JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Apoptosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Blotting, Northern", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Caspase 8", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Caspase 9", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Caspase Inhibitors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Caspases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cysteine Proteinase Inhibitors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cytochrome c Group", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA Fragmentation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Flow Cytometry", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Herpes Simplex Virus Protein Vmw65", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "In Situ Nick-End Labeling", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Intracellular Signaling Peptides and Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mitochondria", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mutation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Oligopeptides", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Poly(ADP-ribose) Polymerases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Proto-Oncogene Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Proto-Oncogene Proteins c-bcl-2", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Reactive Oxygen Species", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Recombinant Fusion Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Sarcoma, Ewing", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Transcriptional Activation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tumor Cells, Cultured", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tumor Suppressor Protein p53", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "bcl-2-Associated X Protein", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Children's Cancer Research Institute, St. Anna Kinderspital, Vienna, Austria", 
          "id": "http://www.grid.ac/institutes/grid.416346.2", 
          "name": [
            "Children's Cancer Research Institute, St. Anna Kinderspital, Vienna, Austria"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kovar", 
        "givenName": "H", 
        "id": "sg:person.0741362200.35", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0741362200.35"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Children's Cancer Research Institute, St. Anna Kinderspital, Vienna, Austria", 
          "id": "http://www.grid.ac/institutes/grid.416346.2", 
          "name": [
            "Children's Cancer Research Institute, St. Anna Kinderspital, Vienna, Austria"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jug", 
        "givenName": "G", 
        "id": "sg:person.01004112075.20", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01004112075.20"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Children's Cancer Research Institute, St. Anna Kinderspital, Vienna, Austria", 
          "id": "http://www.grid.ac/institutes/grid.416346.2", 
          "name": [
            "Children's Cancer Research Institute, St. Anna Kinderspital, Vienna, Austria"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Printz", 
        "givenName": "D", 
        "id": "sg:person.01164336746.44", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01164336746.44"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Children's Cancer Research Institute, St. Anna Kinderspital, Vienna, Austria", 
          "id": "http://www.grid.ac/institutes/grid.416346.2", 
          "name": [
            "Children's Cancer Research Institute, St. Anna Kinderspital, Vienna, Austria"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bartl", 
        "givenName": "S", 
        "id": "sg:person.01266101453.75", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01266101453.75"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute of Cancer Research, University of Vienna, A-1090, Vienna, Austria", 
          "id": "http://www.grid.ac/institutes/grid.10420.37", 
          "name": [
            "Institute of Cancer Research, University of Vienna, A-1090, Vienna, Austria"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Schmid", 
        "givenName": "G", 
        "id": "sg:person.01026526161.48", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01026526161.48"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute of Cancer Research, University of Vienna, A-1090, Vienna, Austria", 
          "id": "http://www.grid.ac/institutes/grid.10420.37", 
          "name": [
            "Institute of Cancer Research, University of Vienna, A-1090, Vienna, Austria"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wesierska-Gadek", 
        "givenName": "J", 
        "id": "sg:person.01157067663.11", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01157067663.11"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/sj.onc.1202533", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028529752", 
          "https://doi.org/10.1038/sj.onc.1202533"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/370220a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001574750", 
          "https://doi.org/10.1038/370220a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1201454", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036240154", 
          "https://doi.org/10.1038/sj.onc.1201454"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1202656", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011044542", 
          "https://doi.org/10.1038/sj.onc.1202656"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1202310", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010614186", 
          "https://doi.org/10.1038/sj.onc.1202310"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1202292", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046143552", 
          "https://doi.org/10.1038/sj.onc.1202292"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng1097-141", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040087526", 
          "https://doi.org/10.1038/ng1097-141"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35008667", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012881410", 
          "https://doi.org/10.1038/35008667"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.cdd.4400419", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016655503", 
          "https://doi.org/10.1038/sj.cdd.4400419"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/38525", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023661637", 
          "https://doi.org/10.1038/38525"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/20959", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031691936", 
          "https://doi.org/10.1038/20959"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/377646a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046371025", 
          "https://doi.org/10.1038/377646a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1203489", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045600742", 
          "https://doi.org/10.1038/sj.onc.1203489"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2000-08-24", 
    "datePublishedReg": "2000-08-24", 
    "description": "To dissect the p53-dependent apoptotic pathway, events following induction of temperature sensitive (ts) p53val138 were studied in a Ewing tumor cell line. Transcriptional deregulation of p53 targets first observable after 1\u2009h at 32\u00b0C preceded activation of caspases and the break-down of mitochondrial respiratory activity. Activation of caspases was first observed 4\u2009h after p53 induction. Using peptide inhibitors we identified activation of caspase 8 upstream of caspases-9 and -3. Although the caspase 8 specific inhibitor z-IETD.fmk did not affect translocation of BAX to the mitochondrial membrane and cytochrome C release it almost completely blocked cleavage of the prototype caspase substrate PARP and DNA fragmentation while enforcing mitochondrial depolarization and production of reactive oxygene species (ROS). Activation of caspase 8 did not involve death-domain receptor signaling. Expression of BCL2 only partially suppressed caspase activation but blocked apoptosis. Replacement of the N-terminus of p53val138 by the related VP16 transactivation domain created a ts p53 with a tanscriptional activity indistinguishable from p53val138 until the time of caspase activation. However, the VP16\u2013p53 fusion failed to trigger caspases and subsequent induction of the ROS producing gene pig3 paralleled by complete loss of apoptotic activity. These results indicate that p53-dependent transcriptional deregulation, triggering of the caspase cascade and the mitochondrial break-down occur in a timely ordered sequence coordinated by the genuine p53 amino terminus and suggest caspase 8 and PIG3 as key regulatory elements in this process.", 
    "genre": "article", 
    "id": "sg:pub.10.1038/sj.onc.1203780", 
    "isAccessibleForFree": false, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.6189318", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1097543", 
        "issn": [
          "0950-9232", 
          "1476-5594"
        ], 
        "name": "Oncogene", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "36", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "19"
      }
    ], 
    "keywords": [
      "reactive oxygene species", 
      "activation of caspases", 
      "caspase-8", 
      "transcriptional deregulation", 
      "caspase activation", 
      "VP16 transactivation domain", 
      "translocation of Bax", 
      "p53-dependent apoptotic pathway", 
      "cytochrome c release", 
      "key regulatory elements", 
      "caspase substrate PARP", 
      "p53-induced apoptosis", 
      "distinct consecutive phases", 
      "rate-limiting role", 
      "mitochondrial respiratory activity", 
      "transactivation domain", 
      "Z-IETD", 
      "regulatory elements", 
      "mitochondrial membrane", 
      "caspase cascade", 
      "c release", 
      "amino terminus", 
      "p53 targets", 
      "substrate PARP", 
      "N-terminus", 
      "apoptotic pathway", 
      "mitochondrial depolarization", 
      "caspase-9", 
      "p53 induction", 
      "DNA fragmentation", 
      "receptor signaling", 
      "expression of Bcl2", 
      "caspases", 
      "tumor cell lines", 
      "apoptotic activity", 
      "peptide inhibitor", 
      "ts p53", 
      "cell lines", 
      "complete loss", 
      "subsequent induction", 
      "respiratory activity", 
      "apoptosis", 
      "activation", 
      "deregulation", 
      "induction", 
      "tumor cells", 
      "fmk", 
      "genes", 
      "terminus", 
      "signaling", 
      "species", 
      "translocation", 
      "PARP", 
      "Bax", 
      "upstream", 
      "pathway", 
      "activity", 
      "p53", 
      "cascade", 
      "BCL2", 
      "sequence", 
      "expression", 
      "membrane", 
      "cleavage", 
      "cells", 
      "inhibitors", 
      "fragmentation", 
      "domain", 
      "target", 
      "fusion", 
      "breaks", 
      "role", 
      "production", 
      "lines", 
      "characterization", 
      "depolarization", 
      "release", 
      "occurs", 
      "consecutive phases", 
      "loss", 
      "events", 
      "elements", 
      "process", 
      "replacement", 
      "results", 
      "time", 
      "phase"
    ], 
    "name": "Characterization of distinct consecutive phases in non-genotoxic p53-induced apoptosis of Ewing tumor cells and the rate-limiting role of caspase 8", 
    "pagination": "4096-4107", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1028224318"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/sj.onc.1203780"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "10962570"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/sj.onc.1203780", 
      "https://app.dimensions.ai/details/publication/pub.1028224318"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-10-01T06:30", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20221001/entities/gbq_results/article/article_319.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1038/sj.onc.1203780"
  }
]

Download the RDF metadata as:  json-ld nt turtle xml License info

This table displays all metadata directly associated to this object as RDF triples.

356 TRIPLES      21 PREDICATES      154 URIs      132 LITERALS      35 BLANK NODES