The Rgr oncogene (homologous to RalGDS) induces transformation and gene expression by activating Ras, Ral and Rho mediated pathways View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2000-05-31

AUTHORS

Inmaculada Hernandez-Muñoz, Marcos Malumbres, Peter Leonardi, Angel Pellicer

ABSTRACT

The effects of the 5′-truncated Rgr oncogene, a previously shown specific guanine exchange factor for Ral in vitro, in stimulating proliferation, cell transformation and gene expression were investigated. We have established TetRgr cell lines in which expression of Rgr can be inhibited by the presence of tetracycline in the medium. Using this system, we show that Rgr overexpressing cells are morphologically transformed and grow in a disorganized manner. At the transcriptional level, Rgr enhances the activity of the serum response element and c-Jun. Rgr induces phosphorylation of ERKs, p38 and JNK kinases, and increases the levels of the GTP-bound forms of Ral and Ras. Ras activation could account for the broad spectra of effects displayed by Rgr. The important role of these pathways is confirmed by experiments in which the transcriptional activation events can be blocked by dominant negative versions of Ras, Ral and Rho. Among all the Rgr-induced pathways, the Ras-Raf-MEK-ERK cascade is essential for the transforming properties of Rgr. Additional analysis has shown that the activation of this pathway by Rgr is not due to a feed back mechanism mediated by the Grb2 adaptor protein. More... »

PAGES

2745-2757

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/sj.onc.1203586

DOI

http://dx.doi.org/10.1038/sj.onc.1203586

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1045326036

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/10851075


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "3T3 Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Division", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Line", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Transformation, Neoplastic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cytoskeleton", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Eye Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Expression Regulation, Neoplastic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genes, jun", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mitogen-Activated Protein Kinases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Receptors, Cell Surface", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Receptors, G-Protein-Coupled", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Response Elements", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Signal Transduction", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "ral GTP-Binding Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "ral Guanine Nucleotide Exchange Factor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "ras Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "rho GTP-Binding Proteins", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Pathology and Kaplan Cancer Center, New York University Medical Center, 10016, New York, NY, USA", 
          "id": "http://www.grid.ac/institutes/grid.240324.3", 
          "name": [
            "Department of Pathology and Kaplan Cancer Center, New York University Medical Center, 10016, New York, NY, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hernandez-Mu\u00f1oz", 
        "givenName": "Inmaculada", 
        "id": "sg:person.0702746040.00", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0702746040.00"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pathology and Kaplan Cancer Center, New York University Medical Center, 10016, New York, NY, USA", 
          "id": "http://www.grid.ac/institutes/grid.240324.3", 
          "name": [
            "Department of Pathology and Kaplan Cancer Center, New York University Medical Center, 10016, New York, NY, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Malumbres", 
        "givenName": "Marcos", 
        "id": "sg:person.0716321250.19", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0716321250.19"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pathology and Kaplan Cancer Center, New York University Medical Center, 10016, New York, NY, USA", 
          "id": "http://www.grid.ac/institutes/grid.240324.3", 
          "name": [
            "Department of Pathology and Kaplan Cancer Center, New York University Medical Center, 10016, New York, NY, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Leonardi", 
        "givenName": "Peter", 
        "id": "sg:person.01136341361.47", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01136341361.47"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pathology and Kaplan Cancer Center, New York University Medical Center, 10016, New York, NY, USA", 
          "id": "http://www.grid.ac/institutes/grid.240324.3", 
          "name": [
            "Department of Pathology and Kaplan Cancer Center, New York University Medical Center, 10016, New York, NY, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pellicer", 
        "givenName": "Angel", 
        "id": "sg:person.012076377472.07", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012076377472.07"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/366643a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005902014", 
          "https://doi.org/10.1038/366643a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1202834", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051601201", 
          "https://doi.org/10.1038/sj.onc.1202834"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1202174", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031087200", 
          "https://doi.org/10.1038/sj.onc.1202174"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1200950", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046300254", 
          "https://doi.org/10.1038/sj.onc.1200950"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1201005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011064863", 
          "https://doi.org/10.1038/sj.onc.1201005"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1201520", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006669082", 
          "https://doi.org/10.1038/sj.onc.1201520"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2000-05-31", 
    "datePublishedReg": "2000-05-31", 
    "description": "The effects of the 5\u2032-truncated Rgr oncogene, a previously shown specific guanine exchange factor for Ral in vitro, in stimulating proliferation, cell transformation and gene expression were investigated. We have established TetRgr cell lines in which expression of Rgr can be inhibited by the presence of tetracycline in the medium. Using this system, we show that Rgr overexpressing cells are morphologically transformed and grow in a disorganized manner. At the transcriptional level, Rgr enhances the activity of the serum response element and c-Jun. Rgr induces phosphorylation of ERKs, p38 and JNK kinases, and increases the levels of the GTP-bound forms of Ral and Ras. Ras activation could account for the broad spectra of effects displayed by Rgr. The important role of these pathways is confirmed by experiments in which the transcriptional activation events can be blocked by dominant negative versions of Ras, Ral and Rho. Among all the Rgr-induced pathways, the Ras-Raf-MEK-ERK cascade is essential for the transforming properties of Rgr. Additional analysis has shown that the activation of this pathway by Rgr is not due to a feed back mechanism mediated by the Grb2 adaptor protein.", 
    "genre": "article", 
    "id": "sg:pub.10.1038/sj.onc.1203586", 
    "inLanguage": "en", 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2634269", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2467699", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2470266", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1097543", 
        "issn": [
          "0950-9232", 
          "1476-5594"
        ], 
        "name": "Oncogene", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "23", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "19"
      }
    ], 
    "keywords": [
      "Rgr oncogene", 
      "gene expression", 
      "Grb2 adaptor protein", 
      "guanine exchange factor", 
      "dominant-negative version", 
      "serum response element", 
      "transcriptional activation events", 
      "MEK-ERK cascade", 
      "exchange factor", 
      "adaptor protein", 
      "Ras-Raf", 
      "phosphorylation of ERK", 
      "Ras activation", 
      "JNK kinase", 
      "transcriptional level", 
      "negative version", 
      "response element", 
      "cell transformation", 
      "overexpressing cells", 
      "RGR", 
      "activation events", 
      "cell lines", 
      "pathway", 
      "presence of tetracycline", 
      "oncogene", 
      "expression", 
      "Ral", 
      "Rho", 
      "RA", 
      "important role", 
      "disorganized manner", 
      "activation", 
      "broad spectrum", 
      "kinase", 
      "phosphorylation", 
      "GTP", 
      "ERK", 
      "p38", 
      "protein", 
      "cascade", 
      "proliferation", 
      "cells", 
      "mechanism", 
      "role", 
      "levels", 
      "lines", 
      "activity", 
      "manner", 
      "Additional analyses", 
      "transformation", 
      "events", 
      "presence", 
      "effect", 
      "feed", 
      "factors", 
      "medium", 
      "analysis", 
      "elements", 
      "form", 
      "tetracycline", 
      "experiments", 
      "system", 
      "properties", 
      "spectra", 
      "version", 
      "specific guanine exchange factor", 
      "TetRgr cell lines", 
      "expression of Rgr", 
      "Rgr overexpressing cells", 
      "forms of Ral", 
      "Rgr-induced pathways", 
      "properties of Rgr"
    ], 
    "name": "The Rgr oncogene (homologous to RalGDS) induces transformation and gene expression by activating Ras, Ral and Rho mediated pathways", 
    "pagination": "2745-2757", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1045326036"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/sj.onc.1203586"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "10851075"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/sj.onc.1203586", 
      "https://app.dimensions.ai/details/publication/pub.1045326036"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2021-11-01T18:03", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20211101/entities/gbq_results/article/article_310.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1038/sj.onc.1203586"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/sj.onc.1203586'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/sj.onc.1203586'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/sj.onc.1203586'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/sj.onc.1203586'


 

This table displays all metadata directly associated to this object as RDF triples.

265 TRIPLES      22 PREDICATES      124 URIs      109 LITERALS      26 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/sj.onc.1203586 schema:about N18126e8764714653a4ab742a5315e901
2 N1b32585c4f9c402fbfa4008cec10a37f
3 N45330f1ea1db499fad8fb9d9bf4719f8
4 N47ac9fc35458434fabcba02a685ebbda
5 N47c9a7bbdd6c4441b2723d4f8c2137c9
6 N6acf254890624204a555cd4293b6d62b
7 N7071f463350045eaa143c5aadea6ea70
8 N82a42835f9644542a1b2ba475ff774c6
9 N964a231531cf415387156203389be391
10 N9e92fe9f87f4486a9b707b3a27ad4567
11 N9edf529d4ec748f5a60669f4bf76bc2a
12 Na3caf03398774c2d812e1f967b6b2deb
13 Naf0faefe449b4469856b88188373b5fc
14 Nb5b8c1df312149fda25250da5a16a90e
15 Nba489ae332754ae8beb069a0f25dcaa3
16 Ne54fd124dc8e4bc2933220852aca794e
17 Nea7b11fcdde14dd3bbb99cd2cc426b41
18 Nf005ae9fb34845159303ecf11e1894f9
19 Nfe8cb6a7ebf94f18a60dbc49a698d1da
20 anzsrc-for:11
21 anzsrc-for:1103
22 anzsrc-for:1112
23 schema:author N7db46b39713d44d28d9935567b91611d
24 schema:citation sg:pub.10.1038/366643a0
25 sg:pub.10.1038/sj.onc.1200950
26 sg:pub.10.1038/sj.onc.1201005
27 sg:pub.10.1038/sj.onc.1201520
28 sg:pub.10.1038/sj.onc.1202174
29 sg:pub.10.1038/sj.onc.1202834
30 schema:datePublished 2000-05-31
31 schema:datePublishedReg 2000-05-31
32 schema:description The effects of the 5′-truncated Rgr oncogene, a previously shown specific guanine exchange factor for Ral in vitro, in stimulating proliferation, cell transformation and gene expression were investigated. We have established TetRgr cell lines in which expression of Rgr can be inhibited by the presence of tetracycline in the medium. Using this system, we show that Rgr overexpressing cells are morphologically transformed and grow in a disorganized manner. At the transcriptional level, Rgr enhances the activity of the serum response element and c-Jun. Rgr induces phosphorylation of ERKs, p38 and JNK kinases, and increases the levels of the GTP-bound forms of Ral and Ras. Ras activation could account for the broad spectra of effects displayed by Rgr. The important role of these pathways is confirmed by experiments in which the transcriptional activation events can be blocked by dominant negative versions of Ras, Ral and Rho. Among all the Rgr-induced pathways, the Ras-Raf-MEK-ERK cascade is essential for the transforming properties of Rgr. Additional analysis has shown that the activation of this pathway by Rgr is not due to a feed back mechanism mediated by the Grb2 adaptor protein.
33 schema:genre article
34 schema:inLanguage en
35 schema:isAccessibleForFree true
36 schema:isPartOf N91610097819343979ab52ac217045bd7
37 Nc2060482484240ecafb66a074974b9be
38 sg:journal.1097543
39 schema:keywords Additional analyses
40 ERK
41 GTP
42 Grb2 adaptor protein
43 JNK kinase
44 MEK-ERK cascade
45 RA
46 RGR
47 Ral
48 Ras activation
49 Ras-Raf
50 Rgr oncogene
51 Rgr overexpressing cells
52 Rgr-induced pathways
53 Rho
54 TetRgr cell lines
55 activation
56 activation events
57 activity
58 adaptor protein
59 analysis
60 broad spectrum
61 cascade
62 cell lines
63 cell transformation
64 cells
65 disorganized manner
66 dominant-negative version
67 effect
68 elements
69 events
70 exchange factor
71 experiments
72 expression
73 expression of Rgr
74 factors
75 feed
76 form
77 forms of Ral
78 gene expression
79 guanine exchange factor
80 important role
81 kinase
82 levels
83 lines
84 manner
85 mechanism
86 medium
87 negative version
88 oncogene
89 overexpressing cells
90 p38
91 pathway
92 phosphorylation
93 phosphorylation of ERK
94 presence
95 presence of tetracycline
96 proliferation
97 properties
98 properties of Rgr
99 protein
100 response element
101 role
102 serum response element
103 specific guanine exchange factor
104 spectra
105 system
106 tetracycline
107 transcriptional activation events
108 transcriptional level
109 transformation
110 version
111 schema:name The Rgr oncogene (homologous to RalGDS) induces transformation and gene expression by activating Ras, Ral and Rho mediated pathways
112 schema:pagination 2745-2757
113 schema:productId N22ebef1b19d241de87cdfd305f355ba9
114 N7cf4eb2941484b528c0e3e8098e282fb
115 Na4728a590f7343b0898a79fad7d0fc6f
116 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045326036
117 https://doi.org/10.1038/sj.onc.1203586
118 schema:sdDatePublished 2021-11-01T18:03
119 schema:sdLicense https://scigraph.springernature.com/explorer/license/
120 schema:sdPublisher N910284fcab13455da3064c0f99180ff0
121 schema:url https://doi.org/10.1038/sj.onc.1203586
122 sgo:license sg:explorer/license/
123 sgo:sdDataset articles
124 rdf:type schema:ScholarlyArticle
125 N18126e8764714653a4ab742a5315e901 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
126 schema:name Response Elements
127 rdf:type schema:DefinedTerm
128 N1b32585c4f9c402fbfa4008cec10a37f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
129 schema:name Mitogen-Activated Protein Kinases
130 rdf:type schema:DefinedTerm
131 N22ebef1b19d241de87cdfd305f355ba9 schema:name dimensions_id
132 schema:value pub.1045326036
133 rdf:type schema:PropertyValue
134 N273bd4eb35de4018a8e1a70217540b71 rdf:first sg:person.012076377472.07
135 rdf:rest rdf:nil
136 N37d3b63b59874fac8cb26b9927d61c35 rdf:first sg:person.01136341361.47
137 rdf:rest N273bd4eb35de4018a8e1a70217540b71
138 N45330f1ea1db499fad8fb9d9bf4719f8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
139 schema:name ral GTP-Binding Proteins
140 rdf:type schema:DefinedTerm
141 N47ac9fc35458434fabcba02a685ebbda schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
142 schema:name Cell Line
143 rdf:type schema:DefinedTerm
144 N47c9a7bbdd6c4441b2723d4f8c2137c9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name Genes, jun
146 rdf:type schema:DefinedTerm
147 N6acf254890624204a555cd4293b6d62b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
148 schema:name Receptors, Cell Surface
149 rdf:type schema:DefinedTerm
150 N7071f463350045eaa143c5aadea6ea70 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
151 schema:name Gene Expression Regulation, Neoplastic
152 rdf:type schema:DefinedTerm
153 N7cf4eb2941484b528c0e3e8098e282fb schema:name pubmed_id
154 schema:value 10851075
155 rdf:type schema:PropertyValue
156 N7db46b39713d44d28d9935567b91611d rdf:first sg:person.0702746040.00
157 rdf:rest N8bbc890cacf0403b92ce30bcddf636fc
158 N82a42835f9644542a1b2ba475ff774c6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
159 schema:name Cytoskeleton
160 rdf:type schema:DefinedTerm
161 N8bbc890cacf0403b92ce30bcddf636fc rdf:first sg:person.0716321250.19
162 rdf:rest N37d3b63b59874fac8cb26b9927d61c35
163 N910284fcab13455da3064c0f99180ff0 schema:name Springer Nature - SN SciGraph project
164 rdf:type schema:Organization
165 N91610097819343979ab52ac217045bd7 schema:issueNumber 23
166 rdf:type schema:PublicationIssue
167 N964a231531cf415387156203389be391 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
168 schema:name ras Proteins
169 rdf:type schema:DefinedTerm
170 N9e92fe9f87f4486a9b707b3a27ad4567 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
171 schema:name Animals
172 rdf:type schema:DefinedTerm
173 N9edf529d4ec748f5a60669f4bf76bc2a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
174 schema:name Cell Transformation, Neoplastic
175 rdf:type schema:DefinedTerm
176 Na3caf03398774c2d812e1f967b6b2deb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
177 schema:name Signal Transduction
178 rdf:type schema:DefinedTerm
179 Na4728a590f7343b0898a79fad7d0fc6f schema:name doi
180 schema:value 10.1038/sj.onc.1203586
181 rdf:type schema:PropertyValue
182 Naf0faefe449b4469856b88188373b5fc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
183 schema:name 3T3 Cells
184 rdf:type schema:DefinedTerm
185 Nb5b8c1df312149fda25250da5a16a90e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
186 schema:name ral Guanine Nucleotide Exchange Factor
187 rdf:type schema:DefinedTerm
188 Nba489ae332754ae8beb069a0f25dcaa3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
189 schema:name Receptors, G-Protein-Coupled
190 rdf:type schema:DefinedTerm
191 Nc2060482484240ecafb66a074974b9be schema:volumeNumber 19
192 rdf:type schema:PublicationVolume
193 Ne54fd124dc8e4bc2933220852aca794e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
194 schema:name rho GTP-Binding Proteins
195 rdf:type schema:DefinedTerm
196 Nea7b11fcdde14dd3bbb99cd2cc426b41 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
197 schema:name Eye Proteins
198 rdf:type schema:DefinedTerm
199 Nf005ae9fb34845159303ecf11e1894f9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
200 schema:name Cell Division
201 rdf:type schema:DefinedTerm
202 Nfe8cb6a7ebf94f18a60dbc49a698d1da schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
203 schema:name Mice
204 rdf:type schema:DefinedTerm
205 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
206 schema:name Medical and Health Sciences
207 rdf:type schema:DefinedTerm
208 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
209 schema:name Clinical Sciences
210 rdf:type schema:DefinedTerm
211 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
212 schema:name Oncology and Carcinogenesis
213 rdf:type schema:DefinedTerm
214 sg:grant.2467699 http://pending.schema.org/fundedItem sg:pub.10.1038/sj.onc.1203586
215 rdf:type schema:MonetaryGrant
216 sg:grant.2470266 http://pending.schema.org/fundedItem sg:pub.10.1038/sj.onc.1203586
217 rdf:type schema:MonetaryGrant
218 sg:grant.2634269 http://pending.schema.org/fundedItem sg:pub.10.1038/sj.onc.1203586
219 rdf:type schema:MonetaryGrant
220 sg:journal.1097543 schema:issn 0950-9232
221 1476-5594
222 schema:name Oncogene
223 schema:publisher Springer Nature
224 rdf:type schema:Periodical
225 sg:person.01136341361.47 schema:affiliation grid-institutes:grid.240324.3
226 schema:familyName Leonardi
227 schema:givenName Peter
228 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01136341361.47
229 rdf:type schema:Person
230 sg:person.012076377472.07 schema:affiliation grid-institutes:grid.240324.3
231 schema:familyName Pellicer
232 schema:givenName Angel
233 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012076377472.07
234 rdf:type schema:Person
235 sg:person.0702746040.00 schema:affiliation grid-institutes:grid.240324.3
236 schema:familyName Hernandez-Muñoz
237 schema:givenName Inmaculada
238 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0702746040.00
239 rdf:type schema:Person
240 sg:person.0716321250.19 schema:affiliation grid-institutes:grid.240324.3
241 schema:familyName Malumbres
242 schema:givenName Marcos
243 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0716321250.19
244 rdf:type schema:Person
245 sg:pub.10.1038/366643a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005902014
246 https://doi.org/10.1038/366643a0
247 rdf:type schema:CreativeWork
248 sg:pub.10.1038/sj.onc.1200950 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046300254
249 https://doi.org/10.1038/sj.onc.1200950
250 rdf:type schema:CreativeWork
251 sg:pub.10.1038/sj.onc.1201005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011064863
252 https://doi.org/10.1038/sj.onc.1201005
253 rdf:type schema:CreativeWork
254 sg:pub.10.1038/sj.onc.1201520 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006669082
255 https://doi.org/10.1038/sj.onc.1201520
256 rdf:type schema:CreativeWork
257 sg:pub.10.1038/sj.onc.1202174 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031087200
258 https://doi.org/10.1038/sj.onc.1202174
259 rdf:type schema:CreativeWork
260 sg:pub.10.1038/sj.onc.1202834 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051601201
261 https://doi.org/10.1038/sj.onc.1202834
262 rdf:type schema:CreativeWork
263 grid-institutes:grid.240324.3 schema:alternateName Department of Pathology and Kaplan Cancer Center, New York University Medical Center, 10016, New York, NY, USA
264 schema:name Department of Pathology and Kaplan Cancer Center, New York University Medical Center, 10016, New York, NY, USA
265 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...