Avian erythroleukemia: a model for corepressor function in cancer View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2001-05

AUTHORS

Luc EG Rietveld, Eric Caldenhoven, Hendrik G Stunnenberg

ABSTRACT

Transcriptional regulation at the level of chromatin plays crucial roles during eukaryotic development and differentiation. A plethora of studies revealed that the acetylation status of histones is controlled by multi-protein complexes containing (de)acetylase activities. In the current model, histone deacetylases and acetyltransferases are recruited to chromatin by DNA-bound repressors and activators, respectively. Shifting the balance between deacetylation, i.e. repressive chromatin and acetylation, i.e. active chromatin can lead to aberrant gene transcription and cancer. In human acute promyelocytic leukemia (APL) and avian erythroleukemia (AEL), chromosomal translocations and/or mutations in nuclear hormone receptors, RARalpha [NR1B1] and TRalpha [NR1A1], yielded oncoproteins that deregulate transcription and alter chromatin structure. The oncogenic receptors are locked in their 'off' mode thereby constitutively repressing transcription of genes that are critical for differentiation of hematopoietic cells. AEL involves an oncogenic version of the chicken TRalpha, v-ErbA. Apart from repression by v-ErbA via recruitment of corepressor complexes, other repressors and corepressors appear to be involved in repression of v-ErbA target genes, such as carbonic anhydrase II (CAII). Reactivation of repressed genes in APL and AEL by chromatin modifying agents such as inhibitors of histone deacetylase or of methylation provides new therapeutic strategies in the treatment of acute myeloid leukemia. More... »

PAGES

1204335

References to SciGraph publications

  • 1998-07. Cloning and characterization of a family of novel mammalian DNA (cytosine-5) methyltransferases in NATURE GENETICS
  • 1999-02. Cancer-epigenetics comes of age in NATURE GENETICS
  • 1989-07. Repression of transcription mediated at a thyroid hormone response element by the v-erb-A oncogene product in NATURE
  • 1995-10. Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor in NATURE
  • 1999-01. Synergy of demethylation and histone deacetylase inhibition in the re-expression of genes silenced in cancer in NATURE GENETICS
  • 2000-02. Aberrant CpG-island methylation has non-random and tumour-type–specific patterns in NATURE GENETICS
  • 1995-10. A transcriptional co-repressor that interacts with nuclear hormone receptors in NATURE
  • 1999-11. Universal and flexible DNA microarray approach: arrayed primer extension in NATURE GENETICS
  • 1998-02. Fusion proteins of the retinoic acid receptor-α recruit histone deacetylase in promyelocytic leukaemia in NATURE
  • 1999-02. A mammalian protein with specific demethylase activity for mCpG DNA in NATURE
  • 1986-12. The c-erb-A protein is a high-affinity receptor for thyroid hormone in NATURE
  • 1999-10. Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2 in NATURE GENETICS
  • 1991-07. The antileukaemic activity of 5-Aza-2 deoxycytidine (Aza-dC) in patients with relapsed and resistant leukaemia in BRITISH JOURNAL OF CANCER
  • 1998-05. Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex in NATURE
  • 1984-02. Close similarity of epidermal growth factor receptor and v-erb-B oncogene protein sequences in NATURE
  • 2000-07. DNMT1 binds HDAC2 and a new co-repressor, DMAP1, to form a complex at replication foci in NATURE GENETICS
  • 1997-05. Role for N-CoR and histone deacetylase in Sin3-mediated transcriptional repression in NATURE
  • 1998-02. Distinct interactions of PML-RARα and PLZF-RARα with co-repressors determine differential responses to RA in APL in NATURE GENETICS
  • 1999-06. DNA methylation represses transcription in vivo in NATURE GENETICS
  • 2000. DNA methylation inhibitors in the treatment of leukemias, myelodysplastic syndromes and hemoglobinopathies: clinical results and possible mechanisms of action. in DNA METHYLATION AND CANCER
  • 2000-01. DNA methyltransferase Dnmt1 associates with histone deacetylase activity in NATURE GENETICS
  • 1995-10. Polarity-specific activities of retinoic acid receptors determined by a co-repressor in NATURE
  • 1999-10. Breaking the silence in Rett syndrome in NATURE GENETICS
  • 1989-06. Protein encoded by v-erbA functions as a thyroid-hormone receptor antagonist in NATURE
  • 1997-05. A complex containing N-CoR, mSln3 and histone deacetylase mediates transcriptional repression in NATURE
  • 1998-12. Regulation of activity of the transcription factor GATA-1 by acetylation in NATURE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/sj.onc.1204335

    DOI

    http://dx.doi.org/10.1038/sj.onc.1204335

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1045181297

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/11420726


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Genetics", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biological Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Alpharetrovirus", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Animals", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Avian Leukosis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Chickens", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Gene Expression Regulation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Leukemia, Erythroblastic, Acute", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Models, Biological", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Neoplasms", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Repressor Proteins", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Retroviridae Infections", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "name": [
                "Department of Molecular Biology, NCMLS, Geert Grooteplein Zuid 26, PO Box 9101 6500 HB Nijmegen, The Netherlands"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Rietveld", 
            "givenName": "Luc EG", 
            "id": "sg:person.01073616435.33", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01073616435.33"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Department of Molecular Biology, NCMLS, Geert Grooteplein Zuid 26, PO Box 9101 6500 HB Nijmegen, The Netherlands"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Caldenhoven", 
            "givenName": "Eric", 
            "id": "sg:person.0617135726.41", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0617135726.41"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Department of Molecular Biology, NCMLS, Geert Grooteplein Zuid 26, PO Box 9101 6500 HB Nijmegen, The Netherlands"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Stunnenberg", 
            "givenName": "Hendrik G", 
            "id": "sg:person.01122244671.11", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01122244671.11"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1038/324635a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000355348", 
              "https://doi.org/10.1038/324635a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/324635a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000355348", 
              "https://doi.org/10.1038/324635a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0092-8674(86)90320-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001336870"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0092-8674(00)80218-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001660495"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/13810", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002301472", 
              "https://doi.org/10.1038/13810"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/13810", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002301472", 
              "https://doi.org/10.1038/13810"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0092-8674(90)90532-j", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002792624"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/mcb.18.12.7176", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005099118"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0955-0674(94)90050-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005390095"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/30764", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005546919", 
              "https://doi.org/10.1038/30764"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m007864200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006018380"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.90.22.10668", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006068688"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/bjc.1991.258", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007413497", 
              "https://doi.org/10.1038/bjc.1991.258"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/bjc.1991.258", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007413497", 
              "https://doi.org/10.1038/bjc.1991.258"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0092-8674(92)90610-o", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007967038"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0145-2126(93)90045-m", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008076246"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/mcb.19.5.3383", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009519332"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.90.19.8832", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009954761"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejm199105163242002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010091774"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/14366", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010692895", 
              "https://doi.org/10.1038/14366"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/14366", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010692895", 
              "https://doi.org/10.1038/14366"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.13.15.1924", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012363514"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0092-8674(00)80214-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013064316"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/mcb.18.11.6538", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013470999"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/mcb.18.12.7185", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013882269"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/(sici)1097-4652(200007)184:1<1::aid-jcp1>3.0.co;2-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013928676"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0092-8674(90)90068-p", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015196639"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.273.46.30175", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015360799"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0092-8674(83)90130-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015578795"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.51.5.786", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016789600"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0168-9525(00)89009-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017055329"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0092-8674(00)80217-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017422643"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1043-2760(99)00215-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019536119"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/5047", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020518662", 
              "https://doi.org/10.1038/5047"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/5047", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020518662", 
              "https://doi.org/10.1038/5047"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0304-419x(96)00032-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020546309"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/mcb.20.17.6612-6625.2000", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021043908"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/9727", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022620843", 
              "https://doi.org/10.1038/9727"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/9727", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022620843", 
              "https://doi.org/10.1038/9727"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0092-8674(82)90071-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022698900"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0092-8674(92)90561-p", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022762688"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.94.17.9028", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023652203"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.96.11.5894", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023941987"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0092-8674(00)00064-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025615996"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/28.9.1921", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025975782"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1096/fj.14.10.1455", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026155560"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/mcb.11.12.6317", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026486873"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0960-9822(98)70040-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026600022"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/387043a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027015027", 
              "https://doi.org/10.1038/387043a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0092-8674(00)81531-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027085920"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.96.6.2639", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027134489"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/71750", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027287559", 
              "https://doi.org/10.1038/71750"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/71750", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027287559", 
              "https://doi.org/10.1038/71750"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/377397a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027459196", 
              "https://doi.org/10.1038/377397a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/mcb.16.10.5458", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028426394"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/emboj/17.15.4291", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029715220"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1096/fj.99-0943rev", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031020267"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/17533", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031395169", 
              "https://doi.org/10.1038/17533"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/17533", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031395169", 
              "https://doi.org/10.1038/17533"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.274.17.11713", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031514653"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0959-437x(99)80006-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031965251"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/5947", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033054502", 
              "https://doi.org/10.1038/5947"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/5947", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033054502", 
              "https://doi.org/10.1038/5947"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/emboj/19.16.4342", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033108449"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/387049a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035667550", 
              "https://doi.org/10.1038/387049a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.96.9.4868", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035789647"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/28.8.1707", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036438346"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/890", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036580135", 
              "https://doi.org/10.1038/890"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/890", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036580135", 
              "https://doi.org/10.1038/890"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0092-8674(00)80216-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037706412"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0092-8674(00)81532-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039422877"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.94.26.14400", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040310287"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/340242a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041139635", 
              "https://doi.org/10.1038/340242a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/340242a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041139635", 
              "https://doi.org/10.1038/340242a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0962-8924(99)01536-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042289700"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.96.7.3519", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042389021"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0092-8674(00)80215-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042913439"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/mcb.18.9.5500", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042917367"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35901", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043182375", 
              "https://doi.org/10.1038/35901"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35901", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043182375", 
              "https://doi.org/10.1038/35901"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.7.7b.1400", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043759986"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.97.3.1056", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044440687"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/72785", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044692091", 
              "https://doi.org/10.1038/72785"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/72785", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044692091", 
              "https://doi.org/10.1038/72785"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0092-8674(88)90535-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045451749"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/339593a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046653072", 
              "https://doi.org/10.1038/339593a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/mcb.16.1.281", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047279413"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejm199307153290307", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048208053"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/emboj/19.15.4074", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048393401"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/mcb.19.5.3496", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048479350"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.13.18.2388", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048512860"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/377454a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048833155", 
              "https://doi.org/10.1038/377454a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/13751", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048840930", 
              "https://doi.org/10.1038/13751"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/13751", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048840930", 
              "https://doi.org/10.1038/13751"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/25166", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048864458", 
              "https://doi.org/10.1038/25166"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/25166", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048864458", 
              "https://doi.org/10.1038/25166"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.5.11.2033", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049204634"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/emboj/17.24.7382", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049697183"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng0298-126", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050256315", 
              "https://doi.org/10.1038/ng0298-126"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.274.4.2440", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050552918"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/377451a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051164807", 
              "https://doi.org/10.1038/377451a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.97.13.7202", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051337746"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/77023", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052260888", 
              "https://doi.org/10.1038/77023"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/77023", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052260888", 
              "https://doi.org/10.1038/77023"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/307521a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052686262", 
              "https://doi.org/10.1038/307521a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m002810200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053040884"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/20.19.5085", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053435019"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0092-8674(92)90408-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1054549992"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/bi0001271", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055157101"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/bi0001271", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055157101"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.272.5260.408", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062552793"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.283.5400.387", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062563872"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1210/me.10.7.813", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064326684"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1210/me.7.4.528", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064329549"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1210/mend.13.7.0305", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064331850"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074488268", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074578269", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074578270", 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/978-3-642-59696-4_9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1074636819", 
              "https://doi.org/10.1007/978-3-642-59696-4_9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074639624", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/j.1460-2075.1992.tb05140.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1075768381"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/j.1460-2075.1992.tb05414.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1075823092"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/j.1460-2075.1990.tb08270.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1077948703"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1078335731", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1079494018", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/j.1460-2075.1988.tb02795.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1079703390"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082416180", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082563797", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082648635", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/j.1460-2075.1993.tb05779.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1082649725"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/j.1460-2075.1996.tb00664.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1082902113"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082940479", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082991371", 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2001-05", 
        "datePublishedReg": "2001-05-01", 
        "description": "Transcriptional regulation at the level of chromatin plays crucial roles during eukaryotic development and differentiation. A plethora of studies revealed that the acetylation status of histones is controlled by multi-protein complexes containing (de)acetylase activities. In the current model, histone deacetylases and acetyltransferases are recruited to chromatin by DNA-bound repressors and activators, respectively. Shifting the balance between deacetylation, i.e. repressive chromatin and acetylation, i.e. active chromatin can lead to aberrant gene transcription and cancer. In human acute promyelocytic leukemia (APL) and avian erythroleukemia (AEL), chromosomal translocations and/or mutations in nuclear hormone receptors, RARalpha [NR1B1] and TRalpha [NR1A1], yielded oncoproteins that deregulate transcription and alter chromatin structure. The oncogenic receptors are locked in their 'off' mode thereby constitutively repressing transcription of genes that are critical for differentiation of hematopoietic cells. AEL involves an oncogenic version of the chicken TRalpha, v-ErbA. Apart from repression by v-ErbA via recruitment of corepressor complexes, other repressors and corepressors appear to be involved in repression of v-ErbA target genes, such as carbonic anhydrase II (CAII). Reactivation of repressed genes in APL and AEL by chromatin modifying agents such as inhibitors of histone deacetylase or of methylation provides new therapeutic strategies in the treatment of acute myeloid leukemia.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1038/sj.onc.1204335", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": true, 
        "isPartOf": [
          {
            "id": "sg:journal.1097543", 
            "issn": [
              "0950-9232", 
              "1476-5594"
            ], 
            "name": "Oncogene", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "24", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "20"
          }
        ], 
        "name": "Avian erythroleukemia: a model for corepressor function in cancer", 
        "pagination": "1204335", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "d736d84595d68c4c6b2796dc8bddd9df21ef8b485b53f2c2246547ca4934ca75"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "11420726"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "8711562"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/sj.onc.1204335"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1045181297"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/sj.onc.1204335", 
          "https://app.dimensions.ai/details/publication/pub.1045181297"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-11T12:12", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000361_0000000361/records_53987_00000001.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "http://www.nature.com/articles/1204335"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/sj.onc.1204335'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/sj.onc.1204335'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/sj.onc.1204335'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/sj.onc.1204335'


     

    This table displays all metadata directly associated to this object as RDF triples.

    493 TRIPLES      21 PREDICATES      156 URIs      32 LITERALS      20 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/sj.onc.1204335 schema:about N1f8905b458ec49f3b82dbde6412b2e3d
    2 N2019127944f1430eb9a3b2445e931a73
    3 N20f4973158a447e4adb0a3bf7e2fcf5c
    4 N2b218c45aa6a46039d32aead83121f1b
    5 N2e0bec0925c342409131c87689323de3
    6 N5f25161e89e148b7bcd6f8420f2087ab
    7 N70f562d3aed04b6b85d6ee395dcea4b6
    8 N83cebb8c342f47cb88750be45432668c
    9 Nac2ad6244d21438190effd5361f5a4ca
    10 Nbd6abc6f3a0a48f7ae5c44a7413fdf34
    11 Nee4dfcc3b1a44e838c029662efa39dd3
    12 anzsrc-for:06
    13 anzsrc-for:0604
    14 schema:author N562bccb60c8a4c8fbcbc5cb293a7d9be
    15 schema:citation sg:pub.10.1007/978-3-642-59696-4_9
    16 sg:pub.10.1038/13751
    17 sg:pub.10.1038/13810
    18 sg:pub.10.1038/14366
    19 sg:pub.10.1038/17533
    20 sg:pub.10.1038/25166
    21 sg:pub.10.1038/307521a0
    22 sg:pub.10.1038/30764
    23 sg:pub.10.1038/324635a0
    24 sg:pub.10.1038/339593a0
    25 sg:pub.10.1038/340242a0
    26 sg:pub.10.1038/35901
    27 sg:pub.10.1038/377397a0
    28 sg:pub.10.1038/377451a0
    29 sg:pub.10.1038/377454a0
    30 sg:pub.10.1038/387043a0
    31 sg:pub.10.1038/387049a0
    32 sg:pub.10.1038/5047
    33 sg:pub.10.1038/5947
    34 sg:pub.10.1038/71750
    35 sg:pub.10.1038/72785
    36 sg:pub.10.1038/77023
    37 sg:pub.10.1038/890
    38 sg:pub.10.1038/9727
    39 sg:pub.10.1038/bjc.1991.258
    40 sg:pub.10.1038/ng0298-126
    41 https://app.dimensions.ai/details/publication/pub.1074488268
    42 https://app.dimensions.ai/details/publication/pub.1074578269
    43 https://app.dimensions.ai/details/publication/pub.1074578270
    44 https://app.dimensions.ai/details/publication/pub.1074639624
    45 https://app.dimensions.ai/details/publication/pub.1078335731
    46 https://app.dimensions.ai/details/publication/pub.1079494018
    47 https://app.dimensions.ai/details/publication/pub.1082416180
    48 https://app.dimensions.ai/details/publication/pub.1082563797
    49 https://app.dimensions.ai/details/publication/pub.1082648635
    50 https://app.dimensions.ai/details/publication/pub.1082940479
    51 https://app.dimensions.ai/details/publication/pub.1082991371
    52 https://doi.org/10.1002/(sici)1097-4652(200007)184:1<1::aid-jcp1>3.0.co;2-7
    53 https://doi.org/10.1002/j.1460-2075.1988.tb02795.x
    54 https://doi.org/10.1002/j.1460-2075.1990.tb08270.x
    55 https://doi.org/10.1002/j.1460-2075.1992.tb05140.x
    56 https://doi.org/10.1002/j.1460-2075.1992.tb05414.x
    57 https://doi.org/10.1002/j.1460-2075.1993.tb05779.x
    58 https://doi.org/10.1002/j.1460-2075.1996.tb00664.x
    59 https://doi.org/10.1016/0092-8674(82)90071-x
    60 https://doi.org/10.1016/0092-8674(83)90130-7
    61 https://doi.org/10.1016/0092-8674(86)90320-x
    62 https://doi.org/10.1016/0092-8674(88)90535-1
    63 https://doi.org/10.1016/0092-8674(90)90068-p
    64 https://doi.org/10.1016/0092-8674(90)90532-j
    65 https://doi.org/10.1016/0092-8674(92)90408-5
    66 https://doi.org/10.1016/0092-8674(92)90561-p
    67 https://doi.org/10.1016/0092-8674(92)90610-o
    68 https://doi.org/10.1016/0145-2126(93)90045-m
    69 https://doi.org/10.1016/0955-0674(94)90050-7
    70 https://doi.org/10.1016/s0092-8674(00)00064-7
    71 https://doi.org/10.1016/s0092-8674(00)80214-7
    72 https://doi.org/10.1016/s0092-8674(00)80215-9
    73 https://doi.org/10.1016/s0092-8674(00)80216-0
    74 https://doi.org/10.1016/s0092-8674(00)80217-2
    75 https://doi.org/10.1016/s0092-8674(00)80218-4
    76 https://doi.org/10.1016/s0092-8674(00)81531-7
    77 https://doi.org/10.1016/s0092-8674(00)81532-9
    78 https://doi.org/10.1016/s0168-9525(00)89009-5
    79 https://doi.org/10.1016/s0304-419x(96)00032-7
    80 https://doi.org/10.1016/s0959-437x(99)80006-9
    81 https://doi.org/10.1016/s0960-9822(98)70040-5
    82 https://doi.org/10.1016/s0962-8924(99)01536-6
    83 https://doi.org/10.1016/s1043-2760(99)00215-5
    84 https://doi.org/10.1021/bi0001271
    85 https://doi.org/10.1056/nejm199105163242002
    86 https://doi.org/10.1056/nejm199307153290307
    87 https://doi.org/10.1073/pnas.51.5.786
    88 https://doi.org/10.1073/pnas.90.19.8832
    89 https://doi.org/10.1073/pnas.90.22.10668
    90 https://doi.org/10.1073/pnas.94.17.9028
    91 https://doi.org/10.1073/pnas.94.26.14400
    92 https://doi.org/10.1073/pnas.96.11.5894
    93 https://doi.org/10.1073/pnas.96.6.2639
    94 https://doi.org/10.1073/pnas.96.7.3519
    95 https://doi.org/10.1073/pnas.96.9.4868
    96 https://doi.org/10.1073/pnas.97.13.7202
    97 https://doi.org/10.1073/pnas.97.3.1056
    98 https://doi.org/10.1074/jbc.273.46.30175
    99 https://doi.org/10.1074/jbc.274.17.11713
    100 https://doi.org/10.1074/jbc.274.4.2440
    101 https://doi.org/10.1074/jbc.m002810200
    102 https://doi.org/10.1074/jbc.m007864200
    103 https://doi.org/10.1093/emboj/17.15.4291
    104 https://doi.org/10.1093/emboj/17.24.7382
    105 https://doi.org/10.1093/emboj/19.15.4074
    106 https://doi.org/10.1093/emboj/19.16.4342
    107 https://doi.org/10.1093/nar/20.19.5085
    108 https://doi.org/10.1093/nar/28.8.1707
    109 https://doi.org/10.1093/nar/28.9.1921
    110 https://doi.org/10.1096/fj.14.10.1455
    111 https://doi.org/10.1096/fj.99-0943rev
    112 https://doi.org/10.1101/gad.13.15.1924
    113 https://doi.org/10.1101/gad.13.18.2388
    114 https://doi.org/10.1101/gad.5.11.2033
    115 https://doi.org/10.1101/gad.7.7b.1400
    116 https://doi.org/10.1126/science.272.5260.408
    117 https://doi.org/10.1126/science.283.5400.387
    118 https://doi.org/10.1128/mcb.11.12.6317
    119 https://doi.org/10.1128/mcb.16.1.281
    120 https://doi.org/10.1128/mcb.16.10.5458
    121 https://doi.org/10.1128/mcb.18.11.6538
    122 https://doi.org/10.1128/mcb.18.12.7176
    123 https://doi.org/10.1128/mcb.18.12.7185
    124 https://doi.org/10.1128/mcb.18.9.5500
    125 https://doi.org/10.1128/mcb.19.5.3383
    126 https://doi.org/10.1128/mcb.19.5.3496
    127 https://doi.org/10.1128/mcb.20.17.6612-6625.2000
    128 https://doi.org/10.1210/me.10.7.813
    129 https://doi.org/10.1210/me.7.4.528
    130 https://doi.org/10.1210/mend.13.7.0305
    131 schema:datePublished 2001-05
    132 schema:datePublishedReg 2001-05-01
    133 schema:description Transcriptional regulation at the level of chromatin plays crucial roles during eukaryotic development and differentiation. A plethora of studies revealed that the acetylation status of histones is controlled by multi-protein complexes containing (de)acetylase activities. In the current model, histone deacetylases and acetyltransferases are recruited to chromatin by DNA-bound repressors and activators, respectively. Shifting the balance between deacetylation, i.e. repressive chromatin and acetylation, i.e. active chromatin can lead to aberrant gene transcription and cancer. In human acute promyelocytic leukemia (APL) and avian erythroleukemia (AEL), chromosomal translocations and/or mutations in nuclear hormone receptors, RARalpha [NR1B1] and TRalpha [NR1A1], yielded oncoproteins that deregulate transcription and alter chromatin structure. The oncogenic receptors are locked in their 'off' mode thereby constitutively repressing transcription of genes that are critical for differentiation of hematopoietic cells. AEL involves an oncogenic version of the chicken TRalpha, v-ErbA. Apart from repression by v-ErbA via recruitment of corepressor complexes, other repressors and corepressors appear to be involved in repression of v-ErbA target genes, such as carbonic anhydrase II (CAII). Reactivation of repressed genes in APL and AEL by chromatin modifying agents such as inhibitors of histone deacetylase or of methylation provides new therapeutic strategies in the treatment of acute myeloid leukemia.
    134 schema:genre research_article
    135 schema:inLanguage en
    136 schema:isAccessibleForFree true
    137 schema:isPartOf N48648dba361d4a248261a29c934dbf27
    138 N9409a97aeb4444d8b4895b2dd0a0079b
    139 sg:journal.1097543
    140 schema:name Avian erythroleukemia: a model for corepressor function in cancer
    141 schema:pagination 1204335
    142 schema:productId N1eecec89986749a5a268f617fe5eba10
    143 N56d276d168e34078afd9b4ffa8f9a6f8
    144 N9e530fcbe3a5482aabf243a5583df581
    145 Nab8ce13c46454cf981a1b50db11036dc
    146 Nf7d287bb395e487487b8c27d44b8826d
    147 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045181297
    148 https://doi.org/10.1038/sj.onc.1204335
    149 schema:sdDatePublished 2019-04-11T12:12
    150 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    151 schema:sdPublisher N8c7ea09dbf0f41579f0e51c306c3e21e
    152 schema:url http://www.nature.com/articles/1204335
    153 sgo:license sg:explorer/license/
    154 sgo:sdDataset articles
    155 rdf:type schema:ScholarlyArticle
    156 N001d2da246ea4ab6aaf51a9d6bc27111 rdf:first sg:person.0617135726.41
    157 rdf:rest Na89193f541f444f391e7260df103d4e7
    158 N1eecec89986749a5a268f617fe5eba10 schema:name dimensions_id
    159 schema:value pub.1045181297
    160 rdf:type schema:PropertyValue
    161 N1f8905b458ec49f3b82dbde6412b2e3d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    162 schema:name Neoplasms
    163 rdf:type schema:DefinedTerm
    164 N2019127944f1430eb9a3b2445e931a73 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    165 schema:name Animals
    166 rdf:type schema:DefinedTerm
    167 N20f4973158a447e4adb0a3bf7e2fcf5c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    168 schema:name Gene Expression Regulation
    169 rdf:type schema:DefinedTerm
    170 N2b218c45aa6a46039d32aead83121f1b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    171 schema:name Avian Leukosis
    172 rdf:type schema:DefinedTerm
    173 N2e0bec0925c342409131c87689323de3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    174 schema:name Leukemia, Erythroblastic, Acute
    175 rdf:type schema:DefinedTerm
    176 N48648dba361d4a248261a29c934dbf27 schema:issueNumber 24
    177 rdf:type schema:PublicationIssue
    178 N562bccb60c8a4c8fbcbc5cb293a7d9be rdf:first sg:person.01073616435.33
    179 rdf:rest N001d2da246ea4ab6aaf51a9d6bc27111
    180 N56d276d168e34078afd9b4ffa8f9a6f8 schema:name nlm_unique_id
    181 schema:value 8711562
    182 rdf:type schema:PropertyValue
    183 N5f25161e89e148b7bcd6f8420f2087ab schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    184 schema:name Retroviridae Infections
    185 rdf:type schema:DefinedTerm
    186 N70f562d3aed04b6b85d6ee395dcea4b6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    187 schema:name Models, Biological
    188 rdf:type schema:DefinedTerm
    189 N83cebb8c342f47cb88750be45432668c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    190 schema:name Repressor Proteins
    191 rdf:type schema:DefinedTerm
    192 N8c7ea09dbf0f41579f0e51c306c3e21e schema:name Springer Nature - SN SciGraph project
    193 rdf:type schema:Organization
    194 N9409a97aeb4444d8b4895b2dd0a0079b schema:volumeNumber 20
    195 rdf:type schema:PublicationVolume
    196 N9a5b8db646df44c2a8ac462b0d78ae94 schema:name Department of Molecular Biology, NCMLS, Geert Grooteplein Zuid 26, PO Box 9101 6500 HB Nijmegen, The Netherlands
    197 rdf:type schema:Organization
    198 N9e530fcbe3a5482aabf243a5583df581 schema:name pubmed_id
    199 schema:value 11420726
    200 rdf:type schema:PropertyValue
    201 Na89193f541f444f391e7260df103d4e7 rdf:first sg:person.01122244671.11
    202 rdf:rest rdf:nil
    203 Nab8ce13c46454cf981a1b50db11036dc schema:name doi
    204 schema:value 10.1038/sj.onc.1204335
    205 rdf:type schema:PropertyValue
    206 Nac2ad6244d21438190effd5361f5a4ca schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    207 schema:name Humans
    208 rdf:type schema:DefinedTerm
    209 Nbd6abc6f3a0a48f7ae5c44a7413fdf34 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    210 schema:name Alpharetrovirus
    211 rdf:type schema:DefinedTerm
    212 Nd141a50ba7ce4e158e3c89a84c3e8f72 schema:name Department of Molecular Biology, NCMLS, Geert Grooteplein Zuid 26, PO Box 9101 6500 HB Nijmegen, The Netherlands
    213 rdf:type schema:Organization
    214 Nd27d81c2273144de89ff2ad8fd02e0de schema:name Department of Molecular Biology, NCMLS, Geert Grooteplein Zuid 26, PO Box 9101 6500 HB Nijmegen, The Netherlands
    215 rdf:type schema:Organization
    216 Nee4dfcc3b1a44e838c029662efa39dd3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    217 schema:name Chickens
    218 rdf:type schema:DefinedTerm
    219 Nf7d287bb395e487487b8c27d44b8826d schema:name readcube_id
    220 schema:value d736d84595d68c4c6b2796dc8bddd9df21ef8b485b53f2c2246547ca4934ca75
    221 rdf:type schema:PropertyValue
    222 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
    223 schema:name Biological Sciences
    224 rdf:type schema:DefinedTerm
    225 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
    226 schema:name Genetics
    227 rdf:type schema:DefinedTerm
    228 sg:journal.1097543 schema:issn 0950-9232
    229 1476-5594
    230 schema:name Oncogene
    231 rdf:type schema:Periodical
    232 sg:person.01073616435.33 schema:affiliation Nd141a50ba7ce4e158e3c89a84c3e8f72
    233 schema:familyName Rietveld
    234 schema:givenName Luc EG
    235 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01073616435.33
    236 rdf:type schema:Person
    237 sg:person.01122244671.11 schema:affiliation Nd27d81c2273144de89ff2ad8fd02e0de
    238 schema:familyName Stunnenberg
    239 schema:givenName Hendrik G
    240 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01122244671.11
    241 rdf:type schema:Person
    242 sg:person.0617135726.41 schema:affiliation N9a5b8db646df44c2a8ac462b0d78ae94
    243 schema:familyName Caldenhoven
    244 schema:givenName Eric
    245 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0617135726.41
    246 rdf:type schema:Person
    247 sg:pub.10.1007/978-3-642-59696-4_9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074636819
    248 https://doi.org/10.1007/978-3-642-59696-4_9
    249 rdf:type schema:CreativeWork
    250 sg:pub.10.1038/13751 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048840930
    251 https://doi.org/10.1038/13751
    252 rdf:type schema:CreativeWork
    253 sg:pub.10.1038/13810 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002301472
    254 https://doi.org/10.1038/13810
    255 rdf:type schema:CreativeWork
    256 sg:pub.10.1038/14366 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010692895
    257 https://doi.org/10.1038/14366
    258 rdf:type schema:CreativeWork
    259 sg:pub.10.1038/17533 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031395169
    260 https://doi.org/10.1038/17533
    261 rdf:type schema:CreativeWork
    262 sg:pub.10.1038/25166 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048864458
    263 https://doi.org/10.1038/25166
    264 rdf:type schema:CreativeWork
    265 sg:pub.10.1038/307521a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052686262
    266 https://doi.org/10.1038/307521a0
    267 rdf:type schema:CreativeWork
    268 sg:pub.10.1038/30764 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005546919
    269 https://doi.org/10.1038/30764
    270 rdf:type schema:CreativeWork
    271 sg:pub.10.1038/324635a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000355348
    272 https://doi.org/10.1038/324635a0
    273 rdf:type schema:CreativeWork
    274 sg:pub.10.1038/339593a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046653072
    275 https://doi.org/10.1038/339593a0
    276 rdf:type schema:CreativeWork
    277 sg:pub.10.1038/340242a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041139635
    278 https://doi.org/10.1038/340242a0
    279 rdf:type schema:CreativeWork
    280 sg:pub.10.1038/35901 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043182375
    281 https://doi.org/10.1038/35901
    282 rdf:type schema:CreativeWork
    283 sg:pub.10.1038/377397a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027459196
    284 https://doi.org/10.1038/377397a0
    285 rdf:type schema:CreativeWork
    286 sg:pub.10.1038/377451a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051164807
    287 https://doi.org/10.1038/377451a0
    288 rdf:type schema:CreativeWork
    289 sg:pub.10.1038/377454a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048833155
    290 https://doi.org/10.1038/377454a0
    291 rdf:type schema:CreativeWork
    292 sg:pub.10.1038/387043a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027015027
    293 https://doi.org/10.1038/387043a0
    294 rdf:type schema:CreativeWork
    295 sg:pub.10.1038/387049a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035667550
    296 https://doi.org/10.1038/387049a0
    297 rdf:type schema:CreativeWork
    298 sg:pub.10.1038/5047 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020518662
    299 https://doi.org/10.1038/5047
    300 rdf:type schema:CreativeWork
    301 sg:pub.10.1038/5947 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033054502
    302 https://doi.org/10.1038/5947
    303 rdf:type schema:CreativeWork
    304 sg:pub.10.1038/71750 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027287559
    305 https://doi.org/10.1038/71750
    306 rdf:type schema:CreativeWork
    307 sg:pub.10.1038/72785 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044692091
    308 https://doi.org/10.1038/72785
    309 rdf:type schema:CreativeWork
    310 sg:pub.10.1038/77023 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052260888
    311 https://doi.org/10.1038/77023
    312 rdf:type schema:CreativeWork
    313 sg:pub.10.1038/890 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036580135
    314 https://doi.org/10.1038/890
    315 rdf:type schema:CreativeWork
    316 sg:pub.10.1038/9727 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022620843
    317 https://doi.org/10.1038/9727
    318 rdf:type schema:CreativeWork
    319 sg:pub.10.1038/bjc.1991.258 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007413497
    320 https://doi.org/10.1038/bjc.1991.258
    321 rdf:type schema:CreativeWork
    322 sg:pub.10.1038/ng0298-126 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050256315
    323 https://doi.org/10.1038/ng0298-126
    324 rdf:type schema:CreativeWork
    325 https://app.dimensions.ai/details/publication/pub.1074488268 schema:CreativeWork
    326 https://app.dimensions.ai/details/publication/pub.1074578269 schema:CreativeWork
    327 https://app.dimensions.ai/details/publication/pub.1074578270 schema:CreativeWork
    328 https://app.dimensions.ai/details/publication/pub.1074639624 schema:CreativeWork
    329 https://app.dimensions.ai/details/publication/pub.1078335731 schema:CreativeWork
    330 https://app.dimensions.ai/details/publication/pub.1079494018 schema:CreativeWork
    331 https://app.dimensions.ai/details/publication/pub.1082416180 schema:CreativeWork
    332 https://app.dimensions.ai/details/publication/pub.1082563797 schema:CreativeWork
    333 https://app.dimensions.ai/details/publication/pub.1082648635 schema:CreativeWork
    334 https://app.dimensions.ai/details/publication/pub.1082940479 schema:CreativeWork
    335 https://app.dimensions.ai/details/publication/pub.1082991371 schema:CreativeWork
    336 https://doi.org/10.1002/(sici)1097-4652(200007)184:1<1::aid-jcp1>3.0.co;2-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013928676
    337 rdf:type schema:CreativeWork
    338 https://doi.org/10.1002/j.1460-2075.1988.tb02795.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1079703390
    339 rdf:type schema:CreativeWork
    340 https://doi.org/10.1002/j.1460-2075.1990.tb08270.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1077948703
    341 rdf:type schema:CreativeWork
    342 https://doi.org/10.1002/j.1460-2075.1992.tb05140.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1075768381
    343 rdf:type schema:CreativeWork
    344 https://doi.org/10.1002/j.1460-2075.1992.tb05414.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1075823092
    345 rdf:type schema:CreativeWork
    346 https://doi.org/10.1002/j.1460-2075.1993.tb05779.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1082649725
    347 rdf:type schema:CreativeWork
    348 https://doi.org/10.1002/j.1460-2075.1996.tb00664.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1082902113
    349 rdf:type schema:CreativeWork
    350 https://doi.org/10.1016/0092-8674(82)90071-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1022698900
    351 rdf:type schema:CreativeWork
    352 https://doi.org/10.1016/0092-8674(83)90130-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015578795
    353 rdf:type schema:CreativeWork
    354 https://doi.org/10.1016/0092-8674(86)90320-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1001336870
    355 rdf:type schema:CreativeWork
    356 https://doi.org/10.1016/0092-8674(88)90535-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045451749
    357 rdf:type schema:CreativeWork
    358 https://doi.org/10.1016/0092-8674(90)90068-p schema:sameAs https://app.dimensions.ai/details/publication/pub.1015196639
    359 rdf:type schema:CreativeWork
    360 https://doi.org/10.1016/0092-8674(90)90532-j schema:sameAs https://app.dimensions.ai/details/publication/pub.1002792624
    361 rdf:type schema:CreativeWork
    362 https://doi.org/10.1016/0092-8674(92)90408-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1054549992
    363 rdf:type schema:CreativeWork
    364 https://doi.org/10.1016/0092-8674(92)90561-p schema:sameAs https://app.dimensions.ai/details/publication/pub.1022762688
    365 rdf:type schema:CreativeWork
    366 https://doi.org/10.1016/0092-8674(92)90610-o schema:sameAs https://app.dimensions.ai/details/publication/pub.1007967038
    367 rdf:type schema:CreativeWork
    368 https://doi.org/10.1016/0145-2126(93)90045-m schema:sameAs https://app.dimensions.ai/details/publication/pub.1008076246
    369 rdf:type schema:CreativeWork
    370 https://doi.org/10.1016/0955-0674(94)90050-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005390095
    371 rdf:type schema:CreativeWork
    372 https://doi.org/10.1016/s0092-8674(00)00064-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025615996
    373 rdf:type schema:CreativeWork
    374 https://doi.org/10.1016/s0092-8674(00)80214-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013064316
    375 rdf:type schema:CreativeWork
    376 https://doi.org/10.1016/s0092-8674(00)80215-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042913439
    377 rdf:type schema:CreativeWork
    378 https://doi.org/10.1016/s0092-8674(00)80216-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037706412
    379 rdf:type schema:CreativeWork
    380 https://doi.org/10.1016/s0092-8674(00)80217-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017422643
    381 rdf:type schema:CreativeWork
    382 https://doi.org/10.1016/s0092-8674(00)80218-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001660495
    383 rdf:type schema:CreativeWork
    384 https://doi.org/10.1016/s0092-8674(00)81531-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027085920
    385 rdf:type schema:CreativeWork
    386 https://doi.org/10.1016/s0092-8674(00)81532-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039422877
    387 rdf:type schema:CreativeWork
    388 https://doi.org/10.1016/s0168-9525(00)89009-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017055329
    389 rdf:type schema:CreativeWork
    390 https://doi.org/10.1016/s0304-419x(96)00032-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020546309
    391 rdf:type schema:CreativeWork
    392 https://doi.org/10.1016/s0959-437x(99)80006-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031965251
    393 rdf:type schema:CreativeWork
    394 https://doi.org/10.1016/s0960-9822(98)70040-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026600022
    395 rdf:type schema:CreativeWork
    396 https://doi.org/10.1016/s0962-8924(99)01536-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042289700
    397 rdf:type schema:CreativeWork
    398 https://doi.org/10.1016/s1043-2760(99)00215-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019536119
    399 rdf:type schema:CreativeWork
    400 https://doi.org/10.1021/bi0001271 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055157101
    401 rdf:type schema:CreativeWork
    402 https://doi.org/10.1056/nejm199105163242002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010091774
    403 rdf:type schema:CreativeWork
    404 https://doi.org/10.1056/nejm199307153290307 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048208053
    405 rdf:type schema:CreativeWork
    406 https://doi.org/10.1073/pnas.51.5.786 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016789600
    407 rdf:type schema:CreativeWork
    408 https://doi.org/10.1073/pnas.90.19.8832 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009954761
    409 rdf:type schema:CreativeWork
    410 https://doi.org/10.1073/pnas.90.22.10668 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006068688
    411 rdf:type schema:CreativeWork
    412 https://doi.org/10.1073/pnas.94.17.9028 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023652203
    413 rdf:type schema:CreativeWork
    414 https://doi.org/10.1073/pnas.94.26.14400 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040310287
    415 rdf:type schema:CreativeWork
    416 https://doi.org/10.1073/pnas.96.11.5894 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023941987
    417 rdf:type schema:CreativeWork
    418 https://doi.org/10.1073/pnas.96.6.2639 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027134489
    419 rdf:type schema:CreativeWork
    420 https://doi.org/10.1073/pnas.96.7.3519 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042389021
    421 rdf:type schema:CreativeWork
    422 https://doi.org/10.1073/pnas.96.9.4868 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035789647
    423 rdf:type schema:CreativeWork
    424 https://doi.org/10.1073/pnas.97.13.7202 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051337746
    425 rdf:type schema:CreativeWork
    426 https://doi.org/10.1073/pnas.97.3.1056 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044440687
    427 rdf:type schema:CreativeWork
    428 https://doi.org/10.1074/jbc.273.46.30175 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015360799
    429 rdf:type schema:CreativeWork
    430 https://doi.org/10.1074/jbc.274.17.11713 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031514653
    431 rdf:type schema:CreativeWork
    432 https://doi.org/10.1074/jbc.274.4.2440 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050552918
    433 rdf:type schema:CreativeWork
    434 https://doi.org/10.1074/jbc.m002810200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053040884
    435 rdf:type schema:CreativeWork
    436 https://doi.org/10.1074/jbc.m007864200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006018380
    437 rdf:type schema:CreativeWork
    438 https://doi.org/10.1093/emboj/17.15.4291 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029715220
    439 rdf:type schema:CreativeWork
    440 https://doi.org/10.1093/emboj/17.24.7382 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049697183
    441 rdf:type schema:CreativeWork
    442 https://doi.org/10.1093/emboj/19.15.4074 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048393401
    443 rdf:type schema:CreativeWork
    444 https://doi.org/10.1093/emboj/19.16.4342 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033108449
    445 rdf:type schema:CreativeWork
    446 https://doi.org/10.1093/nar/20.19.5085 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053435019
    447 rdf:type schema:CreativeWork
    448 https://doi.org/10.1093/nar/28.8.1707 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036438346
    449 rdf:type schema:CreativeWork
    450 https://doi.org/10.1093/nar/28.9.1921 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025975782
    451 rdf:type schema:CreativeWork
    452 https://doi.org/10.1096/fj.14.10.1455 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026155560
    453 rdf:type schema:CreativeWork
    454 https://doi.org/10.1096/fj.99-0943rev schema:sameAs https://app.dimensions.ai/details/publication/pub.1031020267
    455 rdf:type schema:CreativeWork
    456 https://doi.org/10.1101/gad.13.15.1924 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012363514
    457 rdf:type schema:CreativeWork
    458 https://doi.org/10.1101/gad.13.18.2388 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048512860
    459 rdf:type schema:CreativeWork
    460 https://doi.org/10.1101/gad.5.11.2033 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049204634
    461 rdf:type schema:CreativeWork
    462 https://doi.org/10.1101/gad.7.7b.1400 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043759986
    463 rdf:type schema:CreativeWork
    464 https://doi.org/10.1126/science.272.5260.408 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062552793
    465 rdf:type schema:CreativeWork
    466 https://doi.org/10.1126/science.283.5400.387 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062563872
    467 rdf:type schema:CreativeWork
    468 https://doi.org/10.1128/mcb.11.12.6317 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026486873
    469 rdf:type schema:CreativeWork
    470 https://doi.org/10.1128/mcb.16.1.281 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047279413
    471 rdf:type schema:CreativeWork
    472 https://doi.org/10.1128/mcb.16.10.5458 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028426394
    473 rdf:type schema:CreativeWork
    474 https://doi.org/10.1128/mcb.18.11.6538 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013470999
    475 rdf:type schema:CreativeWork
    476 https://doi.org/10.1128/mcb.18.12.7176 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005099118
    477 rdf:type schema:CreativeWork
    478 https://doi.org/10.1128/mcb.18.12.7185 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013882269
    479 rdf:type schema:CreativeWork
    480 https://doi.org/10.1128/mcb.18.9.5500 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042917367
    481 rdf:type schema:CreativeWork
    482 https://doi.org/10.1128/mcb.19.5.3383 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009519332
    483 rdf:type schema:CreativeWork
    484 https://doi.org/10.1128/mcb.19.5.3496 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048479350
    485 rdf:type schema:CreativeWork
    486 https://doi.org/10.1128/mcb.20.17.6612-6625.2000 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021043908
    487 rdf:type schema:CreativeWork
    488 https://doi.org/10.1210/me.10.7.813 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064326684
    489 rdf:type schema:CreativeWork
    490 https://doi.org/10.1210/me.7.4.528 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064329549
    491 rdf:type schema:CreativeWork
    492 https://doi.org/10.1210/mend.13.7.0305 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064331850
    493 rdf:type schema:CreativeWork
     




    Preview window. Press ESC to close (or click here)


    ...