The conserved PI3′K/PTEN/Akt signaling pathway regulates both cell size and survival in Drosophila View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2000-08-17

AUTHORS

Sam E Scanga, Laurent Ruel, Richard C Binari, Brian Snow, Vuk Stambolic, Denis Bouchard, Malte Peters, Batista Calvieri, Tak W Mak, James R Woodgett, Armen S Manoukian

ABSTRACT

Akt (or PKB) is an oncogene involved in the regulation of cell survival. Akt is regulated by phosphatidylinositol 3-OH kinase (PI3′K) signaling and has shown to be hyperactivated through the loss of the PTEN tumor suppressor. In Drosophila, insulin signaling as studied using the Drosophila IRS-4 homolog (Chico) has been shown to be a crucial regulator of cell size. We have studied Drosophila Akt (Dakt1) and have shown that it is also involved in the regulation of cell size. Furthermore we have performed genetic epistasis tests to demonstrate that in Drosophila, PI3′K, PTEN and Akt comprise a signaling cassette that is utilized during multiple stages of development. In addition, we show that this signaling cassette is also involved in the regulation of cell survival during embryogenesis. This study therefore establishes the evolutionary conservation of this signaling pathway in Drosophila. More... »

PAGES

3971-3977

Journal

TITLE

Oncogene

ISSUE

35

VOLUME

19

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/sj.onc.1203739

DOI

http://dx.doi.org/10.1038/sj.onc.1203739

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1007194299

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/10962553


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Size", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Survival", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Drosophila Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Drosophila melanogaster", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Epistasis, Genetic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Eye", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genes, Insect", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Insect Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Insulin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "PTEN Phosphohydrolase", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Phosphatidylinositol 3-Kinases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Phosphoproteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Phosphoric Monoester Hydrolases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein Serine-Threonine Kinases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Proto-Oncogene Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Proto-Oncogene Proteins c-akt", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Signal Transduction", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Transfection", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tumor Suppressor Proteins", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Medical Biophysics, Division of Cell and Molecular Biology, Ontario Cancer Institute, University Health Network, Princess Margaret Hospital, University of Toronto, 610 University Avenue, M5G 2M9, Toronto, Ontario, Canada", 
          "id": "http://www.grid.ac/institutes/grid.17063.33", 
          "name": [
            "Department of Medical Biophysics, Division of Cell and Molecular Biology, Ontario Cancer Institute, University Health Network, Princess Margaret Hospital, University of Toronto, 610 University Avenue, M5G 2M9, Toronto, Ontario, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Scanga", 
        "givenName": "Sam E", 
        "id": "sg:person.0645163250.43", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0645163250.43"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Medical Biophysics, Division of Experimental Therapeutics, Ontario Cancer Institute, University Health Network, Princess Margaret Hospital, University of Toronto, 610 University Avenue, M5G 2M9, Toronto, Ontario, Canada", 
          "id": "http://www.grid.ac/institutes/grid.17063.33", 
          "name": [
            "Department of Medical Biophysics, Division of Experimental Therapeutics, Ontario Cancer Institute, University Health Network, Princess Margaret Hospital, University of Toronto, 610 University Avenue, M5G 2M9, Toronto, Ontario, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ruel", 
        "givenName": "Laurent", 
        "id": "sg:person.01114052246.50", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01114052246.50"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Medical Biophysics, Division of Cell and Molecular Biology, Ontario Cancer Institute, University Health Network, Princess Margaret Hospital, University of Toronto, 610 University Avenue, M5G 2M9, Toronto, Ontario, Canada", 
          "id": "http://www.grid.ac/institutes/grid.17063.33", 
          "name": [
            "Department of Medical Biophysics, Division of Cell and Molecular Biology, Ontario Cancer Institute, University Health Network, Princess Margaret Hospital, University of Toronto, 610 University Avenue, M5G 2M9, Toronto, Ontario, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Binari", 
        "givenName": "Richard C", 
        "id": "sg:person.01274344476.59", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01274344476.59"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Amgen Research Institute, 620 University Avenue, M5G 2C1, Toronto, Ontario, Canada", 
          "id": "http://www.grid.ac/institutes/grid.417979.5", 
          "name": [
            "Amgen Research Institute, 620 University Avenue, M5G 2C1, Toronto, Ontario, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Snow", 
        "givenName": "Brian", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Amgen Research Institute, 620 University Avenue, M5G 2C1, Toronto, Ontario, Canada", 
          "id": "http://www.grid.ac/institutes/grid.417979.5", 
          "name": [
            "Amgen Research Institute, 620 University Avenue, M5G 2C1, Toronto, Ontario, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Stambolic", 
        "givenName": "Vuk", 
        "id": "sg:person.0614146413.18", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0614146413.18"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Amgen Research Institute, 620 University Avenue, M5G 2C1, Toronto, Ontario, Canada", 
          "id": "http://www.grid.ac/institutes/grid.417979.5", 
          "name": [
            "Amgen Research Institute, 620 University Avenue, M5G 2C1, Toronto, Ontario, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bouchard", 
        "givenName": "Denis", 
        "id": "sg:person.01324346023.96", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01324346023.96"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Amgen Research Institute, 620 University Avenue, M5G 2C1, Toronto, Ontario, Canada", 
          "id": "http://www.grid.ac/institutes/grid.417979.5", 
          "name": [
            "Amgen Research Institute, 620 University Avenue, M5G 2C1, Toronto, Ontario, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Peters", 
        "givenName": "Malte", 
        "id": "sg:person.0661466206.52", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0661466206.52"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Electron Microscopy Unit, Medical Sciences Building, Faculty of Medicine, University of Toronto, 8 Taddle Creek Road, M5S 1A8, Toronto, Ontario, Canada", 
          "id": "http://www.grid.ac/institutes/grid.17063.33", 
          "name": [
            "Electron Microscopy Unit, Medical Sciences Building, Faculty of Medicine, University of Toronto, 8 Taddle Creek Road, M5S 1A8, Toronto, Ontario, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Calvieri", 
        "givenName": "Batista", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Amgen Research Institute, 620 University Avenue, M5G 2C1, Toronto, Ontario, Canada", 
          "id": "http://www.grid.ac/institutes/grid.417979.5", 
          "name": [
            "Amgen Research Institute, 620 University Avenue, M5G 2C1, Toronto, Ontario, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mak", 
        "givenName": "Tak W", 
        "id": "sg:person.014440054532.58", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014440054532.58"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Medical Biophysics, Division of Experimental Therapeutics, Ontario Cancer Institute, University Health Network, Princess Margaret Hospital, University of Toronto, 610 University Avenue, M5G 2M9, Toronto, Ontario, Canada", 
          "id": "http://www.grid.ac/institutes/grid.17063.33", 
          "name": [
            "Department of Medical Biophysics, Division of Experimental Therapeutics, Ontario Cancer Institute, University Health Network, Princess Margaret Hospital, University of Toronto, 610 University Avenue, M5G 2M9, Toronto, Ontario, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Woodgett", 
        "givenName": "James R", 
        "id": "sg:person.0731233037.88", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0731233037.88"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Medical Biophysics, Division of Cell and Molecular Biology, Ontario Cancer Institute, University Health Network, Princess Margaret Hospital, University of Toronto, 610 University Avenue, M5G 2M9, Toronto, Ontario, Canada", 
          "id": "http://www.grid.ac/institutes/grid.17063.33", 
          "name": [
            "Department of Medical Biophysics, Division of Cell and Molecular Biology, Ontario Cancer Institute, University Health Network, Princess Margaret Hospital, University of Toronto, 610 University Avenue, M5G 2M9, Toronto, Ontario, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Manoukian", 
        "givenName": "Armen S", 
        "id": "sg:person.01270401450.92", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01270401450.92"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/70293", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008487521", 
          "https://doi.org/10.1038/70293"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/12961", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045874074", 
          "https://doi.org/10.1038/12961"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/376599a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019263292", 
          "https://doi.org/10.1038/376599a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/385544a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031372205", 
          "https://doi.org/10.1038/385544a0"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2000-08-17", 
    "datePublishedReg": "2000-08-17", 
    "description": "Akt (or PKB) is an oncogene involved in the regulation of cell survival. Akt is regulated by phosphatidylinositol 3-OH kinase (PI3\u2032K) signaling and has shown to be hyperactivated through the loss of the PTEN tumor suppressor. In Drosophila, insulin signaling as studied using the Drosophila IRS-4 homolog (Chico) has been shown to be a crucial regulator of cell size. We have studied Drosophila Akt (Dakt1) and have shown that it is also involved in the regulation of cell size. Furthermore we have performed genetic epistasis tests to demonstrate that in Drosophila, PI3\u2032K, PTEN and Akt comprise a signaling cassette that is utilized during multiple stages of development. In addition, we show that this signaling cassette is also involved in the regulation of cell survival during embryogenesis. This study therefore establishes the evolutionary conservation of this signaling pathway in Drosophila.", 
    "genre": "article", 
    "id": "sg:pub.10.1038/sj.onc.1203739", 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1097543", 
        "issn": [
          "0950-9232", 
          "1476-5594"
        ], 
        "name": "Oncogene", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "35", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "19"
      }
    ], 
    "keywords": [
      "genetic epistasis tests", 
      "cell survival", 
      "PTEN tumor suppressor", 
      "cell size", 
      "PTEN/AKT", 
      "evolutionary conservation", 
      "epistasis tests", 
      "Drosophila Akt", 
      "Drosophila", 
      "crucial regulator", 
      "tumor suppressor", 
      "Akt", 
      "regulation", 
      "cassette", 
      "pathway", 
      "homolog", 
      "embryogenesis", 
      "multiple stages", 
      "phosphatidylinositol", 
      "kinase", 
      "suppressor", 
      "oncogene", 
      "regulator", 
      "PTEN", 
      "conservation", 
      "survival", 
      "size", 
      "insulin", 
      "stage", 
      "loss", 
      "development", 
      "addition", 
      "study", 
      "test"
    ], 
    "name": "The conserved PI3\u2032K/PTEN/Akt signaling pathway regulates both cell size and survival in Drosophila", 
    "pagination": "3971-3977", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1007194299"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/sj.onc.1203739"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "10962553"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/sj.onc.1203739", 
      "https://app.dimensions.ai/details/publication/pub.1007194299"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-10-01T06:31", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20221001/entities/gbq_results/article/article_339.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1038/sj.onc.1203739"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/sj.onc.1203739'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/sj.onc.1203739'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/sj.onc.1203739'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/sj.onc.1203739'


 

This table displays all metadata directly associated to this object as RDF triples.

278 TRIPLES      21 PREDICATES      86 URIs      73 LITERALS      29 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/sj.onc.1203739 schema:about N04139b9aaaf6403680e46547184a6ed5
2 N0b7195c097f04e0f823602f8a701ebb8
3 N2087fb8299ff456cb2d834985bafb8b6
4 N21c0861dbeb447e2b13c966f67458291
5 N2debb8dc02b744ebabb969c870a1328d
6 N502f5c3df24d4cbd842fc26e1bdbdf92
7 N50ffa4762d0645a683cb9ace00da8620
8 N5285412a480f4033b8644fdbc3df84fd
9 N5eb5d93b35b740d49d49ab2c62ce48b2
10 N66531223d6344e0daaa2dc035aca9537
11 N66fd1c3b00c94d688b7515688fedce1f
12 N6f5b8255ff6744b6a15321cec6ad7c0d
13 N70b800ca0a18417ea3b2364875bc9e0f
14 N84af1d2133d74147b0b001717c998176
15 N871dab86e77a470ca608c9e5bc773a54
16 N95128cf604f648238200599a8ece44b1
17 N9730d03ab8e14c46bab31fe60066b6c3
18 Na67a6ff4576942acb71c5189866d4287
19 Nba6993d0e40b4f83bf7d4b5c2a66e55c
20 Nc0d0bee7a3d241bbbd3e3490535a4611
21 Nf1c9e1392a004484b5604338e8eadd77
22 Nff44749e535847c19015bea2d245e349
23 anzsrc-for:11
24 anzsrc-for:1103
25 anzsrc-for:1112
26 schema:author Na0dc84574cf3438db9fba5319a07a86f
27 schema:citation sg:pub.10.1038/12961
28 sg:pub.10.1038/376599a0
29 sg:pub.10.1038/385544a0
30 sg:pub.10.1038/70293
31 schema:datePublished 2000-08-17
32 schema:datePublishedReg 2000-08-17
33 schema:description Akt (or PKB) is an oncogene involved in the regulation of cell survival. Akt is regulated by phosphatidylinositol 3-OH kinase (PI3′K) signaling and has shown to be hyperactivated through the loss of the PTEN tumor suppressor. In Drosophila, insulin signaling as studied using the Drosophila IRS-4 homolog (Chico) has been shown to be a crucial regulator of cell size. We have studied Drosophila Akt (Dakt1) and have shown that it is also involved in the regulation of cell size. Furthermore we have performed genetic epistasis tests to demonstrate that in Drosophila, PI3′K, PTEN and Akt comprise a signaling cassette that is utilized during multiple stages of development. In addition, we show that this signaling cassette is also involved in the regulation of cell survival during embryogenesis. This study therefore establishes the evolutionary conservation of this signaling pathway in Drosophila.
34 schema:genre article
35 schema:isAccessibleForFree false
36 schema:isPartOf N35ca821a340049638e014243f4c02e28
37 Nd8ab2e126775469abec5d195755c080c
38 sg:journal.1097543
39 schema:keywords Akt
40 Drosophila
41 Drosophila Akt
42 PTEN
43 PTEN tumor suppressor
44 PTEN/AKT
45 addition
46 cassette
47 cell size
48 cell survival
49 conservation
50 crucial regulator
51 development
52 embryogenesis
53 epistasis tests
54 evolutionary conservation
55 genetic epistasis tests
56 homolog
57 insulin
58 kinase
59 loss
60 multiple stages
61 oncogene
62 pathway
63 phosphatidylinositol
64 regulation
65 regulator
66 size
67 stage
68 study
69 suppressor
70 survival
71 test
72 tumor suppressor
73 schema:name The conserved PI3′K/PTEN/Akt signaling pathway regulates both cell size and survival in Drosophila
74 schema:pagination 3971-3977
75 schema:productId N9c8cd031ef2d4b57ba9912255a4e30df
76 Nd133994b5525487f904cbecd11d86d09
77 Nde89802415f94d86afbeeb4a9b8bbe56
78 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007194299
79 https://doi.org/10.1038/sj.onc.1203739
80 schema:sdDatePublished 2022-10-01T06:31
81 schema:sdLicense https://scigraph.springernature.com/explorer/license/
82 schema:sdPublisher Nf387aa91a244430197d3868f60f67400
83 schema:url https://doi.org/10.1038/sj.onc.1203739
84 sgo:license sg:explorer/license/
85 sgo:sdDataset articles
86 rdf:type schema:ScholarlyArticle
87 N04139b9aaaf6403680e46547184a6ed5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
88 schema:name Transfection
89 rdf:type schema:DefinedTerm
90 N0b7195c097f04e0f823602f8a701ebb8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
91 schema:name Proto-Oncogene Proteins c-akt
92 rdf:type schema:DefinedTerm
93 N182c5b5c1965431491226a9e3776fa35 rdf:first sg:person.01274344476.59
94 rdf:rest N9173bec07cda4688839fb47b2cc9da97
95 N2087fb8299ff456cb2d834985bafb8b6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
96 schema:name Phosphatidylinositol 3-Kinases
97 rdf:type schema:DefinedTerm
98 N21c0861dbeb447e2b13c966f67458291 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
99 schema:name Phosphoric Monoester Hydrolases
100 rdf:type schema:DefinedTerm
101 N2b3cb471cee14076b072aa49d7b97503 rdf:first sg:person.01324346023.96
102 rdf:rest Nde14addc9a2c446a86a949c43c803951
103 N2debb8dc02b744ebabb969c870a1328d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
104 schema:name Insulin
105 rdf:type schema:DefinedTerm
106 N35ca821a340049638e014243f4c02e28 schema:issueNumber 35
107 rdf:type schema:PublicationIssue
108 N3d0684112e4441b5b5671351f570d934 rdf:first N587cc6237a8b43bd8f3962cfb53cbcb2
109 rdf:rest N8f52f1631fab43ae91eff4bd4611da4c
110 N4a5300fb758348e2bb9f39b3d3fe0bfa rdf:first sg:person.01114052246.50
111 rdf:rest N182c5b5c1965431491226a9e3776fa35
112 N502f5c3df24d4cbd842fc26e1bdbdf92 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
113 schema:name Phosphoproteins
114 rdf:type schema:DefinedTerm
115 N50ffa4762d0645a683cb9ace00da8620 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
116 schema:name Animals
117 rdf:type schema:DefinedTerm
118 N5285412a480f4033b8644fdbc3df84fd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
119 schema:name PTEN Phosphohydrolase
120 rdf:type schema:DefinedTerm
121 N587cc6237a8b43bd8f3962cfb53cbcb2 schema:affiliation grid-institutes:grid.17063.33
122 schema:familyName Calvieri
123 schema:givenName Batista
124 rdf:type schema:Person
125 N5eb5d93b35b740d49d49ab2c62ce48b2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
126 schema:name Epistasis, Genetic
127 rdf:type schema:DefinedTerm
128 N63f4732130ca4010b405c7d79c77875e rdf:first sg:person.01270401450.92
129 rdf:rest rdf:nil
130 N66531223d6344e0daaa2dc035aca9537 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
131 schema:name Genes, Insect
132 rdf:type schema:DefinedTerm
133 N66fd1c3b00c94d688b7515688fedce1f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
134 schema:name Signal Transduction
135 rdf:type schema:DefinedTerm
136 N6f5b8255ff6744b6a15321cec6ad7c0d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
137 schema:name Male
138 rdf:type schema:DefinedTerm
139 N70b800ca0a18417ea3b2364875bc9e0f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
140 schema:name Insect Proteins
141 rdf:type schema:DefinedTerm
142 N84af1d2133d74147b0b001717c998176 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
143 schema:name Protein Serine-Threonine Kinases
144 rdf:type schema:DefinedTerm
145 N871dab86e77a470ca608c9e5bc773a54 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
146 schema:name Tumor Suppressor Proteins
147 rdf:type schema:DefinedTerm
148 N8f52f1631fab43ae91eff4bd4611da4c rdf:first sg:person.014440054532.58
149 rdf:rest Ne08e27f030ab4ee0a761fed8feaa1f36
150 N9173bec07cda4688839fb47b2cc9da97 rdf:first Ne57af25ac1464188945c7899d9afd863
151 rdf:rest Nce2a4138c9174847ba95bd996a58703e
152 N95128cf604f648238200599a8ece44b1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
153 schema:name Cell Survival
154 rdf:type schema:DefinedTerm
155 N9730d03ab8e14c46bab31fe60066b6c3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
156 schema:name Drosophila Proteins
157 rdf:type schema:DefinedTerm
158 N9c8cd031ef2d4b57ba9912255a4e30df schema:name dimensions_id
159 schema:value pub.1007194299
160 rdf:type schema:PropertyValue
161 Na0dc84574cf3438db9fba5319a07a86f rdf:first sg:person.0645163250.43
162 rdf:rest N4a5300fb758348e2bb9f39b3d3fe0bfa
163 Na67a6ff4576942acb71c5189866d4287 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
164 schema:name Female
165 rdf:type schema:DefinedTerm
166 Nba6993d0e40b4f83bf7d4b5c2a66e55c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
167 schema:name Drosophila melanogaster
168 rdf:type schema:DefinedTerm
169 Nc0d0bee7a3d241bbbd3e3490535a4611 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
170 schema:name Cell Size
171 rdf:type schema:DefinedTerm
172 Nce2a4138c9174847ba95bd996a58703e rdf:first sg:person.0614146413.18
173 rdf:rest N2b3cb471cee14076b072aa49d7b97503
174 Nd133994b5525487f904cbecd11d86d09 schema:name doi
175 schema:value 10.1038/sj.onc.1203739
176 rdf:type schema:PropertyValue
177 Nd8ab2e126775469abec5d195755c080c schema:volumeNumber 19
178 rdf:type schema:PublicationVolume
179 Nde14addc9a2c446a86a949c43c803951 rdf:first sg:person.0661466206.52
180 rdf:rest N3d0684112e4441b5b5671351f570d934
181 Nde89802415f94d86afbeeb4a9b8bbe56 schema:name pubmed_id
182 schema:value 10962553
183 rdf:type schema:PropertyValue
184 Ne08e27f030ab4ee0a761fed8feaa1f36 rdf:first sg:person.0731233037.88
185 rdf:rest N63f4732130ca4010b405c7d79c77875e
186 Ne57af25ac1464188945c7899d9afd863 schema:affiliation grid-institutes:grid.417979.5
187 schema:familyName Snow
188 schema:givenName Brian
189 rdf:type schema:Person
190 Nf1c9e1392a004484b5604338e8eadd77 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
191 schema:name Eye
192 rdf:type schema:DefinedTerm
193 Nf387aa91a244430197d3868f60f67400 schema:name Springer Nature - SN SciGraph project
194 rdf:type schema:Organization
195 Nff44749e535847c19015bea2d245e349 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
196 schema:name Proto-Oncogene Proteins
197 rdf:type schema:DefinedTerm
198 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
199 schema:name Medical and Health Sciences
200 rdf:type schema:DefinedTerm
201 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
202 schema:name Clinical Sciences
203 rdf:type schema:DefinedTerm
204 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
205 schema:name Oncology and Carcinogenesis
206 rdf:type schema:DefinedTerm
207 sg:journal.1097543 schema:issn 0950-9232
208 1476-5594
209 schema:name Oncogene
210 schema:publisher Springer Nature
211 rdf:type schema:Periodical
212 sg:person.01114052246.50 schema:affiliation grid-institutes:grid.17063.33
213 schema:familyName Ruel
214 schema:givenName Laurent
215 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01114052246.50
216 rdf:type schema:Person
217 sg:person.01270401450.92 schema:affiliation grid-institutes:grid.17063.33
218 schema:familyName Manoukian
219 schema:givenName Armen S
220 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01270401450.92
221 rdf:type schema:Person
222 sg:person.01274344476.59 schema:affiliation grid-institutes:grid.17063.33
223 schema:familyName Binari
224 schema:givenName Richard C
225 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01274344476.59
226 rdf:type schema:Person
227 sg:person.01324346023.96 schema:affiliation grid-institutes:grid.417979.5
228 schema:familyName Bouchard
229 schema:givenName Denis
230 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01324346023.96
231 rdf:type schema:Person
232 sg:person.014440054532.58 schema:affiliation grid-institutes:grid.417979.5
233 schema:familyName Mak
234 schema:givenName Tak W
235 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014440054532.58
236 rdf:type schema:Person
237 sg:person.0614146413.18 schema:affiliation grid-institutes:grid.417979.5
238 schema:familyName Stambolic
239 schema:givenName Vuk
240 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0614146413.18
241 rdf:type schema:Person
242 sg:person.0645163250.43 schema:affiliation grid-institutes:grid.17063.33
243 schema:familyName Scanga
244 schema:givenName Sam E
245 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0645163250.43
246 rdf:type schema:Person
247 sg:person.0661466206.52 schema:affiliation grid-institutes:grid.417979.5
248 schema:familyName Peters
249 schema:givenName Malte
250 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0661466206.52
251 rdf:type schema:Person
252 sg:person.0731233037.88 schema:affiliation grid-institutes:grid.17063.33
253 schema:familyName Woodgett
254 schema:givenName James R
255 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0731233037.88
256 rdf:type schema:Person
257 sg:pub.10.1038/12961 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045874074
258 https://doi.org/10.1038/12961
259 rdf:type schema:CreativeWork
260 sg:pub.10.1038/376599a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019263292
261 https://doi.org/10.1038/376599a0
262 rdf:type schema:CreativeWork
263 sg:pub.10.1038/385544a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031372205
264 https://doi.org/10.1038/385544a0
265 rdf:type schema:CreativeWork
266 sg:pub.10.1038/70293 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008487521
267 https://doi.org/10.1038/70293
268 rdf:type schema:CreativeWork
269 grid-institutes:grid.17063.33 schema:alternateName Department of Medical Biophysics, Division of Cell and Molecular Biology, Ontario Cancer Institute, University Health Network, Princess Margaret Hospital, University of Toronto, 610 University Avenue, M5G 2M9, Toronto, Ontario, Canada
270 Department of Medical Biophysics, Division of Experimental Therapeutics, Ontario Cancer Institute, University Health Network, Princess Margaret Hospital, University of Toronto, 610 University Avenue, M5G 2M9, Toronto, Ontario, Canada
271 Electron Microscopy Unit, Medical Sciences Building, Faculty of Medicine, University of Toronto, 8 Taddle Creek Road, M5S 1A8, Toronto, Ontario, Canada
272 schema:name Department of Medical Biophysics, Division of Cell and Molecular Biology, Ontario Cancer Institute, University Health Network, Princess Margaret Hospital, University of Toronto, 610 University Avenue, M5G 2M9, Toronto, Ontario, Canada
273 Department of Medical Biophysics, Division of Experimental Therapeutics, Ontario Cancer Institute, University Health Network, Princess Margaret Hospital, University of Toronto, 610 University Avenue, M5G 2M9, Toronto, Ontario, Canada
274 Electron Microscopy Unit, Medical Sciences Building, Faculty of Medicine, University of Toronto, 8 Taddle Creek Road, M5S 1A8, Toronto, Ontario, Canada
275 rdf:type schema:Organization
276 grid-institutes:grid.417979.5 schema:alternateName Amgen Research Institute, 620 University Avenue, M5G 2C1, Toronto, Ontario, Canada
277 schema:name Amgen Research Institute, 620 University Avenue, M5G 2C1, Toronto, Ontario, Canada
278 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...