Searching for microsatellite mutations in coding regions in lung, breast, ovarian and colorectal cancers View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2001-02-22

AUTHORS

Eva Forgacs, Jonathan D Wren, Craig Kamibayashi, Masashi Kondo, Xie L Xu, Sanford Markowitz, Gail E Tomlinson, Carolyn Y Muller, Adi F Gazdar, Harold R Garner, John D Minna

ABSTRACT

RepX represents a new informatics approach to probe the UniGene database for potentially polymorphic repeat sequences in the open reading frame (ORF) of genes, 56% of which were found to be actually polymorphic. We now have performed mutational analysis of 17 such sites in genes not found to be polymorphic (<0.03 frequency) in a large panel of human cancer genomic DNAs derived from 31 lung, 21 breast, seven ovarian, 21 (13 microsatellite instability (MSI)+ and eight MSI−) colorectal cancer cell lines. In the lung, breast and ovarian tumor DNAs we found no mutations (<0.03–0.04 rate of tumor associated open reading frame mutations) in these sequences. By contrast, 18 MSI+ colorectal cancers (13 cancer cell lines and five primary tumors) with mismatch repair defects exhibited six mutations in three of the 17 genes (SREBP-2, TAN-1, GR6) (P<0.000003 compared to all other cancers tested). We conclude that coding region microsatellite alterations are rare in lung, breast, ovarian carcinomas and MSI (−) colorectal cancers, but are relatively frequent in MSI (+) colorectal cancers with mismatch repair deficits. More... »

PAGES

1005-1009

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/sj.onc.1204211

DOI

http://dx.doi.org/10.1038/sj.onc.1204211

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1014742578

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/11314036


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