize epitopes within the C-terminus DNA binding domains of Ku 70 and Ku 86 proteins. These results favor the hypothesis of a protein interacting with Ku that would prevent DNA binding of heterodimerized Ku protein by steric hindrance.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/sj.onc.1204571", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1097543", 
        "issn": [
          "0950-9232", 
          "1476-5594"
        ], 
        "name": "Oncogene", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "32", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "20"
      }
    ], 
    "name": "Inhibition of Ku heterodimer DNA end binding activity during granulocytic differentiation of human promyelocytic cell lines", 
    "pagination": "1204571", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "4853443be4814ed727c523fe8a0c56c49a3a14cba10fd8222181b277b381b524"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "11466618"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "8711562"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/sj.onc.1204571"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1015180388"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/sj.onc.1204571", 
      "https://app.dimensions.ai/details/publication/pub.1015180388"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T12:11", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000361_0000000361/records_53984_00000000.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://www.nature.com/articles/1204571"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/sj.onc.1204571'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/sj.onc.1204571'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/sj.onc.1204571'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/sj.onc.1204571'


 

This table displays all metadata directly associated to this object as RDF triples.

342 TRIPLES      21 PREDICATES      108 URIs      41 LITERALS      29 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/sj.onc.1204571 schema:about N0dfd96bcf234444cb436d19f0accfdcc
2 N0ebb856f0119434faa49275ce20de419
3 N13dfcc3e873247089e541e447ed659b8
4 N1f70da51bba742e289273dfe628f5ded
5 N2eb42a6e2a0f415496ef67699194cc4f
6 N37eabba492d74bdc81ab8db5fec72ed6
7 N3a821136ff414fd381daa600b87deb80
8 N3ad53b960e7d4323abb140e013ec76a4
9 N3fddcdc1cb6b45d8ac943d99668219e1
10 N44e3643e49464325a34c64f3dd9f4596
11 N519353dd61c74f9ab47ee4bac3f06374
12 N58db12e140ae4b7fb40a5666785d52e0
13 N7d3d0dafe00543ca806bda331ea203cd
14 N9bca116e00d44fee9571f430707933a7
15 Na10bf0a4d7934971a763818ed1f667c5
16 Na3db09cbf3a44875bf5d79ef458ed18a
17 Nbd88eb2607464ebab858981448e1d517
18 Nc58eb9cd49a44763becf9c3fd2ddb950
19 Nd30cc24fd9b9449093a9a489519841d7
20 Nf795dd1d61e24f3396ea9c39986bc6bc
21 anzsrc-for:06
22 anzsrc-for:0601
23 schema:author Nd112e2b7deee4f899837092779a1ba3a
24 schema:citation sg:pub.10.1007/978-1-59259-455-9_17
25 sg:pub.10.1007/bf01323757
26 sg:pub.10.1038/sj.onc.1201402
27 sg:pub.10.1038/sj.onc.1201676
28 https://app.dimensions.ai/details/publication/pub.1077373932
29 https://app.dimensions.ai/details/publication/pub.1077990249
30 https://app.dimensions.ai/details/publication/pub.1078808704
31 https://app.dimensions.ai/details/publication/pub.1079439212
32 https://app.dimensions.ai/details/publication/pub.1079508296
33 https://app.dimensions.ai/details/publication/pub.1079676708
34 https://app.dimensions.ai/details/publication/pub.1081654129
35 https://app.dimensions.ai/details/publication/pub.1082400232
36 https://app.dimensions.ai/details/publication/pub.1082773357
37 https://app.dimensions.ai/details/publication/pub.1082816710
38 https://app.dimensions.ai/details/publication/pub.1082827747
39 https://app.dimensions.ai/details/publication/pub.1082955588
40 https://app.dimensions.ai/details/publication/pub.1083047820
41 https://app.dimensions.ai/details/publication/pub.1083119791
42 https://app.dimensions.ai/details/publication/pub.1083319614
43 https://doi.org/10.1002/j.1460-2075.1996.tb00688.x
44 https://doi.org/10.1002/stem.5530130731
45 https://doi.org/10.1016/0006-291x(82)91448-6
46 https://doi.org/10.1016/0014-4827(88)90319-9
47 https://doi.org/10.1016/0014-5793(94)00863-9
48 https://doi.org/10.1016/0092-8674(93)90057-w
49 https://doi.org/10.1016/0092-8674(95)90447-6
50 https://doi.org/10.1016/0092-8674(95)90482-4
51 https://doi.org/10.1016/s0006-291x(05)80847-2
52 https://doi.org/10.1016/s0300-9084(99)80044-3
53 https://doi.org/10.1016/s1074-7613(00)80109-0
54 https://doi.org/10.1016/s1074-7613(00)80386-6
55 https://doi.org/10.1016/s1074-7613(00)80619-6
56 https://doi.org/10.1021/bi00366a013
57 https://doi.org/10.1021/bi982584b
58 https://doi.org/10.1042/bj3080131
59 https://doi.org/10.1073/pnas.92.1.320
60 https://doi.org/10.1073/pnas.94.25.13588
61 https://doi.org/10.1073/pnas.95.2.525
62 https://doi.org/10.1073/pnas.97.11.5907
63 https://doi.org/10.1074/jbc.272.47.29919
64 https://doi.org/10.1074/jbc.273.2.842
65 https://doi.org/10.1080/0955300001004237
66 https://doi.org/10.1084/jem.175.6.1677
67 https://doi.org/10.1084/jem.182.6.1625
68 https://doi.org/10.1084/jem.186.6.921
69 https://doi.org/10.1093/emboj/16.16.5098
70 https://doi.org/10.1093/emboj/16.22.6874
71 https://doi.org/10.1093/emboj/17.2.609
72 https://doi.org/10.1093/nar/15.8.3493
73 https://doi.org/10.1101/gad.13.8.916
74 https://doi.org/10.1111/j.1365-2249.1990.tb08110.x
75 https://doi.org/10.1126/science.3175673
76 https://doi.org/10.1128/mcb.10.12.6460
77 https://doi.org/10.1128/mcb.16.1.37
78 https://doi.org/10.1128/mcb.16.9.5186
79 https://doi.org/10.1128/mcb.19.5.3877
80 https://doi.org/10.1128/mcb.20.9.2996-3003.2000
81 https://doi.org/10.1182/blood.v97.7.2084
82 https://doi.org/10.4049/jimmunol.165.11.6347
83 schema:datePublished 2001-07
84 schema:datePublishedReg 2001-07-01
85 schema:description The heterodimeric Ku protein (composed of the Ku 86 and Ku 70 sub-units) is a nuclear protein which binds to DNA termini without sequence specificity. Ku is the DNA-targeting component of the large catalytic sub-unit of the DNA-dependent protein kinase complex that is required for the repair of DNA double-strand breaks in mammalian cells. We studied the expression and function of Ku/DNA-PK during granulocytic differentiation of two human promyelocytic cell lines, HL60 and NB4, a process associated to decreased radiation resistance. After 3 days exposure to differentiating agents (either all-trans-retinoic acid or DMSO), Ku binding to double stranded (ds)-DNA ends declined dramatically whereas Ku protein levels remain unchanged. The nuclear, but not cytoplasmic, fraction of differentiated HL60 cells extracts exhibited a heat-sensitive inhibitory activity towards DNA binding of recombinant Ku heterodimer. We further demonstrate that immunoprecipitation of Ku is impaired in extracts from differentiated cells by using two antibodies that recognize epitopes within the C-terminus DNA binding domains of Ku 70 and Ku 86 proteins. These results favor the hypothesis of a protein interacting with Ku that would prevent DNA binding of heterodimerized Ku protein by steric hindrance.
86 schema:genre research_article
87 schema:inLanguage en
88 schema:isAccessibleForFree true
89 schema:isPartOf N531ba7335a1f455683db004d6ca61e4c
90 Ne5b10cf9aa4043078c58a5af7974739d
91 sg:journal.1097543
92 schema:name Inhibition of Ku heterodimer DNA end binding activity during granulocytic differentiation of human promyelocytic cell lines
93 schema:pagination 1204571
94 schema:productId N5c0eb0c134e745aaa6bcee7bc906eee3
95 N94ea04441d2d4f5997d6d3243c7e6b77
96 Nd52f5f5b75c74c3e8d16b37c18944233
97 Ne2c3a978b4ce475dbf776902e1d326d3
98 Nfcd41a2afc4b4e7b8eb85fb3d7bc6739
99 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015180388
100 https://doi.org/10.1038/sj.onc.1204571
101 schema:sdDatePublished 2019-04-11T12:11
102 schema:sdLicense https://scigraph.springernature.com/explorer/license/
103 schema:sdPublisher N9e356e9cec9f446687661db4f0be4139
104 schema:url http://www.nature.com/articles/1204571
105 sgo:license sg:explorer/license/
106 sgo:sdDataset articles
107 rdf:type schema:ScholarlyArticle
108 N0dfd96bcf234444cb436d19f0accfdcc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
109 schema:name DNA Repair
110 rdf:type schema:DefinedTerm
111 N0ebb856f0119434faa49275ce20de419 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
112 schema:name Nuclear Proteins
113 rdf:type schema:DefinedTerm
114 N13dfcc3e873247089e541e447ed659b8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
115 schema:name Cell Extracts
116 rdf:type schema:DefinedTerm
117 N1756dd68ce044167b01251a6eca43dcf schema:affiliation https://www.grid.ac/institutes/grid.461904.e
118 schema:familyName Gamp
119 schema:givenName Alexander-Christopher
120 rdf:type schema:Person
121 N1f70da51bba742e289273dfe628f5ded schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
122 schema:name Epitopes
123 rdf:type schema:DefinedTerm
124 N2eb42a6e2a0f415496ef67699194cc4f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
125 schema:name Antigens, Nuclear
126 rdf:type schema:DefinedTerm
127 N37eabba492d74bdc81ab8db5fec72ed6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
128 schema:name Humans
129 rdf:type schema:DefinedTerm
130 N3a821136ff414fd381daa600b87deb80 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
131 schema:name Granulocytes
132 rdf:type schema:DefinedTerm
133 N3ad53b960e7d4323abb140e013ec76a4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
134 schema:name Protein Structure, Tertiary
135 rdf:type schema:DefinedTerm
136 N3fddcdc1cb6b45d8ac943d99668219e1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
137 schema:name DNA-Binding Proteins
138 rdf:type schema:DefinedTerm
139 N41f0572d6caf43a6bde57b410a9c0686 rdf:first N1756dd68ce044167b01251a6eca43dcf
140 rdf:rest Nb5b2b1dbba454194a3ab4650b6694112
141 N44e3643e49464325a34c64f3dd9f4596 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
142 schema:name Dimerization
143 rdf:type schema:DefinedTerm
144 N519353dd61c74f9ab47ee4bac3f06374 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name Cell Line
146 rdf:type schema:DefinedTerm
147 N531ba7335a1f455683db004d6ca61e4c schema:issueNumber 32
148 rdf:type schema:PublicationIssue
149 N58db12e140ae4b7fb40a5666785d52e0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
150 schema:name Myeloid Progenitor Cells
151 rdf:type schema:DefinedTerm
152 N5c0eb0c134e745aaa6bcee7bc906eee3 schema:name readcube_id
153 schema:value 4853443be4814ed727c523fe8a0c56c49a3a14cba10fd8222181b277b381b524
154 rdf:type schema:PropertyValue
155 N7d3d0dafe00543ca806bda331ea203cd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
156 schema:name Down-Regulation
157 rdf:type schema:DefinedTerm
158 N94d49aadf6034bcaae5f7e46f76ad15d rdf:first sg:person.01117626560.25
159 rdf:rest rdf:nil
160 N94ea04441d2d4f5997d6d3243c7e6b77 schema:name doi
161 schema:value 10.1038/sj.onc.1204571
162 rdf:type schema:PropertyValue
163 N9bca116e00d44fee9571f430707933a7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
164 schema:name DNA Helicases
165 rdf:type schema:DefinedTerm
166 N9e356e9cec9f446687661db4f0be4139 schema:name Springer Nature - SN SciGraph project
167 rdf:type schema:Organization
168 Na10bf0a4d7934971a763818ed1f667c5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
169 schema:name Ku Autoantigen
170 rdf:type schema:DefinedTerm
171 Na3db09cbf3a44875bf5d79ef458ed18a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
172 schema:name Antibodies, Monoclonal
173 rdf:type schema:DefinedTerm
174 Nb5b2b1dbba454194a3ab4650b6694112 rdf:first sg:person.01150573763.54
175 rdf:rest N94d49aadf6034bcaae5f7e46f76ad15d
176 Nbd88eb2607464ebab858981448e1d517 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
177 schema:name Precipitin Tests
178 rdf:type schema:DefinedTerm
179 Nc58eb9cd49a44763becf9c3fd2ddb950 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
180 schema:name Cell Differentiation
181 rdf:type schema:DefinedTerm
182 Nd112e2b7deee4f899837092779a1ba3a rdf:first sg:person.01330570655.94
183 rdf:rest Nd8d2c3ab9023404a846368eb21881503
184 Nd30cc24fd9b9449093a9a489519841d7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
185 schema:name HL-60 Cells
186 rdf:type schema:DefinedTerm
187 Nd52f5f5b75c74c3e8d16b37c18944233 schema:name pubmed_id
188 schema:value 11466618
189 rdf:type schema:PropertyValue
190 Nd8d2c3ab9023404a846368eb21881503 rdf:first sg:person.01052647563.22
191 rdf:rest N41f0572d6caf43a6bde57b410a9c0686
192 Ne2c3a978b4ce475dbf776902e1d326d3 schema:name nlm_unique_id
193 schema:value 8711562
194 rdf:type schema:PropertyValue
195 Ne5b10cf9aa4043078c58a5af7974739d schema:volumeNumber 20
196 rdf:type schema:PublicationVolume
197 Nf795dd1d61e24f3396ea9c39986bc6bc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
198 schema:name Cell Nucleus
199 rdf:type schema:DefinedTerm
200 Nfcd41a2afc4b4e7b8eb85fb3d7bc6739 schema:name dimensions_id
201 schema:value pub.1015180388
202 rdf:type schema:PropertyValue
203 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
204 schema:name Biological Sciences
205 rdf:type schema:DefinedTerm
206 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
207 schema:name Biochemistry and Cell Biology
208 rdf:type schema:DefinedTerm
209 sg:journal.1097543 schema:issn 0950-9232
210 1476-5594
211 schema:name Oncogene
212 rdf:type schema:Periodical
213 sg:person.01052647563.22 schema:affiliation https://www.grid.ac/institutes/grid.461904.e
214 schema:familyName Monferran
215 schema:givenName Sylvie
216 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01052647563.22
217 rdf:type schema:Person
218 sg:person.01117626560.25 schema:affiliation https://www.grid.ac/institutes/grid.461904.e
219 schema:familyName Salles
220 schema:givenName Bernard
221 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01117626560.25
222 rdf:type schema:Person
223 sg:person.01150573763.54 schema:affiliation https://www.grid.ac/institutes/grid.461904.e
224 schema:familyName Calsou
225 schema:givenName Patrick
226 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01150573763.54
227 rdf:type schema:Person
228 sg:person.01330570655.94 schema:affiliation https://www.grid.ac/institutes/grid.461904.e
229 schema:familyName Muller
230 schema:givenName Catherine
231 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01330570655.94
232 rdf:type schema:Person
233 sg:pub.10.1007/978-1-59259-455-9_17 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002979114
234 https://doi.org/10.1007/978-1-59259-455-9_17
235 rdf:type schema:CreativeWork
236 sg:pub.10.1007/bf01323757 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022504412
237 https://doi.org/10.1007/bf01323757
238 rdf:type schema:CreativeWork
239 sg:pub.10.1038/sj.onc.1201402 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050217602
240 https://doi.org/10.1038/sj.onc.1201402
241 rdf:type schema:CreativeWork
242 sg:pub.10.1038/sj.onc.1201676 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007726776
243 https://doi.org/10.1038/sj.onc.1201676
244 rdf:type schema:CreativeWork
245 https://app.dimensions.ai/details/publication/pub.1077373932 schema:CreativeWork
246 https://app.dimensions.ai/details/publication/pub.1077990249 schema:CreativeWork
247 https://app.dimensions.ai/details/publication/pub.1078808704 schema:CreativeWork
248 https://app.dimensions.ai/details/publication/pub.1079439212 schema:CreativeWork
249 https://app.dimensions.ai/details/publication/pub.1079508296 schema:CreativeWork
250 https://app.dimensions.ai/details/publication/pub.1079676708 schema:CreativeWork
251 https://app.dimensions.ai/details/publication/pub.1081654129 schema:CreativeWork
252 https://app.dimensions.ai/details/publication/pub.1082400232 schema:CreativeWork
253 https://app.dimensions.ai/details/publication/pub.1082773357 schema:CreativeWork
254 https://app.dimensions.ai/details/publication/pub.1082816710 schema:CreativeWork
255 https://app.dimensions.ai/details/publication/pub.1082827747 schema:CreativeWork
256 https://app.dimensions.ai/details/publication/pub.1082955588 schema:CreativeWork
257 https://app.dimensions.ai/details/publication/pub.1083047820 schema:CreativeWork
258 https://app.dimensions.ai/details/publication/pub.1083119791 schema:CreativeWork
259 https://app.dimensions.ai/details/publication/pub.1083319614 schema:CreativeWork
260 https://doi.org/10.1002/j.1460-2075.1996.tb00688.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1082902137
261 rdf:type schema:CreativeWork
262 https://doi.org/10.1002/stem.5530130731 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037803982
263 rdf:type schema:CreativeWork
264 https://doi.org/10.1016/0006-291x(82)91448-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027248182
265 rdf:type schema:CreativeWork
266 https://doi.org/10.1016/0014-4827(88)90319-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032116130
267 rdf:type schema:CreativeWork
268 https://doi.org/10.1016/0014-5793(94)00863-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038020499
269 rdf:type schema:CreativeWork
270 https://doi.org/10.1016/0092-8674(93)90057-w schema:sameAs https://app.dimensions.ai/details/publication/pub.1047151578
271 rdf:type schema:CreativeWork
272 https://doi.org/10.1016/0092-8674(95)90447-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030354983
273 rdf:type schema:CreativeWork
274 https://doi.org/10.1016/0092-8674(95)90482-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050858444
275 rdf:type schema:CreativeWork
276 https://doi.org/10.1016/s0006-291x(05)80847-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015574104
277 rdf:type schema:CreativeWork
278 https://doi.org/10.1016/s0300-9084(99)80044-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004343398
279 rdf:type schema:CreativeWork
280 https://doi.org/10.1016/s1074-7613(00)80109-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019893544
281 rdf:type schema:CreativeWork
282 https://doi.org/10.1016/s1074-7613(00)80386-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006443258
283 rdf:type schema:CreativeWork
284 https://doi.org/10.1016/s1074-7613(00)80619-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036547123
285 rdf:type schema:CreativeWork
286 https://doi.org/10.1021/bi00366a013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055172196
287 rdf:type schema:CreativeWork
288 https://doi.org/10.1021/bi982584b schema:sameAs https://app.dimensions.ai/details/publication/pub.1004751005
289 rdf:type schema:CreativeWork
290 https://doi.org/10.1042/bj3080131 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038512519
291 rdf:type schema:CreativeWork
292 https://doi.org/10.1073/pnas.92.1.320 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049454574
293 rdf:type schema:CreativeWork
294 https://doi.org/10.1073/pnas.94.25.13588 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014375194
295 rdf:type schema:CreativeWork
296 https://doi.org/10.1073/pnas.95.2.525 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026593896
297 rdf:type schema:CreativeWork
298 https://doi.org/10.1073/pnas.97.11.5907 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033914834
299 rdf:type schema:CreativeWork
300 https://doi.org/10.1074/jbc.272.47.29919 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032612007
301 rdf:type schema:CreativeWork
302 https://doi.org/10.1074/jbc.273.2.842 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004618265
303 rdf:type schema:CreativeWork
304 https://doi.org/10.1080/0955300001004237 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024378537
305 rdf:type schema:CreativeWork
306 https://doi.org/10.1084/jem.175.6.1677 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021056467
307 rdf:type schema:CreativeWork
308 https://doi.org/10.1084/jem.182.6.1625 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032535091
309 rdf:type schema:CreativeWork
310 https://doi.org/10.1084/jem.186.6.921 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028423828
311 rdf:type schema:CreativeWork
312 https://doi.org/10.1093/emboj/16.16.5098 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022356293
313 rdf:type schema:CreativeWork
314 https://doi.org/10.1093/emboj/16.22.6874 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012206512
315 rdf:type schema:CreativeWork
316 https://doi.org/10.1093/emboj/17.2.609 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031304476
317 rdf:type schema:CreativeWork
318 https://doi.org/10.1093/nar/15.8.3493 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047465581
319 rdf:type schema:CreativeWork
320 https://doi.org/10.1101/gad.13.8.916 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020704432
321 rdf:type schema:CreativeWork
322 https://doi.org/10.1111/j.1365-2249.1990.tb08110.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1045745062
323 rdf:type schema:CreativeWork
324 https://doi.org/10.1126/science.3175673 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062596396
325 rdf:type schema:CreativeWork
326 https://doi.org/10.1128/mcb.10.12.6460 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008802581
327 rdf:type schema:CreativeWork
328 https://doi.org/10.1128/mcb.16.1.37 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046375593
329 rdf:type schema:CreativeWork
330 https://doi.org/10.1128/mcb.16.9.5186 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045665860
331 rdf:type schema:CreativeWork
332 https://doi.org/10.1128/mcb.19.5.3877 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017597749
333 rdf:type schema:CreativeWork
334 https://doi.org/10.1128/mcb.20.9.2996-3003.2000 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008873869
335 rdf:type schema:CreativeWork
336 https://doi.org/10.1182/blood.v97.7.2084 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018510508
337 rdf:type schema:CreativeWork
338 https://doi.org/10.4049/jimmunol.165.11.6347 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074730895
339 rdf:type schema:CreativeWork
340 https://www.grid.ac/institutes/grid.461904.e schema:alternateName Institute of Pharmacology and Structural Biology
341 schema:name Institut de Pharmacologie et de Biologie Structurale (CNRS, UPR 9062) 205 route de Narbonne, 31077 Toulouse cedex, France
342 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...