Regulation of Cbl phosphorylation by the Abl tyrosine kinase and the Nck SH2/SH3 adaptor View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2001-07-05

AUTHORS

Tohru Miyoshi-Akiyama, Lourdes M Aleman, Jodi M Smith, Carolyn E Adler, Bruce J Mayer

ABSTRACT

The Cbl proto-oncogene product is tyrosine phosphorylated in response to a wide variety of stimuli. Cbl and the Abl nonreceptor tyrosine kinase both bind to SH3 domains from the SH2/SH3 adaptor Nck, and are candidate effectors for Nck function. Numerous additional SH2- and SH3-domain-mediated interactions are also possible between Cbl, Abl, and Nck. We find that these three signaling proteins associate when overexpressed in mammalian cells and can regulate each other's activity. Co-expression of wt Cbl together with c-Abl, the activity of which is normally repressed in vivo, led to extensive Abl-dependent phosphorylation of Cbl. The major proline-rich region of Cbl was required for its phosphorylation by c-Abl, but not by a constitutively activated Abl mutant, suggesting Cbl activates c-Abl by engaging its SH3 domain. Efficient phosphorylation of Cbl and its stable association with Abl required the SH2 domain of Abl, suggesting that SH2-phosphotyrosine interactions prevent dissociation of active Abl from Cbl. We also show that overexpression of Nck could repress the phosphorylation of Cbl by Abl in vivo. Studies with Nck mutants suggested that the Nck SH2 domain is responsible for inhibiting the activity of Abl toward both Cbl and Nck itself, most likely by competing with the Abl SH2 for tyrosine-phosphorylated binding sites. More... »

PAGES

4058-4069

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/sj.onc.1204528

DOI

http://dx.doi.org/10.1038/sj.onc.1204528

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1039685732

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/11494134


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adaptor Proteins, Signal Transducing", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Binding Sites", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Line", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genes, abl", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Kidney", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Macromolecular Substances", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Oncogene Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Phosphorylation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein Binding", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein Processing, Post-Translational", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Proto-Oncogene Mas", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Proto-Oncogene Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Proto-Oncogene Proteins c-abl", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Proto-Oncogene Proteins c-cbl", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Recombinant Fusion Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Structure-Activity Relationship", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Transfection", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Ubiquitin-Protein Ligases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "src Homology Domains", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Microbiology and Immunology, Tokyo Women's Medical University, 8-1 Kawada-cho, Shinjuku-ku, 162, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.410818.4", 
          "name": [
            "Children's Hospital and Department of Microbiology and Molecular Genetics, Laboratory of Molecular Medicine, Harvard Medical School, 300 Longwood Avenue, 02115, Boston, Massachusetts, MA, USA", 
            "Department of Microbiology and Immunology, Tokyo Women's Medical University, 8-1 Kawada-cho, Shinjuku-ku, 162, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Miyoshi-Akiyama", 
        "givenName": "Tohru", 
        "id": "sg:person.01273120102.52", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01273120102.52"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Genetics and Developmental Biology, University of Connecticut Health Center, 263 Farmington Avenue, 06030-3301, Farmington, Connecticut, CT, USA", 
          "id": "http://www.grid.ac/institutes/grid.208078.5", 
          "name": [
            "Children's Hospital and Department of Microbiology and Molecular Genetics, Laboratory of Molecular Medicine, Harvard Medical School, 300 Longwood Avenue, 02115, Boston, Massachusetts, MA, USA", 
            "Department of Genetics and Developmental Biology, University of Connecticut Health Center, 263 Farmington Avenue, 06030-3301, Farmington, Connecticut, CT, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Aleman", 
        "givenName": "Lourdes M", 
        "id": "sg:person.01004010031.92", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01004010031.92"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Genetics and Developmental Biology, University of Connecticut Health Center, 263 Farmington Avenue, 06030-3301, Farmington, Connecticut, CT, USA", 
          "id": "http://www.grid.ac/institutes/grid.208078.5", 
          "name": [
            "Children's Hospital and Department of Microbiology and Molecular Genetics, Laboratory of Molecular Medicine, Harvard Medical School, 300 Longwood Avenue, 02115, Boston, Massachusetts, MA, USA", 
            "Department of Genetics and Developmental Biology, University of Connecticut Health Center, 263 Farmington Avenue, 06030-3301, Farmington, Connecticut, CT, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Smith", 
        "givenName": "Jodi M", 
        "id": "sg:person.01120236431.25", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01120236431.25"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Anatomy, University of California at San Francisco, 94143-0452, San Francisco, CA, USA", 
          "id": "http://www.grid.ac/institutes/grid.266102.1", 
          "name": [
            "Children's Hospital and Department of Microbiology and Molecular Genetics, Laboratory of Molecular Medicine, Harvard Medical School, 300 Longwood Avenue, 02115, Boston, Massachusetts, MA, USA", 
            "Department of Anatomy, University of California at San Francisco, 94143-0452, San Francisco, CA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Adler", 
        "givenName": "Carolyn E", 
        "id": "sg:person.0667561431.41", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0667561431.41"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Genetics and Developmental Biology, University of Connecticut Health Center, 263 Farmington Avenue, 06030-3301, Farmington, Connecticut, CT, USA", 
          "id": "http://www.grid.ac/institutes/grid.208078.5", 
          "name": [
            "Children's Hospital and Department of Microbiology and Molecular Genetics, Laboratory of Molecular Medicine, Harvard Medical School, 300 Longwood Avenue, 02115, Boston, Massachusetts, MA, USA", 
            "Department of Genetics and Developmental Biology, University of Connecticut Health Center, 263 Farmington Avenue, 06030-3301, Farmington, Connecticut, CT, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mayer", 
        "givenName": "Bruce J", 
        "id": "sg:person.01244537451.59", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01244537451.59"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/315550a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045340731", 
          "https://doi.org/10.1038/315550a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/385602a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034217411", 
          "https://doi.org/10.1038/385602a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/385650a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015845219", 
          "https://doi.org/10.1038/385650a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng0398-280", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024412271", 
          "https://doi.org/10.1038/ng0398-280"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1201708", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011515636", 
          "https://doi.org/10.1038/sj.onc.1201708"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/374477a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027028319", 
          "https://doi.org/10.1038/374477a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/385595a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032796118", 
          "https://doi.org/10.1038/385595a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/387520a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029483387", 
          "https://doi.org/10.1038/387520a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/18050", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028294143", 
          "https://doi.org/10.1038/18050"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2001-07-05", 
    "datePublishedReg": "2001-07-05", 
    "description": "The Cbl proto-oncogene product is tyrosine phosphorylated in response to a wide variety of stimuli. Cbl and the Abl nonreceptor tyrosine kinase both bind to SH3 domains from the SH2/SH3 adaptor Nck, and are candidate effectors for Nck function. Numerous additional SH2- and SH3-domain-mediated interactions are also possible between Cbl, Abl, and Nck. We find that these three signaling proteins associate when overexpressed in mammalian cells and can regulate each other's activity. Co-expression of wt Cbl together with c-Abl, the activity of which is normally repressed in vivo, led to extensive Abl-dependent phosphorylation of Cbl. The major proline-rich region of Cbl was required for its phosphorylation by c-Abl, but not by a constitutively activated Abl mutant, suggesting Cbl activates c-Abl by engaging its SH3 domain. Efficient phosphorylation of Cbl and its stable association with Abl required the SH2 domain of Abl, suggesting that SH2-phosphotyrosine interactions prevent dissociation of active Abl from Cbl. We also show that overexpression of Nck could repress the phosphorylation of Cbl by Abl in vivo. Studies with Nck mutants suggested that the Nck SH2 domain is responsible for inhibiting the activity of Abl toward both Cbl and Nck itself, most likely by competing with the Abl SH2 for tyrosine-phosphorylated binding sites.", 
    "genre": "article", 
    "id": "sg:pub.10.1038/sj.onc.1204528", 
    "isAccessibleForFree": false, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2474324", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1097543", 
        "issn": [
          "0950-9232", 
          "1476-5594"
        ], 
        "name": "Oncogene", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "30", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "20"
      }
    ], 
    "keywords": [
      "c-Abl", 
      "tyrosine kinase", 
      "Abl tyrosine kinase", 
      "proto-oncogene product", 
      "nonreceptor tyrosine kinase", 
      "ABL", 
      "vivo", 
      "phosphorylation", 
      "active Abl", 
      "Cbl phosphorylation", 
      "Cbl", 
      "phosphorylation of Cbl", 
      "activity of Abl", 
      "Abl nonreceptor tyrosine kinase", 
      "activity", 
      "kinase", 
      "Abl-dependent phosphorylation", 
      "binding sites", 
      "association", 
      "overexpression", 
      "mammalian cells", 
      "cells", 
      "stimuli", 
      "effectors", 
      "Abl SH2", 
      "response", 
      "ABL mutants", 
      "wide variety", 
      "protein", 
      "candidate effectors", 
      "study", 
      "regulation", 
      "SH3 domain-mediated interactions", 
      "SH2 domain", 
      "proline-rich region", 
      "Nck", 
      "binds", 
      "function", 
      "mutants", 
      "adaptor", 
      "sites", 
      "stable association", 
      "adaptor Nck", 
      "Cbl proto-oncogene product", 
      "SH2", 
      "variety", 
      "SH3 domain", 
      "interaction", 
      "domain", 
      "dissociation", 
      "region", 
      "efficient phosphorylation", 
      "products", 
      "SH2-phosphotyrosine interactions", 
      "overexpression of Nck"
    ], 
    "name": "Regulation of Cbl phosphorylation by the Abl tyrosine kinase and the Nck SH2/SH3 adaptor", 
    "pagination": "4058-4069", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1039685732"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/sj.onc.1204528"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "11494134"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/sj.onc.1204528", 
      "https://app.dimensions.ai/details/publication/pub.1039685732"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-10-01T06:31", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20221001/entities/gbq_results/article/article_339.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1038/sj.onc.1204528"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/sj.onc.1204528'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/sj.onc.1204528'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/sj.onc.1204528'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/sj.onc.1204528'


 

This table displays all metadata directly associated to this object as RDF triples.

275 TRIPLES      21 PREDICATES      110 URIs      92 LITERALS      27 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/sj.onc.1204528 schema:about N0abbece78c2b4e46bef406481dfd5132
2 N22e9a291d236440e9553b0de783b48d3
3 N4223cea81d774a1bba661d2c9cee2cb8
4 N468606d5e423416dab0c6dad11ebe52d
5 N6e2f5db0a45d4398aa2b247ad88255fd
6 N7e8424870788432ab66cd48cb0476578
7 N899dba52bbf549f1b4760c72a6ac5039
8 N96026e9c9ce64872821274f078fcac7d
9 Na7319b5a7154416492e96ce084d25754
10 Nac8fc9a1994646099d62e20853ea2632
11 Naca8757e20334504a4c8c1de15ec5e80
12 Nb544d6dfd2e84009b7ebb334ac7060a3
13 Nba1336aab6e0497eb94098721c6140b3
14 Nbb89d39ab0f043d6a2089edcd02ee510
15 Nbf255731c4164aec9526d445eb13ec08
16 Nbf56f9eef0cf4c69aa3f03c04bf0d9d5
17 Nc8b388114b45473cb6bab98c20432acb
18 Nd703013b9dbc4f59812ae9b64ed17990
19 Nda27353e67d24a1e839547cd98ab2814
20 Ne4be5481f5ed4af89ea830ba06be3bb0
21 anzsrc-for:11
22 anzsrc-for:1103
23 anzsrc-for:1112
24 schema:author N49326a6458c64410ac10a190f61eff36
25 schema:citation sg:pub.10.1038/18050
26 sg:pub.10.1038/315550a0
27 sg:pub.10.1038/374477a0
28 sg:pub.10.1038/385595a0
29 sg:pub.10.1038/385602a0
30 sg:pub.10.1038/385650a0
31 sg:pub.10.1038/387520a0
32 sg:pub.10.1038/ng0398-280
33 sg:pub.10.1038/sj.onc.1201708
34 schema:datePublished 2001-07-05
35 schema:datePublishedReg 2001-07-05
36 schema:description The Cbl proto-oncogene product is tyrosine phosphorylated in response to a wide variety of stimuli. Cbl and the Abl nonreceptor tyrosine kinase both bind to SH3 domains from the SH2/SH3 adaptor Nck, and are candidate effectors for Nck function. Numerous additional SH2- and SH3-domain-mediated interactions are also possible between Cbl, Abl, and Nck. We find that these three signaling proteins associate when overexpressed in mammalian cells and can regulate each other's activity. Co-expression of wt Cbl together with c-Abl, the activity of which is normally repressed in vivo, led to extensive Abl-dependent phosphorylation of Cbl. The major proline-rich region of Cbl was required for its phosphorylation by c-Abl, but not by a constitutively activated Abl mutant, suggesting Cbl activates c-Abl by engaging its SH3 domain. Efficient phosphorylation of Cbl and its stable association with Abl required the SH2 domain of Abl, suggesting that SH2-phosphotyrosine interactions prevent dissociation of active Abl from Cbl. We also show that overexpression of Nck could repress the phosphorylation of Cbl by Abl in vivo. Studies with Nck mutants suggested that the Nck SH2 domain is responsible for inhibiting the activity of Abl toward both Cbl and Nck itself, most likely by competing with the Abl SH2 for tyrosine-phosphorylated binding sites.
37 schema:genre article
38 schema:isAccessibleForFree false
39 schema:isPartOf N330e925a585b48d69299b4db44b3a7ee
40 N91643a3452b94cda92ea7233e9bc7ea6
41 sg:journal.1097543
42 schema:keywords ABL
43 ABL mutants
44 Abl SH2
45 Abl nonreceptor tyrosine kinase
46 Abl tyrosine kinase
47 Abl-dependent phosphorylation
48 Cbl
49 Cbl phosphorylation
50 Cbl proto-oncogene product
51 Nck
52 SH2
53 SH2 domain
54 SH2-phosphotyrosine interactions
55 SH3 domain
56 SH3 domain-mediated interactions
57 active Abl
58 activity
59 activity of Abl
60 adaptor
61 adaptor Nck
62 association
63 binding sites
64 binds
65 c-Abl
66 candidate effectors
67 cells
68 dissociation
69 domain
70 effectors
71 efficient phosphorylation
72 function
73 interaction
74 kinase
75 mammalian cells
76 mutants
77 nonreceptor tyrosine kinase
78 overexpression
79 overexpression of Nck
80 phosphorylation
81 phosphorylation of Cbl
82 products
83 proline-rich region
84 protein
85 proto-oncogene product
86 region
87 regulation
88 response
89 sites
90 stable association
91 stimuli
92 study
93 tyrosine kinase
94 variety
95 vivo
96 wide variety
97 schema:name Regulation of Cbl phosphorylation by the Abl tyrosine kinase and the Nck SH2/SH3 adaptor
98 schema:pagination 4058-4069
99 schema:productId N1044d132ac264346962f8b71d7f985ee
100 N7e82027569cb41f9b4d2f075978d1db6
101 Nf467b38a8cbf4b3eaa65f6cabf47b264
102 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039685732
103 https://doi.org/10.1038/sj.onc.1204528
104 schema:sdDatePublished 2022-10-01T06:31
105 schema:sdLicense https://scigraph.springernature.com/explorer/license/
106 schema:sdPublisher N0ff23830401f4b5a9f11f2b1630e2be3
107 schema:url https://doi.org/10.1038/sj.onc.1204528
108 sgo:license sg:explorer/license/
109 sgo:sdDataset articles
110 rdf:type schema:ScholarlyArticle
111 N0abbece78c2b4e46bef406481dfd5132 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
112 schema:name Proto-Oncogene Proteins
113 rdf:type schema:DefinedTerm
114 N0ff23830401f4b5a9f11f2b1630e2be3 schema:name Springer Nature - SN SciGraph project
115 rdf:type schema:Organization
116 N1044d132ac264346962f8b71d7f985ee schema:name dimensions_id
117 schema:value pub.1039685732
118 rdf:type schema:PropertyValue
119 N22e9a291d236440e9553b0de783b48d3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
120 schema:name src Homology Domains
121 rdf:type schema:DefinedTerm
122 N2e665218d6a14c4f93077b3456d55ebf rdf:first sg:person.01244537451.59
123 rdf:rest rdf:nil
124 N330e925a585b48d69299b4db44b3a7ee schema:issueNumber 30
125 rdf:type schema:PublicationIssue
126 N4223cea81d774a1bba661d2c9cee2cb8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
127 schema:name Adaptor Proteins, Signal Transducing
128 rdf:type schema:DefinedTerm
129 N468606d5e423416dab0c6dad11ebe52d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name Recombinant Fusion Proteins
131 rdf:type schema:DefinedTerm
132 N49326a6458c64410ac10a190f61eff36 rdf:first sg:person.01273120102.52
133 rdf:rest N59b27993cadb4158bf4b00d93bf8ad94
134 N59b27993cadb4158bf4b00d93bf8ad94 rdf:first sg:person.01004010031.92
135 rdf:rest N94b8893daf414c9e8d789cd7c19e22eb
136 N5b6c07174a93429b8da982ab7ddc97d9 rdf:first sg:person.0667561431.41
137 rdf:rest N2e665218d6a14c4f93077b3456d55ebf
138 N6e2f5db0a45d4398aa2b247ad88255fd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
139 schema:name Phosphorylation
140 rdf:type schema:DefinedTerm
141 N7e82027569cb41f9b4d2f075978d1db6 schema:name doi
142 schema:value 10.1038/sj.onc.1204528
143 rdf:type schema:PropertyValue
144 N7e8424870788432ab66cd48cb0476578 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name Proto-Oncogene Proteins c-abl
146 rdf:type schema:DefinedTerm
147 N899dba52bbf549f1b4760c72a6ac5039 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
148 schema:name Humans
149 rdf:type schema:DefinedTerm
150 N91643a3452b94cda92ea7233e9bc7ea6 schema:volumeNumber 20
151 rdf:type schema:PublicationVolume
152 N94b8893daf414c9e8d789cd7c19e22eb rdf:first sg:person.01120236431.25
153 rdf:rest N5b6c07174a93429b8da982ab7ddc97d9
154 N96026e9c9ce64872821274f078fcac7d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
155 schema:name Oncogene Proteins
156 rdf:type schema:DefinedTerm
157 Na7319b5a7154416492e96ce084d25754 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
158 schema:name Protein Binding
159 rdf:type schema:DefinedTerm
160 Nac8fc9a1994646099d62e20853ea2632 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
161 schema:name Proto-Oncogene Proteins c-cbl
162 rdf:type schema:DefinedTerm
163 Naca8757e20334504a4c8c1de15ec5e80 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
164 schema:name Binding Sites
165 rdf:type schema:DefinedTerm
166 Nb544d6dfd2e84009b7ebb334ac7060a3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
167 schema:name Genes, abl
168 rdf:type schema:DefinedTerm
169 Nba1336aab6e0497eb94098721c6140b3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
170 schema:name Kidney
171 rdf:type schema:DefinedTerm
172 Nbb89d39ab0f043d6a2089edcd02ee510 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
173 schema:name Proto-Oncogene Mas
174 rdf:type schema:DefinedTerm
175 Nbf255731c4164aec9526d445eb13ec08 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
176 schema:name Cell Line
177 rdf:type schema:DefinedTerm
178 Nbf56f9eef0cf4c69aa3f03c04bf0d9d5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
179 schema:name Ubiquitin-Protein Ligases
180 rdf:type schema:DefinedTerm
181 Nc8b388114b45473cb6bab98c20432acb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
182 schema:name Transfection
183 rdf:type schema:DefinedTerm
184 Nd703013b9dbc4f59812ae9b64ed17990 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
185 schema:name Macromolecular Substances
186 rdf:type schema:DefinedTerm
187 Nda27353e67d24a1e839547cd98ab2814 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
188 schema:name Protein Processing, Post-Translational
189 rdf:type schema:DefinedTerm
190 Ne4be5481f5ed4af89ea830ba06be3bb0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
191 schema:name Structure-Activity Relationship
192 rdf:type schema:DefinedTerm
193 Nf467b38a8cbf4b3eaa65f6cabf47b264 schema:name pubmed_id
194 schema:value 11494134
195 rdf:type schema:PropertyValue
196 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
197 schema:name Medical and Health Sciences
198 rdf:type schema:DefinedTerm
199 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
200 schema:name Clinical Sciences
201 rdf:type schema:DefinedTerm
202 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
203 schema:name Oncology and Carcinogenesis
204 rdf:type schema:DefinedTerm
205 sg:grant.2474324 http://pending.schema.org/fundedItem sg:pub.10.1038/sj.onc.1204528
206 rdf:type schema:MonetaryGrant
207 sg:journal.1097543 schema:issn 0950-9232
208 1476-5594
209 schema:name Oncogene
210 schema:publisher Springer Nature
211 rdf:type schema:Periodical
212 sg:person.01004010031.92 schema:affiliation grid-institutes:grid.208078.5
213 schema:familyName Aleman
214 schema:givenName Lourdes M
215 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01004010031.92
216 rdf:type schema:Person
217 sg:person.01120236431.25 schema:affiliation grid-institutes:grid.208078.5
218 schema:familyName Smith
219 schema:givenName Jodi M
220 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01120236431.25
221 rdf:type schema:Person
222 sg:person.01244537451.59 schema:affiliation grid-institutes:grid.208078.5
223 schema:familyName Mayer
224 schema:givenName Bruce J
225 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01244537451.59
226 rdf:type schema:Person
227 sg:person.01273120102.52 schema:affiliation grid-institutes:grid.410818.4
228 schema:familyName Miyoshi-Akiyama
229 schema:givenName Tohru
230 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01273120102.52
231 rdf:type schema:Person
232 sg:person.0667561431.41 schema:affiliation grid-institutes:grid.266102.1
233 schema:familyName Adler
234 schema:givenName Carolyn E
235 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0667561431.41
236 rdf:type schema:Person
237 sg:pub.10.1038/18050 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028294143
238 https://doi.org/10.1038/18050
239 rdf:type schema:CreativeWork
240 sg:pub.10.1038/315550a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045340731
241 https://doi.org/10.1038/315550a0
242 rdf:type schema:CreativeWork
243 sg:pub.10.1038/374477a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027028319
244 https://doi.org/10.1038/374477a0
245 rdf:type schema:CreativeWork
246 sg:pub.10.1038/385595a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032796118
247 https://doi.org/10.1038/385595a0
248 rdf:type schema:CreativeWork
249 sg:pub.10.1038/385602a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034217411
250 https://doi.org/10.1038/385602a0
251 rdf:type schema:CreativeWork
252 sg:pub.10.1038/385650a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015845219
253 https://doi.org/10.1038/385650a0
254 rdf:type schema:CreativeWork
255 sg:pub.10.1038/387520a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029483387
256 https://doi.org/10.1038/387520a0
257 rdf:type schema:CreativeWork
258 sg:pub.10.1038/ng0398-280 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024412271
259 https://doi.org/10.1038/ng0398-280
260 rdf:type schema:CreativeWork
261 sg:pub.10.1038/sj.onc.1201708 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011515636
262 https://doi.org/10.1038/sj.onc.1201708
263 rdf:type schema:CreativeWork
264 grid-institutes:grid.208078.5 schema:alternateName Department of Genetics and Developmental Biology, University of Connecticut Health Center, 263 Farmington Avenue, 06030-3301, Farmington, Connecticut, CT, USA
265 schema:name Children's Hospital and Department of Microbiology and Molecular Genetics, Laboratory of Molecular Medicine, Harvard Medical School, 300 Longwood Avenue, 02115, Boston, Massachusetts, MA, USA
266 Department of Genetics and Developmental Biology, University of Connecticut Health Center, 263 Farmington Avenue, 06030-3301, Farmington, Connecticut, CT, USA
267 rdf:type schema:Organization
268 grid-institutes:grid.266102.1 schema:alternateName Department of Anatomy, University of California at San Francisco, 94143-0452, San Francisco, CA, USA
269 schema:name Children's Hospital and Department of Microbiology and Molecular Genetics, Laboratory of Molecular Medicine, Harvard Medical School, 300 Longwood Avenue, 02115, Boston, Massachusetts, MA, USA
270 Department of Anatomy, University of California at San Francisco, 94143-0452, San Francisco, CA, USA
271 rdf:type schema:Organization
272 grid-institutes:grid.410818.4 schema:alternateName Department of Microbiology and Immunology, Tokyo Women's Medical University, 8-1 Kawada-cho, Shinjuku-ku, 162, Tokyo, Japan
273 schema:name Children's Hospital and Department of Microbiology and Molecular Genetics, Laboratory of Molecular Medicine, Harvard Medical School, 300 Longwood Avenue, 02115, Boston, Massachusetts, MA, USA
274 Department of Microbiology and Immunology, Tokyo Women's Medical University, 8-1 Kawada-cho, Shinjuku-ku, 162, Tokyo, Japan
275 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...